All Stories

  1. Ergothioneine Suppresses Amyloid β-Induced Tau Phosphorylation and Cytotoxicity by Inactivating Glycogen Synthase Kinase-3β in Cultured Neurons

    Article • Current Molecular Pharmacologye, June 2025, Elsevier

    Noritaka Nakamichi

  2. Depression-like Behavior Induced by Repeated Administration of Dexamethasone to Lipopolysaccharide-inflamed Mice

    Article • Current Molecular Pharmacologye, February 2024, Elsevier

    Noritaka Nakamichi

  3. Ergothioneine and central nervous system diseases

    Article • Neurochemical Research, July 2022, Springer Science + Business Media

    Noritaka Nakamichi

  4. Oral Administration of the Food-Derived Hydrophilic Antioxidant Ergothioneine Enhances Object Recognition Memory in Mice

    Article • Current Molecular Pharmacologye, December 2020, Bentham Science Publishers

    Noritaka Nakamichi

  5. Homostachydrine is a Xenobiotic Substrate of OCTN1/SLC22A4 and Potentially Sensitizes Pentylenetetrazole-Induced Seizures in Mice

    Article • Neurochemical Research, August 2020, Springer Science + Business Media

    Noritaka Nakamichi

  6. Metabolome Analysis Reveals Dermal Histamine Accumulation in Murine Dermatitis Provoked by Genetic Deletion of P-Glycoprotein and Breast Cancer Resistance Protein

    Article • Pharmaceutical Research, September 2019, Springer Science + Business Media

    Noritaka Nakamichi

  7. Bile Duct Obstruction Leads to Increased Intestinal Expression of Breast Cancer Resistance Protein With Reduced Gastrointestinal Absorption of Imatinib

    Article • Journal of Pharmaceutical Sciences, September 2019, Elsevier

    Noritaka Nakamichi

  8. Maturational Characterization of Mouse Cortical Neurons Three-Dimensionally Cultured in Functional Polymer FP001-Containing Medium

    Article • Biological and Pharmaceutical Bulletin, September 2019, Pharmaceutical Society of Japan

    Noritaka Nakamichi

  9. Elucidation of the Mechanisms Underlying Regulation of Somatic Stem Cell Function: Possible Application to the Treatment of Neuropsychiatric, Metabolic Bone, and Lifestyle Diseases

    Article • YAKUGAKU ZASSHI, June 2019, Pharmaceutical Society of Japan

    Noritaka Nakamichi

  10. Influx and Efflux Transporters Contribute to the Increased Dermal Exposure to Active Metabolite of Regorafenib After Repeated Oral Administration in Mice

    Article • Journal of Pharmaceutical Sciences, June 2019, Elsevier

    Noritaka Nakamichi

  11. Possible Treatment of Neuropsychiatric Disorders by Promotion of Neuronal Differentiation through Organic Cation Transporters

    Article • YAKUGAKU ZASSHI, June 2019, Pharmaceutical Society of Japan

    Noritaka Nakamichi

  12. Hydrolyzed Salmon Milt Extract Enhances Object Recognition and Location Memory Through an Increase in Hippocampal Cytidine Nucleoside Levels in Normal Mice

    Article • Journal of Medicinal Food, April 2019, SAGE Publications

    Noritaka Nakamichi

  13. Ergothioneine-induced neuronal differentiation is mediated through activation of S6K1 and neurotrophin 4/5-TrkB signaling in murine neural stem cells

    Article • Cellular Signalling, January 2019, Elsevier

    Noritaka Nakamichi

  14. Combination Metabolomics Approach for Identifying Endogenous Substrates of Carnitine/Organic Cation Transporter OCTN1

    Article • Pharmaceutical Research, October 2018, Springer Science + Business Media

    Noritaka Nakamichi

  15. Carnitine/Organic Cation Transporter OCTN1 Negatively Regulates Activation in Murine Cultured Microglial Cells

    Article • Neurochemical Research, January 2018, Springer Science + Business Media

    Noritaka Nakamichi

  16. Organic Cation Transporter 1 Is Responsible for Hepatocellular Uptake of the Tyrosine Kinase Inhibitor Pazopanib

    Article • Drug Metabolism and Disposition, October 2017, American Society for Pharmacology & Experimental Therapeutics (ASPET)

    Noritaka Nakamichi

  17. Usefulness of kidney slices for functional analysis of apical reabsorptive transporters

    Article • Scientific Reports, October 2017, Springer Science + Business Media

    Takeo Nakanishi, Noritaka Nakamichi

  18. Involvement of the Transporters P-Glycoprotein and Breast Cancer Resistance Protein in Dermal Distribution of the Multikinase Inhibitor Regorafenib and Its Active Metabolites

    Article • Journal of Pharmaceutical Sciences, September 2017, Elsevier

    Noritaka Nakamichi

  19. P-Glycoprotein in skin contributes to transdermal absorption of topical corticosteroids

    Article • International Journal of Pharmaceutics, April 2017, Elsevier

    Noritaka Nakamichi

  20. Utilization of Liver Microsomes to Estimate Hepatic Intrinsic Clearance of Monoamine Oxidase Substrate Drugs in Humans

    Article • Pharmaceutical Research, March 2017, Springer Science + Business Media

    Noritaka Nakamichi

  21. Physiological Roles of Carnitine/Organic Cation Transporter OCTN1/SLC22A4 in Neural Cells

    Article • Biological and Pharmaceutical Bulletin, January 2017, Pharmaceutical Society of Japan

    Noritaka Nakamichi

  22. L503F variant of carnitine/organic cation transporter 1 efficiently transports metformin and other biguanides

    Article • Journal of Pharmacy and Pharmacology, September 2016, Oxford University Press (OUP)

    Noritaka Nakamichi

  23. Characterization of Long-Lasting Oatp Inhibition by Typical Inhibitor Cyclosporine A and In Vitro–In Vivo Discrepancy in Its Drug Interaction Potential in Rats

    Article • Journal of Pharmaceutical Sciences, July 2016, Elsevier

    Noritaka Nakamichi

  24. Critical evaluation and methodological positioning of the transdermal microdialysis technique. A review

    Article • Journal of Controlled Release, July 2016, Elsevier

    Noritaka Nakamichi

  25. Localization of Xenobiotic Transporter OCTN1/SLC22A4 in Hepatic Stellate Cells and Its Protective Role in Liver Fibrosis

    Article • Journal of Pharmaceutical Sciences, May 2016, Elsevier

    Noritaka Nakamichi

  26. Food‐derived hydrophilic antioxidant ergothioneine is distributed to the brain and exerts antidepressant effect in mice

    Article • Brain and Behavior, April 2016, Wiley

    Noritaka Nakamichi

  27. A mutation in SLC22A4 encoding an organic cation transporter expressed in the cochlea strial endothelium causes human recessive non-syndromic hearing loss DFNB60

    Article • Human Genetics, March 2016, Springer Science + Business Media

    Noritaka Nakamichi

  28. Possible activation by the green tea amino acid theanine of mammalian target of rapamycin signaling in undifferentiated neural progenitor cells in vitro

    Article • Biochemistry and Biophysics Reports, March 2016, Elsevier

    Noritaka Nakamichi

  29. Screening to Identify Multidrug Resistance-Associated Protein Inhibitors with Neuroblastoma-Selective Cytotoxicity

    Article • Biological and Pharmaceutical Bulletin, January 2016, Pharmaceutical Society of Japan

    Noritaka Nakamichi

  30. Organic cation transporter Octn1-mediated uptake of food-derived antioxidant ergothioneine into infiltrating macrophages during intestinal inflammation in mice

    Article • Drug Metabolism and Pharmacokinetics, June 2015, Elsevier

    Noritaka Nakamichi

  31. Upregulation of Slc38a1 Gene Along with Promotion of Neurosphere Growth and Subsequent Neuronal Specification in Undifferentiated Neural Progenitor Cells Exposed to Theanine

    Article • Neurochemical Research, May 2015, Springer Science + Business Media

    Noritaka Nakamichi

  32. Daily oral intake of theanine prevents the decline of 5-bromo-2′-deoxyuridine incorporation in hippocampal dentate gyrus with concomitant alleviation of behavioral abnormalities in adult mice with severe traumatic stress

    Article • Journal of Pharmacological Sciences, March 2015, Elsevier

    Noritaka Nakamichi

  33. Gene Ablation of Carnitine/Organic Cation Transporter 1 Reduces Gastrointestinal Absorption of 5-Aminosalicylate in Mice

    Article • Biological and Pharmaceutical Bulletin, January 2015, Pharmaceutical Society of Japan

    Noritaka Nakamichi

  34. Interaction of Novel Platelet-Increasing Agent Eltrombopag with Rosuvastatin via Breast Cancer Resistance Protein in Humans

    Article • Drug Metabolism and Disposition, April 2014, Elsevier

    Noritaka Nakamichi

  35. Organic Cation Transporter-Mediated Ergothioneine Uptake in Mouse Neural Progenitor Cells Suppresses Proliferation and Promotes Differentiation into Neurons

    Article • PLOS One, February 2014, PLOS

    Noritaka Nakamichi

  36. Involvement of Carnitine/Organic Cation Transporter OCTN1/SLC22A4 in Gastrointestinal Absorption of Metformin

    Article • Journal of Pharmaceutical Sciences, September 2013, Elsevier

    Noritaka Nakamichi

  37. Direct Inhibition and Down-regulation by Uremic Plasma Components of Hepatic Uptake Transporter for SN-38, an Active Metabolite of Irinotecan, in Humans

    Article • Pharmaceutical Research, August 2013, Springer Science + Business Media

    Noritaka Nakamichi

  38. Myosin VI Reduces Proliferation, but Not Differentiation, in Pluripotent P19 Cells

    Article • PLOS One, May 2013, PLOS

    Noritaka Nakamichi

  39. ATP binding cassette transporters in two distinct compartments of the skin contribute to transdermal absorption of a typical substrate

    Article • Journal of Controlled Release, January 2013, Elsevier

    Noritaka Nakamichi

  40. Pharmacokinetic Modeling of Hepatocyte Growth Factor in Experimental Animals and Humans

    Article • Journal of Pharmaceutical Sciences, January 2013, Elsevier

    Noritaka Nakamichi

  41. Role of Organic Cation/Carnitine Transporter 1 in Uptake of Phenformin and Inhibitory Effect on Complex I Respiration in Mitochondria

    Article • Toxicological Sciences, December 2012, Oxford University Press (OUP)

    Noritaka Nakamichi

  42. Functional expression of carnitine/organic cation transporter OCTN1 in mouse brain neurons: Possible involvement in neuronal differentiation

    Article • Neurochemistry International, December 2012, Elsevier

    Noritaka Nakamichi

  43. Promotion of Both Proliferation and Neuronal Differentiation in Pluripotent P19 Cells with Stable Overexpression of the Glutamine Transporter slc38a1

    Article • PLOS One, October 2012, PLOS

    Noritaka Nakamichi

  44. Promoted Neuronal Differentiation after Activation of Alpha4/Beta2 Nicotinic Acetylcholine Receptors in Undifferentiated Neural Progenitors

    Article • PLOS One, October 2012, PLOS

    Noritaka Nakamichi

  45. Possible neuroprotective property of nicotinic acetylcholine receptors in association with predominant upregulation of glial cell line‐derived neurotrophic factor in astrocytes

    Article • Journal of Neuroscience Research, July 2012, Wiley

    Noritaka Nakamichi

  46. Transferrin receptor-1 suppresses neurite outgrowth in neuroblastoma Neuro2A cells

    Article • Neurochemistry International, April 2012, Elsevier

    Noritaka Nakamichi

  47. Delayed Mitochondrial Membrane Potential Disruption by ATP in Cultured Rat Hippocampal Neurons Exposed to <I>N</I>-Methyl-D-Aspartate

    Article • Journal of Pharmacological Sciences, January 2012, Japanese Pharmacological Society

    Noritaka Nakamichi

  48. PDZK1 Regulates Breast Cancer Resistance Protein in Small Intestine

    Article • Drug Metabolism and Disposition, November 2011, Elsevier

    Noritaka Nakamichi

  49. Functional Glutamate Signaling in Neural Progenitor Cells

    Article • YAKUGAKU ZASSHI, September 2011, Pharmaceutical Society of Japan

    Noritaka Nakamichi

  50. A possible pivotal role of mitochondrial free calcium in neurotoxicity mediated by N-methyl-d-aspartate receptors in cultured rat hippocampal neurons

    Article • Neurochemistry International, August 2011, Elsevier

    Noritaka Nakamichi

  51. Pharmacokinetics and Hepatic Uptake of Eltrombopag, a Novel Platelet-Increasing Agent

    Article • Drug Metabolism and Disposition, June 2011, Elsevier

    Noritaka Nakamichi

  52. Exacerbated vulnerability to oxidative stress in astrocytic C6 glioma cells with stable overexpression of the glutamine transporter slc38a1

    Article • Neurochemistry International, March 2011, Elsevier

    Noritaka Nakamichi

  53. Gradual Downregulation of Protein Expression of the Partner GABABR2 Subunit During Postnatal Brain Development in Mice Defective of GABABR1 Subunit

    Article • Journal of Pharmacological Sciences, January 2011, Japanese Pharmacological Society

    Noritaka Nakamichi

  54. Requirement of both NR3A and NR3B subunits for dominant negative properties on Ca2+ mobilization mediated by acquired N-methyl-d-aspartate receptor channels into mitochondria

    Article • Neurochemistry International, December 2010, Elsevier

    Noritaka Nakamichi

  55. Functional Expression of Carnitine/Organic Cation Transporter OCTN1/SLC22A4 in Mouse Small Intestine and Liver

    Article • Drug Metabolism and Disposition, October 2010, Elsevier

    Noritaka Nakamichi

  56. Induced tolerance to glutamate neurotoxicity through down‐regulation of NR2 subunits of N‐methyl‐D‐aspartate receptors in cultured rat striatal neurons

    Article • Journal of Neuroscience Research, June 2010, Wiley

    Noritaka Nakamichi

  57. Preferential inhibition by antidiarrheic 2‐methoxy‐4‐methylphenol of Ca2+ influx across acquired N‐methyl‐D‐aspartate receptor channels composed of NR1/NR2B subunit assembly

    Article • Journal of Neuroscience Research, April 2010, Wiley

    Noritaka Nakamichi

  58. Inhibition by 2-Methoxy-4-ethylphenol of Ca2+ Influx Through Acquired and Native N-Methyl-D-aspartate–Receptor Channels

    Article • Journal of Pharmacological Sciences, January 2010, Japanese Pharmacological Society

    Noritaka Nakamichi

  59. PDZK1 Regulates Organic Anion Transporting Polypeptide Oatpla in Mouse Small Intestine

    Article • Drug Metabolism and Pharmacokinetics, January 2010, Japanese Society for the Study of Xenobiotics

    Noritaka Nakamichi

  60. RAGE-mediated signaling contributes to intraneuronal transport of amyloid-β and neuronal dysfunction

    Article • Proceedings of the National Academy of Sciences, November 2009, Proceedings of the National Academy of Sciences

    Noritaka Nakamichi

  61. A protein–protein interaction of stress‐responsive myosin VI endowed to inhibit neural progenitor self‐replication with RNA binding protein, TLS, in murine hippocampus

    Article • Journal of Neurochemistry, August 2009, Wiley

    Noritaka Nakamichi

  62. Possible promotion of neuronal differentiation in fetal rat brain neural progenitor cells after sustained exposure to static magnetism

    Article • Journal of Neuroscience Research, April 2009, Wiley

    Noritaka Nakamichi

  63. Possible protection by notoginsenoside R1 against glutamate neurotoxicity mediated by N‐methyl‐D‐aspartate receptors composed of an NR1/NR2B subunit assembly

    Article • Journal of Neuroscience Research, February 2009, Wiley

    Noritaka Nakamichi

  64. Neurogenesis Mediated by γ-Aminobutyric Acid and Glutamate Signaling

    Article • Journal of Pharmacological Sciences, January 2009, Japanese Pharmacological Society

    Noritaka Nakamichi

  65. Up‐regulation of ciliary neurotrophic factor receptor expression by GABAA receptors in undifferentiated neural progenitors of fetal mouse brain

    Article • Journal of Neuroscience Research, May 2008, Wiley

    Noritaka Nakamichi

  66. Promotion of neuronal differentiation through activation of N‐methyl‐D‐aspartate receptors transiently expressed by undifferentiated neural progenitor cells in fetal rat neocortex

    Article • Journal of Neuroscience Research, April 2008, Wiley

    Noritaka Nakamichi

  67. Upregulation of Myo6 expression after traumatic stress in mouse hippocampus

    Article • Neuroscience Letters, March 2008, Elsevier

    Noritaka Nakamichi

  68. Modulation of cellular proliferation and differentiation through GABAB receptors expressed by undifferentiated neural progenitor cells isolated from fetal mouse brain

    Article • Journal of Cellular Physiology, February 2008, Wiley

    Noritaka Nakamichi

  69. Group III metabotropic glutamate receptor activation suppresses self‐replication of undifferentiated neocortical progenitor cells

    Article • Journal of Neurochemistry, February 2008, Wiley

    Noritaka Nakamichi

  70. Insensitivity to glutamate neurotoxicity mediated by NMDA receptors in association with delayed mitochondrial membrane potential disruption in cultured rat cortical neurons

    Article • Journal of Neurochemistry, February 2008, Wiley

    Noritaka Nakamichi

  71. Transient suppression of progenitor cell proliferation through NMDA receptors in hippocampal dentate gyrus of mice with traumatic stress experience

    Article • Journal of Neurochemistry, January 2008, Wiley

    Noritaka Nakamichi

  72. Activator protein-1 responsive to the group II metabotropic glutamate receptor subtype in association with intracellular calcium in cultured rat cortical neurons

    Article • Neurochemistry International, December 2007, Elsevier

    Noritaka Nakamichi

  73. Cytoprotective properties of phenolic antidiarrheic ingredients in cultured astrocytes and neurons of rat brains

    Article • European Journal of Pharmacology, July 2007, Elsevier

    Noritaka Nakamichi

  74. Upregulation of the glutamine transporter through transactivation mediated by camp/protein kinase a signals toward exacerbation of vulnerability to oxidative stress in rat neocortical astrocytes

    Article • Journal of Cellular Physiology, May 2007, Wiley

    Noritaka Nakamichi

  75. Dopamine D1 receptors regulate protein synthesis-dependent long-term recognition memory via extracellular signal-regulated kinase 1/2 in the prefrontal cortex

    Article • Learning & Memory, March 2007, Cold Spring Harbor Laboratory Press

    Noritaka Nakamichi

  76. Activation of GABAA receptors facilitates astroglial differentiation induced by ciliary neurotrophic factor in neural progenitors isolated from fetal rat brain

    Article • Journal of Neurochemistry, December 2006, Wiley

    Noritaka Nakamichi

  77. The Rewards of Nicotine: Regulation by Tissue Plasminogen Activator–Plasmin System through Protease Activated Receptor-1

    Article • Journal of Neuroscience, November 2006, Society for Neuroscience

    Noritaka Nakamichi

  78. Involvement of Tissue Plasminogen Activator-Plasmin System in Depolarization-Evoked Dopamine Release in the Nucleus Accumbens of Mice

    Article • Molecular Pharmacology, November 2006, Elsevier

    Noritaka Nakamichi

  79. The magnetism responsive gene Ntan1 in mouse brain

    Article • Neurochemistry International, September 2006, Elsevier

    Noritaka Nakamichi

  80. Glutamate Inhibits Chondral Mineralization through Apoptotic Cell Death Mediated by Retrograde Operation of the Cystine/Glutamate Antiporter

    Article • Journal of Biological Chemistry, August 2006, Elsevier

    Noritaka Nakamichi

  81. Maturation-dependent reduced responsiveness of intracellular free Ca2+ ions to repeated stimulation by N-methyl-d-aspartate in cultured rat cortical neurons

    Article • Neurochemistry International, August 2006, Elsevier

    Noritaka Nakamichi

  82. Functional expression of A glutamine transporter responsive to down‐regulation by lipopolysaccharide through reduced promoter activity in cultured rat neocortical astrocytes

    Article • Journal of Neuroscience Research, March 2006, Wiley

    Noritaka Nakamichi

  83. Chronic vitamin D3treatment protects against neurotoxicity by glutamate in association with upregulation of vitamin D receptor mRNA expression in cultured rat cortical neurons

    Article • Journal of Neuroscience Research, March 2006, Wiley

    Noritaka Nakamichi

  84. Nuclear condensation of cyclic adenosine monophosphate responsive element‐binding protein in discrete murine brain structures

    Article • Journal of Neuroscience Research, May 2005, Wiley

    Noritaka Nakamichi

  85. Protection by exogenous pyruvate through a mechanism related to monocarboxylate transporters against cell death induced by hydrogen peroxide in cultured rat cortical neurons

    Article • Journal of Neurochemistry, February 2005, Wiley

    Noritaka Nakamichi

  86. An increase in intracellular free calcium ions by nicotinic acetylcholine receptors in a single cultured rat cortical astrocyte

    Article • Journal of Neuroscience Research, January 2005, Wiley

    Noritaka Nakamichi

  87. Functional Proteins Involved in Regulation of Intracellular Ca2+ for Drug Development: Desensitization of N-Methyl-D-aspartate Receptor Channels

    Article • Journal of Pharmacological Sciences, January 2005, Japanese Pharmacological Society

    Noritaka Nakamichi

  88. Relevant Modulation by Ferrous Ions of N-Methyl-D-Aspartate Receptors in Ischemic Brain Injuries

    Article • Current Neurovascular Research, December 2004, Bentham Science Publishers

    Noritaka Nakamichi

  89. Effects of intraocular injection of a low concentration of zinc on the rat retina

    Article • Neuropharmacology, October 2003, Elsevier

    Noritaka Nakamichi

  90. Nuclear transcription factors in the hippocampus

    Article • Progress in Neurobiology, October 2002, Elsevier

    Noritaka Nakamichi

  91. Blockade by ferrous iron of Ca2+ influx through N‐methyl‐d‐aspartate receptor channels in immature cultured rat cortical neurons

    Article • Journal of Neurochemistry, September 2002, Wiley

    Noritaka Nakamichi

  92. Activator Protein-1 Complex Expressed by Magnetism in Cultured Rat Hippocampal Neurons

    Article • Biochemical and Biophysical Research Communications, March 2002, Elsevier

    Noritaka Nakamichi

  93. Nuclear Degradation of Particular Fos Family Members Expressed Following Injections of NMDA and Kainate in Murine Hippocampus

    Article • Neurochemical Research, February 2002, Springer Science + Business Media

    Noritaka Nakamichi

  94. Transcription Factors and Drugs in the Brain

    Article • The Japanese Journal of Pharmacology, January 2002, Elsevier

    Noritaka Nakamichi

  95. Dual mechanisms of Ca2+ increases elicited by N‐methyl‐D‐aspartate in immature and mature cultured cortical neurons

    Article • Journal of Neuroscience Research, December 2001, Wiley

    Noritaka Nakamichi

  96. Degradation of c-Fos protein expressed by N-methyl-d-aspartic acid in nuclear fractions of murine hippocampus

    Article • Brain Research, June 2001, Elsevier

    Noritaka Nakamichi

  97. Differential in vitro degradation of particular Fos family members expressed by kainic acid in nuclear and cytosolic fractions of murine hippocampus

    Article • Journal of Neuroscience Research, March 2001, Wiley

    Noritaka Nakamichi