All Stories

  1. Androgens suppress the sialyltransferases ST3GAL1 and ST3GAL4 and modulate mucin 10 glycosylation in the submandibular gland, related to sex differences in commensal microbiota composition in mice

    Article • Bioscience Biotechnology and Biochemistry, November 2024, Oxford University Press (OUP)

    Naoki Harada

  2. CREB coactivator CRTC1 in melanocortin‐4 receptor‐expressing cells regulate dietary fat intake

    Article • FASEB BioAdvances, October 2024, Wiley

    Naoki Harada

  3. Insulin reduces endoplasmic reticulum stress‐induced apoptosis by decreasing mitochondrial hyperpolarization and caspase‐12 in INS‐1 pancreatic β‐cells

    Article • Physiological Reports, June 2024, Wiley

    Naoki Harada

  4. Mogrol stimulates G-protein-coupled bile acid receptor 1 (GPBAR1/TGR5) and insulin secretion from pancreatic β-cells and alleviates hyperglycemia in mice

    Article • Scientific Reports, February 2024, Springer Science + Business Media

    Naoki Harada

  5. Age-dependent sex difference of non-alcoholic fatty liver disease in TSOD and db/db mice

    Article • PLOS One, December 2022, PLOS

    Naoki Harada

  6. Androgen receptor suppresses β-adrenoceptor-mediated CREB activation and thermogenesis in brown adipose tissue of male mice

    Article • Journal of Biological Chemistry, December 2022, Elsevier

    Naoki Harada

  7. Dietary oleamide attenuates obesity induced by housing mice in small cages

    Article • Bioscience Biotechnology and Biochemistry, May 2022, Taylor & Francis

    Naoki Harada

  8. Identification of G protein-coupled receptor 55 (GPR55) as a target of curcumin

    Article • npj Science of Food, January 2022, Springer Science + Business Media

    Naoki Harada

  9. Oleamide rescues tibialis anterior muscle atrophy of mice housed in small cages

    Article • British Journal Of Nutrition, November 2020, Cambridge University Press

    Naoki Harada

  10. Relationship between gut environment, feces-to-food ratio, and androgen deficiency-induced metabolic disorders

    Article • Gut Microbes, September 2020, Taylor & Francis

    Naoki Harada

  11. Food texture affects glucose tolerance by altering pancreatic β-cell function in mice consuming high-fructose corn syrup

    Article • PLOS One, May 2020, PLOS

    Naoki Harada

  12. Role of gut microbiota in sex- and diet-dependent metabolic disorders that lead to early mortality of androgen receptor-deficient male mice

    Article • AJP Endocrinology and Metabolism, April 2020, American Physiological Society

    Naoki Harada

  13. Extracellular transglutaminase 2 induces myotube hypertrophy through G protein-coupled receptor 56

    Article • Biochimica et Biophysica Acta (BBA) - Molecular Cell Research, February 2020, Elsevier

    Naoki Harada

  14. Fetal androgen signaling defects affect pancreatic β-cell mass and function, leading to glucose intolerance in high-fat diet-fed male rats

    Article • AJP Endocrinology and Metabolism, November 2019, American Physiological Society

    Naoki Harada

  15. Tomatidine Reduces Palmitate‐Induced Lipid Accumulation by Activating AMPK via Vitamin D Receptor‐Mediated Signaling in Human HepG2 Hepatocytes

    Article • Molecular Nutrition & Food Research, September 2019, Wiley

    Naoki Harada

  16. 5‐Hydroxy‐7‐methoxyflavone derivatives from Kaempferia parviflora induce skeletal muscle hypertrophy

    Article • Food Science & Nutrition, November 2018, Wiley

    Naoki Harada

  17. Role of testosterone on type 2 diabetes, metabolic syndrome, cardiovascular disease, and longevity.

    Article • Bioscience Biotechnology and Biochemistry, June 2018, Taylor & Francis

    Naoki Harada

  18. Theophylline suppresses interleukin-6 expression by inhibiting glucocorticoid receptor signaling in pre-adipocytes

    Article • Archives of Biochemistry and Biophysics, May 2018, Elsevier

    Dr Tomohide Takaya, Naoki Harada

  19. Stereoselective effects of lactate enantiomers on the enhancement of 3T3-L1 adipocyte differentiation

    Article • Biochemical and Biophysical Research Communications, March 2018, Elsevier

    Naoki Harada

  20. Androgen signaling expands β-cell mass in male rats and β-cell androgen receptor is degraded under high-glucose conditions

    Article • AJP Endocrinology and Metabolism, March 2018, American Physiological Society

    Naoki Harada

  21. Lactoferrin promotes murine C2C12 myoblast proliferation and differentiation and myotube hypertrophy

    Article • Molecular Medicine Reports, February 2018, Spandidos Publications

    Naoki Harada

  22. Daidzein down-regulates ubiquitin-specific protease 19 expression through estrogen receptor β and increases skeletal muscle mass in young female mice

    Article • The Journal of Nutritional Biochemistry, November 2017, Elsevier

    Naoki Harada

  23. Lactoferrin induces tropoelastin expression by activating the lipoprotein receptor-related protein 1-mediated phosphatidylinositol 3-kinase/Akt pathway in human dermal fibroblasts

    Article • Cell Biology International, September 2017, Wiley

    Naoki Harada

  24. S-Equol Activates cAMP Signaling at the Plasma Membrane of INS-1 Pancreatic β-Cells and Protects against Streptozotocin-Induced Hyperglycemia by Increasing β-Cell Function in Male Mice

    Article • Journal of Nutrition, September 2017, Elsevier

    Naoki Harada

  25. Glyceraldehyde-3-phosphate Dehydrogenase (GAPDH) Aggregation Causes Mitochondrial Dysfunction during Oxidative Stress-induced Cell Death

    Article • Journal of Biological Chemistry, March 2017, Elsevier

    Naoki Harada

  26. Hypogonadism alters cecal and fecal microbiota in male mice

    Article • Gut Microbes, September 2016, Taylor & Francis

    Naoki Harada

  27. Mogrol Derived from Siraitia grosvenorii Mogrosides Suppresses 3T3-L1 Adipocyte Differentiation by Reducing cAMP-Response Element-Binding Protein Phosphorylation and Increasing AMP-Activated Protein Kinase Phosphorylation

    Article • PLOS One, September 2016, PLOS

    Naoki Harada

  28. The collagen derived dipeptide hydroxyprolyl-glycine promotes C2C12 myoblast differentiation and myotube hypertrophy

    Article • Biochemical and Biophysical Research Communications, September 2016, Elsevier

    Naoki Harada

  29. pVHL-mediated degradation of HIF-2α regulates estrogen receptor α expression in normoxic breast cancer cells

    Article • FEBS Letters, July 2016, Wiley

    Naoki Harada

  30. Castration influences intestinal microflora and induces abdominal obesity in high-fat diet-fed mice

    Article • Scientific Reports, March 2016, Springer Science + Business Media

    Naoki Harada

  31. Autophagic degradation of the androgen receptor mediated by increased phosphorylation of p62 suppresses apoptosis in hypoxia

    Article • Cellular Signalling, October 2015, Elsevier

    Naoki Harada

  32. Glyceraldehyde-3-phosphate Dehydrogenase Aggregates Accelerate Amyloid-β Amyloidogenesis in Alzheimer Disease

    Article • Journal of Biological Chemistry, October 2015, Elsevier

    Naoki Harada

  33. Protein arginine methyltransferase 10 is required for androgen-dependent proliferation of LNCaP prostate cancer cells

    Article • Bioscience Biotechnology and Biochemistry, September 2015, Taylor & Francis

    Naoki Harada

  34. Female-specific regulation of skeletal muscle mass by USP19 in young mice

    Article • Journal of Endocrinology, April 2015, Bioscientifica

    Naoki Harada

  35. Androgen Receptor Silences Thioredoxin-interacting Protein and Competitively Inhibits Glucocorticoid Receptor-Mediated Apoptosis in Pancreatic β-Cells

    Article • Journal of Cellular Biochemistry, April 2015, Wiley

    Naoki Harada

  36. Inhibitory Effects of Eucalyptus and Banaba Leaf Extracts on Nonalcoholic Steatohepatitis Induced by a High-Fructose/High-Glucose Diet in Rats

    Article • BioMed Research International, January 2015, Wiley

    Naoki Harada

  37. β-Carotene Increases Muscle Mass and Hypertrophy in the Soleus Muscle in Mice

    Article • Journal of Nutritional Science and Vitaminology, January 2015, Center for Academic Publications Japan

    Naoki Harada

  38. Resveratrol Inhibits Hypoxia-Inducible Factor-1^|^alpha;-Mediated Androgen Receptor Signaling and Represses Tumor Progression in Castration-Resistant Prostate Cancer

    Article • Journal of Nutritional Science and Vitaminology, January 2014, Center for Academic Publications Japan

    Naoki Harada

  39. Resveratrol Reduces the Hypoxia-Induced Resistance to Doxorubicin in Breast Cancer Cells

    Article • Journal of Nutritional Science and Vitaminology, January 2014, Center for Academic Publications Japan

    Naoki Harada

  40. S-Equol Enantioselectively Activates cAMP-Protein Kinase A Signaling and Reduces Alloxan-Induced Cell Death in INS-1 Pancreatic ^|^beta;-Cells

    Article • Journal of Nutritional Science and Vitaminology, January 2014, Center for Academic Publications Japan

    Naoki Harada

  41. Identification of Carbonyl Reductase 1 as a Resveratrol-Binding Protein by Affinity Chromatography Using 4'-Amino-3,5-dihydroxy-trans-stilbene

    Article • Journal of Nutritional Science and Vitaminology, January 2013, Center for Academic Publications Japan

    Naoki Harada

  42. The preventive effect of β-carotene on denervation-induced soleus muscle atrophy in mice

    Article • British Journal Of Nutrition, October 2012, Cambridge University Press

    Naoki Harada

  43. Coordinated Action of Hypoxia-inducible Factor-1α and β-Catenin in Androgen Receptor Signaling

    Article • Journal of Biological Chemistry, September 2012, Elsevier

    Naoki Harada

  44. Biochemical characterization of a GH53 endo-β-1,4-galactanase and a GH35 exo-β-1,4-galactanase from Penicillium chrysogenum

    Article • Applied Microbiology and Biotechnology, May 2012, Springer Science + Business Media

    Naoki Harada

  45. Androgen deprivation causes truncation of the C-terminal region of androgen receptor in human prostate cancer LNCaP cells

    Article • Cancer Science, April 2012, Wiley

    Naoki Harada

  46. 17β-Estradiol Represses Myogenic Differentiation by Increasing Ubiquitin-specific Peptidase 19 through Estrogen Receptor α

    Article • Journal of Biological Chemistry, December 2011, Elsevier

    Naoki Harada

  47. Purification, characterization and gene cloning of two forms of a thermostable endo-xylanase from Streptomyces sp. SWU10

    Article • Process Biochemistry, December 2011, Elsevier

    Naoki Harada

  48. Kelch-like 20 up-regulates the expression of hypoxia-inducible factor-2α through hypoxia- and von Hippel–Lindau tumor suppressor protein-independent regulatory mechanisms

    Article • Biochemical and Biophysical Research Communications, September 2011, Elsevier

    Naoki Harada

  49. Up-regulation of glyceraldehyde-3-phosphate dehydrogenase gene expression by HIF-1 activity depending on Sp1 in hypoxic breast cancer cells

    Article • Archives of Biochemistry and Biophysics, May 2011, Elsevier

    Naoki Harada

  50. Suppression of inducible nitric oxide synthase expression and amelioration of lipopolysaccharide-induced liver injury by polyphenolic compounds in Eucalyptus globulus leaf extract

    Article • Food Chemistry, March 2011, Elsevier

    Naoki Harada

  51. Hypoxia enhances transcriptional activity of androgen receptor through hypoxia-inducible factor-1α in a low androgen environment

    Article • The Journal of Steroid Biochemistry and Molecular Biology, January 2011, Elsevier

    Naoki Harada

  52. Inhibitory mechanisms of the transcriptional activity of androgen receptor by resveratrol: Implication of DNA binding and acetylation of the receptor

    Article • The Journal of Steroid Biochemistry and Molecular Biology, January 2011, Elsevier

    Naoki Harada

  53. Construction of a Dominant Negative Form of Human Hypoxia-Inducible Factor-2α

    Article • Bioscience Biotechnology and Biochemistry, October 2010, Oxford University Press (OUP)

    Naoki Harada

  54. A Yeast Bioassay for Androgenic and Anti-Androgenic Compounds Based on the NH2- and COOH-Terminal Interaction of Androgen Receptor

    Article • Bioscience Biotechnology and Biochemistry, September 2010, Taylor & Francis

    Naoki Harada

  55. Involvement of three glutamine tracts in human androgen receptor transactivation

    Article • The Journal of Steroid Biochemistry and Molecular Biology, January 2010, Elsevier

    Naoki Harada

  56. Inhibitive Effects of Alkyl Gallates on Hyaluronidase and Collagenase

    Article • Bioscience Biotechnology and Biochemistry, October 2009, Oxford University Press (OUP)

    Naoki Harada

  57. Cobalamin deficiency results in an abnormal increase inl-methylmalonyl-co-enzyme-A mutase expression in rat liver and COS-7 cells

    Article • British Journal Of Nutrition, August 2008, Cambridge University Press

    Naoki Harada

  58. ARA24/Ran enhances the androgen-dependent NH2- and COOH-terminal interaction of the androgen receptor

    Article • Biochemical and Biophysical Research Communications, August 2008, Elsevier

    Naoki Harada

  59. RanBP10 acts as a novel coactivator for the androgen receptor

    Article • Biochemical and Biophysical Research Communications, March 2008, Elsevier

    Naoki Harada

  60. Glyceraldehyde-3-phosphate Dehydrogenase Enhances Transcriptional Activity of Androgen Receptor in Prostate Cancer Cells

    Article • Journal of Biological Chemistry, August 2007, Elsevier

    Naoki Harada

  61. Resveratrol Down-Regulates the Androgen Receptor at the Post-Translational Level in Prostate Cancer Cells

    Article • Journal of Nutritional Science and Vitaminology, January 2007, Center for Academic Publications Japan

    Naoki Harada

  62. Glyceraldehyde-3-phosphate dehydrogenase in the extracellular space inhibits cell spreading

    Article • Biochimica et Biophysica Acta (BBA) - General Subjects, November 2005, Elsevier

    Naoki Harada