All Stories

  1. Progression from external pilot to definitive randomised controlled trial: a methodological review of progression criteria reporting
  2. Protocol for a cluster randomised controlled trial of the DAFNEplus (Dose Adjustment For Normal Eating) intervention compared with 5x1 DAFNE: a lifelong approach to promote effective self-management in adults with type 1 diabetes
  3. Understanding basic numbers in health and medicine
  4. Methods matter: pilot and feasibility studies in sports medicine
  5. Recurrent sudden unexpected death in infancy: a case series of sibling deaths
  6. Assessing the transparency of informed consent in feasibility and pilot studies: a single-centre quality assurance study protocol
  7. Exploring the implications of different approaches to estimate centre-level adherence using objective adherence data in an adult cystic fibrosis centre – a retrospective observational study
  8. Meeting abstracts from the 5th International Clinical Trials Methodology Conference (ICTMC 2019)
  9. MRI in the diagnosis of fetal developmental brain abnormalities: the MERIDIAN diagnostic accuracy study
  10. Count time series prediction using particle filters
  11. Intravenous antibiotic use and exacerbation events in an adult cystic fibrosis centre: A prospective observational study
  12. Developing new ways of measuring the quality and impact of ambulance service care: the PhOEBE mixed-methods research programme
  13. A Life or “Good Death” Situation? A Worldwide Ecological Study of the National Contexts of Countries That Have and Have Not Implemented Palliative Care
  14. The stepped wedge cluster randomised trial: what it is and when it should be used
  15. A pragmatic behavior-based habit index for adherence to nebulized treatments among adults with cystic fibrosis
  16. Understanding FEV 1 for the purpose of cystic fibrosis registry comparisons: Does bias in annual review FEV 1 affect between‐centre comparison within the UK? An analysis of registry data
  17. Cluster randomised trials
  18. Does evidence support the high expectations placed in precision medicine? A bibliographic review
  19. Reporting of stepped wedge cluster randomised trials: extension of the CONSORT 2010 statement with explanation and elaboration
  20. Emergency hospital care for adults with suspected seizures in the NHS in England 2007–2013: a cross-sectional study
  21. A randomised controlled trial is not a pilot trial simply because it uses a surrogate endpoint
  22. Sample Sizes for Clinical, Laboratory and Epidemiology Studies
  23. The DiPEP study: an observational study of the diagnostic accuracy of clinical assessment, D-dimer and chest x-ray for suspected pulmonary embolism in pregnancy and postpartum
  24. The importance of data issues when comparing cystic fibrosis registry outcomes between countries: Are annual review FEV1 in the UK only collected when subjects are well?
  25. Role of habit in treatment adherence among adults with cystic fibrosis
  26. Basic Design Considerations
  27. Binary Outcomes
  28. Cluster Designs
  29. Confidence Intervals
  30. Continuous Outcomes
  31. Cumulative References
  32. Feasibility and Pilot Studies
  33. Front Matter
  34. Further Design Considerations
  35. Genomic Targets and Dose-Finding
  36. Index
  37. More than Two Groups Designs
  38. Non-Inferiority and Equivalence
  39. Observer Agreement Studies
  40. Ordered Categorical Outcomes
  41. Paired Binary, Ordered Categorical and Continuous Outcomes
  42. Rate Outcomes
  43. Reference Intervals and Receiver Operating Curves
  44. Repeated Outcome Measures
  45. Sample Size Software
  46. Stepped Wedge Designs
  47. Supplemental Images
  48. Survival Time Outcomes
  49. The Correlation Coefficient
  50. Therapeutic Exploratory Trials
  51. Therapeutic Exploratory Trials
  52. Do cystic fibrosis centres with the lowest FEV1 still use the least amount of intravenous antibiotics? A registry-based comparison of intravenous antibiotic use among adult CF centres in the UK
  53. Family lifestyle dynamics and childhood obesity: evidence from the millennium cohort study
  54. Response to Comment on Novodvorsky et al. Diurnal Differences in Risk of Cardiac Arrhythmias During Spontaneous Hypoglycemia in Young People With Type 1 Diabetes. Diabetes Care 2017;40:655–662
  55. Evidence against precision medicine?
  56. 1800 Uk unscheduled admissions for adults with suspected seizures
  57. Use of MRI in the Diagnosis of Fetal Brain Abnormalities in Utero (MERIDIAN)
  58. Predictors of intravenous antibiotic use among adults with cystic fibrosis (CF)
  59. Change in diagnostic confidence brought about by using in utero MRI for fetal structural brain pathology: analysis of the MERIDIAN cohort
  60. Use of MRI in the Diagnosis of Fetal Brain Abnormalities in Utero (MERIDIAN)
  61. Reply
  62. A cluster randomised trial, cost-effectiveness analysis and psychosocial evaluation of insulin pump therapy compared with multiple injections during flexible intensive insulin therapy for type 1 diabetes: the REPOSE Trial
  63. Relative effectiveness of insulin pump treatment over multiple daily injections and structured education during flexible intensive insulin treatment for type 1 diabetes: cluster randomised trial (REPOSE)
  64. Minimum number of clusters and comparison of analysis methods for cross sectional stepped wedge cluster randomised trials with binary outcomes: A simulation study
  65. An empirical method to cluster objective nebulizer adherence data among adults with cystic fibrosis
  66. Severe acute malnutrition in children aged under 5 years can be successfully managed in a non‐emergency routine community healthcare setting in Ghana
  67. Informing efficient randomised controlled trials: exploration of challenges in developing progression criteria for internal pilot studies
  68. Use of MRI in the diagnosis of fetal brain abnormalities in utero (MERIDIAN): a multicentre, prospective cohort study
  69. What is propensity score modelling?
  70. Catheter insertion techniques for improving catheter function and clinical outcomes in peritoneal dialysis patients
  71. Determinants of objective adherence to nebulised medications among adults with cystic fibrosis: an exploratory mixed methods study comparing low and high adherers
  72. Chronic obstructive pulmonary disease in Welsh slate miners
  73. CONSORT 2010 statement: extension to randomised pilot and feasibility trials
  74. CONSORT 2010 statement: extension to randomised pilot and feasibility trials
  75. The effects of breastfeeding on childhood BMI: a propensity score matching approach
  76. Time Series Regression
  77. Acute effects of aircraft noise on cardiovascular admissions – an interrupted time-series analysis of a six-day closure of London Heathrow Airport caused by volcanic ash
  78. Erratum to: Methods and processes for development of a CONSORT extension for reporting pilot randomized controlled trials
  79. Air Pollution and Subtypes, Severity and Vulnerability to Ischemic Stroke—A Population Based Case-Crossover Study
  80. Stepped wedge cluster randomised trials: a review of the statistical methodology used and available
  81. 268 Rescue and prevention in cystic fibrosis: an exploration of the impact of adherence to preventative nebulised therapy upon subsequent rescue therapy with IV antibiotics in adults with CF
  82. WS23.3 Rescue therapy within the UK CF registry: an exploration of the predictors of IV antibiotic use amongst adults with cystic fibrosis
  83. Methods and processes for development of a CONSORT extension for reporting pilot randomized controlled trials
  84. Accurate reporting of adherence to inhaled therapies in adults with cystic fibrosis: methods to calculate normative adherence
  85. Defining Feasibility and Pilot Studies in Preparation for Randomised Controlled Trials: Development of a Conceptual Framework
  86. Defining feasibility and pilot studies in preparation for randomised controlled trials: using consensus methods and validation to develop a conceptual framework
  87. Improving the reporting of randomised pilot and feasibility studies: a consort statement extension
  88. P274 Moving from rescue to prevention: real world evidence of reduction in IV antibiotic requirement following improvement in adherence to maintenance nebulised treatment in an adult cystic fibrosis centre: Abstract P274 Table 1
  89. Lowering bed occupancy: a life-saving intervention?
  90. Who gains clinical benefit from using insulin pump therapy? A qualitative study of the perceptions and views of health professionals involved in the Relative Effectiveness of Pumps over MDI and Structured Education (REPOSE) trial
  91. The mortality and hospitalization rates associated with the long interdialytic gap in thrice-weekly hemodialysis patients
  92. Estimating the sample size for a pilot randomised trial to minimise the overall trial sample size for the external pilot and main trial for a continuous outcome variable
  93. Sample size calculations for the design of cluster randomized trials: A summary of methodology
  94. The BMJ report on mortality cuts in hospitals put into special measures in 2013 is misleading
  95. Mortality of babies enrolled in a community-based support programme: CONI PLUS (Care of Next Infant Plus)
  96. Secondary analysis and literature review of community rehabilitation and intermediate care: an information resource
  97. A cluster randomized controlled non-inferiority trial of 5-day Dose Adjustment for Normal Eating (DAFNE) training delivered over 1 week versus 5-day DAFNE training delivered over 5 weeks: the DAFNE 5 × 1-day trial
  98. Perceptions and experiences of using automated bolus advisors amongst people with type 1 diabetes: A longitudinal qualitative investigation
  99. Improving management of type 1 diabetes in the UK: the Dose Adjustment For Normal Eating (DAFNE) programme as a research test-bed. A mixed-method analysis of the barriers to and facilitators of successful diabetes self-management, a health economic ana...
  100. Adjusting for treatment switching in randomised controlled trials – A simulation study and a simplified two-stage method
  101. Self-monitoring of blood glucose versus self-monitoring of urine glucose in adults with newly diagnosed Type 2 diabetes receiving structured education: a cluster randomized controlled trial
  102. The Potential Value of Ongoing Support In Type-1 Diabetes Mellitus With Dafneplus: Exploratory Pre-Trial Cost-Effectiveness Analysis On Proposed Trial End-Point Target For 12-Month Hba1c Improvement
  103. A hazard ratio was estimated by a ratio of median survival times, but with considerable uncertainty
  104. Clinical Signals
  105. Pulmonary Medicine
  106. Time Series Regression
  107. The Relative Effectiveness of Pumps Over MDI and Structured Education (REPOSE): study protocol for a cluster randomised controlled trial
  108. Challenges of cluster randomized trials
  109. Pilot and feasibility studies: Is there a difference from each other and from a randomised controlled trial?
  110. PERITONEAL DIALYSIS 1
  111. How to Design, Analyse and Report Cluster Randomised Trials in Medicine and Health Related Research
  112. Substantial reductions in the number of diabetic ketoacidosis and severe hypoglycaemia episodes requiring emergency treatment lead to reduced costs after structured education in adults with Type 1 diabetes
  113. Estimated Albumin Excretion Rate Versus Urine Albumin-Creatinine Ratio for the Estimation of Measured Albumin Excretion Rate: Derivation and Validation of an Estimated Albumin Excretion Rate Equation
  114. Adjusting Survival Time Estimates to Account for Treatment Switching in Randomized Controlled Trials—an Economic Evaluation Context
  115. Impact of a GP-led walk-in centre on NHS emergency departments
  116. Outdoor air pollution, subtypes and severity of ischemic stroke – a small-area level ecological study
  117. Cluster Randomized Trials
  118. Prognostic Value of Cardiovascular Magnetic Resonance Imaging Measurements Corrected for Age and Sex in Idiopathic Pulmonary Arterial Hypertension
  119. A Guide to Adjusting Survival Time Estimates to Account for Treatment Switching in Randomised Controlled Trials
  120. Definition and reporting of pilot and feasibility studies
  121. Direct risk standardisation: a new method for comparing casemix adjusted event rates using complex models
  122. Mortality indicators used to rank hospital performance
  123. What do hospital mortality rates tell us about quality of care?: Table 1
  124. Variation in centre-specific survival in patients starting renal replacement therapy in England is explained by enhanced comorbidity information from hospitalization data
  125. Pilot study of a brief intervention based on the theory of planned behaviour and self-identity to increase chlamydia testing among young people living in deprived areas
  126. ABR in newborns: Effects of electrode configuration, stimulus rate, and EEG rejection levels on test efficiency
  127. Good Practice Guidelines for the use of Statistical Regression Models in Economic Evaluations
  128. Did hospital mortality in England change from 2005 to 2010? A retrospective cohort analysis
  129. Patients’ experience and satisfaction with GP led walk-in centres in the UK; a cross sectional study
  130. GP-led walk-in centre in the UK: another way for urgent healthcare provision
  131. Doing clinical trials large enough to achieve adequate reductions in uncertainties about treatment effects
  132. How to reduce the risk of failing to reach recruitment targets: lessons learnt from a pump pilot trial
  133. Disparities in Healthcare Utilisation Rates for Aboriginal and Non-Aboriginal Albertan Residents, 1997–2006: A Population Database Study
  134. The 5x1 DAFNE study protocol: a cluster randomised trial comparing a standard 5 day DAFNE course delivered over 1 week against DAFNE training delivered over 1 day a week for 5 consecutive weeks
  135. Home ovulation tests and stress in women trying to conceive: a randomized controlled trial
  136. Rapid-Throughput Skeletal Phenotyping of 100 Knockout Mice Identifies 9 New Genes That Determine Bone Strength
  137. Tutorial in biostatistics: sample sizes for parallel group clinical trials with binary data
  138. Cognitive behavioural intervention for adults with anxiety complications of asthma: Prospective randomised trial
  139. Improved Biomedical and Psychological Outcomes 1 Year After Structured Education in Flexible Insulin Therapy for People With Type 1 Diabetes: The U.K. DAFNE experience
  140. Effectiveness of a diabetes education and self management programme (DESMOND) for people with newly diagnosed type 2 diabetes mellitus: three year follow-up of a cluster randomised controlled trial in primary care
  141. Does self monitoring of blood glucose as opposed to urinalysis provide additional benefit in patients newly diagnosed with type 2 diabetes receiving structured education? The DESMOND SMBG randomised controlled trial protocol
  142. Developing a summary hospital mortality index: retrospective analysis in English hospitals over five years
  143. The development and validation of a clinical prediction model to determine the probability of MODY in patients with young-onset diabetes
  144. Clinical effectiveness of a patient decision aid to improve decision quality and glycaemic control in people with diabetes making treatment choices: a cluster randomised controlled trial (PANDAs) in general practice
  145. Chapter 13 The Linkage of Incident Renal Replacement Therapy Patients in England (2002–2006) to Hospital Episodes and National Mortality Data: Improved Demography and Hospitalisation Data in Patients Undergoing Renal Replacement Therapy
  146. A pragmatic quasi-experimental multi-site community intervention trial evaluating the impact of Emergency Care Practitioners in different UK health settings on patient pathways (NEECaP Trial)
  147. Seasonality of medical contacts in school-aged children with asthma: Association with school holidays
  148. Outdoor Air Pollution and Incidence of Ischemic and Hemorrhagic Stroke: A Small-Area Level Ecological Study
  149. Reprinted Article “Carotid Artery Plaque Composition—Relationship to Clinical Presentation and Ultrasound B-mode Imaging”
  150. Long-term Outcomes of Patients With Autoimmune Hepatitis Managed at a Nontransplant Center
  151. Epidemiology of scabies prevalence in the U.K. from general practice records
  152. Sixth International French Society of Statistics meeting on statistical methods in biopharmacy: Recent advances and trends in statistics as applied to clinical trials
  153. Comments on ‘The potential for bias in the reporting of industry sponsored clinical trials’ by Stephen Pyke et al. and ‘Proposed best practice for statisticians in the reporting and publication of pharmaceutical industry sponsored clinical trials’ by Jame
  154. Possible Evidence for a Fall in the Prevalence of High-Functioning Pervasive Developmental Disorder with Age?
  155. Authors' reply
  156. Evaluation of triage methods used to select patients with suspected pandemic influenza for hospital admission: cohort study
  157. Delivering the diabetes education and self management for ongoing and newly diagnosed (DESMOND) programme for people with newly diagnosed type 2 diabetes: cost effectiveness analysis
  158. Statistical issues in Primary Care
  159. What is a pilot or feasibility study? A review of current practice and editorial policy
  160. Assessing quality of care from hospital case notes: comparison of reliability of two methods
  161. A statistician on a NICE committee
  162. Trials in primary care: statistical issues in the design, conduct and evaluation of complex interventions
  163. Impact of Outdoor Air Pollution on Survival After Stroke: Population-Based Cohort Study
  164. Comparison of case note review methods for evaluating quality and safety in health care
  165. Do South Asian women with PCOS have poorer health-related quality of life than Caucasian women with PCOS? A comparative cross-sectional study
  166. A randomized, controlled dose-ranging study of risedronate in children with moderate and severe osteogenesis imperfecta
  167. Cluster Randomised Trials by HAYES, R. J. and MOULTON, L. H.
  168. Evaluation of the impact of a health forecast alert service on admissions for chronic obstructive pulmonary disease in Bradford and Airedale
  169. Modified-Release Hydrocortisone to Provide Circadian Cortisol Profiles
  170. Sample Size Tables for Clinical Studies
  171. A RANDOMISED CONTROLLED:TRIAL OF DIFFERENT INTENSITIES OF PHYSIOTHERAPY AND DIFFERENT GOAL-SETTING PROCEDURES IN 44 CHILDREN WITH CEREBRAL PALSY
  172. Misinterpreting P-Values In Research
  173. Recurrence rates for sudden infant death syndrome (SIDS): the importance of risk stratification
  174. Evaluating the efficacy of acupuncture in defined aspects of stroke recovery
  175. How common is repeat sudden infant death syndrome?
  176. Optimal Thresholds, Linear or Nonlinear Relationships of Fracture Risk Reduction With Therapy
  177. Effectiveness of the diabetes education and self management for ongoing and newly diagnosed (DESMOND) programme for people with newly diagnosed type 2 diabetes: cluster randomised controlled trial
  178. Rationale, design, and baseline characteristics for a large international trial of cardiovascular disease prevention in people with dysglycemia: The ORIGIN Trial (Outcome Reduction with an Initial Glargine Intervention)
  179. Impact of a Restraint Training Module on Paramedic Students' Likelihood to Use Restraint Techniques
  180. Fundamentals of Clinical Research: Bridging Medicine, Statistics and Operations by Antonella Bacchieri, Giovanni Della Cioppa
  181. Relationship of Early Changes in Bone Resorption to the Reduction in Fracture Risk With Risedronate: Review of Statistical Analysis
  182. Contamination in trials of educational interventions
  183. Predicting where future means will lie based on the results of the current trial
  184. Invalid methods
  185. Impact of NHS walk-in centres on primary care access times: ecological study
  186. Risk of hypoglycaemia in types 1 and 2 diabetes: effects of treatment modalities and their duration
  187. Combining Growth Hormone Releasing Hormone-Arginine and Synacthen Testing Diminishes the Cortisol Response
  188. Implementing referral guidelines: lessons from a negative outcome cluster randomised factorial trial in general practice
  189. Randomised controlled trial of a short course of traditional acupuncture compared with usual care for persistent non-specific low back pain
  190. Language Ability after Early Detection of Permanent Childhood Hearing Impairment
  191. The effect of helium and oxygen on exercise performance in COPD: A randomised crossover trial
  192. The Effect of Helium and Oxygen on Exercise Performance in Chronic Obstructive Pulmonary Disease
  193. Cost-effectiveness and cost-utility of tricyclic antidepressants, selective serotonin reuptake inhibitors and lofepramine
  194. Editorial
  195. Editorial
  196. Statistics at Square Two
  197. Developments in cluster randomized trials andStatistics in Medicine
  198. Non-inferiority trials: continued advancements in concepts and methodology (special papers for the 25th anniversary ofStatistics in Medicine25(7))
  199. The Mann–Whitney statistic: continuous use and discovery
  200. Editorial
  201. Editorial
  202. Editorial
  203. Hypopituitary patients prefer a touch-screen to paper quality of life questionnaire
  204. Do ‘food deserts’ influence fruit and vegetable consumption?—a cross-sectional study
  205. Outdoor air pollution, mortality, and hospital admissions from coronary heart disease in Sheffield, UK: a small-area level ecological study
  206. Life and death decisions: A statistician on a data monitoring and ethics committee
  207. Universal newborn screening for permanent childhood hearing impairment: an 8-year follow-up of a controlled trial
  208. Longer term clinical and economic benefits of offering acupuncture care to patients with chronic low back pain
  209. Clinical Signals
  210. Pulmonary Medicine
  211. Time Series Regression
  212. A 24 year cohort study of mortality in slate workers in North Wales
  213. A randomised controlled trial to compare the cost-effectiveness of tricyclic antidepressants, selective serotonin reuptake inhibitors and lofepramine
  214. Intraclass correlation coefficient and outcome prevalence are associated in clustered binary data
  215. Design of Studies for Medical Research
  216. Editorial
  217. Surrogate markers: back to the future
  218. Assurance in clinical trial design
  219. Restructuring the editorial board
  220. The use of bootstrap methods for estimating sample size and analysing health-related quality of life outcomes
  221. Outdoor Air Pollution and Stroke in Sheffield, United Kingdom: A Small-Area Level Geographical Study
  222. A survey of statistics in three UK general practice journal
  223. BMJ statistical errors
  224. Patterns of intra-cluster correlation from primary care research to inform study design and analysis
  225. Smoking and Parkinson's disease: Systematic review of prospective studies
  226. Extending CONSORT to include cluster trials
  227. Acupuncture for low back pain: traditional diagnosis and treatment of 148 patients in a clinical trial
  228. Statistical aspects
  229. Combination of APACHE-II score and an obesity score (APACHE-O) for the prediction of severe acute pancreatitis
  230. The Armitage lectures
  231. Editorial
  232. Parkinson’s Disease Protects Against Smoking?
  233. Sensitivity analysis of common statistical models used to study the short-term effects of air pollution on health
  234. Geographical and organisational variation in the structure of primary care services: implications for study design
  235. Statistics in Medicine moves into online submission
  236. Effect on endometrium of long term treatment with continuous combined oestrogen-progestogen replacement therapy: follow up study
  237. Longer-Term Clinical and Economic Benefits of Offering Acupuncture to Patients with Chronic Low Back Pain Assessed as Suitable for Primary Care Management – 3 Month Clinical Outcomes from a Controlled Trial of 241 Patients
  238. Epidemiology research
  239. Discussion on the paper by Spiegelhalter, Aylin, Best, Evans and Murray
  240. A review of ordinal regression models applied on health-related quality of life assessments
  241. La enfermedad de Parkinson y el tabaco: coherencia y plausibilidad
  242. Randomized, Controlled Trial of Acetazolamide and Furosemide in Posthemorrhagic Ventricular Dilation in Infancy: Follow-Up at 1 Year
  243. Atmospheric pressure and sudden infant death syndrome in Cook County, Chicago
  244. The Wessex Recent In-Patient Suicide Study, 2
  245. The Wessex Recent In-Patient Suicide Study, 1
  246. The Safety and Effectiveness of the Le Fort I Approach to Removing Central Skull Base Lesions
  247. Randomized controlled trial of physiotherapy in 56 children with cerebral palsy followed for 18 months
  248. DESIGN AND ANALYSIS OF TRIALS WITH QUALITY OF LIFE AS AN OUTCOME: A PRACTICAL GUIDE
  249. Preface
  250. The endometrial response to sequential and continuous combined oestrogen-progestogen replacement therapy
  251. Sample sizes for cancer trials where Health Related Quality of Life is the primary outcome
  252. The Wessex Head Injury Matrix (WHIM) main scale: a preliminary report on a scale to assess and monitor patient recovery after severe head injury
  253. Causality and temporality in the study of short-term effects of air pollution on health
  254. Cluster randomized trials in general (family) practice research
  255. Effects of a clinical-practice guideline and practice-based education on detection and outcome of depression in primary care: Hampshire Depression Project randomised controlled trial
  256. Statistical review by research ethics committees
  257. Effect of antidepressant drug counselling and information leaflets on adherence to drug treatment in primary care: randomised controlled trial
  258. Modelling influenza epidemics in the relation between black smoke and total mortality. A sensitivity analysis
  259. A GEE moving average analysis of the relationship between air pollution and mortality for asthma in Barcelona, Spain
  260. Patient centred care of diabetes in general practice
  261. Longer term clinical and economic benefits of offering acupuncture to patients with chronic low back pain assessed as suitable for primary care management
  262. ESTIMATING SAMPLE SIZES FOR CONTINUOUS, BINARY, AND ORDINAL OUTCOMES IN PAIRED COMPARISONS: PRACTICAL HINTS
  263. Diabetes Care from Diagnosis: Effects of training in patient-centred care on beliefs, attitudes and behaviour of primary care professionals
  264. Systemic effects of inhaled corticosteroids on growth and bone turnover in childhood asthma: a comparison of fluticasone with beclomethasone
  265. Controlled trial of universal neonatal screening for early identification of permanent childhood hearing impairment
  266. Choosing between randomised and non-randomised studies: a systematic review
  267. Randomised controlled trial of patient centred care of diabetes in general practice: impact on current wellbeing and future disease risk
  268. International randomised controlled trial of acetazolamide and furosemide in posthaemorrhagic ventricular dilatation in infancy
  269. Sample size calculations for paired or matched ordinal data
  270. Investigation of the effect of occult invasive cancer on progress towards successful cervical screening
  271. Clinical significance not statistical significance: a simple Bayesian alternative to p values
  272. Duration of growth suppressive effects of regular inhaled corticosteroids
  273. Trends in asthma
  274. Quality of life and patient preference for sequential versus continuous combined HRT: the UK Kliofem® multicenter study experience
  275. Association between nonadministration of subconjunctival cefuroxime and postoperative endophthalmitis
  276. Half-life of intracameral gentamicin after phacoemulsification
  277. Age specific trends in asthma mortality in England and Wales, 1983-95: results of an observational study
  278. Prevalence of inverted and non-protractile nipples in antenatal women who intend to breast-feed
  279. Circaseptennial rhythm is an artefact
  280. Women Married to Men with Myocardial Infarction are at Increased Risk of Coronary Heart Disease
  281. Double blind placebo controlled trial of nebulised budesonide for croup   Commentary
  282. Using aspects of study design in sample size estimation
  283. Does dietary intake of vitamins C and E influence lung function in older people?
  284. The relationship between upper respiratory infections and hospital admissions for asthma: a time-trend analysis.
  285. Spectral analysis of clinical signals: an interface between medical statisticians and medical engineers
  286. Sample sizes for studies using the short form 36 (SF-36)
  287. Estimating sample sizes for binary, ordered categorical, and continuous outcomes in two group comparisons
  288. Statistics would make Stalin proud
  289. Good long-term outcome following surgical repair of post-infarction ventricular septal defect
  290. Study quoted had flawed design
  291. Assessing the Adequacy of Standard Clinical Definitions of Important Vaginal Bleeding Disorders
  292. Posture, blood velocity in common femoral vein, and prophylaxis of venous thromboembolism
  293. P values are still useful
  294. Commentary: n of 1 trials may be useful for informed decision making
  295. Is the timing of withdrawal bleeding a guide to endometrial safety during sequential oestrogen-progestagen replacement therapy?
  296. Coping with extra poisson variability in the analysis of factors influencing vaginal ring expulsions
  297. Asthma at the interface: bridging the gap between general practice and a district general hospital.
  298. Statistics in medicine: Citations of papers in the first ten years
  299. Does clinical experience with a treatment regimen affect survival of lung cancer patients? An analysis based on consecutive randomized trials of the medical research council in small cell and non-small cell tumours
  300. Time Series Regression for Counts: An Investigation into the Relationship between Sudden Infant Death Syndrome and Environmental Temperature
  301. Sample size in audit.
  302. Determinants of contraceptive method choice after first delivery, before first abortion, and after first abortion in East China
  303. A review of behavioural assessment scales for monitoring recovery in and after coma with pilot data on a new scale of visual awareness
  304. Box-plots
  305. Management of feverish children at home.
  306. The Interaction between Immunoglobulin E and Smoking in Airflow Obstruction in the Elderly
  307. Randomised controlled trial of breast shells and Hoffman's exercises for inverted and non-protractile nipples.
  308. Effects of self-help post-myocardial-infarction rehabilitation on psychological adjustment and use of health services
  309. Adjusting for baseline: Chamge or percentage change
  310. An Evaluation of a Nurse-run Asthma Clinic in General Practice Using an Attitudes and Morbidity Questionnaire
  311. Assessment of the psychological impact of a breast screening programme
  312. Magnesium and chronic fatigue syndrome
  313. Red blood cell magnesium and chronic fatigue syndrome
  314. Coping with extra poisson variability in the analysis of factors influencing vaginal ring expulsions
  315. Sudden infant deaths and cold weather: was the rise in infant mortality in 1986 in England and Wales due to the weather?
  316. Heights and Weights of Children in Ladakh, North India
  317. Response
  318. Comparison of audible sound transmission with ultrasound in screening for congenital dislocation of the hip
  319. Prognostic index for the development of liver metastases in patients with colorectal cancer
  320. Analysis of serial measurements in medical research: Authors' reply
  321. Does anonymity increase response rate in postal questionnaire surveys about sensitive subjects? A randomised trial.
  322. Analysis of serial measurements in medical research.
  323. Sudden infant death syndrome and environmental temperature: further evidence for a time‐lagged relationship (for editorial comment, see page 361)
  324. Is there an increased risk of twinning after discontinuation of the oral contraceptive pill?
  325. Relief care and risk of death in psychogeriatric patients.
  326. Methotrexate dosage in patients aged over 50 with psoriasis.
  327. Letters to the editor
  328. Effect of transdermal glyceryl trinitrate on the survival of peripheral intravenous infusions: A double-blind prospective clinical study
  329. Exercise levels and resting pulse rate in the community.
  330. Further evidence for the effect of passive smoking on neonates.
  331. Assessing changes in vaginal bleeding patterns in contracepting women
  332. Statistics in Medicine: Calculating confidence intervals for some non-parametric analyses
  333. Twenty years' screening for cancer of the uterine cervix in Great Britain, 1964-84: further evidence for its ineffectiveness.
  334. SUGAR AND HEALTH
  335. The success of in situ vein grafting: Early results in comparison with the reversed vein technique
  336. Public knowledge about AIDS increasing.
  337. Sudden infant death syndrome and environmental temperature: an analysis using vital statistics.
  338. Predictive power of progesterone receptor status in early breast carcinoma
  339. Public knowledge of AIDS and the DHSS advertisement campaign: Authors' reply
  340. Public knowledge of AIDS and the DHSS advertisement campaign.
  341. Increased risk of sudden infant death syndrome in older infants at weekends.
  342. Specific causes of death in miners and ex-miners of the Rhondda Fach 1950-80.
  343. Gastric cancer in a south Wales valley.
  344. Respiratory disability in ex-flax workers.
  345. Use of check lists in assessing the statistical content of medical studies.
  346. A comparison of plating and traction in the treatment of tibial shaft fractures
  347. Mortality of men in the Rhondda Fach 1950-80.
  348. AZATHIOPRINE AND CYCLOSPORIN: DIFFERENT TISSUE MATCHING CRITERIA NEEDED?
  349. Multiplicative and additive models with external controls in a cohort study of cancer mortality
  350. Peer review at work
  351. Peer review at work
  352. Can general practitioners influence exercise habits? Controlled trial.
  353. Mortality, haemoglobin level and haematocrit in women
  354. Chest pain in women: a study of prevalence and mortality follow up in south Wales.
  355. Migraine, headache, and survival in women
  356. Trials of live attenuated influenza virus vaccine in patients with chronic obstructive airways disease
  357. Migraine, headache, and survival in women.
  358. HIGH BLOOD PRESSURE AND MORTALITY IN THE ELDERLY
  359. The analysis using genstat of anaemia, sugar intake and Quetelet's index as prognostic indicators in women
  360. Spectral Analysis Applied To Physiological Signals In Human Subjects
  361. IRREGULAR OPACITIES IN COALWORKERS' PNEUMOCONIOSIS—CORRELATION WITH PULMONARY FUNCTION AND PATHOLOGY
  362. Relationship between type of simple coalworkers' pneumoconiosis and lung function. A nine-year follow-up study of subjects with small rounded opacities.
  363. Aetiological factors in rickets of prematurity.
  364. Cardiac frequency during stepping exercise and during treadmill walking as guides to the Harvard Pack Index of physical fitness
  365. A note on the sampling of a point process for spectral analysis
  366. A Survey of Statistical Work on the Mackenzie River Series of Annual Canadian Lynx Trappings for the Years 1821-1934 and a New Analysis
  367. A Review of the Use of the Main Quality of Life Measures, and Sample Size Determination for Quality of Life Measures, Particularly in Cancer Clinical Trials
  368. Answers to Exercises
  369. Appendix 1: Exponentials and Logarithms
  370. Appendix 2: Maximum Likelihood and Significance Tests
  371. Appendix 3: Bootstrapping and Variance Robust Standard Errors
  372. Appendix 4: Bayesian Methods
  373. Frontmatter
  374. Glossary
  375. Index
  376. Logistic Regression
  377. Models, Tests and Data
  378. Multiple Linear Regression
  379. Other Models
  380. Random Effects Models
  381. Survival Analysis