All Stories

  1. Hydrogel Elastic Energy: A Stressor Triggering an Adaptive Stress‐Mediated Cell Response

    Article • Advanced Healthcare Materials, November 2024, Wiley

    Maurizio Romano

  2. Prion-like Spreading of Disease in TDP-43 Proteinopathies

    Article • Brain Sciences, November 2024, MDPI AG

    Maurizio Romano

  3. The long non-coding RNA GAS5 contributes to the suppression of inflammatory responses by inhibiting NF-κB activity

    Article • Frontiers in Pharmacology, October 2024, Frontiers

    Maurizio Romano

  4. Design, Synthesis, and Cytotoxic Assessment of New Haloperidol Analogues as Potential Anticancer Compounds Targeting Sigma Receptors

    Article • Molecules, June 2024, MDPI AG

    Maurizio Romano

  5. “A lactose-modified chitosan accelerates chondrogenic differentiation in mesenchymal stem cells spheroids”

    Article • Biomaterials Advances, June 2024, Elsevier

    Maurizio Romano

  6. Assessing the Impact of Novel BRCA1 Exon 11 Variants on Pre-mRNA Splicing

    Article • Cells, May 2024, MDPI AG

    Maurizio Romano

  7. Changes in the expression of COI1, TIR1, and ERF1 genes and respective MiRNAs in Fusarium basal Rot-Stressed onion

    Article • Gene, May 2024, Elsevier

    Maurizio Romano

  8. Age-Related Alternative Splicing: Driver or Passenger in the Aging Process?

    Article • Cells, December 2023, MDPI AG

    Maurizio Romano

  9. Cytotoxicity Profiles and Neuroprotective Properties of the Novel Ifenprodil Analogues as Sigma Ligands

    Article • Molecules, April 2023, MDPI AG

    Maurizio Romano

  10. Immediate stress dissipation in dual cross-link hydrogels controls osteogenic commitment of mesenchymal stem cells

    Article • Carbohydrate Polymers, February 2023, Elsevier

    Maurizio Romano

  11. Synthesis, Biological Evaluation and Computational Studies of New Hydrazide Derivatives Containing 1,3,4-Oxadiazole as Antitubercular Agents

    Article • International Journal of Molecular Sciences, December 2022, MDPI AG

    Maurizio Romano

  12. NOS1AP is a novel molecular target and critical factor in TDP-43 pathology

    Article • Brain Communications, September 2022, Oxford University Press (OUP)

    Maurizio Romano

  13. Design, synthesis and biological evaluation of novel aminopropylcarboxamide derivatives as sigma ligands

    Article • Bioorganic & Medicinal Chemistry Letters, September 2022, Elsevier

    Maurizio Romano

  14. Unraveling the toxic effects mediated by the neurodegenerative disease–associated S375G mutation of TDP-43 and its S375E phosphomimetic variant

    Article • Journal of Biological Chemistry, August 2022, Elsevier

    Maurizio Romano

  15. Targets to watch in neuroinflammation: focus on RIPK1

    Article • Drugs of the Future, May 2022, Portico

    Maurizio Romano

  16. Cell environment shapes TDP-43 function with implications in neuronal and muscle disease

    Article • Communications Biology, April 2022, Springer Science + Business Media

    Maurizio Romano

  17. Physiological tissue-specific and age-related reduction of mouse TDP-43 levels is regulated by epigenetic modifications

    Article • Disease Models & Mechanisms, April 2022, The Company of Biologists

    Maurizio Romano

  18. Identification of Parkinson's disease biomarkers through RNA sequencing of peripheral blood leukocytes

    Article • Journal of the Neurological Sciences, October 2021, Elsevier

    Maurizio Romano

  19. Characterization of the human TARDBP gene promoter

    Article • Scientific Reports, May 2021, Springer Science + Business Media

    Maurizio Romano

  20. Deferoxamine mesylate improves splicing and GAA activity of the common c.-32-13T>G allele in late-onset PD patient fibroblasts

    Article • Molecular Therapy — Methods & Clinical Development, March 2021, Elsevier

    Maurizio Romano

  21. γ- and δ-lactones as fumarate esters analogues and their neuroprotective effects

    Article • Medicinal Chemistry Research, January 2021, Springer Science + Business Media

    Maurizio Romano

  22. From basic research to the clinic: innovative therapies for ALS and FTD in the pipeline

    Article • Molecular Neurodegeneration, June 2020, Springer Science + Business Media

    Maurizio Romano

  23. Synthesis, Cytotoxicity Evaluation, and Computational Insights of Novel 1,4-Diazepane-Based Sigma Ligands

    Article • ACS Medicinal Chemistry Letters, December 2019, American Chemical Society (ACS)

    Maurizio Romano

  24. Discovery of new potent dual sigma receptor/GluN2b ligands with antioxidant property as neuroprotective agents

    Article • European Journal of Medicinal Chemistry, October 2019, Elsevier

    Maurizio Romano

  25. Dysregulation of TDP‐43 intracellular localization and early onset ALS are associated with a TARDBP S375G variant

    Article • Brain Pathology, December 2018, Wiley

    Maurizio Romano

  26. New piperidine-based derivatives as sigma receptor ligands. Synthesis and pharmacological evaluation

    Article • Bioorganic & Medicinal Chemistry Letters, October 2018, Elsevier

    Maurizio Romano

  27. Systematic Analysis of Gene Expression Profiles Controlled by hnRNP Q and hnRNP R, Two Closely Related Human RNA Binding Proteins Implicated in mRNA Processing Mechanisms

    Article • Frontiers in Molecular Biosciences, August 2018, Frontiers

    Maurizio Romano

  28. Abstract 2382: In silico/in vitro studies of novel hot spot mutations in BCR-ABL1: A multidisciplinary approach to shed a new light on TKI resistance

    Article • Cancer Research, July 2018, American Association for Cancer Research (AACR)

    Maurizio Romano

  29. RhoGAPp190: A potential player in tbph-mediated neurodegeneration in Drosophila

    Article • PLOS One, April 2018, PLOS

    Maurizio Romano

  30. Essential role of hippocampal noradrenaline in the regulation of spatial working memory and TDP-43 tissue pathology

    Article • The Journal of Comparative Neurology, February 2018, Wiley

    Maurizio Romano

  31. Role of the Long Non-Coding RNA Growth Arrest-Specific 5 in Glucocorticoid Response in Children with Inflammatory Bowel Disease

    Article • Basic & Clinical Pharmacology & Toxicology, August 2017, Wiley

    Professor Giuliana Decorti, Maurizio Romano

  32. Major hnRNP proteins act as general TDP-43 functional modifiers both in Drosophila and human neuronal cells

    Article • Nucleic Acids Research, May 2017, Oxford University Press (OUP)

    Maurizio Romano

  33. Keratin14 mRNA expression in human pneumocytes during quiescence, repair and disease

    Article • PLOS One, February 2017, PLOS

    Maurizio Romano

  34. Computer-assisted design, synthesis, binding and cytotoxicity assessments of new 1-(4-(aryl(methyl)amino)butyl)-heterocyclic sigma 1 ligands

    Article • European Journal of Medicinal Chemistry, October 2016, Elsevier

    Maurizio Romano

  35. TBPH/TDP-43 modulates translation of Drosophila futsch mRNA through an UG-rich sequence within its 5′UTR

    Article • Brain Research, September 2016, Elsevier

    Maurizio Romano

  36. New neurogenic lipoic-based hybrids as innovative Alzheimer's drugs with σ-1 agonism and β-secretase inhibition

    Article • Future Medicinal Chemistry, July 2016, Future Science

    Dr Jose A Morales-Garcia, Dr. María Isabel Rodríguez-Franco, Maurizio Romano, Dr Martin Estrada Valencia

  37. Antimycobacterial activity of new N 1 -[1-[1-aryl-3-[4-(1 H -imidazol-1-yl)phenyl]-3-oxo]propyl]-pyridine-2-carboxamidrazone derivatives

    Article • Bioorganic & Medicinal Chemistry Letters, July 2016, Elsevier

    Maurizio Romano

  38. A novelDrosophilamodel of TDP-43 proteinopathies: N-terminal sequences combined with the Q/N domain induce protein functional loss and locomotion defects

    Article • Disease Models & Mechanisms, April 2016, The Company of Biologists

    Maurizio Romano

  39. Exome sequencing of a colorectal cancer family reveals shared mutation pattern and predisposition circuitry along tumor pathways

    Article • Frontiers in Genetics, September 2015, Frontiers

    Khalid Alfarouk, Maurizio Romano

  40. TDP-43 affects splicing profiles and isoform production of genes involved in the apoptotic and mitotic cellular pathways

    Article • Nucleic Acids Research, August 2015, Oxford University Press (OUP)

    Maurizio Romano

  41. Knockdown of MVK does not lead to changes in NALP3 expression or activation

    Article • Journal of Inflammation, January 2015, Springer Science + Business Media

    Dr Fulvio Celsi, Maurizio Romano

  42. A novel anti-aldolase C antibody specifically interacts with residues 85–102 of the protein

    Article • mAbs, February 2014, Taylor & Francis

    Maurizio Romano

  43. Evolutionarily Conserved Heterogeneous Nuclear Ribonucleoprotein (hnRNP) A/B Proteins Functionally Interact with Human and Drosophila TAR DNA-binding Protein 43 (TDP-43)

    Article • Journal of Biological Chemistry, February 2014, American Society for Biochemistry & Molecular Biology (ASBMB)

    Maurizio Romano

  44. Targeting RNA Binding Proteins Involved in Neurodegeneration

    Article • October 2013, SAGE Publications

    Maurizio Romano

  45. TDP-43 high throughput screening analyses in neurodegeneration: Advantages and pitfalls

    Article • Molecular and Cellular Neuroscience, September 2013, Elsevier

    Maurizio Romano

  46. Role of Pseudoexons and Pseudointrons in Human Cancer

    Article • International Journal of Cell Biology, January 2013, Hindawi Publishing Corporation

    Maurizio Romano

  47. Tirasemtiv (CK-2017357)

    Article • Drugs of the Future, January 2013, Prous Science

    Maurizio Romano

  48. Florbetapir F 18 for brain imaging of beta-amyloid plaques

    Article • Drugs of Today, January 2013, Thomson Reuters (Scientific) Inc. & Affiliates

    Maurizio Romano

  49. Small Cytoplasmic Ribonucleoproteins

    Article • January 2013, Elsevier

    Maurizio Romano

  50. Tirasemtiv (CK-2017357)

    Article • Drugs of the Future, January 2013, Portico

    Maurizio Romano

  51. Splicing in the RNA World

    Article • February 2012, Wiley

    Maurizio Romano

  52. Drosophila Answers to TDP-43 Proteinopathies

    Article • Journal of Amino Acids, January 2012, Hindawi Publishing Corporation

    Maurizio Romano

  53. TDP-43 Regulates Drosophila Neuromuscular Junctions Growth by Modulating Futsch/MAP1B Levels and Synaptic Microtubules Organization

    Article • PLOS One, March 2011, PLOS

    Maurizio Romano

  54. TDP-43 regulates its mRNA levels through a negative feedback loop

    Article • The EMBO Journal, December 2010, Wiley

    Maurizio Romano

  55. G runs in Cystathionine β-Synthase c.833C/c.844_845ins68 mRNA are splicing silencers of pathogenic 3′ splice sites

    Article • Biochimica et Biophysica Acta (BBA) - Gene Regulatory Mechanisms, August 2010, Elsevier

    Maurizio Romano

  56. Neuropeptides in saliva of subjects with burning mouth syndrome: a pilot study

    Article • Oral Diseases, May 2010, Wiley

    Maurizio Romano

  57. Nuclear factor TDP-43 can affect selected microRNA levels

    Article • European Journal of Biochemistry, April 2010, Wiley

    Maurizio Romano

  58. Functional mapping of the interaction between TDP-43 and hnRNP A2 in vivo

    Article • Nucleic Acids Research, May 2009, Oxford University Press (OUP)

    Maurizio Romano

  59. Dissecting the splicing mechanism of the Drosophila editing enzyme; dADAR

    Article • Nucleic Acids Research, January 2009, Oxford University Press (OUP)

    Maurizio Romano

  60. Thrombopoietin and its splicing variants: Structure and functions in thrombopoiesis and beyond

    Article • Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease, July 2008, Elsevier

    Maurizio Romano

  61. Origin and evolution of the c.844_845ins68/c.833T>C mutations within the cystathionine β-synthase gene in great apes

    Article • FEBS Letters, January 2008, Wiley

    Maurizio Romano

  62. Aberrant 5′ splice sites in human disease genes: mutation pattern, nucleotide structure and comparison of computational tools that predict their utilization

    Article • Nucleic Acids Research, June 2007, Oxford University Press (OUP)

    Maurizio Romano

  63. Complex splicing control of the human Thrombopoietin gene by intronic G runs

    Article • Nucleic Acids Research, December 2006, Oxford University Press (OUP)

    Maurizio Romano

  64. Photodynamic Therapy of Subfoveal Choroidal Neovascularization Secondary to Reticular Pattern Dystrophy: Three-Year Results of an Uncontrolled, Prospective Case Series

    Article • American Journal of Ophthalmology, June 2006, Elsevier

    Maurizio Romano

  65. Depletion of TDP 43 overrides the need for exonic and intronic splicing enhancers in the human apoA-II gene

    Article • Nucleic Acids Research, October 2005, Oxford University Press (OUP)

    Maurizio Romano

  66. Human, Drosophila, and C.elegans TDP43: Nucleic Acid Binding Properties and Splicing Regulatory Function

    Article • Journal of Molecular Biology, May 2005, Elsevier

    Maurizio Romano

  67. Corrigendum

    Article • Clinical Genetics, August 2004, Wiley

    Maurizio Romano

  68. hnRNP H binding at the 5' splice site correlates with the pathological effect of two intronic mutations in the NF-1 and TSH  genes

    Article • Nucleic Acids Research, August 2004, Oxford University Press (OUP)

    Maurizio Romano

  69. An Exonic Splicing Enhancer Offsets the Atypical GU-rich 3′ Splice Site of Human Apolipoprotein A-II Exon 3

    Article • Journal of Biological Chemistry, July 2004, American Society for Biochemistry & Molecular Biology (ASBMB)

    Maurizio Romano

  70. Genetic characterization of myeloperoxidase deficiency in Italy

    Article • Human Mutation, January 2004, Wiley

    Maurizio Romano

  71. Identification and Subcellular Localization of Neuronal Calcium Sensor-1 (NCS-1) in Human Neutrophils and HL-60 Cells

    Article • Inflammation, December 2003, Springer Science + Business Media

    Maurizio Romano

  72. Genetic heterogeneity in Malattia Leventinese

    Article • Clinical Genetics, November 2002, Wiley

    Maurizio Romano

  73. Regulation of 3′ Splice Site Selection in the 844ins68 Polymorphism of the Cystathionine β-Synthase Gene

    Article • Journal of Biological Chemistry, September 2002, American Society for Biochemistry & Molecular Biology (ASBMB)

    Maurizio Romano

  74. Article • Journal of Inherited Metabolic Disease, January 2002, Wiley

    Maurizio Romano

  75. Minor Role for BRCA2 (Exon11) and p53 (Exon 5–9) Among Sudanese Breast Cancer Patients

    Article • Breast Cancer Research and Treatment, January 2002, Springer Science + Business Media

    Maurizio Romano

  76. Nuclear factor TDP-43 and SR proteins promote in vitro and in vivo CFTR exon 9 skipping

    Article • The EMBO Journal, April 2001, Wiley

    Maurizio Romano

  77. Expression and characterization of recombinant human eosinophil peroxidase

    Article • European Journal of Biochemistry, June 2000, Wiley

    Maurizio Romano

  78. Functional Characterization of the Novel Mutation IVS 8 (−11delC) (−14T>A) in the Intron 8 of the Glucocerebrosidase Gene of Two Italian Siblings with Gaucher Disease Type I

    Article • Blood Cells Molecules and Diseases, June 2000, Elsevier

    Maurizio Romano

  79. Splicing Factors Induce Cystic Fibrosis Transmembrane Regulator Exon 9 Skipping through a Nonevolutionary Conserved Intronic Element

    Article • Journal of Biological Chemistry, April 2000, American Society for Biochemistry & Molecular Biology (ASBMB)

    Maurizio Romano

  80. Myeloperoxidase (MPO) and Eosinophil Peroxidase (EPO) Deficiency in the Region Friuli-Venezia Giulia of North-Eastern Italy

    Article • January 2000, Springer Science + Business Media

    Maurizio Romano

  81. The A/G polymorphism in the −78 position of the apolipoprotein A-I promoter does not have a direct effect on transcriptional efficiency

    Article • Biochimica et Biophysica Acta (BBA) - Gene Structure and Expression, May 1998, Elsevier

    Maurizio Romano

  82. Hereditary eosinophil peroxidase deficiency: immunochemical and spectroscopic studies and evidence for a compound heterozygosity of the defect.

    Article • Proceedings of the National Academy of Sciences, December 1994, Proceedings of the National Academy of Sciences

    Maurizio Romano

  83. cDNA clones of myeloperoxidase (MPO) and eosinophil peroxidase (EPO) from human blood mononuclear cells differentiated into granulocyte precursors in liquid cultures

    Article • Journal of Immunological Methods, October 1992, Elsevier

    Maurizio Romano