All Stories

  1. First inhibitor of a bacterial two-partner secretion system

    Article • January 2026, openRxiv

    Dr Matthew Thomas Doyle

  2. Insights into type IX secretion from PorKN cogwheel structure bound to PorG and attachment complexes

    Article • Nature Communications, August 2025, Springer Science + Business Media

    Dr Matthew Thomas Doyle

  3. A porin-like protein used by bacterial predators defines a wider lipid-trapping superfamily

    Article • Nature Communications, July 2025, Springer Science + Business Media

    Dr Matthew Thomas Doyle

  4. Sequestration of dead-end undecaprenyl phosphate-linked oligosaccharide intermediate

    Article • Microbiology, January 2025, Society for General Microbiology

    Dr Yaoqin Hong, Dr Matthew Thomas Doyle

  5. Molecular Machines that Facilitate Bacterial Outer Membrane Protein Biogenesis

    Article • Annual Review of Biochemistry, August 2024, Annual Reviews

    Dr Matthew Thomas Doyle

  6. β-barrel membrane proteins fold via hybrid-barrel intermediate states

    Article • Current Opinion in Structural Biology, August 2024, Elsevier

    Dr Matthew Thomas Doyle

  7. The patatin-like protein PlpD forms structurally dynamic homodimers in the Pseudomonas aeruginosa outer membrane

    Article • Nature Communications, May 2024, Springer Science + Business Media

    Dr Matthew Thomas Doyle

  8. In Vivo Disulfide-Bond Crosslinking to Study β-Barrel Membrane Protein Interactions, Dynamicity, and Folding Intermediates

    Article • January 2024, Springer Science + Business Media

    Dr Matthew Thomas Doyle

  9. The patatin-like protein PlpD forms novel structurally dynamic homodimers in thePseudomonas aeruginosaouter membrane

    Article • April 2023, Cold Spring Harbor Laboratory Press

    Dr Matthew Thomas Doyle

  10. Small Molecule Antibiotics Inhibit Distinct Stages of Bacterial Outer Membrane Protein Assembly

    Article • mBio, October 2022, ASM Journals

    Dr Matthew Thomas Doyle

  11. Function of the Omp85 Superfamily of Outer Membrane Protein Assembly Factors and Polypeptide Transporters

    Article • Annual Review of Microbiology, September 2022, Annual Reviews

    Dr Matthew Thomas Doyle

  12. Cryo-EM structures reveal multiple stages of bacterial outer membrane protein folding

    Article • Cell, March 2022, Elsevier

    Dr Matthew Thomas Doyle

  13. Cryo-EM structures reveal multiple stages of bacterial outer membrane protein folding

    Article • August 2021, Cold Spring Harbor Laboratory Press

    Dr Matthew Thomas Doyle

  14. BamA forms a translocation channel for polypeptide export across the bacterial outer membrane

    Article • Molecular Cell, May 2021, Elsevier

    Dr Matthew Thomas Doyle

  15. The virulence domain of Shigella IcsA contains a subregion with specific host cell adhesion function

    Article • PLOS One, January 2020, PLOS

    Dr Matthew Thomas Doyle, Dr Renato Morona

  16. Bacterial outer membrane proteins assemble via asymmetric interactions with the BamA β-barrel

    Article • Nature Communications, July 2019, Springer Science + Business Media

    Dr Matthew Thomas Doyle

  17. Unprecedented Abundance of Protein Tyrosine Phosphorylation Modulates Shigella flexneri Virulence

    Article • Journal of Molecular Biology, October 2016, Elsevier

    Dr Matthew Thomas Doyle

  18. A small conserved motif supports polarity augmentation of Shigella flexneri IcsA

    Article • Microbiology, November 2015, Society for General Microbiology

    Dr Matthew Thomas Doyle

  19. PATR-type Autotransporters

    Article • Molecular Microbiology, May 2015, Wiley

    Dr Matthew Thomas Doyle

  20. Lipopolysaccharide surface structure does not influence IcsA polarity

    Article • FEMS Microbiology Letters, March 2015, Oxford University Press (OUP)

    Dr Renato Morona, Dr Matthew Thomas Doyle

  21. Asymmetric localisation of IcsP

    Article • PLOS One, July 2013, PLOS

    Dr Renato Morona, Dr Matthew Thomas Doyle