All Stories

  1. Finding order in chaos – nanocrystals in amorphous protein gels

    Article • Acta Crystallographica Section F Structural Biology Communications, November 2021, International Union of Crystallography

    Dr Matthew W Bowler

  2. Structural plasticity in a human blood transport protein

    Article • Acta Crystallographica Section D Structural Biology, November 2019, International Union of Crystallography

    Bernhard Rupp, Dr Matthew W Bowler

  3. A comparative anatomy of protein crystals

    Article • IUCrJ, July 2019, International Union of Crystallography

    Dr Matthew W Bowler

  4. Fully Autonomous Characterization and Data Collection from Crystals of Biological Macromolecules

    Article • Journal of Visualized Experiments, March 2019, MyJove Corporation

    Dr Matthew W Bowler

  5. A molecular mechanism for transthyretin amyloidogenesis

    Article • Nature Communications, February 2019, Springer Science + Business Media

    Dr Matthew P Blakeley, Dr Matthew W Bowler

  6. MXCuBE2: the dawn of MXCuBE Collaboration

    Article • Journal of Synchrotron Radiation, February 2019, International Union of Crystallography

    Dr Matthew W Bowler

  7. A comparative anatomy of protein crystals: lessons from the automatic processing of 56,000 samples

    Article • February 2019, Cold Spring Harbor Laboratory Press

    Dr Matthew W Bowler

  8. CrystalDirect-To-Beam: Opening the shortest path from crystal to data

    Article • January 2019, American Institute of Physics

    Dr Matthew W Bowler

  9. Structural basis for the bi-functionality of human oxaloacetate decarboxylase FAHD1

    Article • Biochemical Journal, October 2018, Portland Press Ltd.

    Dr Matthew W Bowler

  10. Structural basis for Scc3-dependent cohesin recruitment to chromatin

    Article • eLife, August 2018, eLife

    Dr Matthew W Bowler

  11. Structural basis for reactivating the mutant TERT promoter by cooperative binding of p52 and ETS1

    Article • Nature Communications, August 2018, Springer Science + Business Media

    Dr Matthew W Bowler, Yinghui Li

  12. van der Waals Contact between Nucleophile and Transferring Phosphorus Is Insufficient To Achieve Enzyme Transition-State Architecture

    Article • ACS Catalysis, July 2018, American Chemical Society (ACS)

    Dr Matthew W Bowler

  13. A novel amyloid designable scaffold and potential inhibitor inspired by GAIIG of amyloid beta and the HIV-1 V3 loop

    Article • FEBS Letters, June 2018, Wiley

    Dr Antonio L Llamas-Saiz, Dr Matthew W Bowler

  14. Improving automatic data collection algorithms to cope with the most challenging protein samples

    Article • Acta Crystallographica Section D Structural Biology, April 2018, International Union of Crystallography

    Dr Matthew W Bowler

  15. A new MR-SAD algorithm for the automatic building of protein models from low-resolution X-ray data and a poor starting model

    Article • IUCrJ, January 2018, International Union of Crystallography

    Dr Matthew W Bowler

  16. Structural Evidence for a Role of the Multi-functional Human Glycoprotein Afamin in Wnt Transport

    Article • Structure, December 2017, Elsevier

    Dr Matthew W Bowler, Didier Nurizzo

  17. Towards a compact and precise sample holder for macromolecular crystallography

    Article • Acta Crystallographica Section D Structural Biology, September 2017, International Union of Crystallography

    Dr Matthew W Bowler

  18. FlexED8: the first member of a fast and flexible sample-changer family for macromolecular crystallography

    Article • Acta Crystallographica Section D Structural Biology, September 2017, International Union of Crystallography

    Dr Matthew W Bowler

  19. Assessing the Influence of Mutation on GTPase Transition States by Using X-ray Crystallography, 19 F NMR, and DFT Approaches

    Article • Angewandte Chemie International Edition, May 2017, Wiley

    Dr Matthew W Bowler

  20. Maintaining the correct humidity for biological samples

    Article • Journal of Applied Crystallography, March 2017, International Union of Crystallography

    Dr Matthew W Bowler

  21. Computational design of amyloid self-assembling peptides bearing aromatic residues and the cell adhesive motif Arg-Gly-Asp

    Article • Molecular Systems Design & Engineering, January 2017, Royal Society of Chemistry

    Dr Matthew W Bowler

  22. Observing enzyme ternary transition state analogue complexes by 19F NMR spectroscopy

    Article • Chemical Science, January 2017, Royal Society of Chemistry

    Dr Matthew W Bowler

  23. Self-Assembled Amyloid Peptides with Arg-Gly-Asp (RGD) Motifs As Scaffolds for Tissue Engineering

    Article • ACS Biomaterials Science & Engineering, November 2016, American Chemical Society (ACS)

    Dr Matthew W Bowler

  24. Structural basis for specific recognition of pre-snRNA by Gemin5

    Article • Cell Research, November 2016, Nature

    Dr Matthew W Bowler

  25. Toxoplasma's immunogenic balancing act explained

    Article • Structure, November 2016, Elsevier

    Dr Matthew W Bowler

  26. Designing an autonomous system for protein crystallography

    Article • Acta Crystallographica Section D Structural Biology, July 2016, International Union of Crystallography

    Dr Matthew W Bowler, Didier Nurizzo

  27. Structural basis of suppression of host translation termination by Moloney Murine Leukemia Virus

    Article • Nature Communications, June 2016, Nature

    Dr Matthew W Bowler

  28. Structural basis for blocking PD-1-mediated immune suppression by therapeutic antibody pembrolizumab

    Article • Cell Research, June 2016, Nature

    Dr Matthew W Bowler

  29. An autonomous system to perform complex experiments for biologists

    Article • Crystallography Reviews, March 2016, Taylor & Francis

    Dr Matthew W Bowler, Didier Nurizzo

  30. Automated data collection based on RoboDiff at the ESRF beamline MASSIF-1

    Article • January 2016, American Institute of Physics

    Dr Matthew W Bowler, Didier Nurizzo

  31. A beamline that runs experiments by itself

    Article • Journal of Synchrotron Radiation, October 2015, International Union of Crystallography

    Dr Matthew W Bowler, IUCr Journals

  32. The sweet quartet: Binding of fucose to the norovirus capsid

    Article • Virology, September 2015, Elsevier

    Dr Matthew W Bowler

  33. Protein crystallography becomes hands free

    Article • Acta Crystallographica Section D Biological Crystallography, July 2015, International Union of Crystallography

    Dr Matthew W Bowler, IUCr Journals, Didier Nurizzo

  34. Purification and characterization of DR_2577 (SlpA) a major S-layer protein from Deinococcus radiodurans

    Article • Frontiers in Microbiology, June 2015, Frontiers

    Dr Matthew W Bowler

  35. The status of the macromolecular crystallography beamlines at the European Synchrotron Radiation Facility

    Article • The European Physical Journal Plus, April 2015, Springer Science + Business Media

    Dr Matthew W Bowler, Dr Antoine Royant, Didier Nurizzo

  36. Automation and Experience of Controlled Crystal Dehydration: Results from the European Synchrotron HC1 Collaboration

    Article • Crystal Growth & Design, March 2015, American Chemical Society (ACS)

    Dr Matthew W Bowler

  37. ISPyB for BioSAXS, the gateway to user autonomy in solution scattering experiments

    Article • Acta Crystallographica Section D Biological Crystallography, January 2015, International Union of Crystallography

    Dr Matthew W Bowler

  38. α-Fluorophosphonates reveal how a phosphomutase conserves transition state conformation over hexose recognition in its two-step reaction

    Article • Proceedings of the National Academy of Sciences, August 2014, Proceedings of the National Academy of Sciences

    Dr Matthew W Bowler

  39. New features of the cell wall of the radio-resistant bacterium Deinococcus radiodurans

    Article • Biochimica et Biophysica Acta (BBA) - Biomembranes, July 2014, Elsevier

    Dr Matthew W Bowler

  40. Measuring crystal quality

    Article • Acta Crystallographica Section F Structural Biology Communications, December 2013, International Union of Crystallography

    Dr Matthew W Bowler

  41. QsIA disrupts LasR dimerization in antiactivation of bacterial quorum sensing

    Article • Proceedings of the National Academy of Sciences, December 2013, Proceedings of the National Academy of Sciences

    Dr Matthew W Bowler

  42. Lsm2 and Lsm3 bridge the interaction of the Lsm1-7 complex with Pat1 for decapping activation

    Article • Cell Research, November 2013, Nature

    Dr Matthew W Bowler

  43. Le rayonnement synchrotron : comprendre la relation structure-fonction des macromolécules biologiques

    Article • Reflets de la physique, June 2013, EDP Sciences

    Dr Matthew W Bowler, Didier Nurizzo

  44. Conformational dynamics in phosphoglycerate kinase, an open and shut case?

    Article • FEBS Letters, May 2013, Wiley

    Dr Matthew W Bowler

  45. Automatic processing of macromolecular crystallography X-ray diffraction data at the ESRF

    Article • Journal of Applied Crystallography, May 2013, International Union of Crystallography

    Dr Matthew W Bowler

  46. Recent progress in robot-based systems for crystallography and their contribution to drug discovery

    Article • Expert Opinion on Drug Discovery, May 2013, Informa Healthcare

    Dr Matthew W Bowler, Didier Nurizzo

  47. The Upgrade Programme for the Structural Biology beamlines at the European Synchrotron Radiation Facility – High throughput sample evaluation and automation

    Article • Journal of Physics Conference Series, March 2013, Institute of Physics Publishing

    Dr Matthew W Bowler

  48. Structural Basis of the PNRC2-Mediated Link between mRNA Surveillance and Decapping

    Article • Structure, December 2012, Elsevier

    Dr Matthew W Bowler, Yoon ki Kim

  49. Charge-Balanced Metal Fluoride Complexes for Protein Kinase A with Adenosine Diphosphate and Substrate Peptide SP20

    Article • Angewandte Chemie, November 2012, Wiley

    Dr Matthew W Bowler

  50. Charge-Balanced Metal Fluoride Complexes for Protein Kinase A with Adenosine Diphosphate and Substrate Peptide SP20

    Article • Angewandte Chemie International Edition, November 2012, Wiley

    Dr Matthew W Bowler

  51. Reflections on biocatalysis involving phosphorus

    Article • Biochemistry (Moscow), October 2012, Pleiades Publishing Ltd

    Dr Matthew W Bowler

  52. The Ighmbp2 helicase structure reveals the molecular basis for disease-causing mutations in DMSA1

    Article • Nucleic Acids Research, September 2012, Oxford University Press (OUP)

    Dr Matthew W Bowler

  53. The use of workflows in the design and implementation of complex experiments in macromolecular crystallography

    Article • Acta Crystallographica Section D Biological Crystallography, July 2012, International Union of Crystallography

    Dr Matthew W Bowler

  54. Crystal Structures of Lsm3, Lsm4 and Lsm5/6/7 from Schizosaccharomyces pombe

    Article • PLoS ONE, May 2012, PLOS

    Dr Matthew W Bowler

  55. Near attack conformers dominate β-phosphoglucomutase complexes where geometry and charge distribution reflect those of substrate

    Article • Proceedings of the National Academy of Sciences, April 2012, Proceedings of the National Academy of Sciences

    Dr Matthew W Bowler

  56. Matching the water content in a solution to relative humidity in air

    Article • Acta Crystallographica Section F Structural Biology and Crystallization Communications, December 2011, International Union of Crystallography

    Dr Matthew W Bowler

  57. Cool protein crystals easily

    Article • Acta Crystallographica Section D Biological Crystallography, September 2011, International Union of Crystallography

    Dr Matthew W Bowler

  58. Inducing phase changes in crystals of macromolecules: Status and perspectives for controlled crystal dehydration

    Article • Journal of Structural Biology, August 2011, Elsevier

    Dr Matthew W Bowler

  59. Interaction of Human 3-Phosphoglycerate Kinase with Its Two Substrates: Is Substrate Antagonism a Kinetic Advantage?

    Article • Journal of Molecular Biology, June 2011, Elsevier

    Dr Matthew W Bowler

  60. A Spring-loaded Release Mechanism Regulates Domain Movement and Catalysis in Phosphoglycerate Kinase

    Article • Journal of Biological Chemistry, February 2011, American Society for Biochemistry & Molecular Biology (ASBMB)

    Dr Matthew W Bowler

  61. MX automation: towards a new sample holder standard for frozen crystals

    Article • Acta Crystallographica Section A Foundations of Crystallography, August 2010, International Union of Crystallography

    Dr Matthew W Bowler

  62. MxCuBE: a synchrotron beamline control environment customized for macromolecular crystallography experiments

    Article • Journal of Synchrotron Radiation, July 2010, International Union of Crystallography

    Dr Matthew W Bowler, Dr Martin Austin Walsh

  63. Locating and mapping the internal quality of protein crystals

    Article • Acta Crystallographica Section D Biological Crystallography, July 2010, International Union of Crystallography

    Dr Matthew W Bowler

  64. Transition State Analogue Structures of Human Phosphoglycerate Kinase Establish the Importance of Charge Balance in Catalysis

    Article • Journal of the American Chemical Society, May 2010, American Chemical Society (ACS)

    Dr Matthew W Bowler

  65. Atomic details of near-transition state conformers for enzyme phosphoryl transfer revealed by MgF3- rather than by phosphoranes

    Article • Proceedings of the National Academy of Sciences, February 2010, Proceedings of the National Academy of Sciences

    Dr Matthew W Bowler

  66. Why did Nature select phosphate for its dominant roles in biology?

    Article • New Journal of Chemistry, January 2010, Royal Society of Chemistry

    Dr Matthew W Bowler

  67. MgF 3 − and α-Galactose 1-Phosphate in the Active Site of β-Phosphoglucomutase Form a Transition State Analogue of Phosphoryl Transfer

    Article • Journal of the American Chemical Society, November 2009, American Chemical Society (ACS)

    Dr Matthew W Bowler

  68. Improving diffraction by humidity control: a novel device compatible with X-ray beamlines

    Article • Acta Crystallographica Section D Biological Crystallography, November 2009, International Union of Crystallography

    Dr Matthew W Bowler

  69. Ground State Structure of F1-ATPase from Bovine Heart Mitochondria at 1.9 A Resolution

    Article • Journal of Biological Chemistry, March 2007, American Society for Biochemistry & Molecular Biology (ASBMB)

    Dr Matthew W Bowler

  70. Reproducible improvements in order and diffraction limit of crystals of bovine mitochondrial F1-ATPase by controlled dehydration

    Article • Acta Crystallographica Section D Biological Crystallography, August 2006, International Union of Crystallography

    Dr Matthew W Bowler

  71. How azide inhibits ATP hydrolysis by the F-ATPases

    Article • Proceedings of the National Academy of Sciences, June 2006, Proceedings of the National Academy of Sciences

    Dr Matthew W Bowler

  72. Increasing the diffraction limit and internal order of a membrane protein crystal by dehydration

    Article • Journal of Structural Biology, February 2003, Elsevier

    Dr Matthew W Bowler