All Stories

  1. Four decades of the RET gene: From discovery to tumor-agnostic therapy

    Article • Journal of the Formosan Medical Association, October 2025, Elsevier

    Prof Masahide Takahashi

  2. Response to comment on “Four decades of the RET gene: From discovery to tumor-agnostic therapy”

    Article • Journal of the Formosan Medical Association, October 2025, Elsevier

    Prof Masahide Takahashi

  3. Self-organization of spermatogenic wave coordinates sustained sperm production in the mouse testis

    Article • November 2024, Cold Spring Harbor Laboratory Press

    Prof Masahide Takahashi

  4. RET proto-oncogene

    Article • August 2023, IntechOpen

    Prof Masahide Takahashi

  5. Planar cell polarity induces local microtubule bundling for coordinated ciliary beating

    Article • Journal of Cell Biology, April 2021, Rockefeller University Press

    Prof Masahide Takahashi

  6. Serum CD109 levels reflect the node metastasis status in head and neck squamous cell carcinoma

    Article • Cancer Medicine, February 2021, Wiley

    Prof Masahide Takahashi

  7. Intracellular RET signaling pathways activated by GDNF

    Article • Cell and Tissue Research, August 2020, Springer Science + Business Media

    Prof Masahide Takahashi

  8. Cancer‐associated fibroblasts that restrain cancer progression: Hypotheses and perspectives

    Article • Cancer Science, March 2020, Wiley

    Prof Masahide Takahashi

  9. Meflin-Positive Cancer-Associated Fibroblasts Inhibit Pancreatic Carcinogenesis

    Article • Cancer Research, October 2019, American Association for Cancer Research (AACR)

    Prof Masahide Takahashi

  10. Roles of the Mesenchymal Stromal/Stem Cell Marker Meflin in Cardiac Tissue Repair and the Development of Diastolic Dysfunction

    Article • Circulation Research, August 2019, Wolters Kluwer Health

    Prof Masahide Takahashi

  11. CD109: a multifunctional GPI‐anchored protein with key roles in tumor progression and physiological homeostasis

    Article • Pathology International, May 2019, Wiley

    Prof Masahide Takahashi

  12. Dephosphorylation of Girdin by PP2A inhibits breast cancer metastasis

    Article • Biochemical and Biophysical Research Communications, May 2019, Elsevier

    Prof Masahide Takahashi

  13. Cancer-associated fibroblasts in gastrointestinal cancer

    Article • Nature Reviews Gastroenterology & Hepatology, February 2019, Springer Science + Business Media

    Prof Masahide Takahashi

  14. Aberrant Active cis-Regulatory Elements Associated with Downregulation of RET Finger Protein Overcome Chemoresistance in Glioblastoma

    Article • Cell Reports, February 2019, Elsevier

    Prof Masahide Takahashi

  15. Girdin/GIV regulates collective cancer cell migration by controlling cell adhesion and cytoskeletal organization

    Article • Cancer Science, October 2018, Wiley

    Prof Masahide Takahashi

  16. CD109 deficiency induces osteopenia with an osteoporosis-like phenotype in vivo

    Article • Genes to Cells, May 2018, Wiley

    Prof Masahide Takahashi

  17. Essential Role of Linx/Islr2 in the Development of the Forebrain Anterior Commissure

    Article • Scientific Reports, May 2018, Springer Science + Business Media

    Prof Masahide Takahashi

  18. Negative regulation of amino acid signaling by MAPK-regulated 4F2hc/Girdin complex

    Article • PLoS Biology, March 2018, PLOS

    Prof Masahide Takahashi

  19. Congenic mapping and candidate gene analysis for streptozotocin-induced diabetes susceptibility locus on mouse chromosome 11

    Article • Mammalian Genome, March 2018, Springer Science + Business Media

    Prof Masahide Takahashi

  20. Critical role of rabphilin-3A in the pathophysiology of experimental lymphocytic neurohypophysitis

    Article • The Journal of Pathology, March 2018, Wiley

    Prof Masahide Takahashi

  21. Development of a method to preliminarily embed tissue samples using low melting temperature fish gelatin before sectioning: A technical note

    Article • Pathology International, February 2018, Wiley

    Prof Masahide Takahashi

  22. ASC amino acid transporter 2, defined by enzyme-mediated activation of radical sources, enhances malignancy of GD2-positive small-cell lung cancer

    Article • Cancer Science, January 2018, Wiley

    Prof Masahide Takahashi

  23. Significance of perivascular tumour cells defined by CD109 expression in progression of glioma

    Article • The Journal of Pathology, November 2017, Wiley

    Prof Masahide Takahashi

  24. Daple Coordinates Planar Polarized Microtubule Dynamics in Ependymal Cells and Contributes to Hydrocephalus

    Article • Cell Reports, July 2017, Elsevier

    Prof Masahide Takahashi

  25. Tyrosine Phosphorylation of Girdin Pinpoints Tuft Cells in Mammalian Gut

    Article • Journal of Histochemistry & Cytochemistry, April 2017, SAGE Publications

    M.D., Ph. D. Masato Asai, Prof Masahide Takahashi

  26. Significance of low mTORC1 activity in defining the characteristics of brain tumor stem cells

    Article • Neuro-Oncology, December 2016, Oxford University Press (OUP)

    Prof Masahide Takahashi

  27. Well-differentiated neuroendocrine tumor of the breast with extensive lymphatic and vascular infiltration

    Article • Pathology International, November 2016, Wiley

    Prof Masahide Takahashi

  28. Suppression of skin tumorigenesis in CD109-deficient mice

    Article • Oncotarget, October 2016, Impact Journals, LLC

    Prof Masahide Takahashi

  29. Increased expression levels of ppGalNAc-T13 in lung cancers: Significance in the prognostic diagnosis

    Article • International Journal of Oncology, July 2016, Spandidos Publications

    Prof Masahide Takahashi

  30. Molecular mechanism linking BDNF/TrkB signaling with the NMDA receptor in memory: the role of Girdin in the CNS

    Article • Reviews in the Neurosciences, July 2016, De Gruyter

    Prof Masahide Takahashi

  31. Identification of Meflin as a Potential Marker for Mesenchymal Stromal Cells

    Article • Scientific Reports, February 2016, Springer Science + Business Media

    Prof Masahide Takahashi

  32. CCDC88A mutations cause PEHO-like syndrome in humans and mouse

    Article • Brain, February 2016, Oxford University Press (OUP)

    Prof Masahide Takahashi

  33. Collective invasion of cancer: Perspectives from pathology and development

    Article • Pathology International, February 2016, Wiley

    Prof Masahide Takahashi

  34. CD109 is a component of exosome secreted from cultured cells

    Article • Biochemical and Biophysical Research Communications, January 2016, Elsevier

    Prof Masahide Takahashi

  35. Role for Daple in non‐canonical Wnt signaling during gastric cancer invasion and metastasis

    Article • Cancer Science, December 2015, Wiley

    Prof Masahide Takahashi

  36. Akt-dependent Girdin phosphorylation regulates repair processes after acute myocardial infarction

    Article • Journal of Molecular and Cellular Cardiology, November 2015, Elsevier

    Prof Masahide Takahashi

  37. Akt-Girdin as oncotarget

    Article • Oncoscience, September 2015, Impact Journals, LLC

    Prof Masahide Takahashi

  38. Potential involvement of kinesin-1 in the regulation of subcellular localization of Girdin

    Article • Biochemical and Biophysical Research Communications, August 2015, Elsevier

    Prof Masahide Takahashi

  39. Rabphilin-3A as a Targeted Autoantigen in Lymphocytic Infundibulo-neurohypophysitis

    Article • The Journal of Clinical Endocrinology & Metabolism, July 2015, Endocrine Society

    Prof Masahide Takahashi

  40. Girdin/GIV regulates transendothelial permeability by controlling VE-cadherin trafficking through the small GTPase, R-Ras

    Article • Biochemical and Biophysical Research Communications, May 2015, Elsevier

    Prof Masahide Takahashi

  41. New Endoplasmic Reticulum Stress Regulator, Gipie, Regulates the Survival of Vascular Smooth Muscle Cells and the Neointima Formation After Vascular Injury

    Article • Arteriosclerosis Thrombosis and Vascular Biology, May 2015, Wolters Kluwer Health

    Prof Masahide Takahashi

  42. CD109 attenuates TGF-β1 signaling and enhances EGF signaling in SK-MG-1 human glioblastoma cells

    Article • Biochemical and Biophysical Research Communications, April 2015, Elsevier

    Prof Masahide Takahashi

  43. Congratulations on the 20 years anniversary ofPathology International

    Article • Pathology International, April 2015, Wiley

    Prof Masahide Takahashi

  44. Evaluation of androgen receptor and GATA binding protein 3 as immunohistochemical markers in the diagnosis of metastatic breast carcinoma to the lung

    Article • Pathology International, March 2015, Wiley

    Prof Masahide Takahashi

  45. Akt–Girdin Signaling in Cancer-Associated Fibroblasts Contributes to Tumor Progression

    Article • Cancer Research, March 2015, American Association for Cancer Research (AACR)

    Prof Masahide Takahashi

  46. Functional Differences between GDNF-Dependent and FGF2-Dependent Mouse Spermatogonial Stem Cell Self-Renewal

    Article • Stem Cell Reports, March 2015, Elsevier

    Prof Masahide Takahashi

  47. Girdin is phosphorylated on tyrosine 1798 when associated with structures required for migration

    Article • Biochemical and Biophysical Research Communications, March 2015, Elsevier

    Prof Masahide Takahashi

  48. Special AT-rich sequence-binding protein 2 suppresses invadopodia formation in HCT116 cells via palladin inhibition

    Article • Experimental Cell Research, March 2015, Elsevier

    Prof Masahide Takahashi

  49. SATB2 suppresses the progression of colorectal cancer cells via inactivation of MEK5/ERK5 signaling

    Article • European Journal of Biochemistry, February 2015, Wiley

    Prof Masahide Takahashi

  50. Activating Transcription Factor 6α Is Required for the Vasopressin Neuron System to Maintain Water Balance Under Dehydration in Male Mice

    Article • Endocrinology, December 2014, Endocrine Society

    Prof Masahide Takahashi

  51. Girdin Phosphorylation Is Crucial for Synaptic Plasticity and Memory: A Potential Role in the Interaction of BDNF/TrkB/Akt Signaling with NMDA Receptor

    Article • Journal of Neuroscience, November 2014, Society for Neuroscience

    Prof Masahide Takahashi

  52. SHCBP1 is required for midbody organization and cytokinesis completion

    Article • Cell Cycle, September 2014, Taylor & Francis

    Prof Masahide Takahashi

  53. Role of Girdin in intimal hyperplasia in vein grafts and efficacy of atelocollagen-mediated application of small interfering RNA for vein graft failure

    Article • Journal of Vascular Surgery, August 2014, Elsevier

    Prof Masahide Takahashi

  54. Speed control for neuronal migration in the postnatal brain by Gmip-mediated local inactivation of RhoA

    Article • Nature Communications, July 2014, Springer Science + Business Media

    Prof Masahide Takahashi

  55. Regulation of cargo-selective endocytosis by dynamin 2 GTPase-activating protein girdin

    Article • The EMBO Journal, July 2014, EMBO

    Prof Masahide Takahashi

  56. Evaluation of osteopontin as a potential biomarker for central nervous system embryonal tumors

    Article • Journal of Neuro-Oncology, May 2014, Springer Science + Business Media

    Prof Masahide Takahashi

  57. TRIM27/MRTF-B-Dependent Integrin β1 Expression Defines Leading Cells in Cancer Cell Collectives

    Article • Cell Reports, May 2014, Elsevier

    Prof Masahide Takahashi

  58. Suppression of REV7 enhances cisplatin sensitivity in ovarian clear cell carcinoma cells

    Article • Cancer Science, April 2014, Wiley

    Prof Masahide Takahashi

  59. Arginine vasopressin neuronal loss results from autophagy-associated cell death in a mouse model for familial neurohypophysial diabetes insipidus

    Article • Cell Death and Disease, March 2014, Springer Science + Business Media

    Prof Masahide Takahashi

  60. The involvement of reactive oxygen species derived from NADPH oxidase-1 activation on the constitutive tyrosine auto-phosphorylation of RET proteins

    Article • Free Radical Research, February 2014, Taylor & Francis

    Prof Masahide Takahashi

  61. Detection of a Soluble Form of CD109 in Serum of CD109 Transgenic and Tumor Xenografted Mice

    Article • PLOS One, January 2014, PLOS

    Prof Masahide Takahashi

  62. Mechanisms for the differentiation of postnatal and adult neural stem cells: new insights and pathological issues based on the analysis of Girdin

    Article • Folia Pharmacologica Japonica, January 2014, Japanese Pharmacological Society

    Prof Masahide Takahashi

  63. Silencing of TBC1D15 promotes RhoA activation and membrane blebbing

    Article • Molecular and Cellular Biochemistry, December 2013, Springer Science + Business Media

    Prof Masahide Takahashi

  64. Proteomic analysis of Girdin-interacting proteins in migrating new neurons in the postnatal mouse brain

    Article • Biochemical and Biophysical Research Communications, December 2013, Elsevier

    Prof Masahide Takahashi

  65. Degeneration of Retinal ON Bipolar Cells Induced by Serum Including Autoantibody against TRPM1 in Mouse Model of Paraneoplastic Retinopathy

    Article • PLOS One, November 2013, PLOS

    Prof Masahide Takahashi

  66. The impact of Girdin expression on recurrence-free survival in patients with luminal-type breast cancer

    Article • Breast Cancer, October 2013, Springer Science + Business Media

    Prof Masahide Takahashi

  67. Mycobacterium tuberculosisescapes from the phagosomes of infected human osteoclasts reprograms osteoclast development via dysregulation of cytokines and chemokines

    Article • Pathogens and Disease, September 2013, Oxford University Press (OUP)

    Prof Masahide Takahashi

  68. Pathological analysis of Ki-67 and CD109 expression in tongue squamous cell carcinoma

    Article • Journal of Oral and Maxillofacial Surgery Medicine and Pathology, July 2013, Elsevier

    Prof Masahide Takahashi

  69. The REV7 Subunit of DNA Polymerase ζ Is Essential for Primordial Germ Cell Maintenance in the Mouse

    Article • Journal of Biological Chemistry, April 2013, Elsevier

    Prof Masahide Takahashi

  70. Girdin and Its Phosphorylation Dynamically Regulate Neonatal Vascular Development and Pathological Neovascularization in the Retina

    Article • American Journal Of Pathology, February 2013, Elsevier

    Prof Masahide Takahashi

  71. The Aurora B-mediated phosphorylation of SHCBP1 regulates cytokinetic furrow ingression

    Article • Journal of Cell Science, January 2013, The Company of Biologists

    Prof Masahide Takahashi

  72. Exposure to 1-bromopropane induces microglial changes and oxidative stress in the rat cerebellum

    Article • Toxicology, December 2012, Elsevier

    Prof Masahide Takahashi

  73. Significance of cancer-associated fibroblasts in the regulation of gene expression in the leading cells of invasive lung cancer

    Article • Journal of Cancer Research and Clinical Oncology, October 2012, Springer Science + Business Media

    Prof Masahide Takahashi

  74. Epidermal Hyperplasia and Appendage Abnormalities in Mice Lacking CD109

    Article • American Journal Of Pathology, October 2012, Elsevier

    Prof Masahide Takahashi

  75. Similar phenotypes of Girdin germ-line and conditional knockout mice indicate a crucial role for Girdin in the nestin lineage

    Article • Biochemical and Biophysical Research Communications, October 2012, Elsevier

    Prof Masahide Takahashi

  76. Expression of RET finger protein predicts chemoresistance in epithelial ovarian cancer

    Article • Cancer Medicine, September 2012, Wiley

    Prof Masahide Takahashi

  77. Girdin locates in centrosome and midbody and plays an important role in cell division

    Article • Cancer Science, August 2012, Wiley

    Prof Masahide Takahashi

  78. Indoxyl sulfate promotes vascular smooth muscle cell senescence with upregulation of p53, p21, and prelamin A through oxidative stress

    Article • AJP Cell Physiology, July 2012, American Physiological Society

    Prof Masahide Takahashi

  79. Misshapen-like kinase 1 (MINK1) Is a Novel Component of Striatin-interacting Phosphatase and Kinase (STRIPAK) and Is Required for the Completion of Cytokinesis

    Article • Journal of Biological Chemistry, July 2012, Elsevier

    Prof Masahide Takahashi

  80. The Dishevelled-associating protein Daple controls the non-canonical Wnt/Rac pathway and cell motility

    Article • Nature Communications, May 2012, Springer Science + Business Media

    Prof Masahide Takahashi

  81. Involvement of Girdin in the Determination of Cell Polarity during Cell Migration

    Article • PLOS One, May 2012, PLOS

    Prof Masahide Takahashi

  82. RET finger protein expression is associated with prognosis in lung cancer with epidermal growth factor receptor mutations

    Article • Pathology International, March 2012, Wiley

    Prof Masahide Takahashi

  83. Partial impairment of c-Ret at tyrosine 1062 accelerates age-related hearing loss in mice

    Article • Neurobiology of Aging, March 2012, Elsevier

    Prof Masahide Takahashi, Professor Toyonori Tsuzuki

  84. Role of Palladin Phosphorylation by Extracellular Signal-Regulated Kinase in Cell Migration

    Article • PLOS One, December 2011, PLOS

    Prof Masahide Takahashi

  85. Poly(A) Tail Length of Neurohypophysial Hormones Is Shortened Under Endoplasmic Reticulum Stress

    Article • Endocrinology, December 2011, Endocrine Society

    Prof Masahide Takahashi

  86. Proteomic analysis of hippocampal proteins of F344 rats exposed to 1-bromopropane

    Article • Toxicology and Applied Pharmacology, November 2011, Elsevier

    Prof Masahide Takahashi

  87. Girdin maintains the stemness of glioblastoma stem cells

    Article • Oncogene, October 2011, Springer Science + Business Media

    Prof Masahide Takahashi

  88. Behavioral alterations associated with targeted disruption of exons 2 and 3 of the Disc1 gene in the mouse

    Article • Human Molecular Genetics, September 2011, Oxford University Press (OUP)

    Prof Masahide Takahashi

  89. An effective gene-knockdown using multiple shRNA-expressing adenovirus vectors

    Article • Journal of Controlled Release, July 2011, Elsevier

    Prof Masahide Takahashi

  90. Ret finger protein inhibits muscle differentiation by modulating serum response factor and enhancer of polycomb1

    Article • Cell Death and Differentiation, June 2011, Springer Science + Business Media

    Prof Masahide Takahashi

  91. Analysis of glial cell line–derived neurotrophic factor–inducible zinc finger protein 1 expression in human diseased kidney

    Article • Human Pathology, June 2011, Elsevier

    Prof Masahide Takahashi, Professor Toyonori Tsuzuki

  92. Girdin Is an Intrinsic Regulator of Neuroblast Chain Migration in the Rostral Migratory Stream of the Postnatal Brain

    Article • Journal of Neuroscience, June 2011, Society for Neuroscience

    Prof Masahide Takahashi

  93. The Actin-Binding Protein Girdin and Its Akt-Mediated Phosphorylation Regulate Neointima Formation After Vascular Injury

    Article • Circulation Research, May 2011, Wolters Kluwer Health

    Prof Masahide Takahashi

  94. Protective role of Gipie, a Girdin family protein, in endoplasmic reticulum stress responses in endothelial cells

    Article • Molecular Biology of the Cell, March 2011, American Society for Cell Biology (ASCB)

    Prof Masahide Takahashi

  95. High glucose impairs the proliferation and increases the apoptosis of endothelial progenitor cells by suppression of Akt

    Article • Journal of Diabetes Investigation, January 2011, Wiley

    Prof Masahide Takahashi

  96. Loss of Sprouty2 partially rescues renal hypoplasia and stomach hypoganglionosis but not intestinal aganglionosis in Ret Y1062F mutant mice

    Article • Developmental Biology, January 2011, Elsevier

    Prof Masahide Takahashi

  97. Correlation of pathological grade and tumor stage of urothelial carcinomas with CD109 expression

    Article • Pathology International, October 2010, Wiley

    Prof Masahide Takahashi

  98. c-Ret–mediated hearing loss in mice with Hirschsprung disease

    Article • Proceedings of the National Academy of Sciences, June 2010, Proceedings of the National Academy of Sciences

    Prof Masahide Takahashi, Professor Toyonori Tsuzuki

  99. Analysis of DOK-6 function in downstream signaling of RET in human neuroblastoma cells

    Article • Cancer Science, May 2010, Wiley

    Prof Masahide Takahashi

  100. Girding for migratory cues: roles of the Akt substrate Girdin in cancer progression and angiogenesis

    Article • Cancer Science, April 2010, Wiley

    Prof Masahide Takahashi

  101. Erratum: Etv4 and Etv5 are required downstream of GDNF and Ret for kidney branching morphogenesis

    Article • Nature Genetics, April 2010, Springer Science + Business Media

    Prof Masahide Takahashi

  102. CD109 expression levels in malignant melanoma

    Article • Journal of Dermatological Science, February 2010, Elsevier

    Prof Masahide Takahashi

  103. Processing of CD109 by furin and its role in the regulation of TGF-β signaling

    Article • Oncogene, January 2010, Springer Science + Business Media

    Prof Masahide Takahashi

  104. A Novel Mouse Model for De novo Melanoma

    Article • Cancer Research, January 2010, American Association for Cancer Research (AACR)

    Prof Masahide Takahashi, Professor Toyonori Tsuzuki

  105. A redox-linked novel pathway for arsenic-mediated RET tyrosine kinase activation

    Article • Journal of Cellular Biochemistry, January 2010, Wiley

    Prof Masahide Takahashi

  106. dGirdin a new player of Akt /PKB signaling in Drosophila Melanogaster

    Article • Frontiers in Bioscience, January 2010, IMR Press

    Prof Masahide Takahashi

  107. Etv4 and Etv5 are required downstream of GDNF and Ret for kidney branching morphogenesis

    Article • Nature Genetics, November 2009, Springer Science + Business Media

    Prof Masahide Takahashi

  108. Multiple Endocrine Neoplasia Syndrome

    Article • November 2009, Springer Science + Business Media

    Prof Masahide Takahashi

  109. A novel Drosophila Girdin-like protein is involved in Akt pathway control of cell size

    Article • Experimental Cell Research, November 2009, Elsevier

    Prof Masahide Takahashi

  110. Cell biology of the movement of breast cancer cells: Intracellular signalling and the actin cytoskeleton

    Article • Cancer Letters, November 2009, Elsevier

    Prof Masahide Takahashi

  111. Expression of Ret finger protein correlates with outcomes in endometrial cancer

    Article • Cancer Science, October 2009, Wiley

    Prof Masahide Takahashi

  112. Roles of Disrupted-In-Schizophrenia 1-Interacting Protein Girdin in Postnatal Development of the Dentate Gyrus

    Article • Neuron, September 2009, Elsevier

    Prof Masahide Takahashi

  113. Ret-Dependent Cell Rearrangements in the Wolffian Duct Epithelium Initiate Ureteric Bud Morphogenesis

    Article • Developmental Cell, August 2009, Elsevier

    Prof Masahide Takahashi

  114. Adiponectin promotes migration activities of endothelial progenitor cells via Cdc42/Rac1

    Article • FEBS Letters, July 2009, Wiley

    Prof Masahide Takahashi

  115. RET finger protein expression in invasive breast carcinoma: Relationship between RFP and ErbB2 expression

    Article • Pathology - Research and Practice, June 2009, Elsevier

    Prof Masahide Takahashi

  116. Characterization of the HDAC1 Complex That Regulates the Sensitivity of Cancer Cells to Oxidative Stress

    Article • Cancer Research, April 2009, American Association for Cancer Research (AACR)

    Prof Masahide Takahashi

  117. Indoxyl sulphate induces oxidative stress and the expression of osteoblast-specific proteins in vascular smooth muscle cells

    Article • Nephrology Dialysis Transplantation, January 2009, Oxford University Press (OUP)

    Prof Masahide Takahashi

  118. Up-regulation of CD109 expression is associated with carcinogenesis of the squamous epithelium of the oral cavity

    Article • Cancer Science, September 2008, Wiley

    Prof Masahide Takahashi

  119. Roles of induced expression of MAPK phosphatase-2 in tumor development in RET-MEN2A transgenic mice

    Article • Oncogene, June 2008, Springer Science + Business Media

    Prof Masahide Takahashi

  120. CD109 expression in basal-like breast carcinoma

    Article • Pathology International, May 2008, Wiley

    Prof Masahide Takahashi

  121. GDNF-mediated signaling via RET tyrosine 1062 is essential for maintenance of spermatogonial stem cells

    Article • Genes to Cells, April 2008, Wiley

    Prof Masahide Takahashi

  122. An Actin-Binding Protein Girdin Regulates the Motility of Breast Cancer Cells

    Article • Cancer Research, March 2008, American Association for Cancer Research (AACR)

    Prof Masahide Takahashi

  123. Regulation of VEGF-mediated angiogenesis by the Akt/PKB substrate Girdin

    Article • Nature Cell Biology, February 2008, Springer Science + Business Media

    Prof Masahide Takahashi

  124. A novel GDNF-inducible gene, BMZF3, encodes a transcriptional repressor associated with KAP-1

    Article • Biochemical and Biophysical Research Communications, February 2008, Elsevier

    Prof Masahide Takahashi

  125. High-level expression of CD109 is frequently detected in lung squamous cell carcinomas

    Article • Pathology International, November 2007, Wiley

    Prof Masahide Takahashi

  126. Nucleolin modulates the subcellular localization of GDNF-inducible zinc finger protein 1 and its roles in transcription and cell proliferation

    Article • Experimental Cell Research, October 2007, Elsevier

    Prof Masahide Takahashi

  127. Thermodynamic instability of siRNA duplex is a prerequisite for dependable prediction of siRNA activities

    Article • Nucleic Acids Research, September 2007, Oxford University Press (OUP)

    Prof Masahide Takahashi

  128. Polycomb protein Cbx4 promotes SUMO modification of de novo DNA methyltransferase Dnmt3a

    Article • Biochemical Journal, June 2007, Portland Press Ltd.

    Prof Masahide Takahashi

  129. Sprouty2 regulates growth and differentiation of human neuroblastoma cells through RET tyrosine kinase

    Article • Cancer Science, June 2007, Wiley

    Prof Masahide Takahashi

  130. CD109, a new marker for myoepithelial cells of mammary, salivary, and lacrimal glands and prostate basal cells

    Article • Pathology International, May 2007, Wiley

    Prof Masahide Takahashi

  131. Protective Effect of Hyperpigmented Skin on UV-Mediated Cutaneous Cancer Development

    Article • Journal of Investigative Dermatology, May 2007, Elsevier

    Prof Masahide Takahashi, Professor Toyonori Tsuzuki

  132. RET signaling-induced SPHK1 gene expression plays a role in both GDNF-induced differentiation and MEN2-type oncogenesis

    Article • Journal of Neurochemistry, April 2007, Wiley

    Prof Masahide Takahashi

  133. High-dose chemotherapy and autologous peripheral blood stem cell transfusion for adult and adolescent patients with small round cell sarcomas

    Article • Bone Marrow Transplantation, March 2007, Springer Science + Business Media

    Prof Masahide Takahashi

  134. Enhancer of Polycomb1, a Novel Homeodomain Only Protein-binding Partner, Induces Skeletal Muscle Differentiation

    Article • Journal of Biological Chemistry, March 2007, Elsevier

    Prof Masahide Takahashi

  135. Targeted mutation of serine 697 in theRettyrosine kinase causes migration defect of enteric neural crest cells

    Article • Development, November 2006, The Company of Biologists

    Prof Masahide Takahashi

  136. Girdin, a Novel Actin-Binding Protein, and Its Family of Proteins Possess Versatile Functions in the Akt and Wnt Signaling Pathways

    Article • Annals of the New York Academy of Sciences, November 2006, Wiley

    Prof Masahide Takahashi

  137. Preface: Integrated Molecular Medicine for Neuronal and Neoplastic Disorders

    Article • Annals of the New York Academy of Sciences, November 2006, Wiley

    Prof Masahide Takahashi

  138. Novel Hairless RET-Transgenic Mouse Line with Melanocytic Nevi and Anagen Hair Follicles

    Article • Journal of Investigative Dermatology, November 2006, Elsevier

    Prof Masahide Takahashi, Professor Toyonori Tsuzuki

  139. RET and neuroendocrine tumors

    Article • Pituitary, September 2006, Springer Science + Business Media

    Prof Masahide Takahashi

  140. Dok-4 regulates GDNF-dependent neurite outgrowth through downstream activation of Rap1 and mitogen-activated protein kinase

    Article • Journal of Cell Science, August 2006, The Company of Biologists

    Prof Masahide Takahashi

  141. Change of Editorship

    Article • Pathology International, April 2006, Wiley

    Prof Masahide Takahashi

  142. RET receptor signaling: Dysfunction in thyroid cancer and Hirschsprung's disease

    Article • Pathology International, April 2006, Wiley

    Prof Masahide Takahashi

  143. Analyses of ultraviolet-induced focus formation of hREV1 protein

    Article • Genes to Cells, March 2006, Wiley

    Prof Masahide Takahashi

  144. A PKC-mediated backup mechanism of the MXXCW motif-linked switch for initiating tyrosine kinase activities

    Article • FEBS Letters, January 2006, Wiley

    Prof Masahide Takahashi

  145. Microspherule Protein 1, Mi-2β, and RET Finger Protein Associate in the Nucleolus and Up-regulate Ribosomal Gene Transcription

    Article • Journal of Biological Chemistry, November 2005, Elsevier

    Prof Masahide Takahashi

  146. Akt/PKB Regulates Actin Organization and Cell Motility via Girdin/APE

    Article • Developmental Cell, September 2005, Elsevier

    Prof Masahide Takahashi

  147. PIAS proteins are involved in the SUMO-1 modification, intracellular translocation and transcriptional repressive activity of RET finger protein

    Article • Experimental Cell Research, August 2005, Elsevier

    Prof Masahide Takahashi

  148. GDNF-inducible zinc finger protein 1 is a sequence-specific transcriptional repressor that binds to the HOXA10 gene regulatory region

    Article • Nucleic Acids Research, July 2005, Oxford University Press (OUP)

    Prof Masahide Takahashi

  149. Activation of c-Jun amino-terminal kinase by GDNF induces G2/M cell cycle delay linked with actin reorganization

    Article • Genes to Cells, May 2005, Wiley

    Prof Masahide Takahashi

  150. CD109 expression in squamous cell carcinoma of the uterine cervix

    Article • Pathology International, April 2005, Wiley

    Prof Masahide Takahashi

  151. Amyloid-β peptides induce cell proliferation and macrophage colony-stimulating factor expression via the PI3-kinase/Akt pathway in cultured Ra2 microglial cells

    Article • FEBS Letters, March 2005, Wiley

    Prof Masahide Takahashi

  152. The RET proto-oncogene: A molecular therapeutic target in thyroid cancer

    Article • Cancer Science, March 2005, Wiley

    Prof Masahide Takahashi

  153. Targeted disruption of mouse ortholog of the human MYH9 responsible for macrothrombocytopenia with different organ involvement: hematological, nephrological, and otological studies of heterozygous KO mice

    Article • Biochemical and Biophysical Research Communications, December 2004, Elsevier

    Prof Masahide Takahashi

  154. Identification of a mouse cytoskeleton-associated protein, CKAP2, with microtubule-stabilizing properties

    Article • Cancer Science, October 2004, Wiley

    Prof Masahide Takahashi

  155. Biochemical and biological responses induced by coupling of Gab1 to phosphatidylinositol 3-kinase in RET-expressing cells

    Article • Biochemical and Biophysical Research Communications, October 2004, Elsevier

    Prof Masahide Takahashi

  156. A Targeting Mutation of Tyrosine 1062 in Ret Causes a Marked Decrease of Enteric Neurons and Renal Hypoplasia

    Article • Molecular and Cellular Biology, September 2004, ASM Journals

    Prof Masahide Takahashi

  157. Expression cloning of oligomerization-activated genes with cell-proliferating potency by pseudotype retrovirus vector

    Article • Biochemical and Biophysical Research Communications, July 2004, Elsevier

    Prof Masahide Takahashi

  158. Induction of CRMP-2 by GDNF and analysis of the CRMP-2 promoter region

    Article • Biochemical and Biophysical Research Communications, July 2004, Elsevier

    Prof Masahide Takahashi

  159. Expression of CD109 in human cancer

    Article • Oncogene, April 2004, Springer Science + Business Media

    Prof Masahide Takahashi

  160. Identification of RET Autophosphorylation Sites by Mass Spectrometry

    Article • Journal of Biological Chemistry, April 2004, Elsevier

    Prof Masahide Takahashi

  161. RET and neuroendocrine tumors

    Article • Cancer Letters, February 2004, Elsevier

    Prof Masahide Takahashi

  162. c-Kit-Targeting Immunotherapy for Hereditary Melanoma in a Mouse Model

    Article • Cancer Research, February 2004, American Association for Cancer Research (AACR)

    Prof Masahide Takahashi, Professor Toyonori Tsuzuki

  163. p53 apoptotic pathway molecules are frequently and simultaneously altered in nonsmall cell lung carcinoma

    Article • Cancer, January 2004, Wiley

    Prof Masahide Takahashi

  164. Plakoglobin (γ-catenin) has TCF/LEF family-dependent transcriptional activity in β-catenin-deficient cell line

    Article • Oncogene, December 2003, Springer Science + Business Media

    Prof Masahide Takahashi

  165. Identification of a Novel Glial Cell Line-derived Neurotrophic Factor-inducible Gene Required for Renal Branching Morphogenesis

    Article • Journal of Biological Chemistry, December 2003, Elsevier

    Prof Masahide Takahashi

  166. Mi-2β Associates with BRG1 and RET Finger Protein at the Distinct Regions with Transcriptional Activating and Repressing Abilities

    Article • Journal of Biological Chemistry, December 2003, Elsevier

    Prof Masahide Takahashi

  167. Establishment and characterization of mouse mammary carcinoma cell lines expressing RET with a multiple endocrine neoplasia 2A mutation

    Article • Cancer Science, November 2003, Wiley

    Prof Masahide Takahashi

  168. Identification of human SEP1 as a glial cell line-derived neurotrophic factor-inducible protein and its expression in the nervous system

    Article • Neuroscience, November 2003, Elsevier

    Prof Masahide Takahashi

  169. Loss of heterozygosity of chromosome 12p does not correlate withKRAS mutation in non-small cell lung cancer

    Article • International Journal of Cancer, October 2003, Wiley

    Prof Masahide Takahashi

  170. β-catenin inhibits cell growth of a malignant mesothelioma cell line, NCI-H28, with a 3p21.3 homozygous deletion

    Article • Oncogene, September 2003, Springer Science + Business Media

    Prof Masahide Takahashi

  171. Cell signalling and gene expression mediated by RET tyrosine kinase

    Article • Journal of Internal Medicine, June 2003, Wiley

    Prof Masahide Takahashi

  172. Identification of a Human Homologue of the DREF Transcription Factor with a Potential Role in Regulation of the Histone H1 Gene

    Article • Journal of Biological Chemistry, June 2003, Elsevier

    Prof Masahide Takahashi

  173. Cys611Ser mutation in RET proto-oncogene in a kindred with medullary thyroid carcinoma and Hirschsprung's disease

    Article • European Journal of Human Genetics, May 2003, Springer Science + Business Media

    Prof Masahide Takahashi

  174. Functional Significance of the Specific Sites Phosphorylated in Desmin at Cleavage Furrow: Aurora-B May Phosphorylate and Regulate Type III Intermediate Filaments during Cytokinesis Coordinatedly with Rho-kinase

    Article • Molecular Biology of the Cell, April 2003, American Society for Cell Biology (ASCB)

    Prof Masahide Takahashi

  175. Role for RFX Transcription Factors in Non-neuronal Cell-specific Inactivation of the Microtubule-associated Protein MAP1A Promoter

    Article • Journal of Biological Chemistry, January 2003, Elsevier

    Prof Masahide Takahashi

  176. Overexpression of interleukin‐15 prevents the development of murine retrovirus‐induced acquired immunodeficiency syndrome

    Article • The FASEB Journal, November 2002, Wiley

    Prof Masahide Takahashi

  177. Differential expression of RET finger protein in testicular germ cell tumors

    Article • Pathology International, October 2002, Wiley

    Prof Masahide Takahashi

  178. Role of Dok1 in Cell Signaling Mediated by RET Tyrosine Kinase

    Article • Journal of Biological Chemistry, September 2002, Elsevier

    Prof Masahide Takahashi

  179. Characterization of Gene Expression Induced by RET with MEN2A or MEN2B Mutation

    Article • American Journal Of Pathology, July 2002, Elsevier

    Prof Masahide Takahashi

  180. Activation of RET tyrosine kinase regulates interleukin-8 production by multiple signaling pathways

    Article • Biochemical and Biophysical Research Communications, June 2002, Elsevier

    Prof Masahide Takahashi

  181. Novel Mechanism of Regulation of Rac Activity and Lamellipodia Formation by RET Tyrosine Kinase

    Article • Journal of Biological Chemistry, May 2002, Elsevier

    Prof Masahide Takahashi

  182. Evidence of Both Extra- and Intracellular Cysteine Targets of Protein Modification for Activation of RET Kinase

    Article • Biochemical and Biophysical Research Communications, April 2002, Elsevier

    Prof Masahide Takahashi

  183. Role for O-Glycosylation of RFP in the Interaction with Enhancer of Polycomb

    Article • Biochemical and Biophysical Research Communications, January 2002, Elsevier

    Prof Masahide Takahashi

  184. Expression of glial cell line-derived neurotrophic factor correlates with perineural invasion of bile duct carcinoma

    Article • Cancer, December 2001, Wiley

    Prof Masahide Takahashi

  185. The GDNF/RET signaling pathway and human diseases

    Article • Cytokine & Growth Factor Reviews, December 2001, Elsevier

    Prof Masahide Takahashi

  186. RET tyrosine kinase enhances hair growth in association with promotion of melanogenesis

    Article • Oncogene, November 2001, Springer Science + Business Media

    Prof Masahide Takahashi, Professor Toyonori Tsuzuki

  187. Interactions in the Error-prone Postreplication Repair Proteins hREV1, hREV3, and hREV7

    Article • Journal of Biological Chemistry, September 2001, Elsevier

    Prof Masahide Takahashi

  188. Preserved phosphorylation of RET receptor protein in spinal motor neurons of patients with amyotrophic lateral sclerosis: an immunohistochemical study by a phosphorylation-specific antibody at tyrosine 1062

    Article • Brain Research, August 2001, Elsevier

    Prof Masahide Takahashi

  189. Genetic alteration of the β-catenin gene (CTNNB1) in human lung cancer and malignant mesothelioma and identification of a new 3p21.3 homozygous deletion

    Article • Oncogene, July 2001, Springer Science + Business Media

    Prof Masahide Takahashi

  190. Functional Analysis of RET With Hirschsprung Mutations Affecting Its Kinase Domain

    Article • Gastroenterology, July 2001, Elsevier

    Prof Masahide Takahashi

  191. Induction of antitumor immunity by transduction of CD40 ligand gene and interferon-γ gene into lung cancer

    Article • Cancer Gene Therapy, June 2001, Springer Science + Business Media

    Prof Masahide Takahashi

  192. Osmotic Stress-Mediated Activation of RET Kinases Involves Intracellular Disulfide-Bonded Dimer Formation

    Article • Antioxidants & Redox Signaling, June 2001, Mary Ann Liebert Inc

    Prof Masahide Takahashi

  193. Identification of SNT/FRS2 docking site on RET receptor tyrosine kinase and its role for signal transduction

    Article • Oncogene, April 2001, Springer Science + Business Media

    Prof Masahide Takahashi

  194. Characterization of two promoters that regulate alternative transcripts in the microtubule-associated protein (MAP) 1A gene

    Article • Biochimica et Biophysica Acta (BBA) - Gene Structure and Expression, April 2001, Elsevier

    Prof Masahide Takahashi

  195. Activation of BMK1 via Tyrosine 1062 in RET by GDNF and MEN2A Mutation

    Article • Biochemical and Biophysical Research Communications, March 2001, Elsevier

    Prof Masahide Takahashi

  196. Differential Effects of Leukocyte Common Antigen-related Protein on Biochemical and Biological Activities of RET-MEN2A and RET-MEN2B Mutant Proteins

    Article • Journal of Biological Chemistry, March 2001, Elsevier

    Prof Masahide Takahashi

  197. Molecular Mechanism of Activation and Superactivation of Ret Tyrosine Kinases by Ultraviolet Light Irradiation

    Article • Antioxidants & Redox Signaling, December 2000, Mary Ann Liebert Inc

    Prof Masahide Takahashi

  198. RET Finger Protein Is a Transcriptional Repressor and Interacts with Enhancer of Polycomb That Has Dual Transcriptional Functions

    Article • Journal of Biological Chemistry, December 2000, Elsevier

    Prof Masahide Takahashi

  199. Characterization of intracellular signals via tyrosine 1062 in RET activated by glial cell line-derived neurotrophic factor

    Article • Oncogene, September 2000, Springer Science + Business Media

    Prof Masahide Takahashi

  200. A Two-Hit Model for Development of Multiple Endocrine Neoplasia Type 2B by RET Mutations

    Article • Biochemical and Biophysical Research Communications, February 2000, Elsevier

    Prof Masahide Takahashi

  201. The Role of Amino Acids Surrounding Tyrosine 1062 in Ret in Specific Binding of the Shc Phosphotyrosine-Binding Domain1

    Article • Endocrinology, September 1999, Endocrine Society

    Prof Masahide Takahashi

  202. Oncogenic Activation of the ret Protooncogene in Thyroid Cancer

    Article • Critical Reviews™ in Oncogenesis, January 1995, Begell House

    Prof Masahide Takahashi