All Stories

  1. Development of Bright and Biocompatible Nanoruby and Its Application to Background-Free Time-Gated Imaging of G-Protein-Coupled Receptors
  2. Cannabinoid CB1 and CB2 Receptor Signaling and Bias
  3. Accelerating the search for the missing proteins in the human proteome
  4. Cannabinoid CB2 receptor ligand profiling reveals biased signalling and off-target activity
  5. Pharmacology of Valinate andtert-Leucinate Synthetic Cannabinoids 5F-AMBICA, 5F-AMB, 5F-ADB, AMB-FUBINACA, MDMB-FUBINACA, MDMB-CHMICA, and Their Analogues
  6. Front Cover: Wide-field time-gated photoluminescence microscopy for fast ultrahigh-sensitivity imaging of photoluminescent probes (J. Biophotonics 8/2016)
  7. Wide-field time-gated photoluminescence microscopy for fast ultrahigh-sensitivity imaging of photoluminescent probes
  8. The 2-alkyl-2H-indazole regioisomers of synthetic cannabinoids AB-CHMINACA, AB-FUBINACA, AB-PINACA, and 5F-AB-PINACA are possible manufacturing impurities with cannabimimetic activities
  9. Flexible analogues of WAY-267,464: Synthesis and pharmacology at the human oxytocin and vasopressin 1a receptors
  10. Identification ofN-arachidonoyl dopamine as a highly biased ligand at cannabinoid CB1receptors
  11. Pharmacology of Indole and Indazole Synthetic Cannabinoid Designer Drugs AB-FUBINACA, ADB-FUBINACA, AB-PINACA, ADB-PINACA, 5F-AB-PINACA, 5F-ADB-PINACA, ADBICA, and 5F-ADBICA
  12. Effects of Bioisosteric Fluorine in Synthetic Cannabinoid Designer Drugs JWH-018, AM-2201, UR-144, XLR-11, PB-22, 5F-PB-22, APICA, and STS-135
  13. Distinct Temporal Fingerprint for Cyclic Adenosine Monophosphate (cAMP) Signaling of Indole-2-carboxamides as Allosteric Modulators of the Cannabinoid Receptors
  14. Structure–activity relationships of synthetic cannabinoid designer drug RCS-4 and its regioisomers and C4 homologues
  15. A6V polymorphism of the human μ-opioid receptor decreases signalling of morphine and endogenous opioidsin vitro
  16. Themed section
  17. Fluorescence-Based, High-Throughput Assays for μ-Opioid Receptor Activation Using a Membrane Potential-Sensitive Dye
  18. Nordihydroguaiaretic acid activates hTRPA1 and modulates behavioral responses to noxious cold in mice
  19. Buprenorphine signalling is compromised at the N40D polymorphism of the human μ opioid receptor in vitro
  20. Cellular signalling of non‐synonymous single‐nucleotide polymorphisms of the human μ‐opioid receptor (OPRM1)
  21. β‐Arrestin‐2 knockout prevents development of cellular μ‐opioid receptor tolerance but does not affect opioid‐withdrawal‐related adaptations in single PAG neurons
  22. A Real-Time, Fluorescence-Based Assay for Measuring µ-Opioid Receptor Modulation of Adenylyl Cyclase Activity in Chinese Hamster Ovary Cells
  23. Ligand determinants of fatty acid activation of the pronociceptive ion channel TRPA1
  24. Real-time characterization of cannabinoid receptor 1 (CB1) allosteric modulators reveals novel mechanism of action
  25. The Synthesis and Pharmacological Evaluation of Adamantane-Derived Indoles: Cannabimimetic Drugs of Abuse
  26. A Continuous, Fluorescence-based Assay of µ-Opioid Receptor Activation in AtT-20 Cells
  27. Inhibition of human recombinant T-type calcium channels byN-arachidonoyl 5-HT
  28. Targeting somatostatin receptors using in situ-bioconjugated fluorescent nanoparticles
  29. What would 5-HT do? Regional diversity of 5-HT1 receptor modulation of primary afferent neurotransmission
  30. TRPV1 Antagonists as a Potential Treatment for Hyperalgesia
  31. Sex differences in the expression of serotonin-synthesizing enzymes in mouse trigeminal ganglia
  32. Trigeminal ganglion neuron subtype-specific alterations of CaV2.1 calcium current and excitability in a Cacna1a mouse model of migraine
  33. Pharmacological Characterization of a Recombinant, Fluorescent Somatostatin Receptor Agonist
  34. Interfacing nanodiamonds for single molecular optical-biomedical imaging
  35. The results of an experimental indoor hydroponic Cannabis growing study, using the ‘Screen of Green’ (ScrOG) method—Yield, tetrahydrocannabinol (THC) and DNA analysis
  36. N-Acyl amino acids and N-acyl neurotransmitter conjugates: neuromodulators and probes for new drug targets
  37. Constitutively Active μ-Opioid Receptors
  38. Shadows across μ-Star? Constitutively active μ-opioid receptors revisited
  39. Inhibition of human recombinant T-type calcium channels by the endocannabinoid N-arachidonoyl dopamine
  40. Decreased μ-opioid receptor signalling and a reduction in calcium current density in sensory neurons from chronically morphine-treated mice
  41. Allopurinol for pain relief: more than just crystal clearance?
  42. Sumatriptan Inhibits Synaptic Transmission in the Rat Midbrain Periaqueductal Grey
  43. Inhibition of Recombinant Human T-type Calcium Channels by  9-Tetrahydrocannabinol and Cannabidiol
  44. Methanandamide activation of a novel current in mouse trigeminal ganglion sensory neurons in vitro
  45. Towards a Receptor for Nocistatin?
  46. Lack of functional expression of NMDA receptors in PC12 cells
  47. The Role of Opioid Receptor Phosphorylation and Trafficking in Adaptations to Persistent Opioid Treatment
  48. Has the sun set onκ3-opioid receptors?
  49. TRPV1 Antagonists as a Potential Treatment for Hyperalgesia
  50. Opioid tolerance in periaqueductal gray neurons isolated from mice chronically treated with morphine
  51. Humanizing mice: catching up with elusive B1 receptors
  52. Opioids: cellular mechanisms of tolerance and physical dependence
  53. Contrasting Phenotypes of Putative Proprioceptive and Nociceptive Trigeminal Neurons Innervating Jaw Muscle in Rat
  54. δ-opioid receptor-mediated actions on rostral ventromedial medulla neurons
  55. μ-Opioid receptor desensitization: Is morphine different?
  56. Cellular actions of somatostatin on rat periaqueductal grey neuronsin vitro
  57. Convulsant actions of calycanthine
  58. Opioid Agonists Have Different Efficacy Profiles for G Protein Activation, Rapid Desensitization, and Endocytosis of Mu-opioid Receptors
  59. Gingerols: a novel class of vanilloid receptor (VR1) agonists
  60. Anandamide is a partial agonist at native vanilloid receptors in acutely isolated mouse trigeminal sensory neurons
  61. Capsaicin activation of glutamatergic synaptic transmission in the rat locus coeruleusIn vitro
  62. Prostaglandin E2inhibits calcium current in two sub-populations of acutely isolated mouse trigeminal sensory neurons
  63. Nociceptin inhibits calcium channel currents in a subpopulation of small nociceptive trigeminal ganglion neurons in mouse
  64. Actions of nociceptin/orphanin FQ and other prepronociceptin products on rat rostral ventromedial medulla neuronsin vitro
  65. Cellular Actions Of Opioids And Other Analgesics: Implications For Synergism In Pain Relief
  66. Isolation and pharmacological characterisation of δ-atracotoxin-Hv1b, a vertebrate-selective sodium channel toxin
  67. Isolation of a funnel-web spider polypeptide with homology to mamba intestinal toxin 1 and the embryonic head inducer Dickkopf-1
  68. Continued morphine modulation of calcium channel currents in acutely isolated locus coeruleus neurons from morphine-dependent rats
  69. High-resolution solution structure of gurmarin, a sweet-taste-suppressing plant polypeptide
  70. OPIOID RECEPTOR SIGNALLING MECHANISMS
  71.  -Atracotoxins from Australian Funnel-web Spiders Compete with Scorpion  -Toxin Binding but Differentially Modulate Alkaloid Toxin Activation of Voltage-gated Sodium Channels
  72. Modulation of Ca2+channel currents of acutely dissociated rat periaqueductal grey neurons
  73. Cortistatin increase of a potassium conductance in rat locus coeruleusin vitro
  74. Chronic ethanol promotes the neuronal differentiation of NG108-15 cells independently of toxin-sensitive G-proteins
  75. The structure of a novel insecticidal neurotoxin, ω-atracotoxin-HV1, from the venom of an Australian funnel web spider
  76. Neuropeptide Y Y2 receptor and somatostatin sst2 receptor coupling to mobilization of intracellular calcium in SH-SY5Y human neuroblastoma cells
  77. Bradykinin Inhibition of N- and L-type Calcium Channel Currents in NG108-15 Cells
  78. δ-opioid Receptor Mobilization of Intracellular Calcium in SH-SY5Y Cells: Lack of Evidence for δ-receptor Subtypes
  79. Nociceptin receptor coupling to a potassium conductance in rat locus coeruleus neurones in vitro
  80. The effect of nociceptin on Ca2+ channel current and intracellular Ca2+ in the SH-SY5Y human neuroblastoma cell line
  81. δ- and μ-opioid receptor mobilization of intracellular calcium in SH-SY5Y human neuroblastoma cells
  82. δ and μ opioid receptor mobilization of intracellular calcium in neuroblastoma cells
  83. Oocytes from Xenopus laevis contain an intrinsic σ2-like binding site
  84. Focal stimulation of specific pathways in the rat hippocampus causes a reduction in radioligand binding to the haloperidol-sensitive sigma receptor
  85. Frequency-dependent neuromuscular blockade by textilotoxin in vivo