All Stories

  1. GTPase-activating protein DLC1 spatio-temporally regulates Rho signaling

    Article • eLife, April 2026, eLife

    Dr Maciej Dobrzynski

  2. GTPase-activating protein DLC1 spatio-temporally regulates Rho signaling

    Article • eLife, April 2026, eLife

    Dr Maciej Dobrzynski

  3. Tracking coordinated cellular dynamics in time-lapse microscopy with ARCOS.px

    Article • Journal of Cell Science, November 2025, The Company of Biologists

    Dr Maciej Dobrzynski

  4. Coumarins and betulinic acid analogues from Mammea americana and their inhibitory activities on oncogenic MAPK/ERK and PI3K/AKT pathways in human melanoma cells

    Article • Phytochemistry, October 2025, Elsevier

    Dr Maciej Dobrzynski

  5. Real-time feedback control microscopy for automation of optogenetic targeting

    Article • August 2025, Cold Spring Harbor Laboratory Press

    Dr Maciej Dobrzynski

  6. Tracking Coordinated Cellular Dynamics in Time-Lapse Microscopy with ARCOS.px

    Article • March 2025, Cold Spring Harbor Laboratory Press

    Dr Maciej Dobrzynski

  7. Quantification of collective signalling in time-lapse microscopy images

    Article • Methods in Microscopy, April 2024, De Gruyter

    Dr Maciej Dobrzynski

  8. Automatic detection of spatio-temporal signaling patterns in cell collectives

    Article • Journal of Cell Biology, July 2023, Rockefeller University Press

    Dr Maciej Dobrzynski

  9. A Dimerosesquiterpene and Sesquiterpene Lactones from Artemisia argyi Inhibiting Oncogenic PI3K/AKT Signaling in Melanoma Cells

    Article • Journal of Natural Products, November 2022, American Chemical Society (ACS)

    Dr Maciej Dobrzynski

  10. Spatiotemporal control of ERK pulse frequency coordinates fate decisions during mammary acinar morphogenesis

    Article • Developmental Cell, September 2022, Elsevier

    Dr Maciej Dobrzynski

  11. Automatic detection of spatio-temporal signalling patterns in cell collectives

    Article • July 2022, Cold Spring Harbor Laboratory Press

    Dr Maciej Dobrzynski

  12. Optogenetic actuator – ERK biosensor circuits identify MAPK network nodes that shape ERK dynamics

    Article • Molecular Systems Biology, June 2022, Springer Science + Business Media

    Dr Maciej Dobrzynski

  13. Combining Activity Profiling with Advanced Annotation to Accelerate the Discovery of Natural Products Targeting Oncogenic Signaling in Melanoma

    Article • Journal of Natural Products, May 2022, American Chemical Society (ACS)

    Dr Maciej Dobrzynski

  14. CODEX, a neural network approach to explore signaling dynamics landscapes

    Article • Molecular Systems Biology, April 2021, Springer Science + Business Media

    Dr Maciej Dobrzynski

  15. CODEX, a neural network approach to explore signaling dynamics landscapes

    Article • August 2020, Cold Spring Harbor Laboratory Press

    Dr Maciej Dobrzynski

  16. Collective ERK/Akt activity waves orchestrate epithelial homeostasis by driving apoptosis-induced survival

    Article • June 2020, Cold Spring Harbor Laboratory Press

    Dr Maciej Dobrzynski

  17. Mining single-cell time-series datasets with Time Course Inspector

    Article • Bioinformatics, November 2019, Oxford University Press (OUP)

    Dr Maciej Dobrzynski

  18. Temporal perturbation of ERK dynamics reveals network architecture of FGF2/MAPK signaling

    Article • Molecular Systems Biology, November 2019, EMBO

    Dr Maciej Dobrzynski

  19. Temporal perturbation of Erk dynamics reveals network architecture of FGF2-MAPK signaling

    Article • May 2019, Cold Spring Harbor Laboratory Press

    Dr Maciej Dobrzynski

  20. Automated Comparative Metabolite Profiling of Large LC-ESIMS Data Sets in an ACD/MS Workbook Suite Add-in, and Data Clustering on a New Open-Source Web Platform FreeClust

    Article • Analytical Chemistry, November 2017, American Chemical Society (ACS)

    Dr Maciej Dobrzynski

  21. Looking for specific natural inhibitors targeting aberrant proliferation signaling in melanoma

    Article • October 2017, Thieme Publishing Group

    Dr Maciej Dobrzynski

  22. Stabilization of C-RAF:KSR1 complex by DiRas3 reduces availability of C-RAF for dimerization with B-RAF

    Article • Cellular Signalling, October 2016, Elsevier

    Dr Maciej Dobrzynski

  23. Strategies for structuring interdisciplinary education in Systems Biology: an European perspective

    Article • npj Systems Biology and Applications, May 2016, Nature

    Dr Maciej Dobrzynski

  24. Frequency modulation of ERK activation dynamics rewires cell fate

    Article • Molecular Systems Biology, November 2015, EMBO

    Dr Maciej Dobrzynski

  25. Nonlinear signalling networks and cell-to-cell variability transform external signals into broadly distributed or bimodal responses

    Article • Journal of The Royal Society Interface, June 2014, Royal Society Publishing

    Dr Maciej Dobrzynski, Professor Boris N. Kholodenko

  26. Polyubiquitin chain assembly and organization determine the dynamics of protein activation and degradation

    Article • Frontiers in Physiology, January 2014, Frontiers

    Dr Maciej Dobrzynski, Professor Boris N. Kholodenko

  27. Emergence of bimodal cell population responses from the interplay between analog single-cell signaling and protein expression noise

    Article • BMC Systems Biology, August 2012, Springer Science + Business Media

    Marc Birtwistle, Dr Maciej Dobrzynski, Professor Boris N. Kholodenko

  28. Mammalian protein expression noise: scaling principles and the implications for knockdown experiments

    Article • Molecular BioSystems, January 2012, Royal Society of Chemistry

    Marc Birtwistle, Dr Maciej Dobrzynski, Professor Boris N. Kholodenko

  29. Bimodal Protein Distributions in Heterogeneous Oscillating Systems

    Article • January 2012, Springer Science + Business Media

    Dr Maciej Dobrzynski, Professor Boris N. Kholodenko

  30. Evolution of Bet-Hedging Mechanisms in Cell Cycle and Embryo Development Stimulated by Weak Linkage of Stochastic Processes

    Article • January 2011, Springer Science + Business Media

    Dr Maciej Dobrzynski

  31. Origins of Stochastic Intracellular Processes and Consequences for Cell-to-Cell Variability and Cellular Survival Strategies

    Article • January 2011, Elsevier

    Dr Maciej Dobrzynski

  32. Elongation dynamics shape bursty transcription and translation

    Article • Proceedings of the National Academy of Sciences, February 2009, Proceedings of the National Academy of Sciences

    Dr Maciej Dobrzynski

  33. Computational methods for diffusion-influenced biochemical reactions

    Article • Bioinformatics, May 2007, Oxford University Press (OUP)

    Dr Maciej Dobrzynski

  34. Spatial stochastic modelling of the phosphoenolpyruvate-dependent phosphotransferase (PTS) pathway in Escherichia coli

    Article • Bioinformatics, May 2006, Oxford University Press (OUP)

    Dr Maciej Dobrzynski