All Stories

  1. Treatment of a severe vascular disease using a bespoke CRISPR–Cas9 base editor in mice

    Article • Nature Biomedical Engineering, September 2025, Springer Science + Business Media

    Dr Luke H Chao

  2. Stress-mediated growth determines Escherichia coli division site morphogenesis

    Article • Proceedings of the National Academy of Sciences, July 2025, Proceedings of the National Academy of Sciences

    Dr Luke H Chao

  3. Ancestral sequence reconstruction of the Mic60 Mitofilin domain reveals residues supporting respiration in yeast

    Article • Protein Science, June 2025, Wiley

    Dr Luke H Chao

  4. Contemporary insights into elamipretide’s mitochondrial mechanism of action and therapeutic effects

    Article • Biomedicine & Pharmacotherapy, June 2025, Elsevier

    Dr Luke H Chao

  5. SARM1 loss protects retinal ganglion cells in a mouse model of autosomal dominant optic atrophy

    Article • Journal of Clinical Investigation, May 2025, American Society for Clinical Investigation

    Dr Luke H Chao

  6. The aPBP-type cell wall synthase PBP1b plays a specialized role in fortifying the Escherichia coli division site against osmotic rupture

    Article • April 2025, Cold Spring Harbor Laboratory Press

    Dr Luke H Chao

  7. Identification of SLC25A46 interaction interfaces with mitochondrial membrane fusogens Opa1 and Mfn2

    Article • Journal of Biological Chemistry, October 2024, Elsevier

    Dr Luke H Chao

  8. Stress-mediated growth determinesE. colidivision site morphogenesis

    Article • September 2024, Cold Spring Harbor Laboratory Press

    Dr Luke H Chao

  9. Prominin 1 and Tweety Homology 1 both induce extracellular vesicle formation

    Article • eLife, August 2024, eLife

    Dr Luke H Chao

  10. Click editing enables programmable genome writing using DNA polymerases and HUH endonucleases

    Article • Nature Biotechnology, July 2024, Springer Science + Business Media

    Dr Luke H Chao

  11. Ancestral sequence reconstruction of the Mic60 Mitofilin domain reveals residues supporting respiration in yeast

    Article • April 2024, Cold Spring Harbor Laboratory Press

    Dr Luke H Chao

  12. In situ architecture of Opa1-dependent mitochondrial cristae remodeling

    Article • The EMBO Journal, January 2024, Springer Science + Business Media

    Dr Luke H Chao

  13. Helical reconstruction of VP39 reveals principles for baculovirus nucleocapsid assembly

    Article • Nature Communications, January 2024, Springer Science + Business Media

    Dr Luke H Chao

  14. Identification of SLC25A46 interaction interfaces with mitochondrial membrane fusogens Opa1 and Mfn2

    Article • December 2023, Cold Spring Harbor Laboratory Press

    Dr Luke H Chao

  15. Prominin 1 and Tweety Homology 1 both induce extracellular vesicle formation

    Article • November 2023, Cold Spring Harbor Laboratory Press

    Dr Luke H Chao

  16. Helical reconstruction of VP39 reveals principles for baculovirus nucleocapsid assembly

    Article • June 2023, Cold Spring Harbor Laboratory Press

    Dr Luke H Chao

  17. In situarchitecture of Opa1-dependent mitochondrial cristae remodeling

    Article • January 2023, Cold Spring Harbor Laboratory Press

    Dr Luke H Chao

  18. Cell wall synthesis and remodelling dynamics determine division site architecture and cell shape in Escherichia coli

    Article • Nature Microbiology, September 2022, Springer Science + Business Media

    Dr Luke H Chao

  19. A natural fusion of flavodiiron, rubredoxin, and rubredoxin oxidoreductase domains is a self-sufficient water-forming oxidase of Trichomonas vaginalis

    Article • Journal of Biological Chemistry, August 2022, Elsevier

    Dr Luke H Chao

  20. Absence of Cardiolipin From the Outer Leaflet of a Mitochondrial Inner Membrane Mimic Restricts Opa1-Mediated Fusion

    Article • Frontiers in Molecular Biosciences, December 2021, Frontiers

    Dr Luke H Chao

  21. Absence of cardiolipin from the outer leaflet of a mitochondrial inner membrane mimic restricts Opa1-mediated fusion

    Article • September 2021, Cold Spring Harbor Laboratory Press

    Dr Luke H Chao

  22. NNT mediates redox-dependent pigmentation via a UVB- and MITF-independent mechanism

    Article • Cell, August 2021, Elsevier

    Dr Luke H Chao

  23. Cell Surface Multimeric Assemblies Regulate Canonical and Noncanonical EphA2 Receptor Tyrosine Kinase Signaling

    Article • April 2021, Cold Spring Harbor Laboratory Press

    Dr Luke H Chao

  24. A Model Membrane Platform for Reconstituting Mitochondrial Membrane Dynamics

    Article • Journal of Visualized Experiments, September 2020, MyJove Corporation

    Dr Luke H Chao

  25. Heterogeneity in human hippocampal CaMKII transcripts reveals allosteric hub-dependent regulation

    Article • Science Signaling, July 2020, American Association for the Advancement of Science

    Dr Luke H Chao

  26. Two forms of Opa1 cooperate to complete fusion of the mitochondrial inner-membrane

    Article • eLife, January 2020, eLife

    Dr Luke H Chao

  27. Two forms of Opa1 cooperate to complete fusion of the mitochondrial inner-membrane

    Article • August 2019, Cold Spring Harbor Laboratory Press

    Dr Luke H Chao

  28. Heterogeneity in human hippocampal CaMKII transcripts reveals allosteric hub-dependent regulation

    Article • August 2019, Cold Spring Harbor Laboratory Press

    Dr Luke H Chao

  29. Cryo-EM insight into the structure of MTOR complex 1 and its interactions with Rheb and substrates

    Article • F1000Research, January 2019, Faculty of 1000, Ltd.

    Dr Luke H Chao, Joseph Avruch

  30. The tarantula toxin GxTx detains K+ channel gating charges in their resting conformation

    Article • Journal of General Physiology, November 2018, Rockefeller University Press

    Dr Luke H Chao

  31. How small-molecule inhibitors of dengue-virus infection interfere with viral membrane fusion

    Article • eLife, July 2018, eLife

    Dr Luke H Chao

  32. How small-molecule inhibitors of dengue-virus infection interfere with viral membrane fusion

    Article • March 2018, Cold Spring Harbor Laboratory Press

    Dr Luke H Chao

  33. Identification and Characterization of a Novel Broad-Spectrum Virus Entry Inhibitor

    Article • Journal of Virology, February 2016, ASM Journals

    Dr Luke H Chao, Dr Susan R Ross, Tom Kirchhausen

  34. Correction: Sequential conformational rearrangements in flavivirus membrane fusion

    Article • eLife, May 2015, eLife

    Dr Luke H Chao

  35. Sequential conformational rearrangements in flavivirus membrane fusion

    Article • eLife, December 2014, eLife

    Dr Luke H Chao

  36. Correction: Activation-triggered subunit exchange between CaMKII holoenzymes facilitates the spread of kinase activity

    Article • eLife, February 2014, eLife

    Dr Moitrayee Bhattacharyya, Dr Luke H Chao

  37. Activation-triggered subunit exchange between CaMKII holoenzymes facilitates the spread of kinase activity

    Article • eLife, January 2014, eLife

    Sune Christensen, Margaret Stratton, Il Hyung Lee, Dr Moitrayee Bhattacharyya, Dr Luke H Chao

  38. Structural studies on the regulation of Ca2+/calmodulin dependent protein kinase II

    Article • Current Opinion in Structural Biology, April 2013, Elsevier

    Dr Luke H Chao

  39. A Mechanism for Tunable Autoinhibition in the Structure of a Human Ca2+/Calmodulin- Dependent Kinase II Holoenzyme

    Article • Cell, October 2011, Elsevier

    Dr Luke H Chao

  40. A Mechanism for Tunable Autoinhibition in the Structure of a Human Ca2+/Calmodulin- Dependent Kinase II Holoenzyme

    Article • Cell, September 2011, Elsevier

    Dr Luke H Chao

  41. Intersubunit capture of regulatory segments is a component of cooperative CaMKII activation

    Article • Nature Structural & Molecular Biology, February 2010, Springer Science + Business Media

    Dr Luke H Chao

  42. Structure of the Kinase Domain of an Imatinib-Resistant Abl Mutant in Complex with the Aurora Kinase Inhibitor VX-680

    Article • Cancer Research, January 2006, American Association for Cancer Research (AACR)

    Dr Luke H Chao

  43. Crystal Structure of Tobacco Etch Virus Protease Shows the Protein C Terminus Bound within the Active Site

    Article • Journal of Molecular Biology, July 2005, Elsevier

    Dr Luke H Chao

  44. Abstract

    Article • eLife

    Dr Luke H Chao