Professor Laurent El Kaim
ENSTA-ParisTech
Professor, Chemistry
France
My co-authors include
Professor Jose Paulo Farinha
Paul Fleurat-Lessard
Dr Adinath Majee
My Publications
ChemInform Abstract: Pyrrolidinone and Piperidinone Isocyanides from Isocyano Esters.
ChemInform
February 2015
ChemInform Abstract: The Ugi-Smiles and Passerini-Smiles Couplings: A Story About Pheno...
ChemInform
February 2015
Synthesis, antimicrobial and antioxidant activities of imidazotriazoles and new multico...
Medicinal Chemistry Research
February 2015
ChemInform Abstract: Benzoxazinone Synthesis via Passerini-Smiles Couplings.
ChemInform
February 2015
Formal [3+2] cycloaddition of Ugi adducts towards pyrrolines
Chemical Communications
January 2015
Passerini/Tsuji–Trost strategies towards achieving lactams and cyclopentane derivatives
Chemical Communications
January 2015
ChemInform Abstract: Nitrile Synthesis Through Catalyzed Cascades Involving Acid-Nitril...
ChemInform
December 2014
The Ugi-Smiles and Passerini-Smiles Couplings: A Story About Phenols in Isocyanide-Base...
European Journal of Organic Chemistry
October 2014
Ugi-Smiles and Passerini-Smiles Couplings
October 2014
Benzoxazinone synthesis via Passerini–Smiles couplings
Tetrahedron Letters
September 2014
Pyrrolidinone and Piperidinone Isocyanides from Isocyano Esters
European Journal of Organic Chemistry
July 2014
Kinetic Data on the Synergetic Role of Amines and Water in the Reduction of Phosphine-L...
European Journal of Organic Chemistry
June 2014
ChemInform Abstract: The Nef Reaction of Isocyanides
ChemInform
June 2014
Predicting New Ugi-Smiles Couplings: A Combined Experimental and Theoretical Study
Chemistry - A European Journal
June 2014
ChemInform Abstract: Synthesis of 2-Tetrazolylmethyl-2,3,4,9-tetrahydro-1H-β-carbolines...
ChemInform
June 2014
Reductive Passerini/Tsuji–Trost Strategy towards β,γ-Unsaturated Amides
Synlett
June 2014
ChemInform Abstract: Double Smiles Rearrangement of Passerini Adducts Towards Benzoxazi...
ChemInform
May 2014
Nitrile Synthesis through Catalyzed Cascades Involving Acid–Nitrile Exchange
Synthesis
April 2014
The Nef Reaction of Isocyanides
Synthesis
March 2014
ChemInform Abstract: Cyclization Cascade of Hydrazono Ugi Adducts Towards Pyrazoles.
ChemInform
January 2014
ChemInform Abstract: Pyrrolo[2,3-d]pyrimidine Synthesis Through Activation of N-Benzyl ...
ChemInform
January 2014
Double Smiles rearrangement of Passerini adducts towards benzoxazinones
Chemical Communications
January 2014
ChemInform Abstract: Lewis Acid Mediated Fragmentation of Tetrazoles Towards Triazoles.
ChemInform
December 2013
ChemInform Abstract: Sc(OTf)3Promoted Multicomponent Synthesis of Fluorescent Imidazo[1...
ChemInform
December 2013
ChemInform Abstract: Three-Component Metal-Free Arylation of Isocyanides.
ChemInform
November 2013
Synthesis of 2-Tetrazolylmethyl-2,3,4,9-tetrahydro-1H-β-carbolines by a One-Pot Ugi-Azi...
Synthesis
October 2013
ChemInform Abstract: Metal-Free Aerobic Oxidation of Benzazole Derivatives.
ChemInform
August 2013
Substituent Effects in Ugi–Smiles Reactions
The Journal of Physical Chemistry A
August 2013
Cyclization Cascade of Hydrazono Ugi Adducts towards Pyrazoles
European Journal of Organic Chemistry
August 2013
Sc(OTf)3 promoted multicomponent synthesis of fluorescent imidazo[1,2-c]pyrazolo[3,4-d]...
Tetrahedron Letters
August 2013
Lewis Acid Mediated Fragmentation of Tetrazoles towards Triazoles
European Journal of Organic Chemistry
July 2013
Three-Component Metal-Free Arylation of Isocyanides
Angewandte Chemie
May 2013
Three-Component Metal-Free Arylation of Isocyanides
Angewandte Chemie International Edition
May 2013
ChemInform Abstract: Ugi and Passerini Reactions with Carboxylic Acid Surrogates
ChemInform
March 2013
Metal-free aerobic oxidation of benzazole derivatives
Organic & Biomolecular Chemistry
January 2013
Pyrrolo[2,3-d]pyrimidine synthesis through activation of N-benzyl groups by distal amides
Organic & Biomolecular Chemistry
January 2013
ChemInform Abstract: Oxazole Synthesis from Isocyanides.
ChemInform
August 2012
Ugi and Passerini Reactions with Carboxylic Acid Surrogates
August 2012
ChemInform Abstract: Ugi-Smiles Coupling of Thiouracil Derivatives Towards 2,4-Diamino ...
ChemInform
June 2012
Oxazole Synthesis from Isocyanides
Synlett
May 2012
ChemInform Abstract: Palladium-Catalyzed Ring-Opening of Aminocyclopropyl Ugi Adducts.
ChemInform
May 2012
ChemInform Abstract: Ugi-Smiles Couplings of 4-Substituted Pyridine Derivatives: A Fast...
ChemInform
April 2012
ChemInform Abstract: Four-Component Synthesis of Indazole Through Ugi-Azide Coupling.
ChemInform
April 2012
ChemInform Abstract: Phosphite-Mediated Synthesis of Benzimidazoles: A One-Pot Four-Com...
ChemInform
February 2012
Ugi-Smiles Coupling of Thiouracil Derivatives towards 2,4-Diamino Pyrimidines
Synlett
February 2012
Challenging 50 Years of Established Views on Ugi Reaction: A Theoretical Approach
The Journal of Organic Chemistry
February 2012
Ugi–Smiles Couplings of 4-Substituted Pyridine Derivatives: A Fast Access to Chloroquin...
Organic Letters
January 2012
Palladium-Catalyzed Ring Opening of Aminocyclopropyl Ugi Adducts
Synlett
January 2012
Four-Component Synthesis of Indazole through Ugi-Azide Coupling
Synlett
January 2012
ChemInform Abstract: Allyl and Benzyl Dance under Basic Conditions.
ChemInform
November 2011
Evidences for the Key Role of Hydrogen Bonds in Nucleophilic Aromatic Substitution Reac...
Chemistry - A European Journal
November 2011
Xanthate Based Radical Cascade Toward Multicomponent Formation of Pyrrolopyrimidines
Molecules
November 2011
ChemInform Abstract: Straightforward Four-Component Access to Spiroindolines.
ChemInform
November 2011
ChemInform Abstract: Copper-Catalyzed Aerobic Oxidative Cyclization of Hydrazones to Py...
ChemInform
September 2011
Phosphite-Mediated Synthesis of Benzimidazoles: A One-Pot Four-Component Approach from ...
European Journal of Organic Chemistry
September 2011
Ugi post-condensation copper-triggered oxidative cascade towards pyrazoles
Beilstein Journal of Organic Chemistry
September 2011
ChemInform Abstract: Multicomponent Synthesis of Fused Benzimidazolopiperazines.
ChemInform
August 2011
ChemInform Abstract: A New Multicomponent Reaction for the Synthesis of Pyridines via C...
ChemInform
August 2011
Allyl and Benzyl Dance under Basic Conditions
Synlett
July 2011
A new multicomponent reaction for the synthesis of pyridines via cycloaddition of azadi...
Tetrahedron Letters
June 2011
Copper-Catalyzed Aerobic Oxidative Cyclization of Hydrazones to Pyrazolidinones
European Journal of Organic Chemistry
May 2011
ChemInform Abstract: Three-Component Strategy Toward 5-Membered Heterocycles from Isocy...
ChemInform
April 2011
ChemInform Abstract: Smiles Cascades Toward Heterocyclic Scaffolds.
ChemInform
April 2011
ChemInform Abstract: Palladium Catalyzed Ring Opening of Furans as a Route to α,β-Unsat...
ChemInform
April 2011
Three-Component Strategy toward 5-Membered Heterocycles from Isocyanide Dibromides.
Organic Letters
March 2011
ChemInform Abstract: Ammonia in Ugi-Smiles and Ugi Couplings.
ChemInform
February 2011
ChemInform Abstract: A New Pyridine Synthesis from Azoenamines.
ChemInform
February 2011
Smiles Cascades toward Heterocyclic Scaffolds
Organic Letters
February 2011
ChemInform Abstract: Nef-Perkow Access to Indolizine Derivatives.
ChemInform
January 2011
ChemInform Abstract: Three-Component Fischer Indole Synthesis.
ChemInform
January 2011
Straightforward four-component access to spiroindolines
Chemical Communications
January 2011
Palladium catalyzed ring opening of furans as a route to α,β-unsaturated aldehydes
Chemical Communications
January 2011
ChemInform Abstract: Ugi-Smiles Couplings in Water.
ChemInform
December 2010
ChemInform Abstract: Toward Pyrrolo[2,3-d]pyrimidine Scaffolds.
ChemInform
November 2010
ChemInform Abstract: 1,2,4-Triazole Synthesis via Amidrazones.
ChemInform
November 2010
A new pyridine synthesis from azoenamines
Tetrahedron Letters
November 2010
Ammonia in Ugi-Smiles and Ugi Couplings
Synlett
October 2010
Nef-Perkow Access to Indolizine Derivatives
Synlett
September 2010
Ugi–Smiles couplings in water
Tetrahedron Letters
September 2010
ChemInform Abstract: An Expedient Total Synthesis of (.+-.)-Estrone Derivatives.
ChemInform
August 2010
ChemInform Abstract: An Expedient Access to Trifluoromethyl Ketones from Carboxylic Acids.
ChemInform
August 2010
ChemInform Abstract: Trifluoropyruvamides from Isocyanides and Trifluoroacetic Anhydride.
ChemInform
August 2010
ChemInform Abstract: Trifluoromethyl Ketones from Carboxylic Acids. Part 2. A Versatile...
ChemInform
August 2010
Three-Component Fischer Indole Synthesis
Synlett
August 2010
ChemInform Abstract: New Access to Fluorinated Glycolic Acid Derivatives from Trifluoro...
ChemInform
August 2010
ChemInform Abstract: A New Conversion of Primary Nitro Compounds into Nitriles.
ChemInform
August 2010
ChemInform Abstract: Diazo Esters Addition to Trifluoropyruvamides: New Access to Highl...
ChemInform
August 2010
ChemInform Abstract: New Xanthate-Based Radical Cyclization onto Alkynes.
ChemInform
July 2010
ChemInform Abstract: Efficient Synthesis of Azaspirodienones by Microwave-Assisted Radi...
ChemInform
July 2010
1,2,4-Triazole Synthesis via Amidrazones
Synlett
June 2010
ChemInform Abstract: A New Straightforward Formation of Aminoisoxazoles from Isocyanides.
ChemInform
June 2010
ChemInform Abstract: Thiophenol-Promoted Radical Cyclization of Hydrazones and Oxime Et...
ChemInform
June 2010
ChemInform Abstract: Trifluoropyruvamides from Isocyanides and Trifluoroacetic Anhydride
ChemInform
June 2010
ChemInform Abstract: Trichloroacetic Acid Hydrazones. Part 1: New Formation of 1,3,4-Ox...
ChemInform
June 2010
ChemInform Abstract: A New Multicomponent Reaction of Nitro Compounds with Isocyanides.
ChemInform
June 2010
ChemInform Abstract: Dramatic Solvent Effect in the Multicomponent Reaction of Nitro Co...
ChemInform
June 2010
ChemInform Abstract: Trichloroacetylhydrazones: New Highly Reactive Alkylating Agents.
ChemInform
June 2010
ChemInform Abstract: A New Straightforward Formation of Aminopyrazoles from Isocyanides.
ChemInform
June 2010
ChemInform Abstract: Trichloroacylhydrazones: New Straightforward Preparation of Pyrazo...
ChemInform
June 2010
ChemInform Abstract: α-Nitrohydrazones: Versatile Intermediates for Phosphonate Derivat...
ChemInform
May 2010
ChemInform Abstract: Four-Component Synthesis of Imidazolinium-Fused Heterocycles from ...
ChemInform
May 2010
Efficient Synthesis of Azaspirodienones by Microwave-Assisted Radical Spirocyclization ...
Synthesis
March 2010
New xanthate-based radical cyclization onto alkynes
Chemical Communications
January 2010
ChemInform Abstract: âIsocyanide-Freeâ Ugi Reactions.
ChemInform
December 2009
ChemInform Abstract: One-Pot Synthesis of Oxazoles Using Isocyanide Surrogates.
ChemInform
December 2009
Four-Component Synthesis of Imidazolinium-Fused Heterocycles from Ugi-Smiles Couplings
Synlett
December 2009
ChemInform Abstract: Unconventional Oxazole Formation from Isocyanides.
ChemInform
November 2009
ChemInform Abstract: Isocyanide-Based Multicomponent Reaction “Without” Isocyanides.
ChemInform
October 2009
ChemInform Abstract: Three-Component Nef-Huisgen Access to 1,2,4-Triazoles.
ChemInform
October 2009
ChemInform Abstract: Isocyanide-Based Two-Step Three-Component Keteneimine Formation.
ChemInform
September 2009
One-pot synthesis of oxazoles using isocyanide surrogates
Tetrahedron Letters
September 2009
ChemInform Abstract: Thee-Component Ugi-Smiles Couplings of Cyclic Imines.
ChemInform
July 2009
Ugi–Smiles couplings: new entries to N-aryl carboxamide derivatives
Molecular Diversity
July 2009
ChemInform Abstract: New Benzotriazole and Benzimidazole Scaffolds from Ugi-Smiles Coup...
ChemInform
June 2009
ChemInform Abstract: Beyond the Ugi Reaction: Less Conventional Interactions Between Is...
ChemInform
June 2009
Isocyanide-Based Multicomponent Reaction ‘without’ Isocyanides
Synlett
May 2009
Three-Component Nef-Huisgen Access to 1,2,4-Triazoles
Synlett
May 2009
ChemInform Abstract: Thiols in Ugi- and Passerini-Smiles-Type Couplings.
ChemInform
April 2009
Isocyanide-Based Two-Step Three-Component Keteneimine Formation
Organic Letters
April 2009
Three-component Ugi–Smiles couplings of cyclic imines
Tetrahedron Letters
April 2009
Beyond the Ugi reaction: less conventional interactions between isocyanides and iminium...
Tetrahedron
March 2009
New Benzotriazole and Benzimidazole Scaffolds from Ugi−Smiles Couplings of Isocyanides
Organic Letters
February 2009
“Isocyanide-free” Ugi reactions
Organic & Biomolecular Chemistry
January 2009
Unconventional oxazole formation from isocyanides
Chemical Communications
January 2009
ChemInform Abstract: New MCR-Heck-Isomerization Cascade Toward Indoles.
ChemInform
December 2008
Thiols in Ugi- and Passerini-Smiles-Type Couplings
European Journal of Organic Chemistry
December 2008
ChemInform Abstract: Isocyanide Addition to Acylphosphonates: A Formal Passerini Reacti...
ChemInform
September 2008
ChemInform Abstract: Ugi/Smiles Access to Pyrazine Scaffolds.
ChemInform
August 2008
New MCR−Heck−Isomerization Cascade toward Indoles
Organic Letters
August 2008
ChemInform Abstract: New Palladium-Catalyzed Aerobic Oxidative Cleavage and Cyclization...
ChemInform
July 2008
Ugi/Smiles access to pyrazine scaffolds
Tetrahedron Letters
May 2008
Isocyanide Addition to Acylphosphonates: A Formal Passerini Reaction of Acyl Chlorides
Synlett
May 2008
ChemInform Abstract: Ugi-Smiles Access to Quinoxaline Derivatives.
ChemInform
April 2008
ChemInform Abstract: From Simple Ugi Adducts to Indans and δ-Amidomalonates: New Mangan...
ChemInform
March 2008
New palladium-catalyzed aerobic oxidative cleavage and cyclization of N-aryl peptide de...
Chemical Communications
January 2008
New Ugi—Smiles-Metathesis Strategy Toward the Synthesis of Pyrimidoazepines.
ChemInform
November 2007
From Simple Ugi Adducts to Indanes and δ-Amidomalonates: New Manganese(III)-Induced Ra...
Organic Letters
October 2007
Smiles Rearrangements in Ugi- and Passerini-Type Couplings: New Multicomponent Access t...
ChemInform
September 2007
New Ugi-Smiles-Metathesis Strategy toward the Synthesis of Pyrimido Azepines
The Journal of Organic Chemistry
July 2007
New Indolizine Templates from the Ugi Reaction.
ChemInform
June 2007
New Ugi/Pictet—Spengler Multicomponent Formation of Polycyclic Diketopiperazines from I...
ChemInform
June 2007
New Benzothiazole and Benzoxazole Scaffolds from the Ugi—Smiles Couplings of Heterocycl...
ChemInform
June 2007
Smiles Rearrangements in Ugi- and Passerini-Type Couplings: New Multicomponent Access...
The Journal of Organic Chemistry
May 2007
O-Arylative Passerini Reactions.
ChemInform
February 2007
New Indolizine Template from the Ugi Reaction
Synlett
February 2007
New Benzothiazole and Benzoxazole Scaffolds from the Ugi-Smiles Couplings of Heterocycl...
Synlett
February 2007
New Ugi/Pictet-Spengler Multicomponent Formation of Polycyclic Diketopiperazines from ...
Synlett
February 2007
New ortho-Quinone Methide Formation: Application to Three-Component Coupling of Isocyan...
ChemInform
January 2007
Direct Access to Heterocyclic Scaffolds by New Multicomponent Ugi—Smiles Couplings.
ChemInform
January 2007
Ugi-Smiles Access to Quinoxaline Derivatives
Heterocycles
January 2007
Ugi/xanthate cyclizations as a radical route to lactam scaffolds
Tetrahedron Letters
November 2006
O -Arylative Passerini Reactions
Organic Letters
October 2006
Solvent-Free Preparation of Amidophosphonates from Isocyanides.
ChemInform
September 2006
Direct Access to Heterocyclic Scaffolds by New Multicomponent Ugi−Smiles Couplings
Organic Letters
August 2006
Solvent free preparation of amidophosphonates from isocyanides
Tetrahedron Letters
June 2006
Phenol Ugi—Smiles Systems: Strategies for the Multicomponent N-Arylation of Primary Ami...
ChemInform
April 2006
Formation of New Phosphates from Aldehydes by a DBU-Catalyzed Phospha-Brook Rearrangeme...
ChemInform
January 2006
Phenol Ugi-Smiles Systems: Strategies for the Multicomponent N-Arylation of Primary Ami...
Angewandte Chemie International Edition
December 2005
Phenol Ugi-Smiles Systems: Strategies for the Multicomponent N-Arylation of Primary Ami...
Angewandte Chemie International Edition
December 2005
From Isocyanides to Trichloropyruvamides: Application to a New Preparation of Oxamide D...
ChemInform
February 2005
Towards the Synthesis of Paulitin: New Insights into the Enyne-Metathesis Mechanism
Synlett
January 2005
Formation of New Phosphates from Aldehydes by a DBU-Catalysed Phospha-Brook Rearrangeme...
Synlett
January 2005
New Straightforward Quinoline Synthesis from the Mannich Reaction of α‐Ketohydrazones
Synthetic Communications
December 2004
New Access to Fluorinated Ketoglycolic Acid Derivatives from Trifluoropyruvamides.
ChemInform
November 2004
From isocyanides to trichloropyruvamides: application to a new preparation of oxamide d...
Tetrahedron Letters
October 2004
New Straightforward Quinoline Synthesis from the Mannich Reaction of α-Ketohydrazones.
ChemInform
July 2004
First Carbamates Conversion to Amides by Simple Alkyl Group Transfer from Trialkylalanes.
ChemInform
June 2004
New Trimethylaluminum-Induced Mannich-Type Reaction of Hydrazones.
ChemInform
March 2004
New Insight into the Azaenamine Behavior of N-Arylhydrazones: First Aldol and Improved ...
ChemInform
February 2004
First Carbamates Conversion to Amides by Simple Alkyl Group Transfer from Trialkylalanes
Organic Letters
February 2004
New Trimethylaluminum-Induced Mannich-Type Reaction of Hydrazones
The Journal of Organic Chemistry
October 2003
Amines Addition to α-Nitrohydrazones: Application to Amidrazone and Triazole Formation.
ChemInform
April 2003
Studies Towards the Synthesis of Fipronil.RTM. Analogues: Improved Decarboxylation of α...
ChemInform
January 2003
New Insight into the Azaenamine Behaviour ofN-Arylhydrazones: First Aldol and Improved ...
Synlett
January 2003
Amines addition to α-nitrohydrazones: application to amidrazones and triazoles formation
Tetrahedron Letters
December 2002
ChemInform Abstract: The Use of Hydrazones for Efficient Mannich Type Coupling with Ald...
ChemInform
November 2000
ChemInform Abstract: New Versatile Approach to α-Hydrazonoesters and Amino Acid Derivat...
ChemInform
November 2000
The use of hydrazones for efficient mannich type coupling with aldehydes and secondary ...
Chemical Communications
January 2000
New versatile approach to α-hydrazonoesters and amino acid derivatives through a modifi...
Chemical Communications
January 2000
Dramatic solvent effect in the multicomponent reaction of nitro compounds with isocyanides
Tetrahedron Letters
November 1999
A new multicomponent reaction of nitro compounds with isocyanides
Chemical Communications
January 1999
Trichloroacetylhydrazones: new highly reactive alkylating agents
Chemical Communications
January 1999
Trichloroacetic acid hydrazones I: New formation of 1,3,4-oxadiazoles from aldehydes
Tetrahedron Letters
September 1998
Trifluoropyruvamides from isocyanides and trifluoroacetic anhydride
Tetrahedron
April 1998
Thiophenol promoted radical cyclisation of hydrazones and oxime ethers
Tetrahedron Letters
January 1998
Mechanical Aspects of the Phosphotriesterase Activity of Human Butyrylcholinesterase G1...
January 1998
Mechanical Aspects of the Phosphotriesterase Activity of Human Butyrylcholinesterase G1...
January 1998
A New Straightforward Formation of Aminoisoxazoles from Isocyanides
Tetrahedron Letters
November 1997
Diazo Esters Addition to Trifluoropyruvamides: New Access to Highly Functionalized Trif...
Synlett
July 1997
A new conversion of primary nitro compounds into nitriles
Tetrahedron Letters
May 1997
New access to fluorinated glycolic acid derivatives from trifluoropyruvamides
Tetrahedron Letters
January 1996
An Unprecedented Radical Reaction of Benzotriazole Derivatives. A New Efficient Method ...
The Journal of Organic Chemistry
January 1996
A new and efficient synthesis of trifluoromethyl ketones from carboxylic acids. Part I
Tetrahedron
February 1995
Trifluoromethyl ketones from carboxylic acids. Part II. A versatile access to trifluoro...
Tetrahedron
February 1995
Trifluoropyruvamides from isocyanides and trifluoroacetic anhydride
Tetrahedron Letters
September 1994
An expedient access to trifluoromethyl ketones from carboxylic acids
Tetrahedron Letters
March 1992
An expedient total synthesis of (±)-estrone derivatives
Tetrahedron Letters
January 1991
A novel thermal rearrangement of allylic nitro derivatives into allylic alcohols
Journal of the Chemical Society Chemical Communications
January 1989
