All Stories

  1. Rb1 deficiency induces synthetic lethality with ATR and PKMYT1 coinhibition in breast cancer cell lines and patient-derived xenografts
  2. Phase I trial of hydroxychloroquine to enhance palbociclib and letrozole efficacy in ER+/HER2− breast cancer
  3. Low–Molecular Weight Cyclin E Confers a Vulnerability to PKMYT1 Inhibition in Triple-Negative Breast Cancer
  4. STAT3 protects hematopoietic stem cells by preventing activation of a deleterious autocrine type-I interferon response
  5. Exploring Novel Frontiers: Leveraging STAT3 Signaling for Advanced Cancer Therapeutics
  6. Cell cycle arrest induces lipid droplet formation and confers ferroptosis resistance
  7. Neutrophil Elastase Remodels Mammary Tumors to Facilitate Lung Metastasis
  8. Distinct Mechanisms of Resistance to CDK4/6 Inhibitors Require Specific Subsequent Treatment Strategies: One Size Does Not Fit All
  9. Abemaciclib is effective in palbociclib-resistant hormone receptor-positive metastatic breast cancers
  10. Adavosertib Enhances Antitumor Activity of Trastuzumab Deruxtecan in HER2-Expressing Cancers
  11. Evaluation of Alisertib Alone or Combined With Fulvestrant in Patients With Endocrine-Resistant Advanced Breast Cancer
  12. Multicenter Phase II Trial of the WEE1 Inhibitor Adavosertib in Refractory Solid Tumors Harboring CCNE1 Amplification
  13. Sequential Targeting of Retinoblastoma and DNA Synthesis Pathways Is a Therapeutic Strategy for Sarcomas That Can Be Monitored in Real Time
  14. Low-molecular-weight cyclin E deregulates DNA replication and damage repair to promote genomic instability in breast cancer
  15. CHD1 Promotes Sensitivity to Aurora Kinase Inhibitors by Suppressing Interaction of AURKA with Its Coactivator TPX2
  16. PARP inhibitors as single agents and in combination therapy: the most promising treatment strategies in clinical trials for BRCA-mutant ovarian and triple-negative breast cancers
  17. Palbociclib plus endocrine therapy significantly enhances overall survival of HR+/HER2− metastatic breast cancer patients compared to endocrine therapy alone in the second‐line setting: A large institutional study
  18. LMW cyclin E and its novel catalytic partner CDK5 are therapeutic targets and prognostic biomarkers in salivary gland cancers
  19. Targeting Replicative Stress and DNA Repair by Combining PARP and Wee1 Kinase Inhibitors Is Synergistic in Triple Negative Breast Cancers with Cyclin E or BRCA1 Alteration
  20. Regulation of the Cell Cycle by Kinases and Cyclins
  21. Selective CDK4/6 Inhibitors: Biologic Outcomes, Determinants of Sensitivity, Mechanisms of Resistance, Combinatorial Approaches, and Pharmacodynamic Biomarkers
  22. Cytoplasmic Cyclin E Is an Independent Marker of Aggressive Tumor Biology and Breast Cancer-Specific Mortality in Women over 70 Years of Age
  23. Specific, reversible G1 arrest by UCN-01 in vivo provides cytostatic protection of normal cells against cytotoxic chemotherapy in breast cancer
  24. Cytoplasmic Cyclin E Expression Predicts for Response to Neoadjuvant Chemotherapy in Breast Cancer
  25. Arthur B. Pardee: In Memoriam (1921–2019)
  26. Combined Inhibition of STAT3 and DNA Repair in Palbociclib-Resistant ER-Positive Breast Cancer
  27. Low-Molecular-Weight Cyclin E in Human Cancer: Cellular Consequences and Opportunities for Targeted Therapies
  28. Cyclin E Overexpression Sensitizes Triple-Negative Breast Cancer to Wee1 Kinase Inhibition
  29. Strategic development of AZD1775, a Wee1 kinase inhibitor, for cancer therapy
  30. Leveraging MYC as a therapeutic treatment option for TNBC
  31. Histone modification profiling in breast cancer cell lines highlights commonalities and differences among subtypes
  32. Enhancer transcription reveals subtype-specific gene expression programs controlling breast cancer pathogenesis
  33. Inhibiting CDK in Cancer Therapy: Current Evidence and Future Directions
  34. Synthetic Lethality of PARP Inhibitors in Combination with MYC Blockade Is Independent of BRCA Status in Triple-Negative Breast Cancer
  35. Cytoplasmic Cyclin E Mediates Resistance to Aromatase Inhibitors in Breast Cancer
  36. Abstract 2060: Characterizing acquired resistance to palbociclib in breast cancer
  37. CDK4/6 and autophagy inhibitors synergistically induce senescence in Rb positive cytoplasmic cyclin E negative cancers
  38. CDK4/6 Inhibitors Sensitize Rb-positive Sarcoma Cells to Wee1 Kinase Inhibition through Reversible Cell-Cycle Arrest
  39. Cyclin E overexpression as a biomarker for combination treatment strategies in inflammatory breast cancer
  40. Rapid Breast Cancer Disease Progression Following Cyclin Dependent Kinase 4 and 6 Inhibitor Discontinuation
  41. Cytoplasmic Cyclin E Predicts Recurrence in Patients with Breast Cancer
  42. AXL Inhibition Suppresses the DNA Damage Response and Sensitizes Cells to PARP Inhibition in Multiple Cancers
  43. Cytoplasmic Cyclin E and Phospho–Cyclin-Dependent Kinase 2 Are Biomarkers of Aggressive Breast Cancer
  44. Estrogen receptor alpha is cell cycle-regulated and regulates the cell cycle in a ligand-dependent fashion
  45. Cyclin E Associates with the Lipogenic Enzyme ATP-Citrate Lyase to Enable Malignant Growth of Breast Cancer Cells
  46. PAF-Wnt signaling-induced cell plasticity is required for maintenance of breast cancer cell stemness
  47. Sequential Combination Therapy of CDK Inhibition and Doxorubicin Is Synthetically Lethal in p53-Mutant Triple-Negative Breast Cancer
  48. Targeting the Cell Cycle in Breast Cancer
  49. PKCiota promotes ovarian tumor progression through deregulation of cyclin E
  50. Erratum to: Elafin is downregulated during breast and ovarian tumorigenesis but its residual expression predicts recurrence
  51. A phase 1 study with dose expansion of the CDK inhibitor dinaciclib (SCH 727965) in combination with epirubicin in patients with metastatic triple negative breast cancer
  52. Staurosporine
  53. Staurosporine
  54. Elafin is downregulated during breast and ovarian tumorigenesis but its residual expression predicts recurrence
  55. How will we recruit, train, and retain physicians and scientists to conduct translational cancer research?
  56. The serine protease inhibitor elafin maintains normal growth control by opposing the mitogenic effects of neutrophil elastase
  57. Indole-3-carbinol and its N-alkoxy derivatives preferentially target ERα-positive breast cancer cells
  58. 2′-OMe-phosphorodithioate-modified siRNAs show increased loading into the RISC complex and enhanced anti-tumour activity
  59. Hbo1 Is a Cyclin E/CDK2 Substrate That Enriches Breast Cancer Stem-like Cells
  60. Staurosporine is chemoprotective by inducing G 1 arrest in a Chk1- and pRb-dependent manner
  61. EVI1 splice variants modulate functional responses in ovarian cancer cells
  62. Elafin, an inhibitor of elastase, is a prognostic indicator in breast cancer
  63. Low molecular weight cyclin E is associated with p27-resistant, high-grade, high-stage and invasive bladder cancer
  64. LMW-E/CDK2 Deregulates Acinar Morphogenesis, Induces Tumorigenesis, and Associates with the Activated b-Raf-ERK1/2-mTOR Pathway in Breast Cancer Patients
  65. P5-03-03: Identification of New Substrates for Breast Tumor Specific Low-Molecular-Weight Cyclin E Cyclin-Dependent-Kinase 2.
  66. Targeting low molecular weight cyclin E (LMW-E) in breast cancer
  67. MDA-7 results in downregulation of AKT concomitant with apoptosis and cell cycle arrest in breast cancer cells
  68. Cdk2 is Required for Breast Cancer Mediated by the Low-Molecular-Weight Isoform of Cyclin E
  69. Breaking the cycle: An insight into the role of ERα in eukaryotic cell cycles
  70. Cyclin E amplification/overexpression is a mechanism of trastuzumab resistance in HER2+ breast cancer patients
  71. Staurosporine
  72. Semi-high throughput method of measuring proteasome inhibition in vitro and in cultured cells
  73. The Neutrophil Elastase Inhibitor Elafin Triggers Rb-Mediated Growth Arrest and Caspase-Dependent Apoptosis in Breast Cancer
  74. Cyclin E Deregulation Impairs Mitotic Progression through Premature Activation of Cdc25C
  75. Low Molecular Weight Cyclin E Overexpression Shortens Mitosis, Leading to Chromosome Missegregation and Centrosome Amplification
  76. A novel interaction between HER2/neu and cyclin E in breast cancer
  77. Low-Molecular-Weight Cyclin E Can Bypass Letrozole-Induced G1 Arrest in Human Breast Cancer Cells and Tumors
  78. Post-translational modification and stability of low molecular weight cyclin E
  79. Integrative Analysis of Cyclin Protein Levels Identifies Cyclin B1 as a Classifier and Predictor of Outcomes in Breast Cancer
  80. DEAR1 Is a Dominant Regulator of Acinar Morphogenesis and an Independent Predictor of Local Recurrence-Free Survival in Early-Onset Breast Cancer
  81. Altered Subcellular Localization of Tumor-Specific Cyclin E Isoforms Affects Cyclin-Dependent Kinase 2 Complex Formation and Proteasomal Regulation
  82. Overexpression of LMW cyclin E results in faster M phase progression via Cdc25C interaction leading to chromosome missegragation in breast cancer cells.
  83. CDK2 is required for LMW-cyclin E mediated murine mammary tumorigenesis.
  84. Cyclin E deregulation is an early event in the development of breast cancer
  85. A novel MCM-2 fragment with potential biological function in senescence
  86. Biomarkers in Neoadjuvant Trials
  87. Autophagy: A Novel Mechanism of Synergistic Cytotoxicity between Doxorubicin and Roscovitine in a Sarcoma Model
  88. Synchronization of the cell cycle using Lovastatin
  89. Differential Regulation of Elafin in Normal and Tumor-Derived Mammary Epithelial Cells Is Mediated by CCAAT/Enhancer Binding Protein β
  90. The Double-Stranded RNA-Activated Protein Kinase Mediates Radiation Resistance in Mouse Embryo Fibroblasts through Nuclear Factor κB and Akt Activation
  91. Cyclin E–Associated Kinase Activity Predicts Response to Platinum-Based Chemotherapy
  92. Overexpression of the Low Molecular Weight Cyclin E in Transgenic Mice Induces Metastatic Mammary Carcinomas through the Disruption of the ARF-p53 Pathway
  93. Cell Cycle Deregulation in Breast Cancer: Insurmountable Chemoresistance or Achilles’ Heel?
  94. The Differential Staurosporine-Mediated G1 Arrest in Normal versus Tumor Cells Is Dependent on the Retinoblastoma Protein
  95. Farnesyl and Geranylgeranyl Transferase Inhibitors Induce G1 Arrest by Targeting the Proteasome
  96. Deregulation of cyclin E meets dysfunction in p53: Closing the escape hatch on breast cancer
  97. Clinical outcome of patients with lymph node-negative breast carcinoma who have sentinel lymph node micrometastases detected by immunohistochemistry
  98. Author reply
  99. Atypical PKCι contributes to poor prognosis through loss of apical-basal polarity and Cyclin E overexpression in ovarian cancer
  100. Cyclin E as a prognostic and predictive marker in breast cancer
  101. Targeting the cell cycle for prognosis and therapy of breast cancer
  102. The Tumor-specific Hyperactive Forms of Cyclin E Are Resistant to Inhibition by p21 and p27
  103. Low-molecular-weight cyclin E: the missing link between biology and clinical outcome
  104. Role of cell cycle in mediating sensitivity to radiotherapy
  105. Tumor-Specific Low Molecular Weight Forms of Cyclin E Induce Genomic Instability and Resistance to p21, p27, and Antiestrogens in Breast Cancer
  106. Cyclin E deregulation alters the biologic properties of ovarian cancer cells
  107. Activation of Cyclin-dependent Kinase 2 by Full Length and Low Molecular Weight Forms of Cyclin E in Breast Cancer Cells
  108. Cyclin E in Breast Cancer
  109. Cyclin E is a more powerful predictor of breast cancer outcome than proliferation
  110. Cyclin E and Survival in Patients with Breast Cancer
  111. Tumor-Specific Proteolytic Processing of Cyclin E Generates Hyperactive Lower-Molecular-Weight Forms
  112. Phosphorylation-Dependent Ubiquitination of Cyclin E by the SCFFbw7 Ubiquitin Ligase
  113. Taxol-induced apoptosis depends on MAP kinase pathways (ERK and p38) and is independent of p53
  114. Erratum to “Expression of an estrogen receptor alpha variant protein in cell lines and tumors”
  115. Expression of an estrogen receptor alpha variant protein in cell lines and tumors
  116. The Biphasic Induction of p21 and p27 in Breast Cancer Cells by Modulators of cAMP Is Posttranscriptionally Regulated and Independent of the PKA Pathway
  117. Lovastatin-mediated G 1 arrest is through inhibition of the proteasome, independent of hydroxymethyl glutaryl-CoA reductase
  118. Molecular Cloning, Characterization, and Regulation of the Human Mitochondrial Serine Hydroxymethyltransferase Gene
  119. The role of cyclin E in cell proliferation, development and cancer
  120. Cyclin E, a redundant cyclin in breast cancer
  121. Synchronization of mammalian cells by Lovastatin
  122. Synthesis and Biological Activity of N.omega.-Hemiphthaloyl-.alpha.,.omega.-diaminoalkanoic Acid Analogs of Aminopterin and 3',5-Dichloroaminopterin
  123. Molecules of Deregulated Cell Cycle Control in Cancer
  124. The p21 Cdk-interacting protein Cip1 is a potent inhibitor of G1 cyclin-dependent kinases
  125. Redundant cyclin overexpression and gene amplification in breast cancer cells.
  126. Modification of cell proliferation with inhibitors
  127. Modification of cell proliferation with inhibitors
  128. Modification of cell proliferation with inhibitors
  129. An efficient deletion mutant packaging system for defective herpes simplex virus vectors: potential applications to human gene therapy and neuronal physiology.
  130. Drugs in blood donors.
  131. [47] Preparation of (6S)-5-formyltetrahydrofolate labeled at high specific activity with 14C and 3H
  132. Understanding the Biology of Cancer
  133. Staurosporine