All Stories

  1. Return of the Biennial Circulation of Enterovirus D68 in Colorado Children in 2024 Following the Large 2022 Outbreak

    Article • Viruses, May 2025, MDPI AG

    Dr Kevin Messacar

  2. Predicting the impact of non-pharmaceutical interventions against COVID-19 on Mycoplasma pneumoniae in the United States

    Article • Epidemics, December 2024, Elsevier

    Dr Kevin Messacar

  3. Recruitment and retention of pediatric participants for pandemic preparedness research: Experience from the PREMISE EV-D68 Pilot Study

    Article • Contemporary Clinical Trials Communications, October 2024, Elsevier

    Dr Kevin Messacar

  4. Clinical Impact of Pleural Fluid Streptococcus pneumoniae Polymerase Chain Reaction Testing in Children With Complicated Pneumonia

    Article • Clinical Infectious Diseases, August 2024, Oxford University Press (OUP)

    Dr Kevin Messacar

  5. Predicting the impact of non-pharmaceutical interventions against COVID-19 onMycoplasma pneumoniaein the United States

    Article • August 2024, Cold Spring Harbor Laboratory Press

    Dr Kevin Messacar

  6. Multimodal Surveillance Model for Enterovirus D68 Respiratory Disease and Acute Flaccid Myelitis among Children in Colorado, USA, 2022

    Article • Emerging Infectious Diseases, March 2024, Centers for Disease Control and Prevention (CDC)

    Dr Kevin Messacar

  7. Predicting the impact of COVID-19 non-pharmaceutical intervention on short- and medium-term dynamics of enterovirus D68 in the US

    Article • Epidemics, March 2024, Elsevier

    Dr Kevin Messacar

  8. Acute flaccid myelitis in low- to middle-income countries: diagnosis and surveillance

    Article • Brain Communications, January 2024, Oxford University Press (OUP)

    Dr Kevin Messacar

  9. Gaps in diagnosing suspected infection in immunocompromised children with cancer: A systematic review

    Article • Pediatric Blood & Cancer, December 2023, Wiley

    Dr Kevin Messacar

  10. Duration of Enterovirus D68 RNA Shedding in the Upper Respiratory Tract and Transmission among Household Contacts, Colorado, USA

    Article • Emerging Infectious Diseases, November 2023, Centers for Disease Control and Prevention (CDC)

    Dr Kevin Messacar , Dr Terry Fei Fan Ng

  11. Improving antimicrobial use through better diagnosis: The relationship between diagnostic stewardship and antimicrobial stewardship

    Article • Infection Control, September 2023, Cambridge University Press

    Dr Kevin Messacar

  12. Qualitative detection of enterovirus D68 from PrimeStore® molecular transport medium: implications for home- and self-collection

    Article • Diagnostic Microbiology and Infectious Disease, August 2023, Elsevier

    Dr Kevin Messacar

  13. Predicting the impact of COVID-19 non-pharmaceutical intervention on short- and medium-term dynamics of enterovirus D68 in the US

    Article • July 2023, Cold Spring Harbor Laboratory Press

    Dr Kevin Messacar

  14. Plasma Microbial Cell-Free DNA Sequencing from over 15,000 Patients Identified a Broad Spectrum of Pathogens

    Article • Journal of Clinical Microbiology, July 2023, ASM Journals

    Dr Kevin Messacar

  15. Shifting Epidemiology and Severity of Respiratory Syncytial Virus in Children During the COVID-19 Pandemic

    Article • JAMA Pediatrics, July 2023, American Medical Association (AMA)

    Dr Kevin Messacar

  16. Perspectives on Diagnosis and Management of All-Cause Encephalitis: A National Survey of Adult Infectious Diseases Physicians

    Article • Open Forum Infectious Diseases, March 2023, Oxford University Press (OUP)

    Dr Kevin Messacar

  17. Acute Liver Failure in a Child With Adenovirus Detected by PCR in the Explanted Liver

    Article • PEDIATRICS, January 2023, American Academy of Pediatrics (AAP)

    Dr Kevin Messacar

  18. Plasma Microbial Cell-free DNA Sequencing from Over 15,000 Patients Identified a Broad Spectrum of Pathogens

    Article • January 2023, Cold Spring Harbor Laboratory Press

    Dr Kevin Messacar

  19. Preparing for uncertainty: endemic paediatric viral illnesses after COVID-19 pandemic disruption

    Article • The Lancet, November 2022, Elsevier

    Dr Kevin Messacar

  20. Clinical and Financial Impact of a Diagnostic Stewardship Program for Children with Suspected Central Nervous System Infection

    Article • The Journal of Pediatrics, May 2022, Elsevier

    Dr Kevin Messacar

  21. Preventing enterovirus A71 disease: another promising vaccine for children

    Article • The Lancet, April 2022, Elsevier

    Dr Kevin Messacar

  22. Enterovirus D68: a test case for the use of immunological surveillance to develop tools to mitigate the pandemic potential of emerging pathogens

    Article • The Lancet Microbe, February 2022, Elsevier

    Dr Kevin Messacar

  23. Metagenomic Next-Generation Sequencing for Diagnosis of Pediatric Meningitis and Encephalitis: A Review

    Article • Journal of the Pediatric Infectious Diseases Society, December 2021, Oxford University Press (OUP)

    Dr Kevin Messacar

  24. Author Correction: Pan-viral serology implicates enteroviruses in acute flaccid myelitis

    Article • Nature Medicine, September 2021, Springer Science + Business Media

    Dr Kevin Messacar , Dr Terry Fei Fan Ng

  25. AKI In Suspected Meningitis/Encephalitis May Be “Avoidable Kidney Injury”

    Article • Hospital Pediatrics, August 2021, American Academy of Pediatrics (AAP)

    Dr Kevin Messacar

  26. Epidemiological dynamics of enterovirus D68 in the United States and implications for acute flaccid myelitis

    Article • Science Translational Medicine, March 2021, American Association for the Advancement of Science

    Dr Kevin Messacar

  27. Acute flaccid myelitis: cause, diagnosis, and management

    Article • The Lancet, January 2021, Elsevier

    Dr Kevin Messacar

  28. Variability in the Use of Novel Diagnostic Technology in Children With Suspected Encephalitis and in the Management of Emerging Encephalitides by Pediatric Infectious Disease Providers

    Article • Journal of the Pediatric Infectious Diseases Society, December 2020, Oxford University Press (OUP)

    Dr Kevin Messacar

  29. Foreign Body Esophageal Perforation Leading to Multifocal Brain Abscesses: A Case Report

    Article • Journal of Emergency Medicine, October 2020, Elsevier

    Dr Kevin Messacar

  30. Enterovirus D68 Subclade B3 in Children with Acute Flaccid Paralysis in West Africa, 2016

    Article • Emerging Infectious Diseases, September 2020, Centers for Disease Control and Prevention (CDC)

    Dr Kevin Messacar

  31. Evaluation for Arboviral Infection Among Children Hospitalized in Colorado With Aseptic Meningitis and Encephalitis

    Article • The Pediatric Infectious Disease Journal, August 2020, Wolters Kluwer Health

    Dr Kevin Messacar

  32. Impact of FilmArray meningitis encephalitis panel on HSV testing and empiric acyclovir use in children beyond the neonatal period

    Article • Diagnostic Microbiology and Infectious Disease, August 2020, Elsevier

    Chair of Neurology, Univ. CO School of Medicine Kenneth L Tyler, Dr Kevin Messacar

  33. Epidemiological dynamics of enterovirus D68 in the US: implications for acute flaccid myelitis

    Article • July 2020, Cold Spring Harbor Laboratory Press

    Dr Kevin Messacar

  34. Clinical characteristics of enterovirus A71 neurological disease during an outbreak in children in Colorado, USA, in 2018: an observational cohort study

    Article • The Lancet Infectious Diseases, February 2020, Elsevier

    Dr Kevin Messacar

  35. Two Blood Cultures With Age-Appropriate Volume Enhance Suspected Sepsis Decision-Making

    Article • Open Forum Infectious Diseases, January 2020, Oxford University Press (OUP)

    Dr Kevin Messacar

  36. A Resident-Based, Educational Program to Drive Individual and Institutional Improvement in a Pediatric Training Hospital

    Article • The Journal of Pediatrics, November 2019, Elsevier

    Dr Kevin Messacar

  37. Pan-viral serology implicates enteroviruses in acute flaccid myelitis

    Article • Nature Medicine, October 2019, Springer Science + Business Media

    Dr Terry Fei Fan Ng, Dr Kevin Messacar

  38. Acute Flaccid Myelitis Surveillance: A Signal Through the Noise

    Article • PEDIATRICS, October 2019, American Academy of Pediatrics (AAP)

    Dr Kevin Messacar

  39. Understanding Enterovirus D68-Induced Neurologic Disease: A Basic Science Review

    Article • Viruses, September 2019, MDPI AG

    Chair of Neurology, Univ. CO School of Medicine Kenneth L Tyler, Dr Kevin Messacar

  40. Gastroenteritis, Hepatitis, Encephalopathy, and Human Herpesvirus 6 Detection in an Immunocompetent Child: Benefits and Risks of Syndromic Multiplex Molecular Panel Testing

    Article • The Journal of Pediatrics, September 2019, Elsevier

    Dr Kevin Messacar

  41. Incidence, Risk Factors and Outcomes Among Children With Acute Flaccid Myelitis: A Population-based Cohort Study in a California Health Network Between 2011 and 2016

    Article • The Pediatric Infectious Disease Journal, July 2019, Wolters Kluwer Health

    Dr Kevin Messacar

  42. Picornavirus etiology of acute infections among hospitalized infants

    Article • Journal of Clinical Virology, July 2019, Elsevier

    Dr Kevin Messacar

  43. Clinical Metagenomic Sequencing for Diagnosis of Meningitis and Encephalitis

    Article • The New England Journal of Medicine and Surgery and the Collateral Branches of Science, June 2019, New England Journal of Medicine (NEJM/MMS)

    Dr Kevin Messacar

  44. Serological and metagenomic interrogation of cerebrospinal fluid implicates enteroviruses in pediatric acute flaccid myelitis

    Article • June 2019, Cold Spring Harbor Laboratory Press

    Dr Kevin Messacar

  45. Neonatal parechovirus infection mimicking a surgical abdomen

    Article • BMJ Case Reports, June 2019, BMJ

    Dr Kevin Messacar

  46. Acute Flaccid Myelitis Associated With Enterovirus D68: A Review

    Article • Journal of Child Neurology, April 2019, SAGE Publications

    Alison Christy, Dr Kevin Messacar

  47. Laboratory validation of a clinical metagenomic sequencing assay for pathogen detection in cerebrospinal fluid

    Article • Genome Research, April 2019, Cold Spring Harbor Laboratory Press

    Dr Kevin Messacar

  48. Continued biennial circulation of enterovirus D68 in Colorado

    Article • Journal of Clinical Virology, April 2019, Elsevier

    Dr Kevin Messacar

  49. Enterovirus D68–Associated Acute Flaccid Myelitis

    Article • JAMA, March 2019, American Medical Association (AMA)

    Chair of Neurology, Univ. CO School of Medicine Kenneth L Tyler, Dr Kevin Messacar

  50. Clinical, Radiologic, and Prognostic Features of Myelitis Associated With Myelin Oligodendrocyte Glycoprotein Autoantibody

    Article • JAMA Neurology, March 2019, American Medical Association (AMA)

    Chair of Neurology, Univ. CO School of Medicine Kenneth L Tyler, Dr Kevin Messacar

  51. Acute Flaccid Myelitis—Keys to Diagnosis, Questions About Treatment, and Future Directions

    Article • JAMA Pediatrics, February 2019, American Medical Association (AMA)

    Dr Kevin Messacar

  52. Clinical Subpopulations in a Sample of North American Children Diagnosed With Acute Flaccid Myelitis, 2012-2016

    Article • JAMA Pediatrics, February 2019, American Medical Association (AMA)

    Dr Kevin Messacar

  53. Rapid identification of nonblood sterile site broth cultures using the FilmArray blood culture identification panel

    Article • Diagnostic Microbiology and Infectious Disease, January 2019, Elsevier

    Dr Kevin Messacar

  54. Neurologic Manifestations of Influenza A(H3N2) Infection in Children During the 2016–2017 Season

    Article • Journal of the Pediatric Infectious Diseases Society, December 2018, Oxford University Press (OUP)

    Dr Kevin Messacar

  55. Blood PCR testing for enteroviruses in young children

    Article • The Lancet Infectious Diseases, December 2018, Elsevier

    Dr Kevin Messacar

  56. Safety, tolerability, and efficacy of fluoxetine as an antiviral for acute flaccid myelitis

    Article • Neurology, November 2018, Wolters Kluwer Health

    Dr Kevin Messacar

  57. Letter to the editor: economic analysis lacks external validity to support universal syndromic testing for suspected meningitis/encephalitis

    Article • Future Microbiology, November 2018, Future Medicine

    Dr Kevin Messacar

  58. A 4-Year-Old Boy With an Unusual Bacterial Meningitis Infection

    Article • Journal of the Pediatric Infectious Diseases Society, October 2018, Oxford University Press (OUP)

    Dr Kevin Messacar

  59. Notes from the Field: Enterovirus A71 Neurologic Disease in Children — Colorado, 2018

    Article • MMWR Morbidity and Mortality Weekly Report, September 2018, Centers for Disease Control MMWR Office

    Dr Kevin Messacar

  60. Enterovirus D68 can cause acute flaccid myelitis

    Article • The Lancet Infectious Diseases, August 2018, Elsevier

    Chair of Neurology, Univ. CO School of Medicine Kenneth L Tyler, Dr Kevin Messacar

  61. Laboratory Validation of a Clinical Metagenomic Sequencing Assay for Pathogen Detection in Cerebrospinal Fluid

    Article • May 2018, Cold Spring Harbor Laboratory Press

    Dr Kevin Messacar

  62. Narrow-spectrum, compared with broad-spectrum, antibiotics equally effective with less adverse events

    Article • The Journal of Pediatrics, May 2018, Elsevier

    Dr Kevin Messacar

  63. Encephalitis in US Children

    Article • Infectious Disease Clinics of North America, March 2018, Elsevier

    Chair of Neurology, Univ. CO School of Medicine Kenneth L Tyler, Dr Kevin Messacar

  64. A Child With Intermittent Headaches and Eosinophilic Meningitis

    Article • Journal of the Pediatric Infectious Diseases Society, February 2018, Oxford University Press (OUP)

    Dr Kevin Messacar

  65. Reply to “Integrated Stewardship Model Comprising Antimicrobial, Infection Prevention, and Diagnostic Stewardship (AID Stewardship)”

    Article • Journal of Clinical Microbiology, October 2017, ASM Journals

    Dr Kevin Messacar

  66. The changing epidemiology of acute flaccid paralysis warrants a paradigm shift in surveillance

    Article • Journal of Medical Virology, October 2017, Wiley

    Dr Kevin Messacar

  67. Surveillance for enterovirus D68 in colorado children reveals continued circulation

    Article • Journal of Clinical Virology, July 2017, Elsevier

    Dr Kevin Messacar

  68. Outcomes of Colorado children with acute flaccid myelitis at 1 year

    Article • Neurology, June 2017, Wolters Kluwer Health

    Chair of Neurology, Univ. CO School of Medicine Kenneth L Tyler, Dr Kevin Messacar

  69. Improvement in treatment abandonment in pediatric patients with cancer in Guatemala

    Article • Pediatric Blood & Cancer, April 2017, Wiley

    Dr Kevin Messacar

  70. Antimicrobial stewardship increases ID consults

    Article • Clinical Infectious Diseases, February 2017, Oxford University Press (OUP)

    Dr Kevin Messacar

  71. Diagnostic and Antimicrobial Stewardship for Rapid ID Diagnostics

    Article • Journal of Clinical Microbiology, December 2016, ASM Journals

    Dr Kevin Messacar

  72. Enterovirus D68 in Critically Ill Children

    Article • Pediatric Critical Care Medicine, November 2016, Wolters Kluwer Health

    Dr Kevin Messacar

  73. Impact of New Rapid CSF Diagnostic Test

    Article • Diagnostic Microbiology and Infectious Disease, September 2016, Elsevier

    Dr Kevin Messacar

  74. Clinical Impact and Provider Acceptability of Real-Time Antimicrobial Stewardship Decision Support for Rapid Diagnostics in Children With Positive Blood Culture Results

    Article • Journal of the Pediatric Infectious Diseases Society, August 2016, Oxford University Press (OUP)

    Dr Kevin Messacar

  75. A new densovirus in cerebrospinal fluid from a case of anti-NMDA-receptor encephalitis

    Article • Archives of Virology, August 2016, Springer Science + Business Media

    Dr Kevin Messacar , Antonio Charlys da-Costa

  76. Acute Flaccid Myelitis Review

    Article • Annals of Neurology, August 2016, Wiley

    Dr Kevin Messacar

  77. Case Control Study of EV-D68 and AFM in CO

    Article • Emerging Infectious Diseases, August 2016, Centers for Disease Control and Prevention (CDC)

    Dr Kevin Messacar

  78. Hospitalized Children With Encephalitis in the United States: A Pediatric Health Information System Database Study

    Article • Pediatric Neurology, August 2016, Elsevier

    Dr Kevin Messacar

  79. Do epidural fevers contribute to babies receiving antibiotics?

    Article • Archives of Disease in Childhood Fetal & Neonatal, June 2016, BMJ

    Dr Kevin Messacar

  80. Improvement of Abandonment of Therapy in Pediatric Patients with Cancer in Guatemala

    Article • Journal of Global Oncology, June 2016, American Society of Clinical Oncology (ASCO)

    Dr Kevin Messacar

  81. The Unmeasured Burden of Enterovirus D68 in 2014

    Article • JAMA Pediatrics, March 2016, American Medical Association (AMA)

    Dr Kevin Messacar

  82. Erratum to: Clinical metagenomic identification of Balamuthia mandrillaris encephalitis and assembly of the draft genome: the continuing case for reference genome sequencing

    Article • Genome Medicine, January 2016, Springer Science + Business Media

    Dr Kevin Messacar

  83. The Emergence of Enterovirus-D68

    Article • January 2016, ASM Journals

    Dr Kevin Messacar

  84. Abnormal Neuroimaging in a Case of Infant Botulism

    Article • Frontiers in Pediatrics, December 2015, Frontiers

    Dr Kevin Messacar

  85. Clinical metagenomic identification of Balamuthia mandrillaris encephalitis and assembly of the draft genome: the continuing case for reference genome sequencing

    Article • Genome Medicine, December 2015, Springer Science + Business Media

    Dr Kevin Messacar

  86. 2014 Enterovirus D68 Outbreak

    Article • Journal of Medical Virology, November 2015, Wiley

    Dr Kevin Messacar

  87. Clinical metagenomic identification of Balamuthia mandrillaris encephalitis and assembly of the draft genome: the critical need for reference strain sequencing

    Article • August 2015, Cold Spring Harbor Laboratory Press

    Dr Kevin Messacar

  88. Enterovirus D68 and Acute Flaccid Myelitis in CO 2014

    Article • The Lancet Infectious Diseases, June 2015, Elsevier

    Dr Kevin Messacar , Debra A Wadford

  89. Cluster of Acute Flaccid Myelitis and Enterovirus D68 in CO 2014

    Article • The Lancet, April 2015, Elsevier

    Dr Kevin Messacar

  90. Epidemiology and clinical characteristics of infants with human parechovirus or human herpes virus-6 detected in cerebrospinal fluid tested for enterovirus or herpes simplex virus

    Article • Journal of Medical Virology, February 2015, Wiley

    Dr Kevin Messacar

  91. MRI Findings in Children with Acute Flaccid Paralysis and Cranial Nerve Dysfunction Occurring during the 2014 Enterovirus D68 Outbreak

    Article • American Journal of Neuroradiology, November 2014, American Society of Neuroradiology (ASNR)

    Dr Kevin Messacar

  92. Neuroinvasive Arboviral Disease in the United States: 2003 to 2012

    Article • PEDIATRICS, August 2014, American Academy of Pediatrics (AAP)

    Dr Kevin Messacar

  93. Bacteriology and Risk Factors for Development of Late (Greater Than One Year) Deep Infection Following Spinal Fusion With Instrumentation

    Article • Spine Deformity, May 2014, Elsevier

    Dr Kevin Messacar

  94. Diffuse Nodular Lung Infiltrates in a Well Appearing Three-Year-Old Boy With Recurrent Sinopulmonary Infections and Parotitis

    Article • Journal of the Pediatric Infectious Diseases Society, March 2014, Oxford University Press (OUP)

    Dr Kevin Messacar

  95. Severe neuroinvasive West Nile virus infection in a child with undiagnosed Addison's disease

    Article • IDCases, January 2014, Elsevier

    Dr Kevin Messacar

  96. Rhino/enteroviruses in hospitalized children: A comparison to influenza viruses

    Article • Journal of Clinical Virology, January 2013, Elsevier

    Dr Kevin Messacar