All Stories

  1. Increased HIV Incidence in Wuchereria bancrofti Microfilaria Positive Individuals in Tanzania

    Article • Pathogens, February 2023, MDPI AG

    Dr Kenneth M. Pfarr

  2. Pharmacokinetics and Pharmacodynamics (PK/PD) of Corallopyronin A against Methicillin-Resistant Staphylococcus aureus

    Article • Pharmaceutics, December 2022, MDPI AG

    Dr Kenneth M. Pfarr

  3. Potent In Vitro and Ex Vivo Anti-Gonococcal Activity of the RpoB Inhibitor Corallopyronin A

    Article • mSphere, October 2022, ASM Journals

    Dr Kenneth M. Pfarr

  4. In Vitro–In Vivo Relationship in Mini-Scale—Enabling Formulations of Corallopyronin A

    Article • Pharmaceutics, August 2022, MDPI AG

    Dr Kenneth M. Pfarr

  5. The RNA Polymerase Inhibitor Corallopyronin A Has a Lower Frequency of Resistance Than Rifampicin in Staphylococcus aureus

    Article • Antibiotics, July 2022, MDPI AG

    Dr Kenneth M. Pfarr

  6. Urine metabolites for the identification of Onchocerca volvulus infections in patients from Cameroon

    Article • Parasites & Vectors, August 2021, Springer Science + Business Media

    Dr Kenneth M. Pfarr

  7. Corallopyronin A for short-course anti-wolbachial, macrofilaricidal treatment of filarial infections

    Article • PLoS Neglected Tropical Diseases, December 2020, PLOS

    Dr Kenneth M. Pfarr

  8. Solubility and Stability Enhanced Oral Formulations for the Anti-Infective Corallopyronin A

    Article • Pharmaceutics, November 2020, MDPI AG

    Dr Kenneth M. Pfarr

  9. Morbidity management and surveillance of lymphatic filariasis disease and acute dermatolymphangioadenitis attacks using a mobile phone-based tool by community health volunteers in Ghana

    Article • PLoS Neglected Tropical Diseases, November 2020, PLOS

    Mr Derrick Adu Mensah, Dr Kenneth M. Pfarr

  10. Combinations of registered drugs reduce treatment times required to deplete Wolbachia in the Litomosoides sigmodontis mouse model

    Article • PLoS Neglected Tropical Diseases, January 2018, PLOS

    Dr Kenneth M. Pfarr

  11. NOD2 dependent neutrophil recruitment is required for early protective immune responses against infectious Litomosoides sigmodontis L3 larvae

    Article • Scientific Reports, December 2016, Springer Science + Business Media

    Dr Kenneth M. Pfarr

  12. Risk factors for epilepsy in Bas-Uélé Province, Democratic Republic of the Congo: a case–control study

    Article • International Journal of Infectious Diseases, August 2016, Elsevier

    Dr Kenneth M. Pfarr, Prof Robert Colebunders

  13. Multivariable Regression Analysis in Schistosoma mansoni-Infected Individuals in the Sudan Reveals Unique Immunoepidemiological Profiles in Uninfected, egg+ and Non-egg+ Infected Individuals

    Article • PLoS Neglected Tropical Diseases, May 2016, PLOS

    Dr Kenneth M. Pfarr

  14. Is there a risk of filarial infection during long-term missions in Haiti?

    Article • Travel Medicine and Infectious Disease, March 2016, Elsevier

    Dr Kenneth M. Pfarr

  15. Litomosoides sigmodontis: A jird urine metabolome study

    Article • Bioorganic & Medicinal Chemistry Letters, December 2015, Elsevier

    Dr Kenneth M. Pfarr

  16. Specific K39 antibody response and its persistence after treatment in patients with imported leishmaniasis

    Article • Parasitology Research, October 2015, Springer Science + Business Media

    Dr Kenneth M. Pfarr

  17. Insights into Structure–Activity Relationships of Bacterial RNA Polymerase Inhibiting Corallopyronin Derivatives

    Article • Journal of Natural Products, October 2015, American Chemical Society (ACS)

    Dr Kenneth M. Pfarr

  18. Extracellular Onchocerca-derived small RNAs in host nodules and blood

    Article • Parasites & Vectors, January 2015, Springer Science + Business Media

    Dr Kenneth M. Pfarr

  19. The ratio of calprotectin to total protein as a diagnostic and prognostic marker for spontaneous bacterial peritonitis in patients with liver cirrhosis and ascites

    Article • Clinical Chemistry and Laboratory Medicine (CCLM), January 2015, De Gruyter

    Dr Kenneth M. Pfarr

  20. Repurposing of approved drugs from the human pharmacopoeia to target Wolbachia endosymbionts of onchocerciasis and lymphatic filariasis

    Article • International Journal for Parasitology Drugs and Drug Resistance, December 2014, Elsevier

    Dr Kenneth M. Pfarr

  21. In VitroActivity of wALADin Benzimidazoles against Different Life Cycle Stages of Plasmodium Parasites

    Article • Antimicrobial Agents and Chemotherapy, October 2014, ASM Journals

    Dr Kenneth M. Pfarr

  22. Real-time PCR detection of the HhaI tandem DNA repeat in pre- and post-patent Brugia malayi infections: a study in Indonesian transmigrants

    Article • Parasites & Vectors, March 2014, Springer Science + Business Media

    Dr Kenneth M. Pfarr

  23. Localization of a filarial phosphate permease that is up-regulated in response to depletion of essential Wolbachia endobacteria

    Article • Experimental Parasitology, March 2014, Elsevier

    Dr Kenneth M. Pfarr

  24. wALADin Benzimidazoles Differentially Modulate the Function of Porphobilinogen Synthase Orthologs

    Article • Journal of Medicinal Chemistry, February 2014, American Chemical Society (ACS)

    Dr Kenneth M. Pfarr

  25. Corallopyronin A – A promising antibiotic for treatment of filariasis

    Article • International Journal of Medical Microbiology, January 2014, Elsevier

    Dr Kenneth M. Pfarr

  26. New chemotypes for wALADin1-like inhibitors of delta-aminolevulinic acid dehydratase from Wolbachia endobacteria

    Article • Bioorganic & Medicinal Chemistry Letters, October 2013, Elsevier

    Dr Kenneth M. Pfarr

  27. The ClpP peptidase of Wolbachia endobacteria is a novel target for drug development against filarial infections

    Article • Journal of Antimicrobial Chemotherapy, April 2013, Oxford University Press (OUP)

    Dr Kenneth M. Pfarr

  28. Requirement of lipid II biosynthesis for cell division in cell wall-less Wolbachia, endobacteria of arthropods and filarial nematodes

    Article • International Journal of Medical Microbiology, April 2013, Elsevier

    Dr Kenneth M. Pfarr

  29. A Selective Inhibitor of Heme Biosynthesis in Endosymbiotic Bacteria Elicits Antifilarial Activity In Vitro

    Article • Chemistry & Biology, February 2013, Elsevier

    Dr Kenneth M. Pfarr

  30. Drugs and Targets to Perturb the Symbiosis of Wolbachia and Filarial Nematodes

    Article • August 2012, Wiley

    Dr Kenneth M. Pfarr

  31. Corallopyronin A Specifically Targets and Depletes Essential Obligate Wolbachia Endobacteria From Filarial Nematodes In Vivo

    Article • The Journal of Infectious Diseases, May 2012, Oxford University Press (OUP)

    Dr Kenneth M. Pfarr

  32. Retarded Onchocerca volvulus L1 to L3 larval development in the Simulium damnosum vector after anti-wolbachial treatment of the human host

    Article • Parasites & Vectors, January 2012, Springer Science + Business Media

    Dr Kenneth M. Pfarr

  33. Transforming growth factor–β1 variant Leu10Pro is associated with both lack of microfilariae and differential microfilarial loads in the blood of persons infected with lymphatic filariasis

    Article • Human Immunology, November 2011, Elsevier

    Dr Kenneth M. Pfarr

  34. Filariasis in Africa—treatment challenges and prospects

    Article • Clinical Microbiology and Infection, July 2011, Elsevier

    Dr Kenneth M. Pfarr

  35. Macrofilaricidal Activity inWuchereria bancroftiafter 2 Weeks Treatment with a Combination of Rifampicin plus Doxycycline

    Article • Journal of Parasitology Research, January 2011, Hindawi Publishing Corporation

    Dr Kenneth M. Pfarr

  36. ADLOC: An Aptamer-Displacement Assay Based on Luminescent Oxygen Channeling

    Article • Chemistry - A European Journal, August 2010, Wiley

    Dr Kenneth M. Pfarr

  37. Mitochondrial genes for heme-dependent respiratory chain complexes are up-regulated after depletion of Wolbachia from filarial nematodes

    Article • International Journal for Parasitology, August 2010, Elsevier

    Dr Kenneth M. Pfarr

  38. Filariasis and lymphoedema

    Article • Parasite Immunology, October 2009, Wiley

    Dr Kenneth M. Pfarr

  39. Macrofilaricidal Activity and Amelioration of Lymphatic Pathology in Bancroftian Filariasis after 3 Weeks of Doxycycline Followed by Single-Dose Diethylcarbamazine

    Article • American Journal of Tropical Medicine and Hygiene, October 2009, American Society of Tropical Medicine and Hygiene

    Dr Ashok Kumar Satapathy, Dr Kenneth M. Pfarr

  40. Functional conservation of the lipid II biosynthesis pathway in the cell wall-less bacteriaChlamydiaandWolbachia: why is lipid II needed?

    Article • Molecular Microbiology, September 2009, Wiley

    Dr Kenneth M. Pfarr

  41. Infection of the intermediate mite host with Wolbachia-depleted Litomosoides sigmodontis microfilariae: Impaired L1 to L3 development and subsequent sex-ratio distortion in adult worms

    Article • International Journal for Parasitology, July 2008, Elsevier

    Dr Kenneth M. Pfarr

  42. Doxycycline Treatment ofBrugia malayi–Infected Persons Reduces Microfilaremia and Adverse Reactions after Diethylcarbamazine and Albendazole Treatment

    Article • Clinical Infectious Diseases, May 2008, Oxford University Press (OUP)

    Dr Kenneth M. Pfarr

  43. The mitochondrial heat shock protein 60 (HSP60) is up-regulated inOnchocerca volvulusafter the depletion ofWolbachia

    Article • Parasitology, January 2008, Cambridge University Press

    Dr Kenneth M. Pfarr

  44. Macrofilaricidal effect of 4 weeks of treatment with doxycycline on Wuchereria bancrofti

    Article • Tropical Medicine & International Health, December 2007, Wiley

    Dr Kenneth M. Pfarr

  45. Wolbachia endobacteria depletion by doxycycline as antifilarial therapy has macrofilaricidal activity in onchocerciasis: a randomized placebo-controlled study

    Article • Medical Microbiology and Immunology, November 2007, Springer Science + Business Media

    Dr Kenneth M. Pfarr

  46. On the taxonomic status of the intracellular bacterium Wolbachia pipientis: should this species name include the intracellular bacteria of filarial nematodes?

    Article • INTERNATIONAL JOURNAL OF SYSTEMATIC AND EVOLUTIONARY MICROBIOLOGY, August 2007, Society for General Microbiology

    Prof. Jonathan A. Eisen, Dr Kenneth M. Pfarr

  47. A niche for Wolbachia

    Article • Trends in Parasitology, January 2007, Elsevier

    Dr Kenneth M. Pfarr

  48. It Takes Two: Lessons From the First Nematode Wolbachia Genome Sequence

    Article • January 2007, Karger Publishers

    Dr Kenneth M. Pfarr

  49. Wolbachia Endosymbionts: An Achilles’ Heel of Filarial Nematodes

    Article • January 2007, Karger Publishers

    Dr Kenneth M. Pfarr

  50. Differential display of genes expressed in the filarial nematode Litomosoides sigmodontis reveals a putative phosphate permease up-regulated after depletion of Wolbachia endobacteria

    Article • International Journal of Medical Microbiology, August 2006, Elsevier

    Dr Kenneth M. Pfarr

  51. RNAi mediated silencing of actin expression in adult Litomosoides sigmodontis is specific, persistent and results in a phenotype

    Article • International Journal for Parasitology, May 2006, Elsevier

    Dr Kenneth M. Pfarr

  52. Antibiotics which Target the Wolbachia Endosymbionts of Filarial Parasites: A New Strategy for Control of Filariasis and Amelioration of Pathology

    Article • Mini-Reviews in Medicinal Chemistry, February 2006, Bentham Science Publishers

    Dr Kenneth M. Pfarr

  53. The Annotated Genome of Wolbachia from the Filarial Nematode Brugia malayi: What It Means for Progress in Antifilarial Medicine

    Article • PLoS Medicine, April 2005, PLOS

    Dr Kenneth M. Pfarr

  54. Article • Filaria Journal, January 2005, Springer Science + Business Media

    Dr Kenneth M. Pfarr

  55. Doxycycline as a novel strategy against bancroftian filariasis?depletion of Wolbachia endosymbionts from Wuchereria bancrofti and stop of microfilaria production

    Article • Medical Microbiology and Immunology, November 2003, Springer Science + Business Media

    Dr Kenneth M. Pfarr

  56. Article • Filaria Journal, January 2003, Springer Science + Business Media

    Dr Kenneth M. Pfarr

  57. Nitric Oxide Synthase in Filariae: Demonstration of Nitric Oxide Production by Embryos in Brugia malayi and Acanthocheilonema viteae

    Article • Experimental Parasitology, April 2001, Elsevier

    Dr Kenneth M. Pfarr

  58. Brugia malayi: Localization of Nitric Oxide Synthase in a Lymphatic Filariid

    Article • Experimental Parasitology, February 2000, Elsevier

    Dr Kenneth M. Pfarr

  59. Endo16, a Large Multidomain Protein Found on the Surface and ECM of Endodermal Cells during Sea Urchin Gastrulation, Binds Calcium

    Article • Developmental Biology, September 1994, Elsevier

    Dr Kenneth M. Pfarr