All Stories

  1. trans-Translation inhibitors that kill Mycobacterium tuberculosis and pathogenic non-tuberculous mycobacteria also disrupt metal homeostasis

    Article • Microbiology, May 2026, Society for General Microbiology

    Professor Ken Keiler

  2. Blocked transcription-translation complexes are rescued by transcript release followed by trans -translation

    Article • May 2026, openRxiv

    Professor Ken Keiler

  3. Ribosomal Protein bL27 Protects Translating Ribosomes from tmRNA-SmpB

    Article • January 2026, openRxiv

    Professor Ken Keiler

  4. Targeting Recoding by trans-Translation to Develop Antibiotics

    Article • Cold Spring Harbor Perspectives in Biology, September 2025, Cold Spring Harbor Laboratory Press

    Professor Ken Keiler

  5. A trans -translation inhibitor that targets ribosomal protein bL12 kills Mycobacterium tuberculosis

    Article • Journal of Bacteriology, September 2025, ASM Journals

    Professor Ken Keiler

  6. A trans -translation inhibitor kills Mycobacterium tuberculosis by targeting ribosomal protein bL12

    Article • June 2025, Cold Spring Harbor Laboratory Press

    Professor Ken Keiler

  7. Zinc Boosts New Drug to Kill Tuberculosis and Related Bacteria

    Article • ACS Infectious Diseases, April 2025, American Chemical Society (ACS)

    Professor Ken Keiler

  8. Trans -Translation inhibitors and copper synergize for enhanced antibiotic activity

    Article • November 2024, openRxiv

    Professor Ken Keiler

  9. Antibiotic that inhibits trans -translation blocks binding of EF-Tu to tmRNA but not to tRNA

    Article • mBio, October 2023, ASM Journals

    Professor Ken Keiler

  10. Physiology of trans‐translation deficiency in Bacillus subtilis – a comparative proteomics study

    Article • PROTEOMICS, July 2023, Wiley

    Professor Ken Keiler

  11. Antibiotic that inhibitstrans-translation blocks binding of EF-Tu to tmRNA but not to tRNA

    Article • June 2023, Cold Spring Harbor Laboratory Press

    Professor Ken Keiler

  12. Druggable differences: Targeting mechanistic differences between trans‐ translation and translation for selective antibiotic action

    Article • BioEssays, June 2022, Wiley

    Professor Ken Keiler

  13. Ribosome collisions: New ways to initiate ribosome rescue

    Article • Current Biology, May 2022, Elsevier

    Professor Ken Keiler

  14. Reproducible and accessible analysis of transposon insertion sequencing in Galaxy for qualitative essentiality analyses

    Article • BMC Microbiology, June 2021, Springer Science + Business Media

    Professor Ken Keiler

  15. trans-Translation inhibitors bind to a novel site on the ribosome and clear Neisseria gonorrhoeae in vivo

    Article • Nature Communications, March 2021, Springer Science + Business Media

    Professor Ken Keiler

  16. Pathogen-specific antimicrobials engineered de novo through membrane-protein biomimicry

    Article • Nature Biomedical Engineering, January 2021, Springer Science + Business Media

    Professor Ken Keiler

  17. Comparison of Proteomic Responses as Global Approach to Antibiotic Mechanism of Action Elucidation

    Article • Antimicrobial Agents and Chemotherapy, December 2020, ASM Journals

    Professor Ken Keiler

  18. Reproducible and accessible analysis of transposon insertion data at scale

    Article • May 2020, Cold Spring Harbor Laboratory Press

    Professor Ken Keiler

  19. A Small-Molecule Inhibitor of trans -Translation Synergistically Interacts with Cathelicidin Antimicrobial Peptides To Impair Survival of Staphylococcus aureus

    Article • Antimicrobial Agents and Chemotherapy, April 2019, ASM Journals

    Professor Ken Keiler

  20. Bioresponsive peptide-polysaccharide nanogels — A versatile delivery system to augment the utility of bioactive cargo

    Article • Nanomedicine Nanotechnology Biology and Medicine, April 2019, Elsevier

    Professor Ken Keiler

  21. A New Mechanism for Ribosome Rescue Can Recruit RF1 or RF2 to Nonstop Ribosomes

    Article • mBio, December 2018, ASM Journals

    Professor Ken Keiler

  22. A new mechanism for ribosome rescue can recruit RF1 or RF2 to non-stop ribosomes

    Article • November 2018, Cold Spring Harbor Laboratory Press

    Professor Ken Keiler

  23. Ribosome Rescue Inhibitors Kill Actively Growing and Nonreplicating Persister Mycobacterium tuberculosis Cells

    Article • ACS Infectious Diseases, August 2017, American Chemical Society (ACS)

    Professor Ken Keiler

  24. Tetrazole-Based trans-Translation Inhibitors Kill Bacillus anthracis Spores To Protect Host Cells

    Article • Antimicrobial Agents and Chemotherapy, July 2017, ASM Journals

    Professor Ken Keiler

  25. Anti-tubercular Activity of Pyrazinamide is Independent of trans-Translation and RpsA

    Article • Scientific Reports, July 2017, Springer Science + Business Media

    Professor Ken Keiler

  26. Teaching broader impacts of science with undergraduate research

    Article • PLoS Biology, March 2017, PLOS

    Professor Ken Keiler

  27. Human Cells Require Non-stop Ribosome Rescue Activity in Mitochondria

    Article • PLoS Genetics, March 2016, PLOS

    Professor Ken Keiler

  28. Inhibitors of Ribosome Rescue Arrest Growth of Francisella tularensis at All Stages of Intracellular Replication

    Article • Antimicrobial Agents and Chemotherapy, March 2016, ASM Journals

    Professor Ken Keiler

  29. Clicking on trans-translation drug targets

    Article • Frontiers in Microbiology, May 2015, Frontiers

    Professor Ken Keiler

  30. Mechanisms of ribosome rescue in bacteria

    Article • Nature Reviews Microbiology, April 2015, Springer Science + Business Media

    Professor Ken Keiler

  31. Release of Nonstop Ribosomes Is Essential

    Article • mBio, November 2014, ASM Journals

    Professor Ken Keiler

  32. Identification of Inhibitors of a Bacterial Sigma Factor Using a New High-Throughput Screening Assay

    Article • Antimicrobial Agents and Chemotherapy, October 2014, ASM Journals

    Dr Elena V Sineva, Professor Ken Keiler

  33. Cell-Based Assay To Identify Inhibitors of the Hfq-sRNA Regulatory Pathway

    Article • Antimicrobial Agents and Chemotherapy, July 2014, ASM Journals

    Professor Ken Keiler

  34. Resolving Nonstop Translation Complexes Is a Matter of Life or Death

    Article • Journal of Bacteriology, April 2014, ASM Journals

    Professor Ken Keiler

  35. The potential of trans-translation inhibitors as antibiotics

    Article • Future Microbiology, October 2013, Future Medicine

    Professor Ken Keiler

  36. Small molecule inhibitors of trans -translation have broad-spectrum antibiotic activity

    Article • Proceedings of the National Academy of Sciences, June 2013, Proceedings of the National Academy of Sciences

    Professor Ken Keiler

  37. tmRNA Is Essential in Shigella flexneri

    Article • PLOS One, February 2013, PLOS

    Professor Ken Keiler

  38. Tsp Protease

    Article • January 2013, Elsevier

    Professor Ken Keiler

  39. Pharmacological Inhibition of the ClpXP Protease Increases Bacterial Susceptibility to Host Cathelicidin Antimicrobial Peptides and Cell Envelope-Active Antibiotics

    Article • Antimicrobial Agents and Chemotherapy, January 2012, ASM Journals

    Professor Ken Keiler

  40. Bacterial Regulatory RNA

    Article • January 2012, Springer Science + Business Media

    Professor Ken Keiler

  41. RNA Visualization in Bacteria by Fluorescence In Situ Hybridization

    Article • January 2012, Springer Science + Business Media

    Professor Ken Keiler

  42. Bifunctional transfer-messenger RNA

    Article • Biochimie, November 2011, Elsevier

    Professor Ken Keiler

  43. Corrigendum to: “RNA localization in bacteria” [Curr. Opin. Microbiol. 14 (2011) 155–159]

    Article • Current Opinion in Microbiology, June 2011, Elsevier

    Professor Ken Keiler

  44. RNA localization in bacteria

    Article • Current Opinion in Microbiology, April 2011, Elsevier

    Professor Ken Keiler

  45. Localization of the Bacterial RNA Infrastructure

    Article • January 2011, Springer Science + Business Media

    Professor Ken Keiler

  46. Protein localization and dynamics within a bacterial organelle

    Article • Proceedings of the National Academy of Sciences, March 2010, Proceedings of the National Academy of Sciences

    Professor Ken Keiler

  47. Beyond ribosome rescue: tmRNA and co‐translational processes

    Article • FEBS Letters, November 2009, Wiley

    Professor Ken Keiler

  48. trans-Translation

    Article • October 2009, Springer Science + Business Media

    Professor Ken Keiler

  49. Subcellular localization of a bacterial regulatory RNA

    Article • Proceedings of the National Academy of Sciences, September 2009, Proceedings of the National Academy of Sciences

    Professor Ken Keiler

  50. Correct Timing of dnaA Transcription and Initiation of DNA Replication Requires trans Translation

    Article • Journal of Bacteriology, May 2009, ASM Journals

    Professor Ken Keiler

  51. Biology oftrans-Translation

    Article • Annual Review of Microbiology, October 2008, Annual Reviews

    Professor Ken Keiler

  52. Screen for Localized Proteins in Caulobacter crescentus

    Article • PLOS One, March 2008, PLOS

    Professor Ken Keiler

  53. Proteomic identification of tmRNA substrates

    Article • Proceedings of the National Academy of Sciences, October 2007, Proceedings of the National Academy of Sciences

    Professor Ken Keiler

  54. Peptide Signals Encode Protein Localization

    Article • Journal of Bacteriology, August 2007, ASM Journals

    Professor Ken Keiler

  55. Discovery of antibacterial cyclic peptides that inhibit the ClpXP protease

    Article • Protein Science, August 2007, Wiley

    Professor Ken Keiler

  56. Physiology of tmRNA: what gets tagged and why?

    Article • Current Opinion in Microbiology, April 2007, Elsevier

    Professor Ken Keiler

  57. Proteolytic Adaptor for Transfer-Messenger RNA-Tagged Proteins from α-Proteobacteria

    Article • Journal of Bacteriology, November 2006, ASM Journals

    Professor Ken Keiler

  58. Cell cycle‐regulated degradation of tmRNA is controlled by RNase R and SmpB

    Article • Molecular Microbiology, June 2005, Wiley

    Professor Ken Keiler

  59. tmRNA in Caulobacter crescentus Is Cell Cycle Regulated by Temporally Controlled Transcription and RNA Degradation

    Article • Journal of Bacteriology, March 2003, ASM Journals

    Professor Ken Keiler

  60. tmRNA Is Required for Correct Timing of DNA Replication in Caulobacter crescentus

    Article • Journal of Bacteriology, January 2003, ASM Journals

    Professor Ken Keiler

  61. Tsp and Related Tail-Specific Proteases

    Article • January 2002, Elsevier

    Professor Ken Keiler

  62. Conserved Promoter Motif Is Required for Cell Cycle Timing of dnaX Transcription inCaulobacter

    Article • Journal of Bacteriology, August 2001, ASM Journals

    Professor Ken Keiler

  63. tmRNAs that encode proteolysis-inducing tags are found in all known bacterial genomes: A two-piece tmRNA functions in Caulobacter

    Article • Proceedings of the National Academy of Sciences, July 2000, Proceedings of the National Academy of Sciences

    Professor Ken Keiler

  64. Role of a Peptide Tagging System in Degradation of Proteins Synthesized from Damaged Messenger RNA

    Article • Science, February 1996, American Association for the Advancement of Science

    Professor Ken Keiler

  65. Sequence Determinants of C-terminal Substrate Recognition by the Tsp Protease

    Article • Journal of Biological Chemistry, February 1996, Elsevier

    Professor Ken Keiler

  66. Identification of Active Site Residues of the Tsp Protease

    Article • Journal of Biological Chemistry, December 1995, Elsevier

    Professor Ken Keiler

  67. C‐terminal specific protein degradation: Activity and substrate specificity of the Tsp protease

    Article • Protein Science, August 1995, Wiley

    Professor Ken Keiler

  68. Tsp: a tail-specific protease that selectively degrades proteins with nonpolar C termini.

    Article • Proceedings of the National Academy of Sciences, January 1992, Proceedings of the National Academy of Sciences

    Professor Ken Keiler