All Stories

  1. Identification of Inhibitors of a Bacterial Sigma Factor Using a New High-Throughput Screening Assay

    Article • Antimicrobial Agents and Chemotherapy, October 2014, ASM Journals

    Dr Elena V Sineva, Professor Ken Keiler

  2. GE23077 binds to the RNA polymerase ‘i’ and ‘i+1’ sites and prevents the binding of initiating nucleotides

    Article • eLife, April 2014, eLife

    Richard Ebright, Dr Rolf Jansen, Dr Elena V Sineva

  3. A Large-Scale Allosteric Transition in Cytochrome P450 3A4 Revealed by Luminescence Resonance Energy Transfer (LRET)

    Article • PLoS ONE, December 2013, PLOS

    Dr Elena V Sineva

  4. Pivotal role of P450–P450 interactions in CYP3A4 allostery: the case of α-naphthoflavone

    Article • Biochemical Journal, July 2013, Portland Press Ltd.

    Dr Elena V Sineva

  5. CYP261 enzymes from deep sea bacteria: A clue to conformational heterogeneity in cytochromes P450

    Article • Biotechnology and Applied Biochemistry, January 2013, Wiley

    Dr Elena V Sineva

  6. Iron Regulates Expression of Bacillus cereus Hemolysin II via Global Regulator Fur

    Article • Journal of Bacteriology, April 2012, ASM Journals

    Dr Elena V Sineva

  7. Peripheral Ligand-binding Site in Cytochrome P450 3A4 Located with Fluorescence Resonance Energy Transfer (FRET)

    Article • Journal of Biological Chemistry, December 2011, American Society for Biochemistry & Molecular Biology (ASBMB)

    Dr Elena V Sineva

  8. New target for inhibition of bacterial RNA polymerase: ‘switch region’

    Article • Current Opinion in Microbiology, October 2011, Elsevier

    Richard Ebright, Dr Elena V Sineva

  9. Complex regulation of the global regulatory gene csrA: CsrA‐mediated translational repression, transcription from five promoters by Eσ70 and EσS, and indirect transcriptional activation by CsrA

    Article • Molecular Microbiology, June 2011, Wiley

    Dr Elena V Sineva

  10. Constrained water access to the active site of cytochrome P450 from the piezophilic bacteriumPhotobacterium profundum

    Article • High Pressure Research, December 2010, Taylor & Francis

    Dr Elena V Sineva

  11. Cytochrome P450 fromPhotobacterium profundumSS9, a Piezophilic Bacterium, Exhibits a Tightened Control of Water Access to the Active Site

    Article • Biochemistry, November 2010, American Chemical Society (ACS)

    Dr Elena V Sineva

  12. Quick assessment of cytotoxins effect on Daphnia magna using in vivo fluorescence microscopy

    Article • Environmental Toxicology and Chemistry, May 2010, Wiley

    Dr Elena V Sineva

  13. Electron transfer in the complex of membrane-bound human cytochrome P450 3A4 with the flavin domain of P450BM-3: The effect of oligomerization of the heme protein and intermittent modulation of the spin equilibrium

    Article • Biochimica et Biophysica Acta (BBA) - Bioenergetics, March 2010, Elsevier

    Dr Elena V Sineva

  14. Expression of Bacillus cereus hemolysin II in Bacillus subtilis renders the bacteria pathogenic for the crustacean Daphnia magna

    Article • FEMS Microbiology Letters, October 2009, Oxford University Press (OUP)

    Dr Elena V Sineva

  15. Pore-forming proteins and adaptation of living organisms to environmental conditions

    Article • Biochemistry (Moscow), December 2008, Pleiades Publishing Ltd

    Dr Elena V Sineva

  16. Systematic Structure-Activity Analysis of Microcin J25

    Article • Journal of Biological Chemistry, July 2008, American Society for Biochemistry & Molecular Biology (ASBMB)

    Richard Ebright, Dr Elena V Sineva

  17. Mechanism of hcnA mRNA recognition in the Gac/Rsm signal transduction pathway of Pseudomonas fluorescens

    Article • Molecular Microbiology, September 2007, Wiley

    Dr Elena V Sineva

  18. The properties of Bacillus cereus hemolysin II pores depend on environmental conditions

    Article • Biochimica et Biophysica Acta (BBA) - Biomembranes, February 2007, Elsevier

    Dr Elena V Sineva

  19. Purification and cytotoxic properties of Bacillus cereus hemolysin II

    Article • Protein Expression and Purification, May 2006, Elsevier

    Dr Elena V Sineva

  20. Inhibition of Bacterial RNA Polymerase by Streptolydigin: Stabilization of a Straight-Bridge-Helix Active-Center Conformation

    Article • Cell, August 2005, Elsevier

    Richard Ebright, Dr Elena V Sineva

  21. Purification and characterization of hepatitis C virus non-structural protein 5A expressed in Escherichia coli

    Article • Protein Expression and Purification, September 2004, Elsevier

    Dr Elena V Sineva

  22. Antibacterial Peptide Microcin J25 Inhibits Transcription by Binding within and Obstructing the RNA Polymerase Secondary Channel

    Article • Molecular Cell, June 2004, Elsevier

    Richard Ebright, Dr Elena V Sineva

  23. Structure of Antibacterial Peptide Microcin J25:  A 21-Residue Lariat Protoknot

    Article • Journal of the American Chemical Society, September 2003, American Chemical Society (ACS)

    Richard Ebright, Dr Elena V Sineva

  24. Backbone Dynamics of Escherichia coli Adenylate Kinase at the Extreme Stages of the Catalytic Cycle Studied by 15N NMR Relaxation

    Article • Biochemistry, May 2000, American Chemical Society (ACS)

    Dr Elena V Sineva

  25. Design Consideration and Probes for Fluorescence Resonance Energy Transfer Studies

    Article • Bioconjugate Chemistry, April 2000, American Chemical Society (ACS)

    Dr Elena V Sineva

  26. Towards a mechanism of AMP‐substrate inhibition in adenylate kinase from Escherichia coli

    Article • FEBS Letters, November 1996, Wiley

    Dr Elena V Sineva

  27. Domain Closure in Adenylate Kinase

    Article • Biochemistry, January 1996, American Chemical Society (ACS)

    Dr Elena V Sineva

  28. The cleavage sites and localization of genes encoding the restriction endonucleases Eco1831I and Ecohi

    Article • Gene, July 1993, Elsevier

    Dr Elena V Sineva