All Stories

  1. Mechanisms of Atrial Fibrillation in Obstructive Sleep Apnoea

    Article • Cells, June 2023, MDPI AG

    Dr Keith L. Brain

  2. Effect of Variations in Gap Junctional Coupling on the Frequency of Oscillatory Action Potentials in a Smooth Muscle Syncytium

    Article • Frontiers in Physiology, October 2021, Frontiers

    Dr Keith L. Brain

  3. Resting cardiac sympathetic firing frequencies suppress terminal norepinephrine transporter uptake

    Article • Autonomic Neuroscience, May 2021, Elsevier

    Dr Keith L. Brain

  4. Selected Abstracts From Pharmacology 2020

    Article • British Journal of Pharmacology, December 2020, Wiley

    Dr Keith L. Brain

  5. β-Adrenoceptor blockade prevents carotid body hyperactivity and elevated vascular sympathetic nerve density induced by chronic intermittent hypoxia

    Article • Pflügers Archiv - European Journal of Physiology, November 2020, Springer Science + Business Media

    Dr Keith L. Brain

  6. Program and Abstracts of the 31st International Symposium on the Autonomic Nervous System

    Article • Clinical Autonomic Research, September 2020, Springer Science + Business Media

    Dr Keith L. Brain

  7. Dynamic monitoring of single-terminal norepinephrine transporter rate in the rodent cardiovascular system: A novel fluorescence imaging method

    Article • Autonomic Neuroscience, January 2020, Elsevier

    Dr Keith L. Brain

  8. [Ca 2+ ] changes in sympathetic varicosities and Schwann cells in rat mesenteric arteries – relation to noradrenaline release and contraction

    Article • Acta Physiologica, April 2019, Wiley

    Dr Keith L. Brain

  9. Simulating Normal and Arrhythmic Dynamics: From Sub-Cellular to Tissue and Organ Level

    Article • January 2019, Frontiers

    Dr Keith L. Brain

  10. Analysis of spontaneous depolarization-linked hyperpolarizations in mouse detrusor smooth muscle cells

    Article • Biomedical Research Journal, January 2019, Medknow

    Dr Keith L. Brain

  11. Investigation of the Syncytial Nature of Detrusor Smooth Muscle as a Determinant of Action Potential Shape

    Article • Frontiers in Physiology, September 2018, Frontiers

    Dr Keith L. Brain

  12. A biophysically constrained computational model of the action potential of mouse urinary bladder smooth muscle

    Article • PLoS ONE, July 2018, PLOS

    Dr Keith L. Brain, Chitaranjan Mahapatra

  13. A four-component model of the action potential in mouse detrusor smooth muscle cell

    Article • PLoS ONE, January 2018, PLOS

    Dr Keith L. Brain

  14. A Method for the Analysis of AP Foot Convexity: Insights into Smooth Muscle Biophysics

    Article • Frontiers in Bioengineering and Biotechnology, October 2017, Frontiers

    Dr Keith L. Brain

  15. Modeling extracellular fields for a three-dimensional network of cells using NEURON

    Article • Journal of Neuroscience Methods, October 2017, Elsevier

    Dr Keith L. Brain

  16. High-Probability Neurotransmitter Release Sites Represent an Energy-Efficient Design

    Article • Current Biology, October 2016, Elsevier

    Dr Keith L. Brain

  17. Computational study of ATP gated Potassium ion channel in urinary bladder over activity

    Article • August 2016, Institute of Electrical & Electronics Engineers (IEEE)

    Dr Keith L. Brain

  18. A Regional Reduction in Ito and IKACh in the Murine Posterior Left Atrial Myocardium Is Associated with Action Potential Prolongation and Increased Ectopic Activity

    Article • PLoS ONE, May 2016, PLOS

    Dr Keith L. Brain

  19. Optical mapping design for murine atrial electrophysiology

    Article • Computer Methods in Biomechanics and Biomedical Engineering Imaging & Visualization, November 2015, Taylor & Francis

    Dr Keith L. Brain

  20. Spatiotemporal dynamics of synaptic drive in urinary bladder syncytium: A computational investigation

    Article • August 2015, Institute of Electrical & Electronics Engineers (IEEE)

    Dr Keith L. Brain

  21. Syncytial Basis for Diversity in Spike Shapes and their Propagation in Detrusor Smooth Muscle

    Article • Procedia Computer Science, January 2015, Elsevier

    Dr Keith L. Brain

  22. A computational model of urinary bladder smooth muscle syncytium

    Article • Journal of Computational Neuroscience, October 2014, Springer Science + Business Media

    Dr Keith L. Brain

  23. An automated system using spatial oversampling for optical mapping in murine atria. Development and validation with monophasic and transmembrane action potentials

    Article • Progress in Biophysics and Molecular Biology, August 2014, Elsevier

    Dr Keith L. Brain

  24. 191 Advancement of Optical Mapping through Automated Algorithms and Second Generation CMOS Detectors to Reveal Murine Atrial Activation Patterns and Regional Variation of Action Potential Duration

    Article • Heart, May 2014, BMJ

    Dr Keith L. Brain

  25. 5‐Chloroindole: a potent allosteric modulator of the 5‐HT3 receptor

    Article • British Journal of Pharmacology, June 2013, Wiley

    Dr Keith L. Brain

  26. Real-Time Stochastic Detection of Multiple Neurotransmitters with a Protein Nanopore

    Article • ACS Nano, June 2012, American Chemical Society (ACS)

    Dr Keith L. Brain

  27. Mechanisms Involved in Nicotinic Acetylcholine Receptor-Induced Neurotransmitter Release from Sympathetic Nerve Terminals in the Mouse Vas Deferens

    Article • PLoS ONE, December 2011, PLOS

    Dr Keith L. Brain

  28. Prostaglandin E2 induces spontaneous rhythmic activity in mouse urinary bladder independently of efferent nerves

    Article • British Journal of Pharmacology, December 2011, Wiley

    Dr Keith L. Brain

  29. Obituary: Professor Alison Brading, PhD

    Article • Neurourology and Urodynamics, March 2011, Wiley

    Dr Keith L. Brain

  30. Ion Channel Modulators and Urinary Tract Function

    Article • January 2011, Springer Science + Business Media

    Dr Keith L. Brain

  31. Dynamic monitoring of NET activity in mature murine sympathetic terminals using a fluorescent substrate

    Article • British Journal of Pharmacology, February 2010, Wiley

    Dr Keith L. Brain

  32. Parasympathetic cholinergic transmission, minus the vesicles

    Article • Experimental Physiology, January 2010, Wiley

    Dr Keith L. Brain

  33. P3.7 Cellular mechanism of action of Prostaglandin E2 on mouse urinary bladder

    Article • Autonomic Neuroscience, August 2009, Elsevier

    Dr Keith L. Brain

  34. S14.5 The effects of Δ9-tetrahydrocannabinol on sympathetic cotransmission in the mouse vas deferens

    Article • Autonomic Neuroscience, August 2009, Elsevier

    Dr Keith L. Brain

  35. Focal Ca2+ Transient Detection in Smooth Muscle

    Article • Journal of Visualized Experiments, June 2009, MyJove Corporation

    Dr Keith L. Brain

  36. Effects of 17β-oestradiol on rat detrusor smooth muscle contractility

    Article • Experimental Physiology, June 2009, Wiley

    Dr Keith L. Brain

  37. Prejunctional and postjunctional actions of heptanol and 18β-glycyrretinic acid in the rodent vas deferens

    Article • Autonomic Neuroscience, June 2009, Elsevier

    Dr Keith L. Brain

  38. Neuroeffector Ca2+transients for the direct measurement of purine release and indirect measurement of cotransmitters in rodents

    Article • Experimental Physiology, December 2008, Wiley

    Dr Keith L. Brain

  39. Spontaneous purinergic neurotransmission in the mouse urinary bladder

    Article • The Journal of Physiology, December 2008, Wiley

    Dr Keith L. Brain

  40. Bretylium abolishes neurotransmitter release without necessarily abolishing the nerve terminal action potential in sympathetic terminals

    Article • British Journal of Pharmacology, February 2008, Wiley

    Dr Keith L. Brain

  41. Actions of Two Main Metabolites of Propiverine (M-1 and M-2) on Voltage-Dependent L-Type Ca2+ Currents and Ca2+ Transients in Murine Urinary Bladder Myocytes

    Article • Journal of Pharmacology and Experimental Therapeutics, October 2007, American Society for Pharmacology & Experimental Therapeutics (ASPET)

    Dr Keith L. Brain

  42. Electrical and optical study of nerve impulse-evoked ATP-induced, P2X-receptor-mediated sympathetic neurotransmission at single smooth muscle cells in mouse isolated vas deferens

    Article • Neuroscience, August 2007, Elsevier

    Dr Keith L. Brain

  43. The effect of epibatidine on spontaneous and evoked neurotransmitter release in the mouse and guinea pig isolated vas deferens

    Article • British Journal of Pharmacology, April 2007, Wiley

    Dr Keith L. Brain

  44. The origin of the skewed amplitude distribution of spontaneous excitatory junction potentials in poorly coupled smooth muscle cells

    Article • Neuroscience, March 2007, Elsevier

    Dr Keith L. Brain

  45. Measurement of Urinary Metanephrines to Screen for Pheochromocytoma in an Unselected Hospital Referral Population

    Article • Clinical Chemistry, September 2006, AACC

    Dr Keith L. Brain

  46. Oxaliplatin induces hyperexcitability at motor and autonomic neuromuscular junctions through effects on voltage-gated sodium channels

    Article • British Journal of Pharmacology, December 2005, Wiley

    Dr Keith L. Brain

  47. The sources and sequestration of Ca2+contributing to neuroeffector Ca2+transients in the mouse vas deferens

    Article • The Journal of Physiology, December 2003, Wiley

    Dr Keith L. Brain

  48. Intermittent ATP release from nerve terminals elicits focal smooth muscle Ca2+transients in mouse vas deferens

    Article • The Journal of Physiology, June 2002, Wiley

    Dr Keith L. Brain

  49. Characterization of action potential-evoked calcium transients in mouse postganglionic sympathetic axon bundles

    Article • The Journal of Physiology, November 2001, Wiley

    Dr Keith L. Brain

  50. Nicotine induces calcium spikes in single nerve terminal varicosities: a role for intracellular calcium stores

    Article • Neuroscience, September 2001, Elsevier

    Dr Keith L. Brain

  51. Individual sympathetic varicosities possess different sensitivities to alpha 2 and P2 receptor agonists and antagonists in mouse vas deferens

    Article • British Journal of Pharmacology, December 1999, Wiley

    Dr Keith L. Brain

  52. Phosphorylation of proteins in chick ciliary ganglion under conditions that induce long-lasting changes in synaptic transmission: phosphoprotein targets for nitric oxide action

    Article • Neuroscience, February 1999, Elsevier

    Dr Keith L. Brain

  53. Sympathetic neuromuscular transmission at a varicosity in a syncytium

    Article • Microscopy Research and Technique, September 1998, Wiley

    Dr Keith L. Brain

  54. Calcium in sympathetic boutons of rat superior cervical ganglion during facilitation, augmentation and potentiation

    Article • Journal of the Autonomic Nervous System, August 1998, Elsevier

    Dr Keith L. Brain

  55. Calcium transients evoked by action potentials in the somata of chick ciliary neurons

    Article • Journal of the Autonomic Nervous System, July 1998, Elsevier

    Dr Keith L. Brain

  56. Calcium in sympathetic varicosities of mouse vas deferens during facilitation, augmentation and autoinhibition

    Article • The Journal of Physiology, August 1997, Wiley

    Dr Keith L. Brain

  57. Article • Journal of Neurocytology, January 1997, Springer Science + Business Media

    Dr Keith L. Brain

  58. Article • Journal of Neurocytology, January 1997, Springer Science + Business Media

    Dr Keith L. Brain

  59. Influence of spherical aberration on axial imaging of confocal reflection microscopy

    Article • Applied Optics, February 1994, Optical Society of America (OSA)

    Dr Keith L. Brain