Keisuke Horiuchi

    My co-authors include

    Shintaro Inoue
    George Kalliolias

    My Publications

    ADAM17 protects against elastase-induced emphysema by suppressing CD62L+ leukocyte infi...

    • AJP Lung Cellular and Molecular Physiology
    • June 2020

    ADAM10 is indispensable for longitudinal bone growth in mice

    • Bone
    • February 2020

    Characteristic cerebral structural changes identified using voxel-based morphometry in ...

    • Spinal Cord
    • December 2019

    Expansile calcific myonecrosis arising in the lower leg: A case report and recommendati...

    • Journal of Orthopaedic Science
    • December 2019

    Rice Bodies in a Patient with Oligoarticular Juvenile Idiopathic Arthritis

    • The Journal of Rheumatology
    • September 2019

    Cell-autonomous FLT3L shedding via ADAM10 mediates conventional dendritic cell developm...

    • Proceedings of the National Academy of Sciences
    • July 2019

    Spontaneous Regression of Myxofibrosarcoma of the Thigh after Open Biopsy

    • Case Reports in Oncology
    • May 2019

    Homeostatic Control of Sebaceous Glands by Innate Lymphoid Cells Regulates Commensal Ba...

    • Cell
    • February 2019

    Granulocyte-colony stimulating factor enhances load-induced muscle hypertrophy in mice

    • Biochemical and Biophysical Research Communications
    • November 2018

    Desmoplastic fibroma of bone arising in the cortex of the proximal femur

    • Journal of Orthopaedic Science
    • August 2018

    Targeted ablation of p38α MAPK suppresses denervation-induced muscle atrophy

    • Scientific Reports
    • June 2018

    Malignant Transformation of Nodular Hidradenoma in the Lower Leg

    • Case Reports in Oncology
    • May 2018

    Idiopathic Spinal Epidural Fat Accumulation Is Associated With Hyperlipidemia

    • Spine
    • April 2018

    Inhibition of ADAM10 in satellite cells accelerates muscle regeneration following muscl...

    • March 2018

    Semiquantitative Evaluation of Muscle Repair by Diffusion Tensor Imaging in Mice

    • JBMR Plus
    • March 2018

    Wide-spread ignorance on the treatment of subcutaneous malignant tumors; a questionnair...

    • Japanese Journal of Clinical Oncology
    • December 2017

    The unfolded protein response mediated by PERK is casually related to the pathogenesis ...

    • Journal of Orthopaedic Research®
    • November 2017

    Potential Involvement of the IL-6/JAK/STAT3 Pathway in the Pathogenesis of Intervertebr...

    • Spine
    • July 2017

    Metastasis of Renal Cell Carcinoma to the Trapezium

    • The Journal of Hand Surgery (Asian-Pacific Volume)
    • May 2017

    Hyaluronan-Binding Protein Involved in Hyaluronan Depolymerization Controls Endochondra...

    • American Journal Of Pathology
    • May 2017

    Enhanced Functional Recovery from Spinal Cord Injury in Aged Mice after Stem Cell Trans...

    • Stem Cell Reports
    • March 2017

    Inhibition of PDGFR signaling prevents muscular fatty infiltration after rotator cuff t...

    • Scientific Reports
    • January 2017

    Histomorphometric analysis of minimodeling in the vertebrae in postmenopausal patients ...

    • Bone Reports
    • December 2016

    Potential Involvement of Obesity-Associated Chronic Inflammation in the Pathogenesis of...

    • Spine
    • December 2016

    CT guided cryoablation for locally recurrent or metastatic bone and soft tissue tumor: ...

    • BMC Cancer
    • October 2016

    Conditional abrogation of Atm in osteoclasts extends osteoclast lifespan and results in...

    • Scientific Reports
    • September 2016

    Chordoma-derived cell line U-CH1-N recapitulates the biological properties of notochord...

    • Journal of Orthopaedic Research®
    • August 2016

    Results of sub-analysis of a phase 2 study on trabectedin treatment for extraskeletal m...

    • BMC Cancer
    • July 2016

    Adamantinoma of the distal femur diagnosed 5 years after initial surgery: a case report

    • Journal of Medical Case Reports
    • June 2016

    Generation of heterozygous fibrillin-1 mutant cloned pigs from genome-edited foetal fib...

    • Scientific Reports
    • April 2016

    The unfolded protein response in skeletal development and homeostasis

    • Cellular and Molecular Life Sciences
    • March 2016

    Epithelial Cell-Derived a Disintegrin and Metalloproteinase-17 Confers Resistance to Co...

    • EBioMedicine
    • March 2016

    Fibrous Dysplasia with Massive Cartilaginous Differentiation (Fibrocartilaginous Dyspla...

    • Case Reports in Oncology
    • February 2016

    Novel MR imaging method – MAVRIC – for metal artifact suppression after joint replaceme...

    • BMC Musculoskeletal Disorders
    • December 2015

    Excessive reactive oxygen species are therapeutic targets for intervertebral disc degen...

    • Arthritis Research & Therapy
    • November 2015

    Langerhans Cell Histiocytosis of the Clavicle in an Adult: A Case Report and Review of ...

    • Case Reports in Oncology
    • October 2015

    A Disintegrin and Metalloprotease 10 (ADAM10) Is Indispensable for Maintenance of the M...

    • Journal of Biological Chemistry
    • October 2015

    Successful Treatment with Pazopanib for Multiple Lung Metastases of Inguinal Epithelioi...

    • Case Reports in Oncology
    • September 2015

    ADAM12 and ADAM17 are essential molecules for hypoxia-induced impairment of neural vasc...

    • Scientific Reports
    • August 2015

    IRE1α/XBP1-mediated branch of the unfolded protein response regulates osteoclastogenesis

    • Journal of Clinical Investigation
    • July 2015

    Severe hypercalcemia following denosumab treatment in a juvenile patient

    • Journal of Bone and Mineral Metabolism
    • June 2015

    Generation and characterization of a novel shoulder contracture mouse model

    • Journal of Orthopaedic Research®
    • May 2015

    Synergistic antiproliferative effect of imatinib and adriamycin in platelet‐derived gro...

    • Cancer Science
    • May 2015

    Dysbiosis and Staphylococcus aureus Colonization Drives Inflammation in Atopic Dermatitis

    • Immunity
    • April 2015

    ADAM17 regulates IL-1 signaling by selectively releasing IL-1 receptor type 2 from the ...

    • Cytokine
    • February 2015

    Global gene expression analysis following spinal cord injury in non-human primates

    • Experimental Neurology
    • November 2014

    Clinical Outcome after Bone Metastasis (BM) Surgery in Patients with Differentiated Thy...

    • Japanese Journal of Clinical Oncology
    • August 2014

    Computed tomography-guided resection of osteoid osteoma of the sacrum: a case report

    • Journal of Medical Case Reports
    • June 2014

    Desmoplastic Fibroma Arising in the Distal Phalanx of the Great Toe: A Case Report

    • The Journal of Foot & Ankle Surgery
    • January 2014

    Secondary Aneurysmal Bone Cyst following Chondroblastoma of the Patella

    • Rare Tumors
    • July 2013

    iRHOM2 is a critical pathogenic mediator of inflammatory arthritis

    • Journal of Clinical Investigation
    • January 2013

    Conditional Inactivation of TNFα-Converting Enzyme in Chondrocytes Results in an Elonga...

    • PLoS ONE
    • January 2013

    Systemic Overexpression of TNFα-converting Enzyme Does Not Lead to Enhanced Shedding Ac...

    • PLoS ONE
    • January 2013

    A Brief History of Tumor Necrosis Factor α – converting Enzyme: An Overview of Ectodoma...

    • The Keio Journal of Medicine
    • January 2013

    Histochemical aspects of the vascular invasion at the erosion zone of the epiphyseal ca...

    • Biomedical Research
    • January 2013

    Crowe type IV dislocated hip treated by total hip arthroplasty with subtrochanteric ste...

    • Current Orthopaedic Practice
    • January 2013

    The IRE1α-XBP1 Pathway Positively Regulates Parathyroid Hormone (PTH)/PTH-related Pepti...

    • Journal of Biological Chemistry
    • December 2012

    Detection ofHEY1-NCOA2fusion by fluorescence in-situ hybridization in formalin-fixed pa...

    • Pathology International
    • December 2012

    Epidermal ADAM17 maintains the skin barrier by regulating EGFR ligand-dependent termina...

    • The Journal of Experimental Medicine
    • November 2012

    Activity-Dependent Proteolytic Cleavage of Neuroligin-1

    • Neuron
    • October 2012

    Brief Report: Requirement of TACE/ADAM17 for Hair Follicle Bulge Niche Establishment

    • The International Journal Of Cell Cloning
    • July 2012

    Stress-induced production of chemokines by hair follicles regulates the trafficking of ...

    • Nature Immunology
    • June 2012

    Epidermal ADAM17 maintains the skin barrier by regulating EGFR ligand–dependent termina...

    • The Journal of Experimental Medicine
    • May 2012

    Lung endothelial ADAM17 regulates the acute inflammatory response to lipopolysaccharide

    • EMBO Molecular Medicine
    • February 2012

    A novel multi-kinase inhibitor pazopanib suppresses growth of synovial sarcoma cells th...

    • Journal of Orthopaedic Research®
    • February 2012

    Anaplastic Transformation of Follicular Thyroid Carcinoma in a Metastatic Skeletal Lesi...

    • Thyroid
    • February 2012

    The transient appearance of zipper-like actin superstructures during the fusion of oste...

    • Journal of Cell Science
    • February 2012

    Enhanced susceptibility to lipopolysaccharide-induced arthritis and endotoxin shock in ...

    • Arthritis Research & Therapy
    • January 2012

    Metastatic Patterns of Myxoid/Round Cell Liposarcoma: A Review of a 25-Year Experience

    • Sarcoma
    • January 2012

    Dual functions of cell-autonomous and non-cell-autonomous ADAM10 activity in granulopoi...

    • Blood
    • October 2011

    Tumor necrosis factor-α converting enzyme is a key mediator of abdominal aortic aneurys...

    • Atherosclerosis
    • October 2011

    Gene expression profiling of mouse growth plate cartilage by laser microdissection and ...

    • Journal of Orthopaedic Science
    • September 2011

    TNF-α–Converting Enzyme/A Disintegrin and Metalloprotease−17 Mediates Mechanotransducti...

    • American Journal of Respiratory Cell and Molecular Biology
    • August 2011

    Treatment of collagen-induced arthritis with recombinant plasminogen-related protein B:...

    • Journal of Orthopaedic Science
    • July 2011

    Erratum to: Arthroscopic removal of intra-articular osteoid osteoma in the knee: case r...

    • Journal of Orthopaedic Science
    • July 2011

    TACE (ADAM17) inhibits Schwann cell myelination

    • Nature Neuroscience
    • June 2011

    Leukocyte ADAM17 Regulates Acute Pulmonary Inflammation

    • PLoS ONE
    • May 2011

    Activation of TNFR1 ectodomain shedding by mitochondrial Ca2+ determines the severity o...

    • Journal of Clinical Investigation
    • May 2011

    Arthroscopic removal of intra-articular osteoid osteoma in the knee: case report and re...

    • Journal of Orthopaedic Science
    • May 2011

    The IRE1α–XBP1 pathway is essential for osteoblast differentiation through promoting tr...

    • EMBO Reports
    • March 2011

    Tumor Necrosis Factor-α Converting Enzyme Inactivation Ameliorates High-Fat Diet-Induce...

    • Circulation Journal
    • January 2011

    Identification and analysis of function of a novel splicing variant of mouse receptor a...

    • Molecular and Cellular Biochemistry
    • December 2010

    ADAM17 Deletion in Thymic Epithelial Cells Alters Aire Expression without Affecting T C...

    • PLoS ONE
    • October 2010

    Ectodomain shedding of EGFR ligands and TNFR1 dictates hepatocyte apoptosis during fulm...

    • Journal of Clinical Investigation
    • August 2010

    GRIP1 enhances estrogen receptor α-dependent extracellular matrix gene expression in ch...

    • Osteoarthritis and Cartilage
    • July 2010

    Osteosarcoma with metastasis to the stomach

    • Journal of Orthopaedic Science
    • March 2010

    The waved with open eyelids (woe) Locus Is a Hypomorphic Mouse Mutation in Adam17

    • Genetics
    • March 2010

    In vivo role of leukocyte ADAM17 in the inflammatory and host responses during E. coli ...

    • Journal of Leukocyte Biology
    • February 2010

    The effect of timing in the administration of hepatocyte growth factor to modulate BMP-...

    • Biomaterials
    • February 2010

    Receptor Activator of NF-κB (RANK) Ligand Induces Ectodomain Shedding of RANK in Murine...

    • The Journal of Immunology
    • January 2010

    Pathological Neovascularization Is Reduced by Inactivation of ADAM17 in Endothelial Cel...

    • Circulation Research
    • January 2010

    Inhibition of STAT1 accelerates bone fracture healing

    • Journal of Orthopaedic Research®
    • January 2010

    Ectodomain Shedding of FLT3 Ligand Is Mediated by TNF-  Converting Enzyme

    • The Journal of Immunology
    • June 2009

    Nbl1p: A Borealin/Dasra/CSC-1-like Protein Essential for Aurora/Ipl1 Complex Function a...

    • Molecular Biology of the Cell
    • March 2009

    Conditional Inactivation of TACE by a Sox9 Promoter Leads to Osteoporosis and Increased...

    • The Journal of Immunology
    • February 2009

    Growth suppression and apoptosis induction in synovial sarcoma cell lines by a novel NF...

    • Cancer Letters
    • December 2008

    VEGF-A Stimulates ADAM17-Dependent Shedding of VEGFR2 and Crosstalk Between VEGFR2 and ...

    • Circulation Research
    • July 2008

    Different ADAMs have distinct influences on Kit ligand processing: phorbol-ester-stimul...

    • Journal of Cell Science
    • February 2007

    Substrate Selectivity of Epidermal Growth Factor-Receptor Ligand Sheddases and their Re...

    • Molecular Biology of the Cell
    • October 2006

    Evaluation of the contributions of ADAMs 9, 12, 15, 17, and 19 to heart development and...

    • Developmental Biology
    • July 2005

    Regional migratory osteoporosis: a case report

    • Journal of Orthopaedic Science
    • March 2004

    Essential Role for ADAM19 in Cardiovascular Morphogenesis

    • Molecular and Cellular Biology
    • January 2004

    Metalloprotease-disintegrin ADAM8: Expression analysis and targeted deletion in mice

    • Developmental Dynamics
    • January 2004

    Potential Role for ADAM15 in Pathological Neovascularization in Mice

    • Molecular and Cellular Biology
    • August 2003

    Intramuscular spindle cell lipoma: Case report and review of the literature

    • Pathology International
    • April 2001

    Identification and Characterization of a Novel Protein, Periostin, with Restricted Expr...

    • Journal of Bone and Mineral Research
    • July 1999

    Multiple Smooth Muscle Tumors Arising in Deep Soft Tissue of Lower Limbs With Uterine L...

    • The American Journal of Surgical Pathology
    • July 1998