All Stories

  1. Fluoro HIP, a new software for intraoperative evaluation of the cup angles based on fluoroscopic images

    Article • Journal of Joint Surgery and Research, June 2024, Elsevier

    Keisuke Horiuchi

  2. Bone Health in Osteosarcoma and Ewing's Sarcoma Survivors: A Scoping Review

    Article • Journal of Bone Oncology, December 2022, Elsevier

    Keisuke Horiuchi

  3. Abrogation of LBX1 in skeletal muscle results in hypoplastic limbs and progressive kyphosis in mice

    Article • Journal of Orthopaedic Research®, July 2022, Wiley

    Keisuke Horiuchi

  4. Risk assessment of femoral pathological fracture in prostate cancer patients by computed tomography analysis

    Article • Journal of Bone and Mineral Metabolism, May 2022, Springer Science + Business Media

    Keisuke Horiuchi

  5. Aging Aggravates the Progression of Muscle Degeneration After Rotator Cuff Tears in Mice

    Article • Arthroscopy The Journal of Arthroscopic and Related Surgery, September 2021, Elsevier

    Keisuke Horiuchi

  6. Eribulin induces tumor vascular remodeling through intussusceptive angiogenesis in a sarcoma xenograft model

    Article • Biochemical and Biophysical Research Communications, September 2021, Elsevier

    Keisuke Horiuchi

  7. Trabectedin suppresses osteosarcoma pulmonary metastasis in a mouse tumor xenograft model

    Article • Journal of Orthopaedic Research®, June 2021, Wiley

    Keisuke Horiuchi

  8. ADAM17 protects against elastase-induced emphysema by suppressing CD62L+ leukocyte infiltration in mice

    Article • AJP Lung Cellular and Molecular Physiology, June 2020, American Physiological Society

    Keisuke Horiuchi

  9. ADAM10 is indispensable for longitudinal bone growth in mice

    Article • Bone, February 2020, Elsevier

    Keisuke Horiuchi

  10. Characteristic cerebral structural changes identified using voxel-based morphometry in patients with post-surgical chronic myelopathic pain

    Article • Spinal Cord, December 2019, Springer Science + Business Media

    Keisuke Horiuchi

  11. Expansile calcific myonecrosis arising in the lower leg: A case report and recommendation for treatment

    Article • Journal of Orthopaedic Science, December 2019, Elsevier

    Keisuke Horiuchi

  12. Rice Bodies in a Patient with Oligoarticular Juvenile Idiopathic Arthritis

    Article • The Journal of Rheumatology, September 2019, The Journal of Rheumatology

    Keisuke Horiuchi

  13. Cell-autonomous FLT3L shedding via ADAM10 mediates conventional dendritic cell development in mouse spleen

    Article • Proceedings of the National Academy of Sciences, July 2019, Proceedings of the National Academy of Sciences

    Keisuke Horiuchi

  14. Spontaneous Regression of Myxofibrosarcoma of the Thigh after Open Biopsy

    Article • Case Reports in Oncology, May 2019, Karger Publishers

    Keisuke Horiuchi

  15. Homeostatic Control of Sebaceous Glands by Innate Lymphoid Cells Regulates Commensal Bacteria Equilibrium

    Article • Cell, February 2019, Elsevier

    Keisuke Horiuchi

  16. Granulocyte-colony stimulating factor enhances load-induced muscle hypertrophy in mice

    Article • Biochemical and Biophysical Research Communications, November 2018, Elsevier

    Keisuke Horiuchi

  17. Desmoplastic fibroma of bone arising in the cortex of the proximal femur

    Article • Journal of Orthopaedic Science, August 2018, Elsevier

    Keisuke Horiuchi

  18. Targeted ablation of p38α MAPK suppresses denervation-induced muscle atrophy

    Article • Scientific Reports, June 2018, Springer Science + Business Media

    Keisuke Horiuchi

  19. Malignant Transformation of Nodular Hidradenoma in the Lower Leg

    Article • Case Reports in Oncology, May 2018, Karger Publishers

    Keisuke Horiuchi

  20. Idiopathic Spinal Epidural Fat Accumulation Is Associated With Hyperlipidemia

    Article • Spine, April 2018, Wolters Kluwer Health

    Keisuke Horiuchi

  21. Inhibition of ADAM10 in satellite cells accelerates muscle regeneration following muscle injury

    Article • March 2018, Wiley

    Keisuke Horiuchi

  22. Semiquantitative Evaluation of Muscle Repair by Diffusion Tensor Imaging in Mice

    Article • JBMR Plus, March 2018, Wiley

    Keisuke Horiuchi

  23. Wide-spread ignorance on the treatment of subcutaneous malignant tumors; a questionnaire-based study

    Article • Japanese Journal of Clinical Oncology, December 2017, Oxford University Press (OUP)

    Keisuke Horiuchi

  24. The unfolded protein response mediated by PERK is casually related to the pathogenesis of intervertebral disc degeneration

    Article • Journal of Orthopaedic Research®, November 2017, Wiley

    Keisuke Horiuchi

  25. Potential Involvement of the IL-6/JAK/STAT3 Pathway in the Pathogenesis of Intervertebral Disc Degeneration

    Article • Spine, July 2017, Wolters Kluwer Health

    Keisuke Horiuchi

  26. Metastasis of Renal Cell Carcinoma to the Trapezium

    Article • The Journal of Hand Surgery (Asian-Pacific Volume), May 2017, World Scientific Pub Co Pte Lt

    Keisuke Horiuchi

  27. Hyaluronan-Binding Protein Involved in Hyaluronan Depolymerization Controls Endochondral Ossification through Hyaluronan Metabolism

    Article • American Journal Of Pathology, May 2017, Elsevier

    Shintaro Inoue, Keisuke Horiuchi

  28. Enhanced Functional Recovery from Spinal Cord Injury in Aged Mice after Stem Cell Transplantation through HGF Induction

    Article • Stem Cell Reports, March 2017, Elsevier

    Keisuke Horiuchi

  29. Inhibition of PDGFR signaling prevents muscular fatty infiltration after rotator cuff tear in mice

    Article • Scientific Reports, January 2017, Springer Science + Business Media

    Keisuke Horiuchi

  30. Histomorphometric analysis of minimodeling in the vertebrae in postmenopausal patients treated with anti-osteoporotic agents

    Article • Bone Reports, December 2016, Elsevier

    Keisuke Horiuchi

  31. Potential Involvement of Obesity-Associated Chronic Inflammation in the Pathogenesis of Idiopathic Spinal Epidural Lipomatosis

    Article • Spine, December 2016, Wolters Kluwer Health

    Keisuke Horiuchi

  32. CT guided cryoablation for locally recurrent or metastatic bone and soft tissue tumor: initial experience

    Article • BMC Cancer, October 2016, Springer Science + Business Media

    Keisuke Horiuchi

  33. Conditional abrogation of Atm in osteoclasts extends osteoclast lifespan and results in reduced bone mass

    Article • Scientific Reports, September 2016, Springer Science + Business Media

    Keisuke Horiuchi

  34. Chordoma-derived cell line U-CH1-N recapitulates the biological properties of notochordal nucleus pulposus cells

    Article • Journal of Orthopaedic Research®, August 2016, Wiley

    Keisuke Horiuchi

  35. Results of sub-analysis of a phase 2 study on trabectedin treatment for extraskeletal myxoid chondrosarcoma and mesenchymal chondrosarcoma

    Article • BMC Cancer, July 2016, Springer Science + Business Media

    Keisuke Horiuchi

  36. Adamantinoma of the distal femur diagnosed 5 years after initial surgery: a case report

    Article • Journal of Medical Case Reports, June 2016, Springer Science + Business Media

    Keisuke Horiuchi

  37. Generation of heterozygous fibrillin-1 mutant cloned pigs from genome-edited foetal fibroblasts

    Article • Scientific Reports, April 2016, Springer Science + Business Media

    Keisuke Horiuchi

  38. The unfolded protein response in skeletal development and homeostasis

    Article • Cellular and Molecular Life Sciences, March 2016, Springer Science + Business Media

    Keisuke Horiuchi

  39. Epithelial Cell-Derived a Disintegrin and Metalloproteinase-17 Confers Resistance to Colonic Inflammation Through EGFR Activation

    Article • EBioMedicine, March 2016, Elsevier

    Keisuke Horiuchi

  40. Fibrous Dysplasia with Massive Cartilaginous Differentiation (Fibrocartilaginous Dysplasia) in the Proximal Femur: A Case Report and Review of the Literature

    Article • Case Reports in Oncology, February 2016, Karger Publishers

    Keisuke Horiuchi

  41. Novel MR imaging method – MAVRIC – for metal artifact suppression after joint replacement in musculoskeletal tumor patients

    Article • BMC Musculoskeletal Disorders, December 2015, Springer Science + Business Media

    Keisuke Horiuchi

  42. Excessive reactive oxygen species are therapeutic targets for intervertebral disc degeneration

    Article • Arthritis Research & Therapy, November 2015, Springer Science + Business Media

    Keisuke Horiuchi

  43. Langerhans Cell Histiocytosis of the Clavicle in an Adult: A Case Report and Review of the Literature

    Article • Case Reports in Oncology, October 2015, Karger Publishers

    Keisuke Horiuchi

  44. A Disintegrin and Metalloprotease 10 (ADAM10) Is Indispensable for Maintenance of the Muscle Satellite Cell Pool

    Article • Journal of Biological Chemistry, October 2015, American Society for Biochemistry & Molecular Biology (ASBMB)

    Keisuke Horiuchi

  45. Successful Treatment with Pazopanib for Multiple Lung Metastases of Inguinal Epithelioid Sarcoma: A Case Report

    Article • Case Reports in Oncology, September 2015, Karger Publishers

    Keisuke Horiuchi

  46. ADAM12 and ADAM17 are essential molecules for hypoxia-induced impairment of neural vascular barrier function

    Article • Scientific Reports, August 2015, Springer Science + Business Media

    Keisuke Horiuchi

  47. IRE1α/XBP1-mediated branch of the unfolded protein response regulates osteoclastogenesis

    Article • Journal of Clinical Investigation, July 2015, American Society for Clinical Investigation

    Keisuke Horiuchi

  48. Severe hypercalcemia following denosumab treatment in a juvenile patient

    Article • Journal of Bone and Mineral Metabolism, June 2015, Springer Science + Business Media

    Keisuke Horiuchi

  49. Generation and characterization of a novel shoulder contracture mouse model

    Article • Journal of Orthopaedic Research®, May 2015, Wiley

    Keisuke Horiuchi

  50. Synergistic antiproliferative effect of imatinib and adriamycin in platelet‐derived growth factor receptor‐expressing osteosarcoma cells

    Article • Cancer Science, May 2015, Wiley

    Keisuke Horiuchi

  51. Dysbiosis and Staphylococcus aureus Colonization Drives Inflammation in Atopic Dermatitis

    Article • Immunity, April 2015, Elsevier

    Keisuke Horiuchi

  52. ADAM17 regulates IL-1 signaling by selectively releasing IL-1 receptor type 2 from the cell surface

    Article • Cytokine, February 2015, Elsevier

    Keisuke Horiuchi

  53. Global gene expression analysis following spinal cord injury in non-human primates

    Article • Experimental Neurology, November 2014, Elsevier

    Keisuke Horiuchi

  54. Clinical Outcome after Bone Metastasis (BM) Surgery in Patients with Differentiated Thyroid Carcinoma (DTC): A Retrospective Study of 40 Cases

    Article • Japanese Journal of Clinical Oncology, August 2014, Oxford University Press (OUP)

    Keisuke Horiuchi

  55. Computed tomography-guided resection of osteoid osteoma of the sacrum: a case report

    Article • Journal of Medical Case Reports, June 2014, Springer Science + Business Media

    Keisuke Horiuchi

  56. Desmoplastic Fibroma Arising in the Distal Phalanx of the Great Toe: A Case Report

    Article • The Journal of Foot & Ankle Surgery, January 2014, Elsevier

    Keisuke Horiuchi

  57. Secondary Aneurysmal Bone Cyst following Chondroblastoma of the Patella

    Article • Rare Tumors, July 2013, SAGE Publications

    Keisuke Horiuchi

  58. iRHOM2 is a critical pathogenic mediator of inflammatory arthritis

    Article • Journal of Clinical Investigation, January 2013, American Society for Clinical Investigation

    George Kalliolias, Keisuke Horiuchi

  59. Conditional Inactivation of TNFα-Converting Enzyme in Chondrocytes Results in an Elongated Growth Plate and Shorter Long Bones

    Article • PLoS ONE, January 2013, PLOS

    Keisuke Horiuchi

  60. Systemic Overexpression of TNFα-converting Enzyme Does Not Lead to Enhanced Shedding Activity In Vivo

    Article • PLoS ONE, January 2013, PLOS

    Keisuke Horiuchi

  61. A Brief History of Tumor Necrosis Factor α – converting Enzyme: An Overview of Ectodomain Shedding

    Article • The Keio Journal of Medicine, January 2013, Keio Journal of Medicine

    Keisuke Horiuchi

  62. Histochemical aspects of the vascular invasion at the erosion zone of the epiphyseal cartilage in MMP-9-deficient mice

    Article • Biomedical Research, January 2013, Biomedical Research Press

    Keisuke Horiuchi

  63. Crowe type IV dislocated hip treated by total hip arthroplasty with subtrochanteric step-cut femoral shortening osteotomy and Wagner cone stem

    Article • Current Orthopaedic Practice, January 2013, Wolters Kluwer Health

    Keisuke Horiuchi

  64. The IRE1α-XBP1 Pathway Positively Regulates Parathyroid Hormone (PTH)/PTH-related Peptide Receptor Expression and Is Involved in PTH-induced Osteoclastogenesis

    Article • Journal of Biological Chemistry, December 2012, American Society for Biochemistry & Molecular Biology (ASBMB)

    Keisuke Horiuchi

  65. Detection ofHEY1-NCOA2fusion by fluorescence in-situ hybridization in formalin-fixed paraffin-embedded tissues as a possible diagnostic tool for mesenchymal chondrosarcoma

    Article • Pathology International, December 2012, Wiley

    Keisuke Horiuchi

  66. Epidermal ADAM17 maintains the skin barrier by regulating EGFR ligand-dependent terminal keratinocyte differentiation

    Article • The Journal of Experimental Medicine, November 2012, Rockefeller University Press

    Keisuke Horiuchi

  67. Activity-Dependent Proteolytic Cleavage of Neuroligin-1

    Article • Neuron, October 2012, Elsevier

    Keisuke Horiuchi

  68. Brief Report: Requirement of TACE/ADAM17 for Hair Follicle Bulge Niche Establishment

    Article • Stem Cells, July 2012, Wiley

    Keisuke Horiuchi

  69. Stress-induced production of chemokines by hair follicles regulates the trafficking of dendritic cells in skin

    Article • Nature Immunology, June 2012, Nature

    Keisuke Horiuchi

  70. Epidermal ADAM17 maintains the skin barrier by regulating EGFR ligand–dependent terminal keratinocyte differentiation

    Article • The Journal of Experimental Medicine, May 2012, Rockefeller University Press

    Keisuke Horiuchi

  71. Lung endothelial ADAM17 regulates the acute inflammatory response to lipopolysaccharide

    Article • EMBO Molecular Medicine, February 2012, EMBO

    Keisuke Horiuchi

  72. A novel multi-kinase inhibitor pazopanib suppresses growth of synovial sarcoma cells through inhibition of the PI3K-AKT pathway

    Article • Journal of Orthopaedic Research®, February 2012, Wiley

    Keisuke Horiuchi

  73. Anaplastic Transformation of Follicular Thyroid Carcinoma in a Metastatic Skeletal Lesion Presenting with Paraneoplastic Leukocytosis

    Article • Thyroid, February 2012, Mary Ann Liebert Inc

    Keisuke Horiuchi

  74. The transient appearance of zipper-like actin superstructures during the fusion of osteoclasts

    Article • Journal of Cell Science, February 2012, The Company of Biologists

    Keisuke Horiuchi

  75. Enhanced susceptibility to lipopolysaccharide-induced arthritis and endotoxin shock in interleukin-32 alpha transgenic mice through induction of tumor necrosis factor alpha

    Article • Arthritis Research & Therapy, January 2012, Springer Science + Business Media

    Keisuke Horiuchi

  76. Metastatic Patterns of Myxoid/Round Cell Liposarcoma: A Review of a 25-Year Experience

    Article • Sarcoma, January 2012, Hindawi Publishing Corporation

    Keisuke Horiuchi

  77. Dual functions of cell-autonomous and non-cell-autonomous ADAM10 activity in granulopoiesis

    Article • Blood, October 2011, American Society of Hematology

    Keisuke Horiuchi

  78. Tumor necrosis factor-α converting enzyme is a key mediator of abdominal aortic aneurysm development

    Article • Atherosclerosis, October 2011, Elsevier

    Keisuke Horiuchi

  79. Gene expression profiling of mouse growth plate cartilage by laser microdissection and microarray analysis

    Article • Journal of Orthopaedic Science, September 2011, Elsevier

    Keisuke Horiuchi

  80. TNF-α–Converting Enzyme/A Disintegrin and Metalloprotease−17 Mediates Mechanotransduction in Murine Tracheal Epithelial Cells

    Article • American Journal of Respiratory Cell and Molecular Biology, August 2011, American Thoracic Society

    Keisuke Horiuchi

  81. Treatment of collagen-induced arthritis with recombinant plasminogen-related protein B: a novel inhibitor of angiogenesis

    Article • Journal of Orthopaedic Science, July 2011, Elsevier

    Keisuke Horiuchi

  82. Erratum to: Arthroscopic removal of intra-articular osteoid osteoma in the knee: case report and review of the literature

    Article • Journal of Orthopaedic Science, July 2011, Elsevier

    Keisuke Horiuchi

  83. TACE (ADAM17) inhibits Schwann cell myelination

    Article • Nature Neuroscience, June 2011, Nature

    Keisuke Horiuchi

  84. Leukocyte ADAM17 Regulates Acute Pulmonary Inflammation

    Article • PLoS ONE, May 2011, PLOS

    Keisuke Horiuchi

  85. Activation of TNFR1 ectodomain shedding by mitochondrial Ca2+ determines the severity of inflammation in mouse lung microvessels

    Article • Journal of Clinical Investigation, May 2011, American Society for Clinical Investigation

    Keisuke Horiuchi

  86. Arthroscopic removal of intra-articular osteoid osteoma in the knee: case report and review of the literature

    Article • Journal of Orthopaedic Science, May 2011, Elsevier

    Keisuke Horiuchi

  87. The IRE1α–XBP1 pathway is essential for osteoblast differentiation through promoting transcription of Osterix

    Article • EMBO Reports, March 2011, Wiley

    Keisuke Horiuchi

  88. Tumor Necrosis Factor-α Converting Enzyme Inactivation Ameliorates High-Fat Diet-Induced Insulin Resistance and Altered Energy Homeostasis

    Article • Circulation Journal, January 2011, Japanese Circulation Society

    Keisuke Horiuchi

  89. Identification and analysis of function of a novel splicing variant of mouse receptor activator of NF-κB

    Article • Molecular and Cellular Biochemistry, December 2010, Springer Science + Business Media

    Keisuke Horiuchi

  90. ADAM17 Deletion in Thymic Epithelial Cells Alters Aire Expression without Affecting T Cell Developmental Progression

    Article • PLoS ONE, October 2010, PLOS

    Keisuke Horiuchi

  91. Ectodomain shedding of EGFR ligands and TNFR1 dictates hepatocyte apoptosis during fulminant hepatitis in mice

    Article • Journal of Clinical Investigation, August 2010, American Society for Clinical Investigation

    Keisuke Horiuchi

  92. GRIP1 enhances estrogen receptor α-dependent extracellular matrix gene expression in chondrogenic cells

    Article • Osteoarthritis and Cartilage, July 2010, Elsevier

    Keisuke Horiuchi

  93. Osteosarcoma with metastasis to the stomach

    Article • Journal of Orthopaedic Science, March 2010, Elsevier

    Keisuke Horiuchi

  94. The waved with open eyelids (woe) Locus Is a Hypomorphic Mouse Mutation in Adam17

    Article • Genetics, March 2010, Genetics Society of America

    Keisuke Horiuchi

  95. In vivo role of leukocyte ADAM17 in the inflammatory and host responses during E. coli -mediated peritonitis

    Article • Journal of Leukocyte Biology, February 2010, Wiley

    Keisuke Horiuchi

  96. The effect of timing in the administration of hepatocyte growth factor to modulate BMP-2-induced osteoblast differentiation

    Article • Biomaterials, February 2010, Elsevier

    Keisuke Horiuchi

  97. Receptor Activator of NF-κB (RANK) Ligand Induces Ectodomain Shedding of RANK in Murine RAW264.7 Macrophages

    Article • The Journal of Immunology, January 2010, The American Association of Immunologists

    Keisuke Horiuchi

  98. Pathological Neovascularization Is Reduced by Inactivation of ADAM17 in Endothelial Cells but Not in Pericytes

    Article • Circulation Research, January 2010, Wolters Kluwer Health

    Keisuke Horiuchi

  99. Inhibition of STAT1 accelerates bone fracture healing

    Article • Journal of Orthopaedic Research®, January 2010, Wiley

    Keisuke Horiuchi

  100. Ectodomain Shedding of FLT3 Ligand Is Mediated by TNF-  Converting Enzyme

    Article • The Journal of Immunology, June 2009, The American Association of Immunologists

    Keisuke Horiuchi

  101. Nbl1p: A Borealin/Dasra/CSC-1-like Protein Essential for Aurora/Ipl1 Complex Function and Integrity in Saccharomyces cerevisiae

    Article • Molecular Biology of the Cell, March 2009, American Society for Cell Biology (ASCB)

    Keisuke Horiuchi

  102. Conditional Inactivation of TACE by a Sox9 Promoter Leads to Osteoporosis and Increased Granulopoiesis via Dysregulation of IL-17 and G-CSF

    Article • The Journal of Immunology, February 2009, The American Association of Immunologists

    Keisuke Horiuchi

  103. Growth suppression and apoptosis induction in synovial sarcoma cell lines by a novel NF-κB inhibitor, dehydroxymethylepoxyquinomicin (DHMEQ)

    Article • Cancer Letters, December 2008, Elsevier

    Keisuke Horiuchi

  104. VEGF-A Stimulates ADAM17-Dependent Shedding of VEGFR2 and Crosstalk Between VEGFR2 and ERK Signaling

    Article • Circulation Research, July 2008, Wolters Kluwer Health

    Keisuke Horiuchi

  105. Different ADAMs have distinct influences on Kit ligand processing: phorbol-ester-stimulated ectodomain shedding of Kitl1 by ADAM17 is reduced by ADAM19

    Article • Journal of Cell Science, February 2007, The Company of Biologists

    Keisuke Horiuchi

  106. Substrate Selectivity of Epidermal Growth Factor-Receptor Ligand Sheddases and their Regulation by Phorbol Esters and Calcium Influx

    Article • Molecular Biology of the Cell, October 2006, American Society for Cell Biology (ASCB)

    Keisuke Horiuchi

  107. Evaluation of the contributions of ADAMs 9, 12, 15, 17, and 19 to heart development and ectodomain shedding of neuregulins β1 and β2

    Article • Developmental Biology, July 2005, Elsevier

    Keisuke Horiuchi

  108. Regional migratory osteoporosis: a case report

    Article • Journal of Orthopaedic Science, March 2004, Elsevier

    Keisuke Horiuchi

  109. Essential Role for ADAM19 in Cardiovascular Morphogenesis

    Article • Molecular and Cellular Biology, January 2004, ASM Journals

    Keisuke Horiuchi

  110. Metalloprotease-disintegrin ADAM8: Expression analysis and targeted deletion in mice

    Article • Developmental Dynamics, January 2004, Wiley

    Keisuke Horiuchi

  111. Potential Role for ADAM15 in Pathological Neovascularization in Mice

    Article • Molecular and Cellular Biology, August 2003, ASM Journals

    Keisuke Horiuchi

  112. Intramuscular spindle cell lipoma: Case report and review of the literature

    Article • Pathology International, April 2001, Wiley

    Keisuke Horiuchi

  113. Identification and Characterization of a Novel Protein, Periostin, with Restricted Expression to Periosteum and Periodontal Ligament and Increased Expression by Transforming Growth Factor β

    Article • Journal of Bone and Mineral Research, July 1999, Wiley

    Keisuke Horiuchi

  114. Multiple Smooth Muscle Tumors Arising in Deep Soft Tissue of Lower Limbs With Uterine Leiomyomas

    Article • The American Journal of Surgical Pathology, July 1998, Wolters Kluwer Health

    Keisuke Horiuchi