All Stories

  1. Soymilk-fermented with Lactobacillus delbrueckii subsp. delbrueckii TUA4408L improves immune-health in pigs

    Article • Beneficial Microbes, February 2022, Wageningen Academic Publishers

    Dr Julio Villena

  2. New immunobiotics from highly proteolytic Lactobacillus delbrueckii strains: their impact on intestinal antiviral innate immune response

    Article • Beneficial Microbes, August 2020, Wageningen Academic Publishers

    Dr Julio Villena, Elvira Maria Hebert

  3. Modulation of Toll-like receptor-mediated innate immunity in bovine intestinal epithelial cells by lactic acid bacteria isolated from feedlot cattle

    Article • Beneficial Microbes, May 2020, Wageningen Academic Publishers

    Dr Julio Villena

  4. Deciphering the influence of paraimmunobiotic bifidobacteria on the innate antiviral immune response of bovine intestinal epitheliocytes by transcriptomic analysis

    Article • Beneficial Microbes, March 2019, Wageningen Academic Publishers

    Dr Julio Villena, Hideki Takahashi

  5. Draft Genome Sequence of Probiotic Lactobacillus brevis TUCO-5E, Isolated from Porcine Milk

    Article • Microbiology Resource Announcements, November 2018, ASM Journals

    Dr Julio Villena

  6. Lactobacillus fermentum UCO-979C beneficially modulates the innate immune response triggered by Helicobacter pylori infection in vitro

    Article • Beneficial Microbes, September 2018, Wageningen Academic Publishers

    Dr Julio Villena

  7. Draft Genome Sequence of Immunobiotic Lactobacillus rhamnosus Strain IBL027, a Potential Adjuvant for Mucosal Vaccine Development

    Article • Genome Announcements, December 2017, ASM Journals

    Dr Julio Villena

  8. Exopolysaccharide-producing Streptococcus thermophilus CRL1190 reduces the inflammatory response caused by Helicobacter pylori

    Article • Beneficial Microbes, May 2017, Wageningen Academic Publishers

    Dr Julio Villena, GRACIELA FONT DE VALDEZ

  9. Development of an in vitro immunobiotic evaluation system against rotavirus infection in bovine intestinal epitheliocytes

    Article • Beneficial Microbes, April 2017, Wageningen Academic Publishers

    Dr Julio Villena

  10. Draft Genome Sequence of the Immunobiotic Strain Lactobacillus jensenii TL2937

    Article • Genome Announcements, March 2017, ASM Journals

    Dr Julio Villena

  11. Modulation of porcine intestinal epitheliocytes immunetranscriptome response by Lactobacillus jensenii TL2937

    Article • Beneficial Microbes, November 2016, Wageningen Academic Publishers

    Dr Julio Villena

  12. Draft Genome Sequence of Lactobacillus plantarum TL2766, a Strain with the Ability To Ferment Wakame

    Article • Genome Announcements, November 2016, ASM Journals

    Dr Julio Villena

  13. Isolation of lactic acid bacteria from swine milk and characterization of potential probiotic strains with antagonistic effects against swine-associated gastrointestinal pathogens

    Article • Canadian Journal of Microbiology, June 2016, Canadian Science Publishing

    Dr Julio Villena

  14. Immunobiotic Bifidobacteria Strains Modulate Rotavirus Immune Response in Porcine Intestinal Epitheliocytes via Pattern Recognition Receptor Signaling

    Article • PLoS ONE, March 2016, PLOS

    Dr Julio Villena

  15. Draft Genome Sequence of Lactobacillus plantarum CRL1506, an Immunomodulatory Strain Isolated from Goat Milk

    Article • Genome Announcements, March 2016, ASM Journals

    Dr Julio Villena

  16. Draft Genome Sequence of a Probiotic Strain, Lactobacillus fermentum UCO-979C

    Article • Genome Announcements, December 2015, ASM Journals

    Andrey Karlyshev, Dr Julio Villena

  17. Nasal priming with immunobiotic Lactobacillus rhamnosus modulates inflammation–coagulation interactions and reduces influenza virus-associated pulmonary damage

    Article • Inflammation Research, June 2015, Springer Science + Business Media

    Dr Julio Villena

  18. Non-viable immunobiotic Lactobacillus rhamnosus CRL1505 and its peptidoglycan improve systemic and respiratory innate immune response during recovery of immunocompromised-malnourished mice

    Article • International Immunopharmacology, April 2015, Elsevier

    Dr Julio Villena

  19. Advanced Application of Porcine Intramuscular Adipocytes for Evaluating Anti-Adipogenic and Anti-Inflammatory Activities of Immunobiotics

    Article • PLoS ONE, March 2015, PLOS

    Dr Julio Villena

  20. The toll-like receptor family protein RP105/MD1 complex is involved in the immunoregulatory effect of exopolysaccharides from Lactobacillus plantarum N14

    Article • Molecular Immunology, March 2015, Elsevier

    Dr Julio Villena

  21. Recent Advances and Future Perspective in Microbiota and Probiotics

    Article • BioMed Research International, January 2015, Hindawi Publishing Corporation

    Dr Julio Villena

  22. Soluble Factors from Lactobacillus reuteri CRL1098 Have Anti-Inflammatory Effects in Acute Lung Injury Induced by Lipopolysaccharide in Mice

    Article • PLoS ONE, October 2014, PLOS

    Dr Julio Villena

  23. Regulation of Toll-Like Receptors-Mediated Inflammation by Immunobiotics in Bovine Intestinal Epitheliocytes: Role of Signaling Pathways and Negative Regulators

    Article • Frontiers in Immunology, September 2014, Frontiers

    Dr Julio Villena

  24. Probiotic Lactobacillus strains protect against myelosuppression and immunosuppression in cyclophosphamide-treated mice

    Article • International Immunopharmacology, September 2014, Elsevier

    Dr Julio Villena

  25. Lactobacillus delbrueckii TUA4408L and its extracellular polysaccharides attenuate enterotoxigenic Escherichia coli- induced inflammatory response in porcine intestinal epitheliocytes via Toll-like receptor-2 and 4

    Article • Molecular Nutrition & Food Research, August 2014, Wiley

    Dr Julio Villena

  26. Modulation of the inflammation-coagulation interaction during pneumococcal pneumonia by immunobioticLactobacillus rhamnosusCRL1505: Role of Toll-like receptor 2

    Article • Microbiology and Immunology, July 2014, Wiley

    Dr Julio Villena

  27. Modulation of Respiratory TLR3-Anti-Viral Response by Probiotic Microorganisms: Lessons Learned from Lactobacillus rhamnosus CRL1505

    Article • Frontiers in Immunology, May 2014, Frontiers

    Dr Julio Villena

  28. Dietary Supplementation with Lactobacilli Improves Emergency Granulopoiesis in Protein-Malnourished Mice and Enhances Respiratory Innate Immune Response

    Article • PLoS ONE, April 2014, PLOS

    Dr Julio Villena

  29. Immunobiotic lactobacilli reduce viral-associated pulmonary damage through the modulation of inflammation–coagulation interactions

    Article • International Immunopharmacology, March 2014, Elsevier

    Dr Julio Villena

  30. Modulation of Intestinal TLR4-Inflammatory Signaling Pathways by Probiotic Microorganisms: Lessons Learned from Lactobacillus jensenii TL2937

    Article • Frontiers in Immunology, January 2014, Frontiers

    Dr Julio Villena

  31. Immunobiotic Lactobacillus jensenii as immune-health promoting factor to improve growth performance and productivity in post-weaning pigs

    Article • BMC Immunology, January 2014, Springer Science + Business Media

    Dr Julio Villena

  32. Bifidobacterium breve MCC-117 Induces Tolerance in Porcine Intestinal Epithelial Cells: Study of the Mechanisms Involved in the Immunoregulatory Effect

    Article • Bioscience of Microbiota Food and Health, January 2014, BMFH Press

    Dr Julio Villena

  33. Immunobiotic Lactobacillus rhamnosus strains differentially modulate antiviral immune response in porcine intestinal epithelial and antigen presenting cells

    Article • BMC Microbiology, January 2014, Springer Science + Business Media

    Dr Julio Villena

  34. Evaluation of the Immunoregulatory Capacities of Feed Microbial Materials in Porcine Intestinal Immune and Epithelial Cells

    Article • Open Journal of Veterinary Medicine, January 2014, Scientific Research Publishing, Inc,

    Dr Julio Villena

  35. Advanced application of porcine intestinal epithelial cells for the selection of immunobiotics modulating toll-like receptor 3-mediated inflammation

    Article • Journal of Microbiology Immunology and Infection, December 2013, Elsevier

    Dr Julio Villena

  36. Lactobacillus rhamnosus CRL1505 enhances systemic and respiratory innate immune response in immunocompromised malnourished mice

    Article • Journal of Functional Foods, October 2013, Elsevier

    Dr Julio Villena, Susana Alvarez

  37. Lactobacillus reuteri CRL1101 beneficially modulate lipopolysaccharide-mediated inflammatory response in a mouse model of endotoxic shock

    Article • Journal of Functional Foods, October 2013, Elsevier

    Dr Julio Villena

  38. Immunobiotic Lactobacillus rhamnosus improves resistance of infant mice against respiratory syncytial virus infection

    Article • International Immunopharmacology, October 2013, Elsevier

    Dr Julio Villena

  39. Lactobacillus rhamnosus CRL1505 beneficially modulates the immuno-coagulative response after pneumococcal infection in immunocompromised malnourished mice

    Article • Canadian Journal of Microbiology, October 2013, Canadian Science Publishing

    Dr Julio Villena

  40. Introduction

    Article • September 2013, Taylor & Francis

    Dr Julio Villena

  41. Immunobiotics for the Prevention of Bacterial and Viral Respiratory Infections

    Article • September 2013, Taylor & Francis

    Dr Julio Villena

  42. Role of Toll-like Receptors in the Modulation of Intestinal Inflammation by Immunobiotics

    Article • September 2013, Taylor & Francis

    Dr Julio Villena

  43. Immunogenics

    Article • September 2013, Taylor & Francis

    Dr Julio Villena

  44. Can Immunobiotics Beneficially Modulate Hemato-Immune Responses in Immunocompromised Hosts?

    Article • September 2013, Taylor & Francis

    Dr Julio Villena

  45. Immunoregulatory Effect of Bifidobacteria Strains in Porcine Intestinal Epithelial Cells through Modulation of Ubiquitin-Editing Enzyme A20 Expression

    Article • PLoS ONE, March 2013, PLOS

    Dr Julio Villena

  46. Nasally administered Lactobacillus rhamnosus strains differentially modulate respiratory antiviral immune responses and induce protection against respiratory syncytial virus infection

    Article • BMC Immunology, January 2013, Springer Science + Business Media

    Dr Julio Villena

  47. Bifidobacteria Upregulate Expression of Toll-Like Receptor Negative Regulators Counteracting Enterotoxigenic <i>Escherichia coli</i> Mediated Inflammation in Bovine Intestinal Epitheliocytes

    Article • Open Journal of Veterinary Medicine, January 2013, Scientific Research Publishing, Inc,

    Dr Julio Villena

  48. Advanced application of bovine intestinal epithelial cell line for evaluating regulatory effect of lactobacilli against heat-killed enterotoxigenic Escherichia coli-mediated inflammation

    Article • BMC Microbiology, January 2013, Springer Science + Business Media

    Dr Julio Villena

  49. Lactobacillus reuteri CRL1098 soluble factors modulate tumor necrosis factor alpha production in peripheral blood mononuclear cells: Involvement of lipid rafts

    Article • International Immunopharmacology, December 2012, Elsevier

    Dr Julio Villena

  50. Stimulation of macrophages by immunobioticLactobacillusstrains: influence beyond the intestinal tract

    Article • Microbiology and Immunology, October 2012, Wiley

    Dr Julio Villena

  51. A newly established bovine intestinal epithelial cell line is effective for in vitro screening of potential antiviral immunobiotic microorganisms for cattle

    Article • Research in Veterinary Science, October 2012, Elsevier

    Dr Julio Villena

  52. Orally administered Lactobacillus rhamnosus modulates the respiratory immune response triggered by the viral pathogen-associated molecular pattern poly(I:C)

    Article • BMC Immunology, January 2012, Springer Science + Business Media

    Dr Julio Villena

  53. Lactic acid bacteria in the prevention of pneumococcal respiratory infection: Future opportunities and challenges

    Article • International Immunopharmacology, November 2011, Elsevier

    Dr Julio Villena

  54. Toll-like receptor-2-activating bifidobacteria strains differentially regulate inflammatory cytokines in the porcine intestinal epithelial cell culture system: finding new anti-inflammatory immunobiotics

    Article • FEMS Immunology & Medical Microbiology, October 2011, Oxford University Press (OUP)

    Dr Julio Villena

  55. Immunomodulatory and protective effect of probiotic Lactobacillus casei against Candida albicans infection in malnourished mice

    Article • Microbiology and Immunology, May 2011, Wiley

    Dr Julio Villena

  56. Development of a fermented goats' milk containing Lactobacillus rhamnosus: in vivo study of health benefits

    Article • Journal of the Science of Food and Agriculture, May 2011, Wiley

    Dr Julio Villena

  57. Immunobiotic lactic acid bacteria beneficially regulate immune response triggered by poly(I:C) in porcine intestinal epithelial cells

    Article • Veterinary Research, January 2011, Springer Science + Business Media

    Dr Julio Villena

  58. Lactococcus lactisas an adjuvant and delivery vehicle of antigens against pneumococcal respiratory infections

    Article • Bioengineered Bugs, September 2010, Taylor & Francis

    Dr Julio Villena

  59. Immunomodulatory activity of Lactobacillus rhamnosus strains isolated from goat milk: Impact on intestinal and respiratory infections

    Article • International Journal of Food Microbiology, June 2010, Elsevier

    Dr Julio Villena

  60. Resistance of Young Mice to Pneumococcal Infection can be Improved by Oral Vaccination with Recombinant Lactococcus lactis

    Article • Journal of Microbiology Immunology and Infection, February 2010, Elsevier

    Dr Julio Villena

  61. Enhanced immune response to pneumococcal infection in malnourished mice nasally treated with heat-killedLactobacillus casei

    Article • Microbiology and Immunology, November 2009, Wiley

    Dr Julio Villena

  62. Influence of yogurt consumption on the respiratory immune response

    Article • Food and Agricultural Immunology, September 2009, Taylor & Francis

    Dr Julio Villena

  63. Lactobacillus casei modulates the inflammation-coagulation interaction in a pneumococcal pneumonia experimental model

    Article • Journal of Inflammation, January 2009, Springer Science + Business Media

    Dr Julio Villena

  64. Oral immunization with recombinant Lactococcus lactis confers protection against respiratory pneumococcal infection

    Article • Canadian Journal of Microbiology, October 2008, Canadian Science Publishing

    Dr Julio Villena

  65. Lactobacillus casei addition to a repletion diet-induced early normalisation of cytokine profils during a pneumococcal infection in malnourished mice

    Article • Food and Agricultural Immunology, September 2008, Taylor & Francis

    Dr Julio Villena

  66. Nasal administration ofLactococcus lactisimproves local and systemic immune responses againstStreptococcus pneumoniae

    Article • Microbiology and Immunology, August 2008, Wiley

    Dr Julio Villena

  67. Stimulation of respiratory immunity by oral administration of Lactococcus lactis

    Article • Canadian Journal of Microbiology, August 2008, Canadian Science Publishing

    Dr Julio Villena

  68. Lactobacillus casei administration reduces lung injuries in a Streptococcus pneumoniae infection in mice

    Article • Microbes and Infection, August 2006, Elsevier

    Dr Julio Villena

  69. Beneficial immunomodulatory activity of Lactobacillus casei in malnourished mice pneumonia: effect on inflammation and coagulation

    Article • Nutrition, July 2006, Elsevier

    Dr Julio Villena

  70. Yoghurt accelerates the recovery of defence mechanisms against Streptococcus pneumoniae in protein-malnourished mice

    Article • British Journal Of Nutrition, March 2006, Cambridge University Press

    Dr Julio Villena