All Stories

  1. Chaperone-mediated autophagy sustains muscle stem cell regenerative functions but declines with age

    Article • Nature Metabolism, December 2025, Springer Science + Business Media

    Dr Joan Isern

  2. Overexpression of Wild-Type TMEM43 Improves Cardiac Function in Arrhythmogenic Right Ventricular Cardiomyopathy Type 5

    Article • Circulation Research, April 2025, Wolters Kluwer Health

    Dr Joan Isern

  3. Muscle aging and sarcopenia: The pathology, etiology, and most promising therapeutic targets

    Article • Molecular Aspects of Medicine, December 2024, Elsevier

    Dr Joan Isern

  4. The G4 resolvase Dhx36 modulates cardiomyocyte differentiation and ventricular conduction system development

    Article • Nature Communications, October 2024, Springer Science + Business Media

    Dr Joan Isern

  5. Multimodal cell atlas of the ageing human skeletal muscle

    Article • Nature, April 2024, Springer Science + Business Media

    Dr Joan Isern

  6. Mitochondrial dynamics maintain muscle stem cell regenerative competence throughout adult life by regulating metabolism and mitophagy

    Article • Cell Stem Cell, September 2022, Elsevier

    Dr Joan Isern

  7. Cell transcriptomic atlas of the non-human primate Macaca fascicularis

    Article • Nature, April 2022, Springer Science + Business Media

    Dr Joan Isern

  8. In vivo transcriptomic profiling using cell encapsulation identifies effector pathways of systemic aging

    Article • eLife, March 2022, eLife

    Dr Joan Isern

  9. Stem cell aging in the skeletal muscle: The importance of communication

    Article • Ageing Research Reviews, January 2022, Elsevier

    Dr Joan Isern

  10. Translational control by DHX36 binding to 5′UTR G-quadruplex is essential for muscle stem-cell regenerative functions

    Article • Nature Communications, August 2021, Springer Science + Business Media

    Dr Joan Isern

  11. Assessing Autophagy in Muscle Stem Cells

    Article • Frontiers in Cell and Developmental Biology, January 2021, Frontiers

    Dr Joan Isern

  12. Sox17 Controls Emergence and Remodeling of Nestin-Expressing Coronary Vessels

    Article • Circulation Research, November 2020, Wolters Kluwer Health

    Dr Joan Isern

  13. The pluripotency factor NANOG controls primitive hematopoiesis and directly regulates Tal1

    Article • The EMBO Journal, February 2019, EMBO

    Dr Joan Isern

  14. Dual cholinergic signals regulate daily migration of hematopoietic stem cells and leukocytes

    Article • Blood, October 2018, American Society of Hematology

    Dr Joan Isern

  15. Replication stress caused by low MCM expression limits fetal erythropoiesis and hematopoietic stem cell functionality

    Article • Nature Communications, October 2015, Nature

    Dr Joan Isern

  16. Estrogen Signaling Selectively Induces Apoptosis of Hematopoietic Progenitors and Myeloid Neoplasms without Harming Steady-State Hematopoiesis

    Article • Cell Stem Cell, December 2014, Elsevier

    Dr Joan Isern

  17. Low/Negative Expression of PDGFR-α Identifies the Candidate Primary Mesenchymal Stromal Cells in Adult Human Bone Marrow

    Article • Stem Cell Reports, December 2014, Elsevier

    Dr Joan Isern

  18. The neural crest is a source of mesenchymal stem cells with specialized hematopoietic stem cell niche function

    Article • eLife, September 2014, eLife

    Dr Simon Mendez-Ferrer, Dr Daniel Martin-Perez, Dr Joan Isern

  19. Clonal analysis identifies hemogenic endothelium as the source of the blood-endothelial common lineage in the mouse embryo

    Article • Blood, August 2014, American Society of Hematology

    Dr Joan Isern

  20. Neuropathy of haematopoietic stem cell niche is essential for myeloproliferative neoplasms

    Article • Nature, June 2014, Springer Science + Business Media

    Dr Joan Isern

  21. Expression of Podocalyxin Separates the Hematopoietic and Vascular Potentials of Mouse Embryonic Stem Cell-Derived Mesoderm

    Article • Stem Cells, January 2014, Wiley

    Dr Joan Isern, Dr Stuart Fraser

  22. Analysis of primitive erythroid cell proliferation and enucleation using a cyan fluorescent reporter in transgenic mice

    Article • genesis, August 2013, Wiley

    Dr Joan Isern, Dr Stuart Fraser

  23. Self-Renewing Human Bone Marrow Mesenspheres Promote Hematopoietic Stem Cell Expansion

    Article • Cell Reports, May 2013, Elsevier

    Dr Joan Isern

  24. Isern J, He Z, Fraser ST, et al. Single-lineage transcriptome analysis reveals key regulatory pathways in primitive erythroid progenitors in the mouse embryo. Blood. 2011;117(18):4924-4934.

    Article • Blood, December 2012, American Society of Hematology

    Dr Stuart Fraser, Dr Joan Isern

  25. The embryonic origins of erythropoiesis in mammals

    Article • Blood, February 2012, American Society of Hematology

    Dr Joan Isern, Dr Stuart Fraser

  26. BMP4 signaling directs primitive endoderm-derived XEN cells to an extraembryonic visceral endoderm identity

    Article • Developmental Biology, January 2012, Elsevier

    Dr Joan Isern

  27. Stem Cell Interactions in a Bone Marrow Niche

    Article • Current Osteoporosis Reports, September 2011, Springer Science + Business Media

    Dr Joan Isern

  28. Single-lineage transcriptome analysis reveals key regulatory pathways in primitive erythroid progenitors in the mouse embryo

    Article • Blood, January 2011, American Society of Hematology

    Dr Joan Isern, Dr Stuart Fraser

  29. Dose-dependent regulation of primitive erythroid maturation and identity by the transcription factor Eklf

    Article • Blood, August 2010, American Society of Hematology

    Dr Joan Isern, Dr Stuart Fraser

  30. Developmental niches for embryonic erythroid cells

    Article • Blood Cells Molecules and Diseases, April 2010, Elsevier

    Dr Joan Isern, Dr Stuart Fraser

  31. Use of Transgenic Fluorescent Reporter Mouse Lines to Monitor Hematopoietic and Erythroid Development During Embryogenesis

    Article • January 2010, Elsevier

    Dr Joan Isern, Dr Stuart Fraser

  32. The fetal liver is a niche for maturation of primitive erythroid cells

    Article • Proceedings of the National Academy of Sciences, May 2008, Proceedings of the National Academy of Sciences

    Dr Joan Isern, Dr Stuart Fraser

  33. Returning to the primitive: A new perspective on an overlooked hematopoietic lineage

    Article • Blood Cells Molecules and Diseases, March 2007, Elsevier

    Dr Joan Isern, Dr Stuart Fraser

  34. Maturation and enucleation of primitive erythroblasts during mouse embryogenesis is accompanied by changes in cell-surface antigen expression

    Article • Blood, January 2007, American Society of Hematology

    Dr Joan Isern, Dr Stuart Fraser

  35. Tg(Afp-GFP) expression marks primitive and definitive endoderm lineages during mouse development

    Article • Developmental Dynamics, January 2006, Wiley

    Dr Joan Isern, Dr Stuart Fraser

  36. Sex steroid regulation and identification of different transcription units of the SA gene in mouse kidney

    Article • October 2004, Bioscientifica

    Dr Joan Isern

  37. Hormonal regulation and characterisation of the mouse Cyp4b1 gene 5′-flanking region

    Article • Biochemical and Biophysical Research Communications, July 2003, Elsevier

    Dr Joan Isern

  38. Functional analysis and androgen-regulated expression of mouse organic anion transporting polypeptide 1 (Oatp1) in the kidney

    Article • Biochimica et Biophysica Acta (BBA) - Gene Structure and Expression, March 2001, Elsevier

    Dr Joan Isern, Bruno Stieger

  39. Role of fucosyltransferases in the association between apomucin and Lewis antigen expression in normal and malignant gastric epithelium

    Article • Gut, September 2000, BMJ

    Dr Joan Isern