All Stories

  1. Recruitment of C4b-binding protein is not a complement evasion strategy employed by Staphylococcus aureus

    Article • Microbiology, September 2023, Society for General Microbiology

    Joan A Geoghegan

  2. von Willebrand factor-binding protein (vWbp)-activated factor XIII and transglutaminase 2 (TG2) promote cross-linking between FnBPA from Staphylococcus aureus and fibrinogen

    Article • Scientific Reports, July 2023, Springer Science + Business Media

    Joan A Geoghegan

  3. The A domain of clonal complex 1-type fibronectin binding protein B promotes adherence and biofilm formation in Staphylococcus aureus

    Article • Microbiology, June 2023, Society for General Microbiology

    Joan A Geoghegan

  4. The A domain of clonal complex 1-type fibronectin binding protein B promotes adherence and biofilm formation inStaphylococcus aureus

    Article • April 2023, Cold Spring Harbor Laboratory Press

    Joan A Geoghegan

  5. High-force catch bonds between the Staphylococcus aureus surface protein SdrE and complement regulator factor H drive immune evasion

    Article • Communications Biology, March 2023, Springer Science + Business Media

    Joan A Geoghegan

  6. Staphylococcal Periscope proteins Aap, SasG, and Pls project noncanonical legume-like lectin adhesin domains from the bacterial surface

    Article • Journal of Biological Chemistry, March 2023, Elsevier

    Joan A Geoghegan

  7. Non-canonical inflammasome activation mediates the adjuvanticity of nanoparticles

    Article • Cell Reports Medicine, January 2023, Elsevier

    Joan A Geoghegan

  8. Interaction of the Staphylococcus aureus Surface Protein FnBPB with Corneodesmosin Involves Two Distinct, Extremely Strong Bonds

    Article • ACS Nanoscience Au, October 2022, American Chemical Society (ACS)

    Joan A Geoghegan

  9. Allantodapsone is a Pan-Inhibitor of Staphylococcus aureus Adhesion to Fibrinogen, Loricrin, and Cytokeratin 10

    Article • Microbiology Spectrum, June 2022, ASM Journals

    Joan A Geoghegan

  10. Fibronectin binding protein B binds to loricrin and promotes corneocyte adhesion by Staphylococcus aureus

    Article • Nature Communications, May 2022, Springer Science + Business Media

    Joan A Geoghegan

  11. Enantioselective effect of cysteine functionalized mesoporous silica nanoparticles in U87 MG and GM08680 human cells and Staphylococcus aureus bacteria

    Article • Journal of Materials Chemistry B, January 2021, Royal Society of Chemistry

    Joan A Geoghegan

  12. Staphylococcus aureus binds to the N-terminal region of corneodesmosin to adhere to the stratum corneum in atopic dermatitis

    Article • Proceedings of the National Academy of Sciences, December 2020, Proceedings of the National Academy of Sciences

    Joan A Geoghegan

  13. Editorial overview: Bacterial regulatory hierarchies and networks

    Article • Current Opinion in Microbiology, June 2020, Elsevier

    Professor Charles J Dorman, Joan A Geoghegan

  14. Structures of lipoprotein signal peptidase II from Staphylococcus aureus complexed with antibiotics globomycin and myxovirescin

    Article • Nature Communications, January 2020, Springer Science + Business Media

    Joan A Geoghegan

  15. Host-specialized fibrinogen-binding by a bacterial surface protein promotes biofilm formation and innate immune evasion

    Article • PLoS Pathogens, June 2019, PLOS

    Joan A Geoghegan

  16. Clumping factor B is an important virulence factor during Staphylococcus aureus skin infection and a promising vaccine target

    Article • PLoS Pathogens, April 2019, PLOS

    Joan A Geoghegan

  17. Fibronectin-binding protein B (FnBPB) from Staphylococcus aureus protects against the antimicrobial activity of histones

    Article • Journal of Biological Chemistry, March 2019, Elsevier

    Joan A Geoghegan

  18. Mobile-Genetic-Element-Encoded Hypertolerance to Copper Protects Staphylococcus aureus from Killing by Host Phagocytes

    Article • mBio, October 2018, ASM Journals

    Joan A Geoghegan, Marta Zapotoczna

  19. Adhesion of Staphylococcus aureus to Corneocytes from Atopic Dermatitis Patients Is Controlled by Natural Moisturizing Factor Levels

    Article • mBio, August 2018, ASM Journals

    Joan A Geoghegan

  20. Mechanomicrobiology: How Mechanical Forces Activate Staphylococcus aureus Adhesion

    Article • Trends in Microbiology, August 2018, Elsevier

    Joan A Geoghegan

  21. The widespread use of topical antimicrobials enriches for resistance in Staphylococcus aureus isolated from patients with atopic dermatitis

    Article • British Journal of Dermatology, July 2018, Wiley

    Dr Robert Stewart Dawe, Joan A Geoghegan

  22. Staphylococcus aureus and Atopic Dermatitis: A Complex and Evolving Relationship

    Article • Trends in Microbiology, June 2018, Elsevier

    Joan A Geoghegan

  23. Staphylococcus aureus clumping factor A is a force-sensitive molecular switch that activates bacterial adhesion

    Article • Proceedings of the National Academy of Sciences, May 2018, Proceedings of the National Academy of Sciences

    Joan A Geoghegan

  24. A horizontally gene transferred copper resistance locus confers hyper‐resistance to antibacterial copper toxicity and enables survival of community acquired methicillin resistant Staphylococcus aureus USA3...

    Article • Environmental Microbiology, March 2018, Wiley

    Joan A Geoghegan

  25. Force-Induced Strengthening of the Interaction between Staphylococcus aureus Clumping Factor B and Loricrin

    Article • mBio, December 2017, ASM Journals

    Joan A Geoghegan, David Alsteens

  26. The Staphylococcus aureus Cell Wall-Anchored Protein Clumping Factor A Is an Important T Cell Antigen

    Article • Infection and Immunity, September 2017, ASM Journals

    Joan A Geoghegan

  27. Live-Cell Nanoscopy in Antiadhesion Therapy

    Article • Trends in Microbiology, July 2017, Elsevier

    Joan A Geoghegan

  28. Conjugate of an IgG Binding Domain with Botulinum Neurotoxin A Lacking the Acceptor Moiety Targets Its SNARE Protease into TrkA-Expressing Cells When Coupled to Anti-TrkA IgG or Fc-βNGF

    Article • Bioconjugate Chemistry, May 2017, American Chemical Society (ACS)

    Joan A Geoghegan

  29. Adherence of Staphylococcus aureus to skin corneocytes

    Article • Infection and Immunity, April 2017, ASM Journals

    Joan A Geoghegan

  30. Molecular interactions and inhibition of the staphylococcal biofilm-forming protein SdrC

    Article • Proceedings of the National Academy of Sciences, March 2017, Proceedings of the National Academy of Sciences

    Joan A Geoghegan

  31. Lessons from the Crystal Structure of the S. aureus Surface Protein Clumping Factor A in Complex With Tefibazumab, an Inhibiting Monoclonal Antibody

    Article • EBioMedicine, November 2016, Elsevier

    Joan A Geoghegan

  32. Molecular Interactions of Human Plasminogen with Fibronectin-binding Protein B (FnBPB), a Fibrinogen/Fibronectin-binding Protein fromStaphylococcus aureus

    Article • Journal of Biological Chemistry, July 2016, American Society for Biochemistry & Molecular Biology (ASBMB)

    Joan A Geoghegan

  33. CRIg Functions as a Macrophage Pattern Recognition Receptor to Directly Bind and Capture Blood-Borne Gram-Positive Bacteria

    Article • Cell Host & Microbe, July 2016, Elsevier

    Joan A Geoghegan

  34. The Role of Staphylococcus aureus Virulence Factors in Skin Infection and Their Potential as Vaccine Antigens

    Article • Pathogens, February 2016, MDPI AG

    Joan A Geoghegan

  35. Forces between Staphylococcus aureus and human skin

    Article • Nanoscale Horizons, January 2016, Royal Society of Chemistry

    Joan A Geoghegan

  36. Zinc-dependent mechanical properties of Staphylococcus aureus biofilm-forming surface protein SasG

    Article • Proceedings of the National Academy of Sciences, December 2015, Proceedings of the National Academy of Sciences

    Joan A Geoghegan

  37. Memory Th1 Cells Are Protective in Invasive Staphylococcus aureus Infection

    Article • PLoS Pathogens, November 2015, PLOS

    Dr Micheál Mac Aogáin, Joan A Geoghegan

  38. Fibronectin Binding Proteins SpsD and SpsL Both Support Invasion of Canine Epithelial Cells by Staphylococcus pseudintermedius

    Article • Infection and Immunity, August 2015, ASM Journals

    Pietro Speziale, Joan A Geoghegan

  39. Staphylokinase Control ofStaphylococcus aureusBiofilm Formation and Detachment Through Host Plasminogen Activation

    Article • The Journal of Infectious Diseases, July 2015, Oxford University Press (OUP)

    Joan A Geoghegan

  40. Manipulation of Autophagy in Phagocytes Facilitates Staphylococcus aureus Bloodstream Infection

    Article • Infection and Immunity, June 2015, ASM Journals

    Dr Mieszko M Wilk, Joan A Geoghegan

  41. Staphylococcus aureus Fibronectin-Binding Protein A Mediates Cell-Cell Adhesion through Low-Affinity Homophilic Bonds

    Article • mBio, May 2015, ASM Journals

    Joan A Geoghegan

  42. Biofilm formation by staphylococci and streptococci: structural, functional, and regulatory aspects and implications for pathogenesis

    Article • Frontiers in Cellular and Infection Microbiology, April 2015, Frontiers

    Joan A Geoghegan

  43. Protein A Is Released into the Staphylococcus aureus Culture Supernatant with an Unprocessed Sorting Signal

    Article • Infection and Immunity, February 2015, ASM Journals

    Joan A Geoghegan

  44. Staphylococcus aureus

    Article • January 2015, Elsevier

    Joan A Geoghegan

  45. Cell Wall-Anchored Surface Proteins of Staphylococcus aureus: Many Proteins, Multiple Functions

    Article • January 2015, Springer Science + Business Media

    Joan A Geoghegan

  46. Protein-based biofilm matrices in Staphylococci

    Article • Frontiers in Cellular and Infection Microbiology, December 2014, Frontiers

    Joan A Geoghegan

  47. Role for the A Domain of Unprocessed Accumulation-Associated Protein (Aap) in the Attachment Phase of the Staphylococcus epidermidis Biofilm Phenotype

    Article • Journal of Bacteriology, September 2014, ASM Journals

    Professor James P. O'Gara, Joan A Geoghegan

  48. The binding force of the staphylococcal adhesin SdrG is remarkably strong

    Article • Molecular Microbiology, June 2014, Wiley

    Joan A Geoghegan

  49. Fibronectin-binding proteins are required for biofilm formation by community-associated methicillin-resistantStaphylococcus aureusstrain LAC

    Article • FEMS Microbiology Letters, April 2014, Oxford University Press (OUP)

    Joan A Geoghegan, Professor James P. O'Gara

  50. A short sequence within subdomain N1 of region A of the Staphylococcus aureus MSCRAMM clumping factor A is required for export and surface display

    Article • Microbiology, April 2014, Society for General Microbiology

    Joan A Geoghegan

  51. IsdC from Staphylococcus lugdunensis Induces Biofilm Formation under Low-Iron Growth Conditions

    Article • Infection and Immunity, March 2014, ASM Journals

    Pietro Speziale, Joan A Geoghegan

  52. Adhesion, invasion and evasion: the many functions of the surface proteins of Staphylococcus aureus

    Article • Nature Reviews Microbiology, December 2013, Springer Science + Business Media

    Joan A Geoghegan

  53. Targeted Nasal Vaccination Provides Antibody-Independent Protection Against Staphylococcus aureus

    Article • The Journal of Infectious Diseases, November 2013, Oxford University Press (OUP)

    Joan A Geoghegan

  54. Forces Driving the Attachment of Staphylococcus epidermidis to Fibrinogen-Coated Surfaces

    Article • Langmuir, October 2013, American Chemical Society (ACS)

    Joan A Geoghegan

  55. Nlrp-3-Driven Interleukin 17 Production by γδT Cells Controls Infection Outcomes during Staphylococcus aureus Surgical Site Infection

    Article • Infection and Immunity, September 2013, ASM Journals

    Dr Mieszko M Wilk, Joan A Geoghegan

  56. Molecular Characterization of the Multiple Interactions of SpsD, a Surface Protein from Staphylococcus pseudintermedius, with Host Extracellular Matrix Proteins

    Article • PLOS One, June 2013, PLOS

    Joan A Geoghegan, Pietro Speziale

  57. Subdomains N2N3 of Fibronectin Binding Protein A Mediate Staphylococcus aureus Biofilm Formation and Adherence to Fibrinogen Using Distinct Mechanisms

    Article • Journal of Bacteriology, April 2013, ASM Journals

    Joan A Geoghegan

  58. Complement regulator C4BP binds to Staphylococcus aureus surface proteins SdrE and Bbp inhibiting bacterial opsonization and killing

    Article • Results in Immunology, January 2013, Elsevier

    Joan A Geoghegan

  59. Nasal Colonisation by Staphylococcus aureus Depends upon Clumping Factor B Binding to the Squamous Epithelial Cell Envelope Protein Loricrin

    Article • PLoS Pathogens, December 2012, PLOS

    Joan A Geoghegan

  60. Staphylococcus aureus surface protein SdrE binds the complement regulator factor H to evade the immune response

    Article • Immunobiology, November 2012, Elsevier

    Joan A Geoghegan

  61. Socializing, networking and development: a report from the second ‘Young Microbiologists Symposium on Microbe Signalling, Organization and Pathogenesis’

    Article • Molecular Microbiology, September 2012, Wiley

    Joan A Geoghegan

  62. Staphylococcus aureus Surface Protein SdrE Binds Complement Regulator Factor H as an Immune Evasion Tactic

    Article • PLOS One, May 2012, PLOS

    Joan A Geoghegan

  63. Staphylococcal biofilm-forming protein has a contiguous rod-like structure

    Article • Proceedings of the National Academy of Sciences, April 2012, Proceedings of the National Academy of Sciences

    Joan A Geoghegan

  64. The immune evasion protein Sbi of Staphylococcus aureus occurs both extracellularly and anchored to the cell envelope by binding lipoteichoic acid

    Article • Molecular Microbiology, January 2012, Wiley

    Joan A Geoghegan, Pietro Speziale, Dr Angelika Grundling

  65. The immune evasion protein Sbi ofStaphylococcus aureusoccurs both extracellularly and anchored to the cell envelope by binding lipoteichoic acid

    Article • Molecular Microbiology, January 2012, Wiley

    Joan A Geoghegan, Pietro Speziale, Dr Angelika Grundling

  66. Genome sequence of Staphylococcus lugdunensis N920143 allows identification of putative colonization and virulence factors

    Article • FEMS Microbiology Letters, July 2011, Oxford University Press (OUP)

    Joan A Geoghegan, Professor Julian Parkhill

  67. Functional analysis of a murine monoclonal antibody against the repetitive region of the fibronectin‐binding adhesins fibronectin‐binding protein A and fibronectin‐binding protein B from Staphylococcus aureus

    Article • European Journal of Biochemistry, September 2010, Wiley

    Pietro Speziale, Matteo Stravalaci, Joan A Geoghegan

  68. Role of Surface Protein SasG in Biofilm Formation by Staphylococcus aureus

    Article • Journal of Bacteriology, September 2010, ASM Journals

    Joan A Geoghegan

  69. Direct interaction of iron-regulated surface determinant IsdB of Staphylococcus aureus with the GPIIb/IIIa receptor on platelets

    Article • Microbiology, March 2010, Society for General Microbiology

    Joan A Geoghegan

  70. Molecular Characterization of the Interaction of Staphylococcal Microbial Surface Components Recognizing Adhesive Matrix Molecules (MSCRAMM) ClfA and Fbl with Fibrinogen

    Article • Journal of Biological Chemistry, February 2010, Elsevier

    Joan A Geoghegan

  71. Clumping Factor A Interaction with Complement Factor I Increases C3b Cleavage on the Bacterial Surface of Staphylococcus aureus and Decreases Complement-Mediated Phagocytosis

    Article • Infection and Immunity, January 2010, ASM Journals

    Joan A Geoghegan

  72. Staphylococcus pseudintermedius expresses surface proteins that closely resemble those from Staphylococcus aureus

    Article • Veterinary Microbiology, September 2009, Elsevier

    Joan A Geoghegan, Pietro Speziale