All Stories

  1. Curated and Structure-Based Drug–Target Interactions Improve Underprediction of Drug Side Effects in Network Models
  2. Uncovering New Therapeutic Targets for Amyotrophic Lateral Sclerosis and Neurological Diseases Using Real‐World Data
  3. Learning good therapeutic targets in ALS, neurodegeneration, using observational studies
  4. Preclinical side effect prediction through pathway engineering of protein interaction network models
  5. Beta-2 adrenergic receptor agonism alters astrocyte phagocytic activity and has potential applications to psychiatric disease
  6. Beta-2 adrenergic receptor agonism alters astrocyte phagocytic activity and has potential applications to psychiatric disease
  7. A network paradigm predicts drug synergistic effects using downstream protein–protein interactions
  8. Controlling astrocyte-mediated synaptic pruning signals for schizophrenia drug repurposing with deep graph networks
  9. From random to predictive: a context-specific interaction framework improves selection of drug protein–protein interactions for unknown drug pathways
  10. Controlling astrocyte-mediated synaptic pruning signals for schizophrenia drug repurposing with Deep Graph Networks
  11. PhenClust, a standalone tool for identifying trends within sets of biological phenotypes using semantic similarity and the Unified Medical Language System metathesaurus
  12. From random to predictive: a context-specific interaction framework improves selection of drug protein-protein interactions for unknown drug pathways
  13. Scientific considerations for global drug development
  14. An in vitro quantitative systems pharmacology approach for deconvolving mechanisms of drug-induced, multilineage cytopenias
  15. An in vitro quantitative systems pharmacology approach for deconvolving mechanisms of drug-induced, multilineage cytopenias
  16. An Overview of Genomic Biomarker Use in Cardiovascular Disease Clinical Trials
  17. PathFXweb: a web application for identifying drug safety and efficacy phenotypes
  18. PathFX provides mechanistic insights into drug efficacy and safety for regulatory review and therapeutic development
  19. A scientist engineer’s contribution to therapeutic discovery and development
  20. Evaluating Angiogenic Potential of Small Molecules Using Genetic Network Approaches
  21. Biomarkers: Delivering on the expectation of molecularly driven, quantitative health
  22. Functional Genomics Approach Identifies Novel Signaling Regulators of TGFα Ectodomain Shedding
  23. Using network models to better understand novel genes affecting acute lymphoblastic leukemia.
  24. Integrated network analyses for functional genomic studies in cancer
  25. Harnessing Systems Biology Approaches to Engineer Functional Microvascular Networks