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  1. Interactomes of Glycogen Synthase Kinase-3 Isoforms

    Article • Journal of Proteome Research, February 2023, American Chemical Society (ACS)

    Dr James R Woodgett

  2. Cardiomyocyte‐GSK‐3β deficiency induces cardiac progenitor cell proliferation in the ischemic heart through paracrine mechanisms

    Article • Journal of Cellular Physiology, November 2021, Wiley

    Dr James R Woodgett

  3. GSK-3 mediates nuclear translocation of p62/SQSTM1 in MPTP-induced mouse model of Parkinson’s disease

    Article • Neuroscience Letters, October 2021, Elsevier

    Dr James R Woodgett

  4. Cardiomyocyte GSK-3β deficiency induces cardiac progenitor cell proliferation in the ischemic heart through paracrine mechanisms

    Article • August 2021, Cold Spring Harbor Laboratory Press

    Dr James R Woodgett

  5. Glycogen synthase kinase 3 alpha/beta deletion induces precocious growth plate remodeling in mice

    Article • Journal of Molecular Medicine, February 2021, Springer Science + Business Media

    Dr James R Woodgett

  6. Glycogen synthase kinase 3 alpha/beta deletion induces precocious growth plate remodeling and cell loss in mice

    Article • April 2020, Cold Spring Harbor Laboratory Press

    Dr James R Woodgett

  7. Molecular stratification within triple-negative breast cancer subtypes

    Article • Scientific Reports, December 2019, Springer Science + Business Media

    Dr James R Woodgett

  8. A Low-Therapeutic Dose of Lithium Inhibits GSK3 and Enhances Myoblast Fusion in C2C12 Cells

    Article • Cells, October 2019, MDPI AG

    Dr James R Woodgett

  9. Who Actually Funds Cancer Research?

    Article • JNCI Cancer Spectrum, October 2019, Oxford University Press (OUP)

    Dr James R Woodgett

  10. Regulation of thymocyte β-selection, development and positive selection by glycogen synthase kinase-3

    Article • July 2019, Cold Spring Harbor Laboratory Press

    Dr James R Woodgett

  11. Cardiomyocyte-GSK-3α promotes mPTP opening and heart failure in mice with chronic pressure overload

    Article • Journal of Molecular and Cellular Cardiology, May 2019, Elsevier

    Dr James R Woodgett

  12. Development of a drug repressible β-catenin mutant mouse to examine effect of activated β-catenin signaling on long-term maintenance of mammary tumor growth

    Article • March 2019, Cold Spring Harbor Laboratory Press

    Dr James R Woodgett

  13. A subgroup of microRNAs defines PTEN-deficient, triple-negative breast cancer patients with poorest prognosis and alterations in RB1, MYC, and Wnt signaling

    Article • January 2019, Springer Science + Business Media

    Dong-Yu Wang, Dr James R Woodgett

  14. Podocyte GSK3 is an evolutionarily conserved critical regulator of kidney function

    Article • Nature Communications, January 2019, Springer Science + Business Media

    Dr James R Woodgett

  15. Polypharmacological Profiles Underlying the Antitumor Property ofSalvia miltiorrhizaRoot (Danshen) Interfering with NOX-Dependent Neutrophil Extracellular Traps

    Article • Oxidative Medicine and Cellular Longevity, August 2018, Hindawi Publishing Corporation

    Dr James R Woodgett

  16. Identification of CDC25 as a Common Therapeutic Target for Triple-Negative Breast Cancer

    Article • Cell Reports, April 2018, Elsevier

    Dr James R Woodgett

  17. A Hematogenous Route for Medulloblastoma Leptomeningeal Metastases

    Article • Cell, February 2018, Elsevier

    Dr James R Woodgett

  18. Gimap5-dependent inactivation of GSK3β is required for CD4+ T cell homeostasis and prevention of immune pathology

    Article • Nature Communications, January 2018, Springer Science + Business Media

    Dr James R Woodgett

  19. Isoform-specific requirement for GSK3α in sperm for male fertility†

    Article • Biology of Reproduction, January 2018, Oxford University Press (OUP)

    Dr James R Woodgett

  20. Glycogen Synthase Kinase-3

    Article • January 2018, Springer Science + Business Media

    Dr James R Woodgett

  21. Glycogen Synthase Kinase-3 Modulates Cbl-b and Constrains T Cell Activation

    Article • The Journal of Immunology, December 2017, The American Association of Immunologists

    Dr James R Woodgett

  22. Correction of GSK3β at young age prevents muscle pathology in mice with myotonic dystrophy type 1

    Article • The FASEB Journal, December 2017, Federation of American Societies For Experimental Biology (FASEB)

    Dr James R Woodgett

  23. A review of new science in understanding the role of GSK-3 in coordination of signal transduction

    Article • F1000Research, February 2017, Faculty of 1000, Ltd.

    Dr Kevin W Cormier, Dr James R Woodgett

  24. Gsk3 is a metabolic checkpoint regulator in B cells

    Article • Nature Immunology, January 2017, Springer Science + Business Media

    Dr James R Woodgett

  25. A ZIP6-ZIP10 heteromer controls NCAM1 phosphorylation and integration into focal adhesion complexes during epithelial-to-mesenchymal transition

    Article • Scientific Reports, January 2017, Springer Science + Business Media

    Dr James R Woodgett

  26. Glycogen Synthase Kinase 3

    Article • January 2017, Elsevier

    Dr James R Woodgett

  27. Enabling the Next 25 Years of Cell Biology

    Article • Trends in Cell Biology, November 2016, Elsevier

    Dr James R Woodgett

  28. Xanthatin anti-tumor cytotoxicity is mediated via glycogen synthase kinase-3β and β-catenin

    Article • Biochemical Pharmacology, September 2016, Elsevier

    Dr James R Woodgett

  29. Nuclear GSK3β promotes tumorigenesis by phosphorylating KDM1A and inducing its deubiquitylation by USP22

    Article • Nature Cell Biology, August 2016, Springer Science + Business Media

    Dr James R Woodgett

  30. Protein Kinases: Physiological Roles in Cell Signalling

    Article • July 2016, Wiley

    Dr Kevin W Cormier, Dr James R Woodgett

  31. Loss of Adult Cardiac Myocyte GSK-3 Leads to Mitotic Catastrophe Resulting in Fatal Dilated Cardiomyopathy

    Article • Circulation Research, April 2016, Wolters Kluwer Health

    Dr James R Woodgett

  32. Mutational Analysis of Glycogen Synthase Kinase 3β Protein Kinase Together with Kinome-Wide Binding and Stability Studies Suggests Context-Dependent Recognition of Kinases by the Chaperone Heat Shock Protein 90

    Article • Molecular and Cellular Biology, March 2016, ASM Journals

    Dr James R Woodgett

  33. Ras Signaling Is a Key Determinant for Metastatic Dissemination and Poor Survival of Luminal Breast Cancer Patients

    Article • Cancer Research, November 2015, American Association for Cancer Research (AACR)

    Dr James R Woodgett

  34. Global Approaches to Understanding Protein Kinase Functions

    Article • September 2015, Wiley

    Dr James R Woodgett

  35. Fine-Tuning of the RIG-I-Like Receptor/Interferon Regulatory Factor 3-Dependent Antiviral Innate Immune Response by the Glycogen Synthase Kinase 3/β-Catenin Pathway

    Article • Molecular and Cellular Biology, June 2015, ASM Journals

    Dr James R Woodgett

  36. Glycogen synthase kinase-3β promotes cyst expansion in polycystic kidney disease

    Article • Kidney International, June 2015, Elsevier

    Dr James R Woodgett

  37. Glycogen synthase kinase 3α regulates urine concentrating mechanism in mice

    Article • AJP Renal Physiology, March 2015, American Physiological Society

    Dr James R Woodgett

  38. The GSK-3 Family as Therapeutic Target for Myocardial Diseases

    Article • Circulation Research, January 2015, Wolters Kluwer Health

    Dr James R Woodgett

  39. mTOR regulates brain morphogenesis by mediating GSK3 signaling

    Article • Development, November 2014, The Company of Biologists

    Dr James R Woodgett

  40. How to Become a Control FreakReview and commentary on Signal Transduction: Principles, Pathways, and Processes , edited by Lewis C. Cantley, Tony Hunter, Richard Sever,and Jeremy Thorner. Cold Spring Harbor Laboratory Pr...

    Article • Science Signaling, October 2014, American Association for the Advancement of Science

    Dr James R Woodgett

  41. Burning platforms: friending social media's role in #scicomm

    Article • Trends in Cell Biology, October 2014, Elsevier

    Dr James R Woodgett

  42. Effect of glycogen synthase kinase-3 inactivation on mouse mammary gland development and oncogenesis

    Article • Oncogene, September 2014, Springer Science + Business Media

    Dr James R Woodgett

  43. Cardiomyocyte-Specific Deletion of Gsk3α Mitigates Post–Myocardial Infarction Remodeling, Contractile Dysfunction, and Heart Failure

    Article • Journal of the American College of Cardiology, August 2014, Elsevier

    Dr James R Woodgett

  44. Cardiac Fibroblast Glycogen Synthase Kinase-3β Regulates Ventricular Remodeling and Dysfunction in Ischemic Heart

    Article • Circulation, July 2014, Wolters Kluwer Health

    Dr James R Woodgett

  45. Signals Controlling Un‐Differentiated States in Embryonic Stem and Cancer Cells: Role of the Phosphatidylinositol 3′ Kinase Pathway

    Article • Journal of Cellular Physiology, June 2014, Wiley

    Dr James R Woodgett

  46. Neuronal deletion of GSK3β increases microtubule speed in the growth cone and enhances axon regeneration via CRMP-2 and independently of MAP1B and CLASP2

    Article • BMC Biology, June 2014, Springer Science + Business Media

    Dr James R Woodgett

  47. Impact: Akin to quantifying dreams

    Article • Nature, November 2013, Springer Science + Business Media

    Dr James R Woodgett

  48. GSK-3β Function in Bone Regulates Skeletal Development, Whole-Body Metabolism, and Male Life Span

    Article • Endocrinology, October 2013, Endocrine Society

    Dr James R Woodgett

  49. The responses of neural stem cells to the level of GSK-3 depend on the tissue of origin

    Article • Biology Open, June 2013, The Company of Biologists

    Dr James R Woodgett

  50. Regulation of Th1 Cells and Experimental Autoimmune Encephalomyelitis by Glycogen Synthase Kinase-3

    Article • The Journal of Immunology, May 2013, The American Association of Immunologists

    Dr James R Woodgett

  51. Single Unpurified Breast Tumor-Initiating Cells from Multiple Mouse Models Efficiently Elicit Tumors in Immune-Competent Hosts

    Article • PLOS One, March 2013, PLOS

    Dr James R Woodgett

  52. GSK-3α is a central regulator of age-related pathologies in mice

    Article • Journal of Clinical Investigation, March 2013, American Society for Clinical Investigation

    Dr James R Woodgett

  53. Activation of PDK-1 maintains mouse embryonic stem cell self-renewal in a PKB-dependent manner

    Article • Oncogene, March 2013, Springer Science + Business Media

    Dr James R Woodgett

  54. Glycogen Synthase Kinase-3

    Article • January 2013, Elsevier

    Dr James R Woodgett

  55. Energy Metabolism | Glycogen Synthase Kinase-3

    Article • January 2013, Elsevier

    Dr James R Woodgett

  56. Inhibition of GSK3β-mediated BACE1 expression reduces Alzheimer-associated phenotypes

    Article • Journal of Clinical Investigation, December 2012, American Society for Clinical Investigation

    Dr James R Woodgett

  57. Thousand-citation papers are outliers

    Article • Nature, December 2012, Springer Science + Business Media

    Dr James R Woodgett

  58. GSK3β mediates muscle pathology in myotonic dystrophy

    Article • Journal of Clinical Investigation, November 2012, American Society for Clinical Investigation

    Dr James R Woodgett

  59. Inactivation of the Enzyme GSK3α by the Kinase IKKi Promotes AKT-mTOR Signaling Pathway that Mediates Interleukin-1-Induced Th17 Cell Maintenance

    Article • Immunity, November 2012, Elsevier

    Dr James R Woodgett

  60. Specific deletion of glycogen synthase kinase-3β in the renal proximal tubule protects against acute nephrotoxic injury in mice

    Article • Kidney International, November 2012, Elsevier

    Dr James R Woodgett

  61. We must be open about our mistakes

    Article • Nature, September 2012, Springer Science + Business Media

    Dr James R Woodgett

  62. The Effects of Glycogen Synthase Kinase-3beta in Serotonin Neurons

    Article • PLOS One, August 2012, PLOS

    Dr James R Woodgett

  63. GSK-3α and GSK-3β Proteins Are Involved in Early Stages of Chondrocyte Differentiation with Functional Redundancy through RelA Protein Phosphorylation

    Article • Journal of Biological Chemistry, August 2012, Elsevier

    Dr James R Woodgett

  64. Acute WNT signalling activation perturbs differentiation within the adult stomach and rapidly leads to tumour formation

    Article • Oncogene, June 2012, Springer Science + Business Media

    Dr James R Woodgett

  65. Can a Two-Faced Kinase be Exploited for Osteosarcoma?

    Article • JNCI Journal of the National Cancer Institute, April 2012, Oxford University Press (OUP)

    Dr James R Woodgett

  66. Towards the preparation of radiolabeled 1-aryl-3-benzyl ureas: Radiosynthesis of [11C-carbonyl] AR-A014418 by [11C]CO2 fixation

    Article • Bioorganic & Medicinal Chemistry Letters, March 2012, Elsevier

    Dr James R Woodgett

  67. Glycogen Synthase Kinase-3

    Article • January 2012, Springer Science + Business Media

    Dr James R Woodgett

  68. Glycogen Synthase Kinase-3 in Neurological Diseases

    Article • January 2012, Springer Science + Business Media

    Dr James R Woodgett

  69. Glycogen Synthase Kinase-3α Limits Ischemic Injury, Cardiac Rupture, Post–Myocardial Infarction Remodeling and Death

    Article • Circulation, January 2012, Wolters Kluwer Health

    Dr James R Woodgett

  70. Neurological Functions of the Masterswitch Protein Kinase – Gsk-3

    Article • Frontiers in Molecular Neuroscience, January 2012, Frontiers

    Dr James R Woodgett

  71. GSK-3α/β kinases and amyloid production in vivo

    Article • Nature, December 2011, Springer Science + Business Media

    Dr James R Woodgett

  72. Targeting GSK-3 family members in the heart: A very sharp double-edged sword

    Article • Journal of Molecular and Cellular Cardiology, October 2011, Elsevier

    Dr James R Woodgett

  73. Genetic inactivation of GSK3α rescues spine deficits in Disc1-L100P mutant mice

    Article • Schizophrenia Research, June 2011, Elsevier

    Dr James R Woodgett

  74. Deletion of Glycogen Synthase Kinase-3β in Cartilage Results in Up-Regulation of Glycogen Synthase Kinase-3α Protein Expression

    Article • Endocrinology, May 2011, Endocrine Society

    Dr James R Woodgett

  75. Selective loss of glycogen synthase kinase-3α in birds reveals distinct roles for GSK-3 isozymes in tau phosphorylation

    Article • FEBS Letters, March 2011, Wiley

    Dr James R Woodgett, Shmuel Pietrokovski

  76. Assessment of Social Interaction Behaviors

    Article • Journal of Visualized Experiments, February 2011, MyJove Corporation

    Dr James R Woodgett

  77. Tissue-Specific Analysis of Glycogen Synthase Kinase-3α (GSK-3α) in Glucose Metabolism: Effect of Strain Variation

    Article • PLOS One, January 2011, PLOS

    Dr James R Woodgett

  78. GSK-3: Functional Insights from Cell Biology and Animal Models

    Article • Frontiers in Molecular Neuroscience, January 2011, Frontiers

    Dr James R Woodgett

  79. Genetic and pharmacological evidence for schizophrenia-related Disc1 interaction with GSK-3

    Article • Synapse, December 2010, Wiley

    Dr James R Woodgett

  80. Inhibitory Phosphorylation of GSK-3 by CaMKII Couples Depolarization to Neuronal Survival

    Article • Journal of Biological Chemistry, December 2010, Elsevier

    Dr James R Woodgett

  81. Does GSK-3 provide a shortcut for PI3K activation of Wnt signalling?

    Article • F1000 Biology Reports, November 2010, F1000Research

    Dr James R Woodgett

  82. Conditional ablation of Gsk-3β in islet beta cells results in expanded mass and resistance to fat feeding-induced diabetes in mice

    Article • Diabetologia, September 2010, Springer Science + Business Media

    Dr James R Woodgett

  83. β-Catenin activation synergizes with PTEN loss to cause bladder cancer formation

    Article • Oncogene, September 2010, Springer Science + Business Media

    Dr James R Woodgett

  84. Basic research: bizarre but essential

    Article • Nature, September 2010, Springer Science + Business Media

    Dr James R Woodgett

  85. Role of Phosphoinositide 3-Kinase α, Protein Kinase C, and L-Type Ca 2+ Channels in Mediating the Complex Actions of Angiotensin II on Mouse Cardiac Contractility

    Article • Hypertension, September 2010, Wolters Kluwer Health

    Dr James R Woodgett

  86. Defining the role of APC in the mitotic spindle checkpoint in vivo: APC-deficient cells are resistant to Taxol

    Article • Oncogene, August 2010, Springer Science + Business Media

    Dr James R Woodgett

  87. GSK-3α directly regulates β-adrenergic signaling and the response of the heart to hemodynamic stress in mice

    Article • Journal of Clinical Investigation, July 2010, American Society for Clinical Investigation

    Dr James R Woodgett

  88. Glycogen Synthase Kinase-3β Regulates Post–Myocardial Infarction Remodeling and Stress-Induced Cardiomyocyte Proliferation In Vivo

    Article • Circulation Research, May 2010, Wolters Kluwer Health

    Dr James R Woodgett

  89. When pathways collide: collaboration and connivance among signalling proteins in development

    Article • Nature Reviews Molecular Cell Biology, May 2010, Springer Science + Business Media

    Dr James R Woodgett

  90. GSK3β Mediates Renal Response to Vasopressin by Modulating Adenylate Cyclase Activity

    Article • Journal of the American Society of Nephrology, March 2010, Wolters Kluwer Health

    Dr James R Woodgett

  91. Mitogen-Activated Protein Kinases

    Article • January 2010, Elsevier

    Dr James R Woodgett

  92. GSK-3 is a master regulator of neural progenitor homeostasis

    Article • Nature Neuroscience, October 2009, Springer Science + Business Media

    Dr James R Woodgett

  93. Akt1 and Akt2 Play Distinct Roles in the Initiation and Metastatic Phases of Mammary Tumor Progression

    Article • Cancer Research, June 2009, American Association for Cancer Research (AACR)

    Dr James R Woodgett

  94. Lef1 Haploinsufficient Mice Display a Low Turnover and Low Bone Mass Phenotype in a Gender- and Age-Specific Manner

    Article • PLOS One, May 2009, PLOS

    Dr James R Woodgett

  95. Unique and Overlapping Functions of GSK-3 Isoforms in Cell Differentiation and Proliferation and Cardiovascular Development

    Article • Journal of Biological Chemistry, April 2009, Elsevier

    Dr James R Woodgett

  96. IL-17 Receptor Signaling Inhibits C/EBPβ by Sequential Phosphorylation of the Regulatory 2 Domain

    Article • Science Signaling, February 2009, American Association for the Advancement of Science

    Dr James R Woodgett

  97. Exploring Pluripotency with Chemical Genetics

    Article • Cell Stem Cell, February 2009, Elsevier

    Dr James R Woodgett

  98. Abnormalities in brain structure and behavior in GSK-3alpha mutant mice

    Article • Molecular Brain, January 2009, Springer Science + Business Media

    Dr James R Woodgett, Tsuyoshi Miyakawa

  99. Deletion of GSK-3β in mice leads to hypertrophic cardiomyopathy secondary to cardiomyoblast hyperproliferation

    Article • Journal of Clinical Investigation, November 2008, American Society for Clinical Investigation

    Dr James R Woodgett

  100. Glycogen Synthase Kinase-3 and Cancer: Good Cop, Bad Cop?

    Article • Cancer Cell, November 2008, Elsevier

    Dr James R Woodgett

  101. Targeting glycogen synthase kinase-3 (GSK-3) in the treatment of Type 2 diabetes

    Article • Expert Opinion on Therapeutic Targets, September 2008, Informa Healthcare

    Dr James R Woodgett

  102. Tissue-Specific Role of Glycogen Synthase Kinase 3β in Glucose Homeostasis and Insulin Action

    Article • Molecular and Cellular Biology, August 2008, ASM Journals

    Dr James R Woodgett

  103. Micromanaging ideas risks impeding flow of potential benefits

    Article • Nature, August 2008, Springer Science + Business Media

    Dr James R Woodgett

  104. Phosphorylation of GSK-3β by cGMP-dependent protein kinase II promotes hypertrophic differentiation of murine chondrocytes

    Article • Journal of Clinical Investigation, August 2008, American Society for Clinical Investigation

    Dr James R Woodgett

  105. Glycogen synthase kinase-3β heterozygote knockout mice as a model of findings in postmortem schizophrenia brain or as a model of behaviors mimicking lithium action: negative results

    Article • Behavioural Pharmacology, May 2008, Wolters Kluwer Health

    Dr James R Woodgett

  106. Rationally designed PKA inhibitors for positron emission tomography: Synthesis and cerebral biodistribution of N-(2-(4-bromocinnamylamino)ethyl)-N-[11C]methyl-isoquinoline-5-sulfonamide

    Article • Bioorganic & Medicinal Chemistry, May 2008, Elsevier

    Dr James R Woodgett

  107. The ground state of embryonic stem cell self-renewal

    Article • Nature, May 2008, Springer Science + Business Media

    Dr James R Woodgett

  108. Utility of metformin in breast cancer treatment, is neoangiogenesis a risk factor?

    Article • Breast Cancer Research and Treatment, April 2008, Springer Science + Business Media

    Dr James R Woodgett

  109. Homozygous deletion of glycogen synthase kinase 3β bypasses senescence allowing Ras transformation of primary murine fibroblasts

    Article • Proceedings of the National Academy of Sciences, April 2008, Proceedings of the National Academy of Sciences

    Dr James R Woodgett

  110. Frequent accumulation of nuclear E-cadherin and alterations in the Wnt signaling pathway in esophageal squamous cell carcinomas

    Article • Modern Pathology, March 2008, Elsevier

    Dr James R Woodgett

  111. Genetic Deficiency of Glycogen Synthase Kinase-3β Corrects Diabetes in Mouse Models of Insulin Resistance

    Article • PLoS Biology, February 2008, PLOS

    Dr James R Woodgett

  112. Initiation of Wnt signaling: control of Wnt coreceptor Lrp6 phosphorylation/activation via frizzled, dishevelled and axin functions

    Article • Development, January 2008, The Company of Biologists

    Dr James R Woodgett

  113. Clinical Uses of Microarrays in Cancer Research

    Article • January 2008, Springer Science + Business Media

    Dr James R Woodgett

  114. Glycogen Synthase Kinase 3α-Specific Regulation of Murine Hepatic Glycogen Metabolism

    Article • Cell Metabolism, October 2007, Elsevier

    Dr James R Woodgett

  115. Glycogen Synthase Kinase-3β Induces Neuronal Cell Death via Direct Phosphorylation of Mixed Lineage Kinase 3

    Article • Journal of Biological Chemistry, October 2007, Elsevier

    Dr James R Woodgett

  116. GSK-3β Controls Osteogenesis through Regulating Runx2 Activity

    Article • PLOS One, September 2007, PLOS

    Dr James R Woodgett

  117. Functional Redundancy of GSK-3α and GSK-3β in Wnt/β-Catenin Signaling Shown by Using an Allelic Series of Embryonic Stem Cell Lines

    Article • Developmental Cell, June 2007, Elsevier

    Dr James R Woodgett

  118. Systematic Discovery of In Vivo Phosphorylation Networks

    Article • Cell, June 2007, Elsevier

    Dr James R Woodgett

  119. R-spondin1 Is a High Affinity Ligand for LRP6 and Induces LRP6 Phosphorylation and β-Catenin Signaling

    Article • Journal of Biological Chemistry, May 2007, Elsevier

    Dr James R Woodgett

  120. Glycogen synthase kinase 3, circadian rhythms, and bipolar disorder: a molecular link in the therapeutic action of lithium

    Article • Journal of Circadian Rhythms, February 2007, Ubiquity Press, Ltd.

    Dr James R Woodgett

  121. Role of Glycogen Synthase Kinase-3 in Cell Fate and Epithelial-Mesenchymal Transitions

    Article • Cells Tissues Organs, January 2007, Karger Publishers

    Dr James R Woodgett

  122. Essential Roles for GSK-3s and GSK-3-Primed Substrates in Neurotrophin-Induced and Hippocampal Axon Growth

    Article • Neuron, December 2006, Elsevier

    Dr James R Woodgett

  123. Functional distinctions of protein kinase B/Akt isoforms defined by their influence on cell migration

    Article • Trends in Cell Biology, September 2006, Elsevier

    Dr James R Woodgett

  124. Role of the Phox Homology Domain and Phosphorylation in Activation of Serum and Glucocorticoid-regulated Kinase-3

    Article • Journal of Biological Chemistry, August 2006, Elsevier

    Dr James R Woodgett

  125. IFN-γ Suppresses IL-10 Production and Synergizes with TLR2 by Regulating GSK3 and CREB/AP-1 Proteins

    Article • Immunity, May 2006, Elsevier

    Dr James R Woodgett

  126. Expression of Wnt-signaling pathway proteins in intraductal papillary mucinous neoplasms of the pancreas: a tissue microarray analysis

    Article • Human Pathology, February 2006, Elsevier

    Dr James R Woodgett

  127. Serum and glucocorticoid-regulated protein kinases: Variations on a theme

    Article • Journal of Cellular Biochemistry, January 2006, Wiley

    Dr James R Woodgett

  128. A dual-kinase mechanism for Wnt co-receptor phosphorylation and activation

    Article • Nature, December 2005, Springer Science + Business Media

    Dr James R Woodgett

  129. Differential gene expression profiling of short and long term denervated muscle

    Article • The FASEB Journal, November 2005, Wiley

    Dr James R Woodgett

  130. Modulating autoimmunity: pick your PI3 kinase

    Article • Nature Medicine, September 2005, Springer Science + Business Media

    Dr James R Woodgett

  131. GSK3: an in-Toll-erant protein kinase?

    Article • Nature Immunology, August 2005, Springer Science + Business Media

    Dr James R Woodgett

  132. Differential gene expression profile reveals deregulation of pregnancy specific β1 glycoprotein 9 early during colorectal carcinogenesis

    Article • BMC Cancer, June 2005, Springer Science + Business Media

    Dr James R Woodgett

  133. Chronic activation of protein kinase Bβ/Akt2 leads to multinucleation and cell fusion in human epithelial kidney cells: events associated with tumorigenesis

    Article • Oncogene, June 2005, Springer Science + Business Media

    Dr James R Woodgett

  134. CpG Island microarray probe sequences derived from a physical library are representative of CpG Islands annotated on the human genome

    Article • Nucleic Acids Research, May 2005, Oxford University Press (OUP)

    Dr James R Woodgett

  135. Cardioprotective stress response in the human fetal heart

    Article • Journal of Thoracic and Cardiovascular Surgery, May 2005, Elsevier

    Dr James R Woodgett

  136. Recent advances in the protein kinase B signaling pathway

    Article • Current Opinion in Cell Biology, April 2005, Elsevier

    Dr James R Woodgett

  137. Phosphoinositide-Dependent Phosphorylation of PDK1 Regulates Nuclear Translocation

    Article • Molecular and Cellular Biology, March 2005, ASM Journals

    Dr James R Woodgett

  138. The links between axin and carcinogenesis

    Article • Journal of Clinical Pathology, March 2005, BMJ

    Dr James R Woodgett

  139. Glycogen Synthase Kinase 3β Is a Negative Regulator of Growth Factor-induced Activation of the c-Jun N-terminal Kinase

    Article • Journal of Biological Chemistry, December 2004, Elsevier

    Dr James R Woodgett

  140. Glycogen synthase kinase-3 in insulin and Wnt signalling: a double-edged sword?

    Article • Biochemical Society Transactions, October 2004, Portland Press Ltd.

    Dr James R Woodgett

  141. Proteomic, Functional, and Domain-Based Analysis of In Vivo 14-3-3 Binding Proteins Involved in Cytoskeletal Regulation and Cellular Organization

    Article • Current Biology, August 2004, Elsevier

    Dr James R Woodgett

  142. Glycogen Synthase Kinase-3β Haploinsufficiency Mimics the Behavioral and Molecular Effects of Lithium

    Article • Journal of Neuroscience, July 2004, Society for Neuroscience

    Dr James R Woodgett

  143. Activation of Akt-1 (PKB-α) Can Accelerate ErbB-2-Mediated Mammary Tumorigenesis but Suppresses Tumor Invasion

    Article • Cancer Research, May 2004, American Association for Cancer Research (AACR)

    Dr James R Woodgett

  144. Lithium antagonizes dopamine-dependent behaviors mediated by an AKT/glycogen synthase kinase 3 signaling cascade

    Article • Proceedings of the National Academy of Sciences, March 2004, Proceedings of the National Academy of Sciences

    Dr James R Woodgett

  145. Glycogen Synthase Kinase-3

    Article • January 2004, Elsevier

    Dr James R Woodgett

  146. Kinase-dead PKB gene therapy combined with hyperthermia for human breast cancer

    Article • Cancer Gene Therapy, December 2003, Springer Science + Business Media

    Dr James R Woodgett

  147. Unravelling the activation mechanisms of protein kinase B/Akt

    Article • FEBS Letters, May 2003, Wiley

    Dr James R Woodgett

  148. Mental plaque removal

    Article • Nature, May 2003, Springer Science + Business Media

    Dr James R Woodgett

  149. GSK-3: tricks of the trade for a multi-tasking kinase

    Article • Journal of Cell Science, April 2003, The Company of Biologists

    Dr James R Woodgett

  150. Jnk1 activity lowers the cellular production of H2O2 and modulates the growth arrest response to scavenging of H2O2 by catalase

    Article • Experimental Cell Research, April 2003, Elsevier

    Dr James R Woodgett

  151. Stabilization of β-catenin by a Wnt-independent mechanism regulates cardiomyocyte growth

    Article • Proceedings of the National Academy of Sciences, March 2003, Proceedings of the National Academy of Sciences

    Dr James R Woodgett

  152. Negative Regulation of Mixed Lineage Kinase 3 by Protein Kinase B/AKT Leads to Cell Survival

    Article • Journal of Biological Chemistry, February 2003, Elsevier

    Dr James R Woodgett

  153. Negative regulation of phosphatidylinositol 3-kinase and Akt signalling pathway by PKC

    Article • Cellular Signalling, January 2003, Elsevier

    Dr James R Woodgett

  154. MAP Kinases

    Article • January 2003, Elsevier

    Dr James R Woodgett

  155. Open Heart Surgery of PI-3 Kinase Signaling

    Article • Cell Cycle, November 2002, Taylor & Francis

    Dr James R Woodgett

  156. A molecular compendium of genes expressed in multiple myeloma

    Article • Blood, September 2002, American Society of Hematology

    Dr James R Woodgett

  157. Multiple Phosphoinositide 3-Kinase-Dependent Steps in Activation of Protein Kinase B

    Article • Molecular and Cellular Biology, September 2002, ASM Journals

    Dr James R Woodgett

  158. CD28-dependent Activation of Protein Kinase B/Akt Blocks Fas-mediated Apoptosis by Preventing Death-inducing Signaling Complex Assembly

    Article • Journal of Experimental Medicine, August 2002, Rockefeller University Press

    Dr James R Woodgett

  159. Convergence of Multiple Signaling Cascades at Glycogen Synthase Kinase 3: Edg Receptor-Mediated Phosphorylation and Inactivation by Lysophosphatidic Acid through a Protein Kinase C-Dependent Intracellular Pathway

    Article • Molecular and Cellular Biology, April 2002, ASM Journals

    Dr James R Woodgett

  160. The active form of glycogen synthase kinase-3? is associated with granulovacuolar degeneration in neurons in Alzheimer's disease

    Article • Acta Neuropathologica, February 2002, Springer Science + Business Media

    Dr James R Woodgett

  161. DREAM Is a Critical Transcriptional Repressor for Pain Modulation

    Article • Cell, January 2002, Elsevier

    Dr James R Woodgett

  162. Role of glycogen synthase kinase-3 in cancer: Regulation by Wnts and other signaling pathways

    Article • January 2002, Elsevier

    Dr James R Woodgett

  163. PTEN--Coupling Tumor Suppression to Stem Cells?

    Article • Science, December 2001, American Association for the Advancement of Science

    Dr James R Woodgett

  164. Regulation of Drosophila Tracheal System Development by Protein Kinase B

    Article • Developmental Cell, December 2001, Elsevier

    Dr James R Woodgett

  165. PKB/AKT: functional insights from genetic models

    Article • Nature Reviews Molecular Cell Biology, October 2001, Springer Science + Business Media

    Dr James R Woodgett

  166. Judging a Protein by More Than Its Name: GSK-3

    Article • Science Signaling, September 2001, American Association for the Advancement of Science

    Dr James R Woodgett

  167. Glycogen Synthase Kinase-3:  Properties, Functions, and Regulation

    Article • Chemical Reviews, August 2001, American Chemical Society (ACS)

    Dr James R Woodgett

  168. The role of protein kinase B (PKB) in modulating heat sensitivity in a human breast cancer cell line

    Article • International Journal of Radiation Oncology*Biology*Physics, July 2001, Elsevier

    Dr James R Woodgett

  169. Protein Kinases: Physiological Roles

    Article • April 2001, Wiley

    Dr James R Woodgett

  170. Extracellular matrix composition determines the transcriptional response to epidermal growth factor receptor activation

    Article • Proceedings of the National Academy of Sciences, April 2001, Proceedings of the National Academy of Sciences

    Dr James R Woodgett

  171. Activation of Akt (Protein Kinase B) in Mammary Epithelium Provides a Critical Cell Survival Signal Required for Tumor Progression

    Article • Molecular and Cellular Biology, March 2001, ASM Journals

    Dr James R Woodgett

  172. Opposing regulation of B cell receptor-induced activation of mitogen-activated protein kinases by CD45

    Article • FEBS Letters, February 2001, Wiley

    Dr James R Woodgett

  173. Chapter 13 Mitogen-activated protein kinases and stress

    Article • January 2001, Elsevier

    Dr James R Woodgett

  174. Article • Journal of Mammary Gland Biology and Neoplasia, January 2001, Springer Science + Business Media

    Dr James R Woodgett

  175. Phosphorylation and inactivation of glycogen synthase kinase 3 by protein kinase A

    Article • Proceedings of the National Academy of Sciences, October 2000, Proceedings of the National Academy of Sciences

    Dr James R Woodgett

  176. Glycogen Synthase Kinase-3β Is a Negative Regulator of Cardiomyocyte Hypertrophy

    Article • Journal of Cell Biology, October 2000, Rockefeller University Press

    Dr James R Woodgett

  177. Protein Kinase Functions

    Article • August 2000, Oxford University Press (OUP)

    Dr James R Woodgett

  178. Negative Regulation of T Cell Proliferation and Interleukin 2 Production by the Serine Threonine Kinase Gsk-3

    Article • Journal of Experimental Medicine, July 2000, Rockefeller University Press

    Dr James R Woodgett

  179. Requirement for glycogen synthase kinase-3β in cell survival and NF-κB activation

    Article • Nature, July 2000, Springer Science + Business Media

    Dr James R Woodgett

  180. Protein Kinase B Regulates T Lymphocyte Survival, Nuclear Factor κb Activation, and Bcl-XL Levels in Vivo

    Article • Journal of Experimental Medicine, May 2000, Rockefeller University Press

    Dr James R Woodgett

  181. Protein kinases: Six degrees of separation?

    Article • Current Biology, March 2000, Elsevier

    Dr James R Woodgett

  182. Mediation of TNF receptor-associated factor effector functions by apoptosis signal-regulating kinase-1 (ASK1)

    Article • Oncogene, October 1999, Springer Science + Business Media

    Dr James R Woodgett

  183. The stress-activated protein kinase pathways

    Article • Cellular and Molecular Life Sciences, August 1999, Springer Science + Business Media

    Dr James R Woodgett

  184. Regulation of the Protein Kinase Activity of ShaggyZeste-white3 by Components of the Wingless Pathway in Drosophila Cells and Embryos

    Article • Journal of Biological Chemistry, July 1999, Elsevier

    Dr James R Woodgett

  185. Bcl-2 targeted to the endoplasmic reticulum can inhibit apoptosis induced by Myc but not etoposide in Rat-1 fibroblasts

    Article • Oncogene, June 1999, Springer Science + Business Media

    Dr James R Woodgett

  186. Presenilin mutations associated with Alzheimer disease cause defective intracellular trafficking of β-catenin,a component of the presenilin protein complex

    Article • Nature Medicine, February 1999, Springer Science + Business Media

    Dr James R Woodgett

  187. Protein kinase B (c-Akt): a multifunctional mediator of phosphatidylinositol 3-kinase activation

    Article • Biochemical Journal, October 1998, Portland Press Ltd.

    Dr James R Woodgett

  188. Phosphoinositide-3-OH kinase-dependent regulation of glycogen synthase kinase 3 and protein kinase B/AKT by the integrin-linked kinase

    Article • Proceedings of the National Academy of Sciences, September 1998, Proceedings of the National Academy of Sciences

    Dr James R Woodgett

  189. Activation of Stress-activated Protein Kinases/c-Jun N-terminal Protein Kinases (SAPKs/JNKs) by a Novel Mitogen-activated Protein Kinase Kinase (MKK7)

    Article • Journal of Biological Chemistry, December 1997, Elsevier

    Dr James R Woodgett

  190. Opioid Effects on Mitogen-activated Protein Kinase Signaling Cascades 

    Article • Anesthesiology, November 1997, Wolters Kluwer Health

    Dr James R Woodgett

  191. Impaired CD28-mediated Interleukin 2 Production and Proliferation in Stress Kinase SAPK/ERK1 Kinase (SEK1)/Mitogen-activated Protein Kinase Kinase 4 (MKK4)-deficient T Lymphocytes

    Article • Journal of Experimental Medicine, September 1997, Rockefeller University Press

    Dr James R Woodgett

  192. Chromosomal mapping and mutational analysis of the coding region of the glycogen synthase kinase-3α and β isoforms in patients with NIDDM

    Article • Diabetologia, July 1997, Springer Science + Business Media

    Dr James R Woodgett

  193. Cytosolic Alkalinization Increases Stress-activated Protein Kinase/c-Jun NH2-terminal Kinase (SAPK/JNK) Activity and p38 Mitogen-activated Protein Kinase Activity by a Calcium-independent Mechanism

    Article • Journal of Biological Chemistry, May 1997, Elsevier

    Dr James R Woodgett

  194. Activation of SAPK/JNK by TNF Receptor 1 Through a Noncytotoxic TRAF2-Dependent Pathway

    Article • Science, January 1997, American Association for the Advancement of Science

    Dr James R Woodgett

  195. Stress-signalling kinase Sek1 protects thymocytes from apoptosis mediated by CD95 and CD3

    Article • Nature, January 1997, Springer Science + Business Media

    Dr James R Woodgett

  196. Creating a home page

    Article • Trends in Biochemical Sciences, January 1997, Elsevier

    Dr James R Woodgett

  197. Lithium inhibits glycogen synthase kinase-3 activity and mimics Wingless signalling in intact cells

    Article • Current Biology, December 1996, Elsevier

    Dr James R Woodgett

  198. Mammalian Mitogen-activated Protein Kinase Pathways Are Regulated through Formation of Specific Kinase-Activator Complexes

    Article • Journal of Biological Chemistry, November 1996, Elsevier

    Dr James R Woodgett

  199. CD28 signal transduction pathways. A comparison of B7-1 and B7-2 regulation of the MAP kinases: ERK2 and Jun kinases

    Article • Molecular Immunology, January 1996, Elsevier

    Dr Jacques A NUNES, Dr James R Woodgett

  200. Overexpressed tau protein in cultured cells is phosphorylated without formation of PHF: implication of phosphoprotein phosphatase involvement

    Article • Molecular Brain Research, December 1995, Elsevier

    Dr James R Woodgett

  201. The Stress-activated Protein Kinases.

    Article • Annals of the New York Academy of Sciences, September 1995, Wiley

    Dr James R Woodgett

  202. Ionizing Radiation Stimulates a Grb2-mediated Association of the Stress-activated Protein Kinase with Phosphatidylinositol 3-Kinase

    Article • Journal of Biological Chemistry, August 1995, Elsevier

    Dr James R Woodgett

  203. Stimulation of MAP kinase by v-raftransformation of fibroblasts fails to induce hyperphosphorylation of transfected tau

    Article • FEBS Letters, May 1995, Wiley

    Dr James R Woodgett

  204. Modulation of PHF-like tau phosphorylation in cultured neurones and transfected cells

    Article • Neurobiology of Aging, May 1995, Elsevier

    Dr James R Woodgett

  205. GSK3

    Article • January 1995, Elsevier

    Dr James R Woodgett

  206. Mitogen inactivation of glycogen synthase kinase-3β in intact cells via serine 9 phosphorylation

    Article • Biochemical Journal, November 1994, Portland Press Ltd.

    Dr James R Woodgett

  207. PHF-tau from Alzheimer's brain comprises four species on SDS-PAGE which can be mimicked by in vitro phosphorylation of human brain tau by glycogen synthase kinase-3β

    Article • FEBS Letters, August 1994, Wiley

    Dr James R Woodgett

  208. The stress-activated protein kinase subfamily of c-Jun kinases

    Article • Nature, May 1994, Springer Science + Business Media

    Dr James R Woodgett

  209. Differential Subcellular Localization of Two Isoforms of p70 S6 Protein Kinase

    Article • Biochemical and Biophysical Research Communications, January 1994, Elsevier

    Dr James R Woodgett

  210. A Saccharomyces cerevisiae protein-serine kinase related to mammalian glycogen synthase kinase-3 and the Drosophila melanogaster gene shaggy product

    Article • Gene, November 1993, Elsevier

    Dr James R Woodgett

  211. A kinase with Ku-dos

    Article • Current Biology, July 1993, Elsevier

    Dr James R Woodgett

  212. Glycogen synthase kinase-3: functions in oncogenesis and development

    Article • Biochimica et Biophysica Acta (BBA) - Reviews on Cancer, December 1992, Elsevier

    Dr James R Woodgett

  213. Glycogen synthase kinase-3 induces Alzheimer's disease-like phosphorylation of tau: Generation of paired helical filament epitopes and neuronal localisation of the kinase

    Article • Neuroscience Letters, November 1992, Elsevier

    Dr James R Woodgett

  214. Analysis of protein phosphorylation in cell lines

    Article • August 1992, Oxford University Press (OUP)

    Dr James R Woodgett

  215. Phorbol ester-induced amino-terminal phosphorylation of human JUN but not JUNB regulates transcriptional activation.

    Article • Proceedings of the National Academy of Sciences, August 1992, Proceedings of the National Academy of Sciences

    Dr James R Woodgett

  216. Finding the stepping stones downstream of ras

    Article • Current Biology, July 1992, Elsevier

    Dr James R Woodgett

  217. Phosphorylation of c-jun mediated by MAP kinases

    Article • Nature, October 1991, Springer Science + Business Media

    Dr James R Woodgett

  218. Powering the cell cycle

    Article • Current Biology, April 1991, Elsevier

    Dr James R Woodgett

  219. trking neurotrophic receptors

    Article • Nature, April 1991, Springer Science + Business Media

    Dr James R Woodgett

  220. Activation of protein kinase C decreases phosphorylation of c-Jun at sites that negatively regulate its DNA-binding activity

    Article • Cell, February 1991, Elsevier

    Dr James R Woodgett

  221. Phosphorylation of pp60c-src

    Article • January 1991, Elsevier

    Dr James R Woodgett

  222. Studies on the primary sequence requirements for PKC-α, -β1and -γ peptide substrates

    Article • FEBS Letters, December 1990, Wiley

    Dr James R Woodgett

  223. Use of peptide substrates for affinity purification of protein-serine kinases

    Article • Analytical Biochemistry, August 1989, Elsevier

    Dr James R Woodgett

  224. Early gene induction by growh factors

    Article • British Medical Bulletin, January 1989, Oxford University Press (OUP)

    Dr James R Woodgett

  225. Protein Kinase C and its Role in Cell Growth

    Article • January 1987, Springer Science + Business Media

    Dr James R Woodgett

  226. Selective effects of CAPP1-calmodulin on its target proteins

    Article • Biochimica et Biophysica Acta (BBA) - Molecular Cell Research, June 1985, Elsevier

    Dr James R Woodgett

  227. Characterization of the sites phosphorylated on tyrosine hydroxylase by Ca2+and phospholipid-dependent protein kinase, calmodulin-dependent multiprotein kinase and cyclic AMP-dependent protein kinase

    Article • FEBS Letters, March 1985, Wiley

    Dr James R Woodgett

  228. Multisite phosphorylation of glycogen synthase

    Article • Biochimica et Biophysica Acta (BBA) - Protein Structure and Molecular Enzymology, August 1984, Elsevier

    Dr James R Woodgett

  229. Comparison of calmodulin-dependent glycogen synthase kinase from skeletal muscle and calmodulin-dependent protein kinase-II from brain

    Article • FEBS Letters, May 1984, Wiley

    Dr James R Woodgett

  230. A multifunctional calmodulin-dependent protein kinase

    Article • FEBS Letters, November 1983, Wiley

    Dr James R Woodgett

  231. Evidence that amiloride antagonises insulin-stimulated protein phosphorylation by inhibiting protein kinase activity

    Article • FEBS Letters, April 1983, Wiley

    Dr James R Woodgett

  232. Identification of a calmodulin-dependent glycogen synthase kinase in rabbit skeletal muscle, distinct from phosphorylase kinase

    Article • FEBS Letters, November 1982, Wiley

    Dr James R Woodgett

  233. Cell Survival Signaling through Phosphoinositide 3-kinase and Protein Kinase B

    Article • Wiley

    Dr James R Woodgett