All Stories

  1. Five decades of cancer research in Jordan: A thematic mapping of clinical, translational, and emerging technological trends (1974–2024)
  2. Elevated Circulating Follistatin Is Associated With Diabetic Status and Glycemic Dysregulation in Patients With β‐Thalassemia Major
  3. Distinct Cardiometabolic Profiles for Overweight/Obese People with Different Haptoglobin Phenotypes: A Cross-Sectional Study
  4. Impact of PPP1R1A Knockdown on the Proteomic Landscape of INS-1 Cells: A Focus on Significant Modulated Pathways
  5. Vitamin D augments insulin secretion via calcium influx and upregulation of voltage calcium channels: Findings from INS-1 cells and human islets
  6. The Aryl Hydrocarbon Receptor (AhR) Is a Novel Gene Involved in Proper Physiological Functions of Pancreatic β-Cells
  7. Unraveling the Interplay of Autophagy Genes and KLF3/KLF8 in Colorectal Cancer Metastasis: A Bioinformatics and cellular Exploration
  8. Investigating the Impact of IL6 on Insulin Secretion: Evidence from INS-1 Cells, Human Pancreatic Islets, and Serum Analysis
  9. Preservation of β-Cells as a Therapeutic Strategy for Diabetes
  10. Targeting Hypoxia-Inducible Factor-1 (HIF-1) in Cancer: Emerging Therapeutic Strategies and Pathway Regulation
  11. β-Thalassemia and Diabetes Mellitus: Current State and Future Directions
  12. Disrupting of family with sequence similarity 105, member A (Fam105a) deteriorates pancreatic β-cell physiology and insulin secretion in INS-1 cells
  13. Dual Role of Mitogen-Activated Protein Kinase 8 Interacting Protein-1 in Inflammasome and Pancreatic β-Cell Function
  14. Expression Silencing of Mitogen-Activated Protein Kinase 8 Interacting Protein-1 Conferred Its Role in Pancreatic β-Cell Physiology and Insulin Secretion
  15. GDF15plays a critical role in insulin secretion in INS-1 cells and human pancreatic islets
  16. Reduced Retinoic Acid Receptor Beta (Rarβ) Affects Pancreatic β-Cell Physiology
  17. Profiling Levels of Serum microRNAs and Soluble ACE2 in COVID-19 Patients
  18. Carnosic Acid Protects INS-1 β-Cells against Streptozotocin-Induced Damage by Inhibiting Apoptosis and Improving Insulin Secretion and Glucose Uptake
  19. EXOC6 (Exocyst Complex Component 6) Is Associated with the Risk of Type 2 Diabetes and Pancreatic β-Cell Dysfunction
  20. Heme Oxygenase-1 (HMOX-1) and inhibitor of differentiation proteins (ID1, ID3) are key response mechanisms against iron-overload in pancreatic β-cells
  21. The Coffee Diterpene, Kahweol, Ameliorates Pancreatic β-Cell Function in Streptozotocin (STZ)-Treated Rat INS-1 Cells through NF-kB and p-AKT/Bcl-2 Pathways
  22. Expression of SARS-CoV-2 receptor “ACE2” in human pancreatic β cells: to be or not to be!
  23. Carnosic Acid Induces Apoptosis and Inhibits Akt/mTOR Signaling in Human Gastric Cancer Cell Lines
  24. Expression Profile of SARS-CoV-2 Host Receptors in Human Pancreatic Islets Revealed Upregulation of ACE2 in Diabetic Donors
  25. Genetic Variants of the PLCXD3 Gene Are Associated with Risk of Metabolic Syndrome in the Emirati Population
  26. An Integrative Phenotype–Genotype Approach Using Phenotypic Characteristics from the UAE National Diabetes Study Identifies HSD17B12 as a Candidate Gene for Obesity and Type 2 Diabetes
  27. Estrogen Signaling Induces Mitochondrial Dysfunction-Associated Autophagy and Senescence in Breast Cancer Cells
  28. Orphan G-protein coupled receptor 183 (GPR183) potentiates insulin secretion and prevents glucotoxicity-induced β-cell dysfunction
  29. Prediabetes and diabetes prevalence and risk factors comparison between ethnic groups in the United Arab Emirates
  30. Reduced Expression of PLCXD3 Associates With Disruption of Glucose Sensing and Insulin Signaling in Pancreatic β-Cells
  31. Potential role of hypothalamic microRNAs in regulation of FOS and FTO expression in response to hypoglycemia
  32. Reduced Expression of Chl1 gene Impairs Insulin Secretion by Down-Regulating the Expression of Key Molecules of β-cell ...
  33. GNAS gene is an important regulator of insulin secretory capacity in pancreatic β-cells
  34. Dimethyloxalylglycine (DMOG) and the Caspase Inhibitor “Ac-LETD-CHO” Protect Neuronal ND7/23 Cells of Gluocotoxicity
  35. The Case for an Estrogen-iron Axis in Health and Disease
  36. RORB and RORC associate with human islet dysfunction and inhibit insulin secretion in INS-1 cells
  37. Silencing of the FTO gene inhibits insulin secretion: An in vitro study using GRINCH cells
  38. Maturity-Onset Diabetes of the Young: An Overview with Focus on the Middle East
  39. Identification of novel genes for glucose metabolism based upon expression pattern in human islets and effect on insulin secretion and glycemia
  40. Global genomic and transcriptomic analysis of human pancreatic islets reveals novel genes influencing glucose metabolism
  41. A Central Role for GRB10 in Regulation of Islet Function in Man
  42. Downregulation of Type II Diabetes Mellitus and Maturity Onset Diabetes of Young Pathways in Human Pancreatic Islets from Hyperglycemic Donors
  43. Autoimmunity against INS-IGF2 Protein Expressed in Human Pancreatic Islets
  44. Expression profiling of cell cycle genes in human pancreatic islets with and without type 2 diabetes
  45. Effects of Common Genetic Variants Associated With Type 2 Diabetes and Glycemic Traits on α- and β-Cell Function and Insulin Action in Humans
  46. Reduced insulin secretion correlates with decreased expression of exocytotic genes in pancreatic islets from patients with type 2 diabetes
  47. Secreted Frizzled-Related Protein 4 Reduces Insulin Secretion and Is Overexpressed in Type 2 Diabetes
  48. A Systems Genetics Approach Identifies Genes and Pathways for Type 2 Diabetes in Human Islets
  49. Erratum
  50. γ-Aminobutyric acid (GABA) signalling in human pancreatic islets is altered in type 2 diabetes
  51. Decreased expression of genes involved in oxidative phosphorylation in human pancreatic islets from patients with type 2 diabetes
  52. A common variant upstream of the PAX6 gene influences islet function in man
  53. Genome-Wide Association Identifies Nine Common Variants Associated With Fasting Proinsulin Levels and Provides New Insights Into the Pathophysiology of Type 2 Diabetes
  54. Pleiotropic Effects of GIP on Islet Function Involve Osteopontin
  55. A Common Variant in TFB1M Is Associated with Reduced Insulin Secretion and Increased Future Risk of Type 2 Diabetes
  56. Insulin promoter DNA methylation correlates negatively with insulin gene expression and positively with HbA1c levels in human pancreatic islets
  57. Genetic variation in GIPR influences the glucose and insulin responses to an oral glucose challenge
  58. Enhancement of glucagon secretion in mouse and human pancreatic alpha cells by protein kinase C (PKC) involves intracellular trafficking of PKCα and PKCδ
  59. Tight Coupling between Glucose and Mitochondrial Metabolism in Clonal β-Cells Is Required for Robust Insulin Secretion
  60. A Variant in the KCNQ1 Gene Predicts Future Type 2 Diabetes and Mediates Impaired Insulin Secretion
  61. Long‐term accumulation of microglia with proneurogenic phenotype concomitant with persistent neurogenesis in adult subventricular zone after stroke
  62. Failure of Transplanted Bone Marrow Cells to Adopt a Pancreatic  -Cell Fate
  63. Bone marrow–derived hematopoietic cells generate cardiomyocytes at a low frequency through cell fusion, but not transdifferentiation
  64. Letters to the Editor