All Stories

  1. Distinct Cardiometabolic Profiles for Overweight/Obese People with Different Haptoglobin Phenotypes: A Cross-Sectional Study
  2. Impact of PPP1R1A Knockdown on the Proteomic Landscape of INS-1 Cells: A Focus on Significant Modulated Pathways
  3. Vitamin D augments insulin secretion via calcium influx and upregulation of voltage calcium channels: Findings from INS-1 cells and human islets
  4. The Aryl Hydrocarbon Receptor (AhR) Is a Novel Gene Involved in Proper Physiological Functions of Pancreatic β-Cells
  5. Unraveling the Interplay of Autophagy Genes and KLF3/KLF8 in Colorectal Cancer Metastasis: A Bioinformatics and cellular Exploration
  6. Investigating the Impact of IL6 on Insulin Secretion: Evidence from INS-1 Cells, Human Pancreatic Islets, and Serum Analysis
  7. Preservation of β-Cells as a Therapeutic Strategy for Diabetes
  8. Targeting Hypoxia-Inducible Factor-1 (HIF-1) in Cancer: Emerging Therapeutic Strategies and Pathway Regulation
  9. β-Thalassemia and Diabetes Mellitus: Current State and Future Directions
  10. Disrupting of family with sequence similarity 105, member A (Fam105a) deteriorates pancreatic β-cell physiology and insulin secretion in INS-1 cells
  11. Dual Role of Mitogen-Activated Protein Kinase 8 Interacting Protein-1 in Inflammasome and Pancreatic β-Cell Function
  12. Expression Silencing of Mitogen-Activated Protein Kinase 8 Interacting Protein-1 Conferred Its Role in Pancreatic β-Cell Physiology and Insulin Secretion
  13. GDF15plays a critical role in insulin secretion in INS-1 cells and human pancreatic islets
  14. Reduced Retinoic Acid Receptor Beta (Rarβ) Affects Pancreatic β-Cell Physiology
  15. Profiling Levels of Serum microRNAs and Soluble ACE2 in COVID-19 Patients
  16. Carnosic Acid Protects INS-1 β-Cells against Streptozotocin-Induced Damage by Inhibiting Apoptosis and Improving Insulin Secretion and Glucose Uptake
  17. EXOC6 (Exocyst Complex Component 6) Is Associated with the Risk of Type 2 Diabetes and Pancreatic β-Cell Dysfunction
  18. Heme Oxygenase-1 (HMOX-1) and inhibitor of differentiation proteins (ID1, ID3) are key response mechanisms against iron-overload in pancreatic β-cells
  19. The Coffee Diterpene, Kahweol, Ameliorates Pancreatic β-Cell Function in Streptozotocin (STZ)-Treated Rat INS-1 Cells through NF-kB and p-AKT/Bcl-2 Pathways
  20. Expression of SARS-CoV-2 receptor “ACE2” in human pancreatic β cells: to be or not to be!
  21. Carnosic Acid Induces Apoptosis and Inhibits Akt/mTOR Signaling in Human Gastric Cancer Cell Lines
  22. Expression Profile of SARS-CoV-2 Host Receptors in Human Pancreatic Islets Revealed Upregulation of ACE2 in Diabetic Donors
  23. Genetic Variants of the PLCXD3 Gene Are Associated with Risk of Metabolic Syndrome in the Emirati Population
  24. An Integrative Phenotype–Genotype Approach Using Phenotypic Characteristics from the UAE National Diabetes Study Identifies HSD17B12 as a Candidate Gene for Obesity and Type 2 Diabetes
  25. Estrogen Signaling Induces Mitochondrial Dysfunction-Associated Autophagy and Senescence in Breast Cancer Cells
  26. Orphan G-protein coupled receptor 183 (GPR183) potentiates insulin secretion and prevents glucotoxicity-induced β-cell dysfunction
  27. Prediabetes and diabetes prevalence and risk factors comparison between ethnic groups in the United Arab Emirates
  28. Reduced Expression of PLCXD3 Associates With Disruption of Glucose Sensing and Insulin Signaling in Pancreatic β-Cells
  29. Potential role of hypothalamic microRNAs in regulation of FOS and FTO expression in response to hypoglycemia
  30. Reduced Expression of Chl1 gene Impairs Insulin Secretion by Down-Regulating the Expression of Key Molecules of β-cell ...
  31. GNAS gene is an important regulator of insulin secretory capacity in pancreatic β-cells
  32. Dimethyloxalylglycine (DMOG) and the Caspase Inhibitor “Ac-LETD-CHO” Protect Neuronal ND7/23 Cells of Gluocotoxicity
  33. The Case for an Estrogen-iron Axis in Health and Disease
  34. RORB and RORC associate with human islet dysfunction and inhibit insulin secretion in INS-1 cells
  35. Silencing of the FTO gene inhibits insulin secretion: An in vitro study using GRINCH cells
  36. Maturity-Onset Diabetes of the Young: An Overview with Focus on the Middle East
  37. Identification of novel genes for glucose metabolism based upon expression pattern in human islets and effect on insulin secretion and glycemia
  38. Global genomic and transcriptomic analysis of human pancreatic islets reveals novel genes influencing glucose metabolism
  39. A Central Role for GRB10 in Regulation of Islet Function in Man
  40. Downregulation of Type II Diabetes Mellitus and Maturity Onset Diabetes of Young Pathways in Human Pancreatic Islets from Hyperglycemic Donors
  41. Autoimmunity against INS-IGF2 Protein Expressed in Human Pancreatic Islets
  42. Expression profiling of cell cycle genes in human pancreatic islets with and without type 2 diabetes
  43. Effects of Common Genetic Variants Associated With Type 2 Diabetes and Glycemic Traits on α- and β-Cell Function and Insulin Action in Humans
  44. Reduced insulin secretion correlates with decreased expression of exocytotic genes in pancreatic islets from patients with type 2 diabetes
  45. Secreted Frizzled-Related Protein 4 Reduces Insulin Secretion and Is Overexpressed in Type 2 Diabetes
  46. A Systems Genetics Approach Identifies Genes and Pathways for Type 2 Diabetes in Human Islets
  47. Erratum
  48. γ-Aminobutyric acid (GABA) signalling in human pancreatic islets is altered in type 2 diabetes
  49. Decreased expression of genes involved in oxidative phosphorylation in human pancreatic islets from patients with type 2 diabetes
  50. A common variant upstream of the PAX6 gene influences islet function in man
  51. Genome-Wide Association Identifies Nine Common Variants Associated With Fasting Proinsulin Levels and Provides New Insights Into the Pathophysiology of Type 2 Diabetes
  52. Pleiotropic Effects of GIP on Islet Function Involve Osteopontin
  53. A Common Variant in TFB1M Is Associated with Reduced Insulin Secretion and Increased Future Risk of Type 2 Diabetes
  54. Insulin promoter DNA methylation correlates negatively with insulin gene expression and positively with HbA1c levels in human pancreatic islets
  55. Genetic variation in GIPR influences the glucose and insulin responses to an oral glucose challenge
  56. Enhancement of glucagon secretion in mouse and human pancreatic alpha cells by protein kinase C (PKC) involves intracellular trafficking of PKCα and PKCδ
  57. Tight Coupling between Glucose and Mitochondrial Metabolism in Clonal β-Cells Is Required for Robust Insulin Secretion
  58. A Variant in the KCNQ1 Gene Predicts Future Type 2 Diabetes and Mediates Impaired Insulin Secretion
  59. Long‐term accumulation of microglia with proneurogenic phenotype concomitant with persistent neurogenesis in adult subventricular zone after stroke
  60. Failure of Transplanted Bone Marrow Cells to Adopt a Pancreatic  -Cell Fate
  61. Bone marrow–derived hematopoietic cells generate cardiomyocytes at a low frequency through cell fusion, but not transdifferentiation
  62. Letters to the Editor