All Stories

  1. Maternal late gestation undernutrition in sheep is associated with increased ductus venosus shunting and reduced cerebral oxygen consumption

    Article • The Journal of Physiology, January 2026, Wiley

    Jack R.T. Darby

  2. Fetal glucose availability: a key regulator of the metabolic, hormonal and contractility profiles of the fetal sheep heart

    Article • The Journal of Physiology, May 2025, Wiley

    Jack R.T. Darby

  3. Feasibility of multimodal magnetic resonance imaging to assess maternal hyperoxygenation in sheep pregnancy

    Article • The Journal of Physiology, February 2025, Wiley

    Jack R.T. Darby, Dr Vasileios Vavourakis

  4. Pregnancy does not affect progression of mild experimental asthma in sheep

    Article • The Journal of Physiology, February 2025, Wiley

    Jack R.T. Darby

  5. In utero exposure to experimental maternal asthma alters fetal airway development in sheep

    Article • Experimental Physiology, January 2025, Wiley

    Jack R.T. Darby

  6. Late‐gestation maternal undernutrition induces circulatory redistribution while preserving uteroplacental function independent of fetal glycaemic state

    Article • The Journal of Physiology, November 2024, Wiley

    Jack R.T. Darby

  7. Betamethasone improved near‐term neonatal lamb lung maturation in experimental maternal asthma

    Article • Experimental Physiology, October 2024, Wiley

    Jack R.T. Darby

  8. Cardiac growth patterns and metabolism before and after birth in swine: Role of miR in proliferation, hypertrophy and metabolism

    Article • Journal of Molecular and Cellular Cardiology Plus, September 2024, Elsevier

    Jack R.T. Darby

  9. Maternal high fat–high energy diet alters metabolic factors in the non‐human primate fetal heart

    Article • The Journal of Physiology, August 2024, Wiley

    Jack R.T. Darby

  10. Post‐Myocardial Infarction Remodeling and Hyperkinetic Remote Myocardium in Sheep Measured by Cardiac MRI Feature Tracking

    Article • Journal of Magnetic Resonance Imaging, June 2024, Wiley

    Jack R.T. Darby

  11. Acute-on-chronic: using magnetic resonance imaging to disentangle the haemodynamic responses to acute and chronic fetal hypoxaemia

    Article • Frontiers in Medicine, June 2024, Frontiers

    Jack R.T. Darby

  12. Echocardiographic assessment of cardiovascular physiology of preterm miniature piglets supported with a pumped artificial placenta system

    Article • Prenatal Diagnosis, May 2024, Wiley

    Jack R.T. Darby

  13. Maternal tadalafil treatment does not increase uterine artery blood flow or oxygen delivery in the pregnant ewe

    Article • Experimental Physiology, April 2024, Wiley

    Jack R.T. Darby

  14. Pulmonary Vascular Regulation in the Fetal and Transitional Lung

    Article • Clinics in Perinatology, March 2024, Elsevier

    Jack R.T. Darby

  15. Reduced in utero substrate supply decreases mitochondrial abundance and alters the expression of metabolic signalling molecules in the fetal sheep heart

    Article • The Journal of Physiology, November 2023, Wiley

    Jack R.T. Darby

  16. Feasibility of MRI assessment of maternal–fetal oxygen transport and consumption relative to maternal position in healthy late gestational pregnancies

    Article • The Journal of Physiology, October 2023, Wiley

    Jack R.T. Darby

  17. Placentome- and sex-specific differences in glucocorticoids and their receptor variants in the growth restricted sheep

    Article • Placenta, September 2023, Elsevier

    Jack R.T. Darby

  18. Cardiac growth and metabolism of the fetal sheep are not vulnerable to a 10 day increase in fetal glucose and insulin concentrations during late gestation

    Article • Heliyon, July 2023, Elsevier

    Jack R.T. Darby

  19. Acute resveratrol exposure does not impact hemodynamics of the fetal sheep

    Article • Physiological Reports, June 2023, Wiley

    Jack R.T. Darby

  20. Advanced imaging of fetal cardiac function

    Article • Frontiers in Cardiovascular Medicine, May 2023, Frontiers

    Jack R.T. Darby

  21. Automated Proteomics Workflows for High-Throughput Library Generation and Biomarker Detection Using Data-Independent Acquisition

    Article • Journal of Proteome Research, May 2023, American Chemical Society (ACS)

    Jack R.T. Darby

  22. A change of heart: Understanding the mechanisms regulating cardiac proliferation and metabolism before and after birth

    Article • The Journal of Physiology, March 2023, Wiley

    Jack R.T. Darby

  23. Characterisation of cytochrome P450 isoenzyme activity in sheep liver and placental microsomes

    Article • Placenta, January 2023, Elsevier

    Jack R.T. Darby

  24. MRI Characterization of Blood Flow and Oxygen Delivery in the Fetal Sheep whilst Exposed to Sildenafil Citrate

    Article • Neonatology, October 2022, Karger Publishers

    Jack R.T. Darby

  25. Placental MRI Predicts Fetal Oxygenation and Growth Rates in Sheep and Human Pregnancy

    Article • Advanced Science, August 2022, Wiley

    Jack R.T. Darby

  26. A no brainer: Intervening early to protect against perinatal brain injury

    Article • The Journal of Physiology, August 2022, Wiley

    Jack R.T. Darby

  27. Impact of the Addition of a Centrifugal Pump in a Preterm Miniature Pig Model of the Artificial Placenta

    Article • Frontiers in Physiology, July 2022, Frontiers

    Jack R.T. Darby

  28. Something worth waiting for: is delayed cord clamping always beneficial?

    Article • The Journal of Physiology, July 2022, Wiley

    Jack R.T. Darby

  29. Maternal-placental-fetal drug metabolism is altered by late gestation undernutrition in the pregnant ewe

    Article • Life Sciences, June 2022, Elsevier

    Jack R.T. Darby

  30. Does the growth restricted fetal heart burn less fat?

    Article • The Journal of Physiology, March 2022, Wiley

    Jack R.T. Darby

  31. Development of an optical fiber‐based redox monitoring system for tissue metabolism

    Article • Journal of Biophotonics, January 2022, Wiley

    Jack R.T. Darby

  32. Hepatic cytochrome P450 function is reduced by life-long Western diet consumption in guinea pig independent of birth weight

    Article • Life Sciences, December 2021, Elsevier

    Jack R.T. Darby

  33. Intrauterine growth restriction alters the activity of drug metabolising enzymes in the maternal-placental-fetal unit

    Article • Life Sciences, November 2021, Elsevier

    Jack R.T. Darby

  34. Impact of maternal late gestation undernutrition on surfactant maturation, pulmonary blood flow and oxygen delivery measured by magnetic resonance imaging in the sheep fetus

    Article • The Journal of Physiology, September 2021, Wiley

    Jack R.T. Darby

  35. Redox ratio in the left ventricle of the growth restricted fetus is positively correlated with cardiac output

    Article • Journal of Biophotonics, September 2021, Wiley

    Jack R.T. Darby

  36. Open or closed: Changes in ductus arteriosus flow patterns at birth using 4D flow MRI in newborn piglets

    Article • Physiological Reports, August 2021, Wiley

    Jack R.T. Darby

  37. Placental insufficiency induces a sexually dimorphic response in the expression of cardiac growth and metabolic signalling molecules upon exposure to a postnatal western diet in guinea pigs

    Article • Journal of Developmental Origins of Health and Disease, July 2021, Cambridge University Press

    Jack R.T. Darby

  38. Let’s Talk about Placental Sex, Baby: Understanding Mechanisms That Drive Female- and Male-Specific Fetal Growth and Developmental Outcomes

    Article • International Journal of Molecular Sciences, June 2021, MDPI AG

    Jack R.T. Darby

  39. Haemodynamics and cerebral oxygenation of neonatal piglets in the immediate ex utero period supported by mechanical ventilation or ex utero oxygenator

    Article • The Journal of Physiology, April 2021, Wiley

    Jack R.T. Darby

  40. Inside Cover

    Article • Journal of Biophotonics, April 2021, Wiley

    Jack R.T. Darby

  41. Impact of resveratrol‐mediated increase in uterine artery blood flow on fetal haemodynamics, blood pressure and oxygenation in sheep

    Article • Experimental Physiology, March 2021, Wiley

    Jack R.T. Darby, Professor Nico H Voelcker

  42. An MRI approach to assess placental function in healthy humans and sheep

    Article • The Journal of Physiology, March 2021, Wiley

    Jack R.T. Darby, Dr Janna Morrison

  43. Achieving sustained extrauterine life: Challenges of an artificial placenta in fetal pigs as a model of the preterm human fetus

    Article • Physiological Reports, March 2021, Wiley

    Jack R.T. Darby, Ayman Sheta

  44. Magnetic resonance imaging of placentome development in the pregnant Ewe

    Article • Placenta, February 2021, Elsevier

    Jack R.T. Darby

  45. Themed issue on the DOHaD workshop on Fetal, Placental and Pediatric Imaging

    Article • Journal of Developmental Origins of Health and Disease, January 2021, Cambridge University Press

    Dr Janna Morrison, Jack R.T. Darby

  46. COVID-19: can we treat the mother without harming her baby?

    Article • Journal of Developmental Origins of Health and Disease, January 2021, Cambridge University Press

    Jack R.T. Darby, Dr Janna Morrison

  47. In utero substrate restriction by placental insufficiency or maternal undernutrition decreases optical redox ratio in foetal perirenal fat

    Article • Journal of Biophotonics, January 2021, Wiley

    Jack R.T. Darby, Dr Janna Morrison

  48. PPARγ activation in late gestation does not promote surfactant maturation in the fetal sheep lung

    Article • Journal of Developmental Origins of Health and Disease, January 2021, Cambridge University Press

    Jack R.T. Darby, Dr Janna Morrison

  49. The reliance on α‐adrenergic receptor stimuli for blood pressure regulation in the chronically hypoxaemic fetus is not dependent on post‐ganglionic activation

    Article • The Journal of Physiology, December 2020, Wiley

    Jack R.T. Darby, Dr Janna Morrison

  50. Impact of in vitro embryo culture and transfer on blood pressure regulation in the adolescent lamb

    Article • Journal of Developmental Origins of Health and Disease, November 2020, Cambridge University Press

    Jack R.T. Darby, Dr Janna Morrison

  51. Seeing the fetus from a DOHaD perspective: discussion paper from the advanced imaging techniques of DOHaD applications workshop held at the 2019 DOHaD World Congress

    Article • Journal of Developmental Origins of Health and Disease, September 2020, Cambridge University Press

    Jack R.T. Darby, Dr Janna Morrison

  52. The impact of intrauterine growth restriction on cytochrome P450 enzyme expression and activity

    Article • Placenta, September 2020, Elsevier

    Jack R.T. Darby, Dr Janna Morrison

  53. Umbilical vein infusion of Prostaglandin I 2 increases ductus venosus shunting of oxygen rich blood but does not increase cerebral oxygen delivery in the fetal sheep

    Article • The Journal of Physiology, August 2020, Wiley

    Jack R.T. Darby, Dr Janna Morrison

  54. Sildenafil: how to make a bad situation worse

    Article • The Journal of Physiology, August 2020, Wiley

    Jack R.T. Darby

  55. Technique for comprehensive fetal hepatic blood flow assessment in sheep using 4D flow MRI

    Article • The Journal of Physiology, June 2020, Wiley

    Jack R.T. Darby, Dr Janna Morrison

  56. Identification of Novel miRNAs Involved in Cardiac Repair Following Infarction in Fetal and Adolescent Sheep Hearts

    Article • Frontiers in Physiology, June 2020, Frontiers

    Jack R.T. Darby, Dr Janna Morrison

  57. Feasibility of ventricular volumetry by cardiovascular MRI to assess cardiac function in the fetal sheep

    Article • The Journal of Physiology, May 2020, Wiley

    Jack R.T. Darby, Dr Janna Morrison

  58. Normal human and sheep fetal vessel oxygen saturations by T2 magnetic resonance imaging

    Article • The Journal of Physiology, May 2020, Wiley

    Jack R.T. Darby, Dr Janna Morrison

  59. Differential gene responses 3 days following infarction in the fetal and adolescent sheep heart

    Article • Physiological Genomics, March 2020, American Physiological Society

    Jack R.T. Darby, Dr Janna Morrison

  60. Fetal cardiovascular response to acute hypoxia during maternal anesthesia

    Article • Physiological Reports, February 2020, Wiley

    Jack R.T. Darby, Dr Janna Morrison

  61. Cardiorespiratory consequences of intrauterine growth restriction: Influence of timing, severity and duration of hypoxaemia

    Article • Theriogenology, February 2020, Elsevier

    Jack R.T. Darby, Dr Janna Morrison

  62. Detecting metabolic differences in fetal and adult sheep adipose and skeletal muscle tissue

    Article • Journal of Biophotonics, December 2019, Wiley

    Jack R.T. Darby, Dr Janna Morrison

  63. Subcutaneous maternal resveratrol treatment increases uterine artery blood flow in the pregnant ewe and increases fetal but not cardiac growth

    Article • The Journal of Physiology, September 2019, Wiley

    Jack R.T. Darby, Dr Janna Morrison

  64. Arginine Vasopressin improves cerebral perfusion following controlled haemorrhage in adult ewes

    Article • The Journal of Physiology, July 2019, Wiley

    Jack R.T. Darby, Dr Janna Morrison

  65. Considerations in selecting postoperative analgesia for pregnant sheep following fetal instrumentation surgery

    Article • Animal Frontiers, June 2019, Oxford University Press (OUP)

    Jack R.T. Darby, Dr Janna Morrison

  66. Systematic review: Impact of resveratrol exposure during pregnancy on maternal and fetal outcomes in animal models of human pregnancy complications—Are we ready for the clinic?

    Article • Pharmacological Research, June 2019, Elsevier

    Jack R.T. Darby, Dr Janna Morrison

  67. Differential Response to Injury in Fetal and Adolescent Sheep Hearts in the Immediate Post-myocardial Infarction Period

    Article • Frontiers in Physiology, March 2019, Frontiers

    Jack R.T. Darby, Dr Janna Morrison

  68. Fetal hemodynamics and cardiac streaming assessed by 4D flow cardiovascular magnetic resonance in fetal sheep

    Article • Journal of Cardiovascular Magnetic Resonance, January 2019, Springer Science + Business Media

    Jack R.T. Darby, Dr Janna Morrison

  69. Improving pregnancy outcomes in humans through studies in sheep

    Article • AJP Regulatory Integrative and Comparative Physiology, December 2018, American Physiological Society

    Jack R.T. Darby, A/Prof Tim Moss, Dr Janna Morrison

  70. And the beat goes on

    Article • The Journal of Physiology, October 2018, Wiley

    Dr Janna Morrison, Jack R.T. Darby

  71. Guinea pig models for translation of the developmental origins of health and disease hypothesis into the clinic

    Article • The Journal of Physiology, May 2018, Wiley

    Dr Janna Morrison, Jack R.T. Darby

  72. Mitochondrial imaging in live or fixed tissues using a luminescent iridium complex

    Article • Scientific Reports, May 2018, Springer Science + Business Media

    Professor Nico H Voelcker, Jack R.T. Darby, Dr Janna Morrison

  73. Maternal undernutrition in late gestation increases IGF2 signalling molecules and collagen deposition in the right ventricle of the fetal sheep heart

    Article • The Journal of Physiology, May 2018, Wiley

    Dr Janna Morrison, Jack R.T. Darby

  74. A fibre optic fluorescence sensor to measure redox level in tissues

    Article • January 2018, SPIE

    Jack R.T. Darby, Dr Janna Morrison

  75. Feasibility of phase-contrast cine magnetic resonance imaging for measuring blood flow in the sheep fetus

    Article • AJP Regulatory Integrative and Comparative Physiology, December 2017, American Physiological Society

    Jack R.T. Darby, Dr Janna Morrison

  76. Label-free imaging of redox status and collagen deposition showing metabolic differences in the heart

    Article • Journal of Biophotonics, October 2017, Wiley

    Dr Janna Morrison, Jack R.T. Darby

  77. Feasibility of detecting myocardial infarction in the sheep fetus using late gadolinium enhancement CMR imaging

    Article • Journal of Cardiovascular Magnetic Resonance, September 2017, Springer Science + Business Media

    Jack R.T. Darby, Dr Janna Morrison

  78. Maternal Undernutrition Increases Fibrosis in the Late Gestation Fetal Heart

    Article • Heart Lung and Circulation, January 2017, Elsevier

    Jack R.T. Darby, Dr Janna Morrison

  79. miR-133a and Target Gene Expression in the Foetus and 6 Month Old Sheep Heart in Response to Myocardial Infarction

    Article • Heart Lung and Circulation, August 2016, Elsevier

    Jack R.T. Darby, Dr Janna Morrison

  80. Late gestation over nutrition alters the cardiac metabolic profile

    Article • Heart Lung and Circulation, January 2015, Elsevier

    Jack R.T. Darby, Dr Janna Morrison