All Stories

  1. Epigenetic control of the angiotensin-converting enzyme in endothelial cells during inflammation

    Article • PLoS ONE, May 2019, PLOS

    Professor Ingrid Fleming

  2. miR-223–IGF-IR signalling in hypoxia- and load-induced right-ventricular failure: a novel therapeutic approach

    Article • Cardiovascular Research, March 2016, European Society of Cardiology

    Professor Ingrid Fleming

  3. Whatever Happened to the Epoxyeicosatrienoic Acid-Like Endothelium-Derived Hyperpolarizing Factor? The Identification of Novel Classes of Lipid Mediators and Their Role in Vascular Homeostasis

    Article • Antioxidants & Redox Signaling, May 2015, Mary Ann Liebert Inc

    Professor Ingrid Fleming

  4. Increased cerebrospinal fluid calpain activity and microparticle levels in Alzheimer's disease

    Article • Alzheimer s & Dementia, May 2015, Elsevier

    Professor Ingrid Fleming

  5. HIF-2α attenuates lymphangiogenesis by up-regulating IGFBP1 in hepatocellular carcinoma

    Article • Biology of the Cell, April 2015, Wiley

    Professor Ingrid Fleming

  6. Role of secreted modular calcium-binding protein 1 (SMOC1) in transforming growth factor β signalling and angiogenesis

    Article • Cardiovascular Research, March 2015, European Society of Cardiology

    Professor Ingrid Fleming

  7. HIF-2alpha-dependent PAI-1 induction contributes to angiogenesis in hepatocellular carcinoma

    Article • Experimental Cell Research, February 2015, Elsevier

    Professor Ingrid Fleming

  8. The number of cardiac myocytes in the hypertrophic and hypotrophic left ventricle of the obese and calorie-restricted mouse heart

    Article • Journal of Anatomy, October 2014, Wiley

    Professor Ingrid Fleming

  9. Electrophilic Fatty Acid Species Inhibit 5-Lipoxygenase and Attenuate Sepsis-Induced Pulmonary Inflammation

    Article • Antioxidants & Redox Signaling, June 2014, Mary Ann Liebert Inc

    Professor Ingrid Fleming

  10. Methylglyoxal Induces Platelet Hyperaggregation and Reduces Thrombus Stability by Activating PKC and Inhibiting PI3K/Akt Pathway

    Article • PLoS ONE, September 2013, PLOS

    Professor Ingrid Fleming

  11. Ca2+-sensing Receptor Cleavage by Calpain Partially Accounts for Altered Vascular Reactivity in Mice Fed a High-fat Diet

    Article • Journal of Cardiovascular Pharmacology, June 2013, Wolters Kluwer Health

    Professor Ingrid Fleming

  12. Soluble epoxide hydrolase disruption as therapeutic target for wound healing

    Article • Journal of Surgical Research, June 2013, Elsevier

    Professor Ingrid Fleming

  13. Mena/VASP and αII-Spectrin complexes regulate cytoplasmic actin networks in cardiomyocytes and protect from conduction abnormalities and dilated cardiomyopathy

    Article • Cell Communication and Signaling, January 2013, Springer Science + Business Media

    Professor Ingrid Fleming

  14. Cytochrome P4502S1: a novel monocyte/macrophage fatty acid epoxygenase in human atherosclerotic plaques

    Article • Basic Research in Cardiology, December 2012, Springer Science + Business Media

    Professor Ingrid Fleming, Manuel Mayr

  15. Correction: 11,12-EET Stimulates the Association of BK Channel α and β1Subunits in Mitochondria to Induce Pulmonary Vasoconstriction

    Article • PLoS ONE, December 2012, PLOS

    Professor Ingrid Fleming

  16. Hypoxic pulmonary vasoconstriction requires connexin 40–mediated endothelial signal conduction

    Article • Journal of Clinical Investigation, October 2012, American Society for Clinical Investigation

    Professor Ingrid Fleming

  17. 11,12-EET Stimulates the Association of BK Channel α and β1 Subunits in Mitochondria to Induce Pulmonary Vasoconstriction

    Article • PLoS ONE, September 2012, PLOS

    Professor Ingrid Fleming

  18. Platelet Function and Signaling in Diabetes Mellitus

    Article • Current Vascular Pharmacology, July 2012, Bentham Science Publishers

    Professor Ingrid Fleming

  19. Stereological characterization of left ventricular cardiomyocytes, capillaries, and innervation in the nondiabetic, obese mouse

    Article • Cardiovascular Pathology, July 2012, Elsevier

    Professor Ingrid Fleming

  20. The F-BAR protein NOSTRIN participates in FGF signal transduction and vascular development

    Article • The EMBO Journal, June 2012, Wiley

    Professor Ingrid Fleming

  21. All cut up! The consequences of calpain activation on platelet function

    Article • Vascular Pharmacology, May 2012, Elsevier

    Professor Ingrid Fleming

  22. The role of calpain in regulating platelet physiology and crosstalk with the vasculature

    Article • Vascular Pharmacology, May 2012, Elsevier

    Professor Ingrid Fleming

  23. The AMP-activated protein kinase modifies gene expression in endothelial cells by interfering with protein lysine acetylation

    Article • Vascular Pharmacology, May 2012, Elsevier

    Professor Ingrid Fleming

  24. Identification of septin-5 as a novel calpain substrate and its role in platelet secretion

    Article • Vascular Pharmacology, May 2012, Elsevier

    Professor Ingrid Fleming

  25. Human secreted modular Ca2+-binding protein 1 is involved in inflammatory matrix remodelling through interference in cytokine signalling

    Article • Vascular Pharmacology, May 2012, Elsevier

    Professor Ingrid Fleming

  26. Complementary Screening Techniques Yielded Fragments that Inhibit the Phosphatase Activity of Soluble Epoxide Hydrolase

    Article • ChemMedChem, October 2011, Wiley

    Professor Ingrid Fleming

  27. The cytochrome P450 pathway in angiogenesis and endothelial cell biology

    Article • Cancer and Metastasis Reviews, October 2011, Springer Science + Business Media

    Professor Ingrid Fleming

  28. Cytochrome P450-dependent eicosanoid production and crosstalk

    Article • Current Opinion in Lipidology, October 2011, Wolters Kluwer Health

    Professor Ingrid Fleming

  29. Cytochrome P450-derived epoxyeicosatrienoic acids accelerate wound epithelialization and neovascularization in the hairless mouse ear wound model

    Article • Langenbeck s Archives of Surgery, September 2011, Springer Science + Business Media

    Professor Ingrid Fleming

  30. Nitric Oxide-Induced Activation of the AMP-Activated Protein Kinase α2 Subunit Attenuates IκB Kinase Activity and Inflammatory Responses in Endothelial Cells

    Article • PLoS ONE, June 2011, PLOS

    Professor Ingrid Fleming

  31. Lipid Signaling Mediators ‘mEET’ TRP Channels: Highlighted Presentations From the March 2010 Winter Eicosanoid Conference

    Article • Journal of Cardiovascular Pharmacology, February 2011, Wolters Kluwer Health

    Professor Ingrid Fleming

  32. Cytochrome P450-Derived Epoxyeicosatrienoic Acids and Pulmonary Hypertension: Central Role of Transient Receptor Potential C6 Channels

    Article • Journal of Cardiovascular Pharmacology, February 2011, Wolters Kluwer Health

    Professor Ingrid Fleming

  33. Activation of Adenosine-Monophosphate–Activated Protein Kinase Abolishes Desflurane-Induced Preconditioning Against Myocardial Infarction In Vivo

    Article • Journal of Cardiothoracic and Vascular Anesthesia, February 2011, Elsevier

    Professor Ingrid Fleming

  34. Biology of Nitric Oxide Synthases

    Article • January 2011, Wiley

    Professor Ingrid Fleming

  35. Soluble Epoxide Hydrolase Limits Mechanical Hyperalgesia during Inflammation

    Article • Molecular Pain, January 2011, SAGE Publications

    Professor Ingrid Fleming

  36. Adipocyte-derived lipids increase angiotensin-converting enzyme (ACE) expression and modulate macrophage phenotype

    Article • Basic Research in Cardiology, December 2010, Springer Science + Business Media

    Professor Ingrid Fleming

  37. Epoxyeicosatrienoic acids and endothelium-dependent responses

    Article • Pflügers Archiv - European Journal of Physiology, March 2010, Springer Science + Business Media

    Professor Ingrid Fleming

  38. The Role of Calpain in Diabetes-Associated Platelet Hyperactivation

    Article • January 2010, Elsevier

    Professor Ingrid Fleming

  39. Molecular mechanisms underlying the activation of eNOS

    Article • Pflügers Archiv - European Journal of Physiology, December 2009, Springer Science + Business Media

    Professor Ingrid Fleming

  40. Inhibition of the soluble epoxide hydrolase attenuates monocrotaline-induced pulmonary hypertension in rats

    Article • Journal of Hypertension, February 2009, Wolters Kluwer Health

    Professor Ingrid Fleming

  41. The S1P2 receptor expressed in human platelets is linked to the RhoA-Rho kinase pathway and is down regulated in type 2 diabetes

    Article • Basic Research in Cardiology, January 2009, Springer Science + Business Media

    Professor Ingrid Fleming

  42. AT1-receptor blockade by telmisartan upregulates GTP-cyclohydrolase I and protects eNOS in diabetic rats

    Article • Free Radical Biology and Medicine, September 2008, Elsevier

    Professor Ingrid Fleming, Professor Thomas Munzel or Muenzel

  43. Impaired interaction of platelets with endothelial progenitor cells in patients with cardiovascular risk factors

    Article • Basic Research in Cardiology, July 2008, Springer Science + Business Media

    Professor Ingrid Fleming

  44. Biology of Nitric Oxide Synthases

    Article • January 2008, Elsevier

    Professor Ingrid Fleming

  45. Vascular Cytochrome P450 Enzymes: Physiology and Pathophysiology

    Article • Trends in Cardiovascular Medicine, January 2008, Elsevier

    Professor Ingrid Fleming

  46. O75. Angiotensin II inactivates eNOS through tyrosine phosphorylation

    Article • Nitric Oxide, January 2008, Elsevier

    Professor Ingrid Fleming

  47. Dr. Rudi Busse

    Article • Vascular Pharmacology, October 2007, Elsevier

    Professor Ingrid Fleming

  48. Rudi Busse

    Article • Journal of Cardiovascular Pharmacology, September 2007, Wolters Kluwer Health

    Professor Ingrid Fleming

  49. Cytochrome P450 2C9 is involved in flow-dependent vasodilation of peripheral conduit arteries in healthy subjects and in patients with chronic heart failure

    Article • European Journal of Heart Failure, August 2007, Wiley

    Professor Ingrid Fleming

  50. The effects of COX-2 selective and non-selective NSAIDs on the initiation and progression of atherosclerosis in ApoE−/− mice

    Article • Journal of Molecular Medicine, February 2007, Springer Science + Business Media

    Professor Ingrid Fleming

  51. Epoxyeicosatrienoic acids, cell signaling and angiogenesis

    Article • Prostaglandins & Other Lipid Mediators, January 2007, Elsevier

    Professor Ingrid Fleming

  52. From endothelium-derived hyperpolarizing factor (EDHF) to angiogenesis: Epoxyeicosatrienoic acids (EETs) and cell signaling

    Article • Pharmacology & Therapeutics, September 2006, Elsevier

    Professor Ingrid Fleming

  53. The shear stress-induced activation of the AMP-activated protein kinase (AMPK) regulates FoxO1a activity and angiopoietin-2 expression in endothelial cells

    Article • Vascular Pharmacology, September 2006, Elsevier

    Professor Ingrid Fleming

  54. Angiotensin converting enzyme (ACE) inhibitors induce an ACE-dependent signalling in endothelial cells via the initial dimerisation of ACE

    Article • Vascular Pharmacology, September 2006, Elsevier

    Professor Ingrid Fleming

  55. P186. Tyrosine phosphorylation of the nitric oxide synthase by PYK2 attenuates enzyme activity

    Article • Nitric Oxide, June 2006, Elsevier

    Professor Ingrid Fleming

  56. Epoxyeicosatrienoic acids: regulators of vascular homeostasis

    Article • April 2006, Elsevier

    Professor Ingrid Fleming

  57. The tissue renin–angiotensin system and intracellular signalling

    Article • Current Opinion in Nephrology & Hypertension, January 2006, Wolters Kluwer Health

    Professor Ingrid Fleming

  58. Nitric oxide– and EDHF-mediated arteriolar tone in uremia is unaffected by selective inhibition of vascular cytochrome P450 2C9

    Article • Kidney International, May 2005, Elsevier

    Professor Ingrid Fleming

  59. Analysis of Dichlorodihydrofluorescein and Dihydrocalcein as Probes for the Detection of Intracellular Reactive Oxygen Species

    Article • Free Radical Research, December 2004, Taylor & Francis

    Professor Ingrid Fleming

  60. The Physiology of Nitric Oxide: Control and Consequences

    Article • Current Medicinal Chemistry - Anti-Inflammatory & Anti-Allergy Agents, September 2004, Bentham Science Publishers

    Professor Ingrid Fleming

  61. Bradykinin-induced relaxation of coronary microarteries: S -nitrosothiols as EDHF?

    Article • British Journal of Pharmacology, May 2004, Wiley

    Professor Ingrid Fleming

  62. OUTSIDE-IN SIGNALLING BY THE ANGIOTENSIN CONVERTING ENZYME IN ENDOTHELIAL CELLS: A NOVEL SIGNALLING PATHWAY

    Article • Cardiovascular Pathology, May 2004, Elsevier

    Professor Ingrid Fleming

  63. INSULIN INDUCES THE RELEASE OF VASODILATOR COMPOUNDS FROM PLATELETS BY A NITRIC OXIDE/G KINASE/VAMP-3-DEPENDENT PATHWAY: A NOVEL MECHANISM OF INSULIN-INDUCED VASODILATATION

    Article • Cardiovascular Pathology, May 2004, Elsevier

    Professor Ingrid Fleming

  64. 865-1 Endothelium-derived hyperpolarizing factor is involved in flow-dependent dilation of peripheral conduit arteries in healthy volunteers

    Article • Journal of the American College of Cardiology, March 2004, Elsevier

    Professor Ingrid Fleming

  65. Dialogue entre cellules endothéliales et cellules musculaires lisses

    Article • médecine/sciences, December 2003, EDP Sciences

    Professor Ingrid Fleming

  66. Baseline blood flow and bradykinin-induced vasodilator responses in the human forearm are insensitive to the cytochrome P450 2C9 (CYP2C9) inhibitor sulphaphenazole

    Article • Clinical Science, October 2003, Portland Press Ltd.

    Professor Ingrid Fleming

  67. AMP-activated protein kinase (AMPK) regulates the insulin-induced activation of the nitric oxide synthase in human platelets

    Article • Thrombosis and Haemostasis, August 2003, Schattauer GmbH

    Professor Ingrid Fleming

  68. Identification of a cis -Element Regulating Transcriptional Activity in Response to Fluid Shear Stress in Bovine Aortic Endothelial Cells

    Article • Endothelium, July 2003, Taylor & Francis

    Professor Ingrid Fleming

  69. Insulin enhances the expression of the endothelial nitric oxide synthase in native endothelial cells: a dual role for Akt and AP-1

    Article • Nitric Oxide, June 2003, Elsevier

    Professor Ingrid Fleming

  70. Characterization of the endothelium-derived hyperpolarizing factor (EDHF) response in the human interlobar artery

    Article • Kidney International, May 2003, Elsevier

    Professor Ingrid Fleming

  71. Cytochrome P450 epoxygenases and vascular tone: novel role for HMG-CoA reductase inhibitors in the regulation of CYP 2C expression

    Article • Biochimica et Biophysica Acta (BBA) - General Subjects, February 2003, Elsevier

    Professor Ingrid Fleming

  72. Regulation of endothelium-derived vasoactive autacoid production by hemodynamic forces

    Article • Trends in Pharmacological Sciences, January 2003, Elsevier

    Professor Ingrid Fleming

  73. Cytochrome P450 2C9 plays an important role in the regulation of exercise‐induced skeletal muscle blood flow and oxygen uptake in humans

    Article • The Journal of Physiology, January 2003, Wiley

    Professor Ingrid Fleming

  74. Molecular mechanisms involved in the regulation of the endothelial nitric oxide synthase: Fig. 1.

    Article • AJP Regulatory Integrative and Comparative Physiology, January 2003, American Physiological Society

    Professor Ingrid Fleming

  75. The Na-K-ATPase is a target for an EDHF displaying characteristics similar to potassium ions in the porcine renal interlobar artery

    Article • British Journal of Pharmacology, November 2002, Wiley

    Professor Ingrid Fleming

  76. EDHF: bringing the concepts together

    Article • Trends in Pharmacological Sciences, August 2002, Elsevier

    Professor Ingrid Fleming

  77. Cirrhosis serum induces a nitric oxide-associated vascular hyporeactivity of aortic segments from healthy rats in vitro

    Article • August 2001, Wolters Kluwer Health

    Professor Ingrid Fleming

  78. The coronary endothelium-derived hyperpolarizing factor (EDHF) stimulates multiple signalling pathways and proliferation in vascular cells

    Article • Pflügers Archiv - European Journal of Physiology, July 2001, Springer Science + Business Media

    Professor Ingrid Fleming

  79. EDHF: A cytochrome P450 metabolite in coronary arteries

    Article • Seminars in Perinatology, February 2000, Elsevier

    Professor Ingrid Fleming

  80. Endothelium-Derived Hyperpolarizing Factor and Its Interaction with NO

    Article • January 2000, Elsevier

    Professor Ingrid Fleming

  81. Activation of NOS by Ca2+-Dependent and Ca2+-Independent Mechanisms

    Article • January 2000, Elsevier

    Professor Ingrid Fleming

  82. Nitric oxide, nitric oxide synthase, and hypertensive vascular disease

    Article • Current Hypertension Reports, January 1999, Springer Science + Business Media

    Professor Ingrid Fleming

  83. Regulation of NO Synthesis in Endothelial Cells

    Article • Kidney and Blood Pressure Research, January 1998, Karger Publishers

    Professor Ingrid Fleming

  84. Pulsatile Stretch and Shear Stress: Physical Stimuli Determining the Production of Endothelium-Derived Relaxing Factors

    Article • Journal of Vascular Research, January 1998, Karger Publishers

    Professor Ingrid Fleming

  85. Tyrosine Phosphorylation and Bradykinin-Induced Signaling in Endothelial Cells

    Article • The American Journal of Cardiology, August 1997, Elsevier

    Professor Ingrid Fleming

  86. Vascular Effects of NO

    Article • January 1997, Springer Science + Business Media

    Professor Ingrid Fleming

  87. Calcium-Dependent and Calcium-Independent Activation of the Endothelial NO Synthase

    Article • Journal of Vascular Research, January 1997, Karger Publishers

    Professor Ingrid Fleming

  88. Paracrine functions of the coronary vascular endothelium

    Article • Molecular and Cellular Biochemistry, April 1996, Springer Science + Business Media

    Professor Ingrid Fleming

  89. Endothelial Dysfunction in Atherosclerosis

    Article • Journal of Vascular Research, January 1996, Karger Publishers

    Professor Ingrid Fleming

  90. Paracrine functions of the coronary vascular endothelium

    Article • January 1996, Springer Science + Business Media

    Professor Ingrid Fleming

  91. Calcium Signalling and Autacoid Production in Endothelial Cells Are Modulated by Changes in Tyrosine Kinase and Phosphatase Activity

    Article • Journal of Vascular Research, January 1996, Karger Publishers

    Professor Ingrid Fleming

  92. Regulation and Functional Consequences of Endothelial Nitric Oxide Formation

    Article • Annals of Medicine, January 1995, Taylor & Francis

    Professor Ingrid Fleming

  93. Control and Consequences of Endothelial Nitric Oxide Formation

    Article • January 1995, Elsevier

    Professor Ingrid Fleming

  94. Regulation of Platelet Function by Flow-Induced Release of Endothelial Autacoids

    Article • January 1995, Springer Science + Business Media

    Professor Ingrid Fleming

  95. Mechanisms of Shear Stress-Dependent Endothelial Nitric Oxide Release: Cardiovascular Implications

    Article • January 1995, Springer Science + Business Media

    Professor Ingrid Fleming

  96. The endothelial organ

    Article • Current Opinion in Cardiology, September 1993, Wolters Kluwer Health

    Professor Ingrid Fleming

  97. Endothelium-Derived Bradykinin

    Article • Journal of Cardiovascular Pharmacology, January 1993, Wolters Kluwer Health

    Professor Ingrid Fleming

  98. Endothelium-Derived Kinins Account for the Immediate Response of Endothelial Cells to Bacterial Lipopoly saccharide

    Article • Journal of Cardiovascular Pharmacology, April 1992, Wolters Kluwer Health

    Professor Ingrid Fleming

  99. Effect of endotoxin on circulating cyclic GMP in the rat

    Article • European Journal of Pharmacology, February 1992, Elsevier

    Professor Ingrid Fleming

  100. Inducible but not constitutive production of nitric oxide by vascular smooth muscle cells

    Article • European Journal of Pharmacology, August 1991, Elsevier

    Professor Ingrid Fleming

  101. The effect of inhibitors of the l-arginine/nitric oxide pathway on endotoxin-induced loss of vascular responsiveness in anaesthetized rats

    Article • British Journal of Pharmacology, May 1991, Wiley

    Professor Ingrid Fleming

  102. Evidence that an l-arginine/nitric oxide dependent elevation of tissue cyclic GMP content is involved in depression of vascular reactivity by endotoxin

    Article • British Journal of Pharmacology, May 1991, Wiley

    Professor Ingrid Fleming

  103. Activation of the l-Arginine-Nitric Oxide Pathway Is Involved in Vascular Hyporeactivity Induced by Endotoxin

    Article • Journal of Cardiovascular Pharmacology, January 1991, Wolters Kluwer Health

    Professor Ingrid Fleming

  104. Activation of the L-Arginine-Nitric Oxide Pathway Is Involved in Vascular Hyporeactivity Induced by Endotoxin

    Article • Journal of Cardiovascular Pharmacology, January 1991, Wolters Kluwer Health

    Professor Ingrid Fleming

  105. An L-arginine-derived factor mediates endotoxin-induced vascular hyposensitivity to calcium

    Article • European Journal of Pharmacology, November 1990, Elsevier

    Professor Ingrid Fleming

  106. Incubation with endotoxin activates the L-arginine pathway in vascular tissue

    Article • Biochemical and Biophysical Research Communications, September 1990, Elsevier

    Professor Ingrid Fleming

  107. Incubation with endotoxin (ETX) induces vascular hyporeactivity which is reversed by NGmonomethyl-L-arginine (L-NMMA)

    Article • Journal of Molecular and Cellular Cardiology, May 1990, Elsevier

    Professor Ingrid Fleming

  108. Endothelial function is impaired in aortae from lipopolysaccharide (LPS)-treated rats

    Article • Journal of Molecular and Cellular Cardiology, May 1990, Elsevier

    Professor Ingrid Fleming