All Stories

  1. Iron-sulfur cluster biogenesis and regulation of intracellular iron homeostasis in Escherichia coli

    Article • Metallomics, November 2025, Oxford University Press (OUP)

    Professor Huangen Ding

  2. Exploring CISD1 as a multifaceted biomarker in cancer: Implications for diagnosis, prognosis, and immunotherapeutic response

    Article • Genes & Diseases, November 2025, Tsinghua University Press

    Jia Zhou, Professor Huangen Ding

  3. Binding of a [2Fe–2S] cluster drives dimerization of ferric uptake regulator (Fur) in Escherichia coli

    Article • Journal of Biological Chemistry, October 2025, Elsevier

    Professor Huangen Ding

  4. Iron–sulfur cluster assembly scaffold protein IscU is required for activation of ferric uptake regulator (Fur) in Escherichia coli

    Article • Journal of Biological Chemistry, April 2024, Elsevier

    Professor Huangen Ding

  5. Ferric uptake regulator (Fur) binds a [2Fe-2S] cluster to regulate intracellular iron homeostasis in Escherichia coli

    Article • Journal of Biological Chemistry, June 2023, Elsevier

    Professor Huangen Ding

  6. Electron transfer activity of the nanodisc-bound mitochondrial outer membrane protein mitoNEET

    Article • Free Radical Biology and Medicine, July 2022, Elsevier

    Professor Huangen Ding

  7. Ferric uptake regulators (Fur) from Vibrio cholerae and Helicobacter pylori bind a [2Fe–2S] cluster in response to elevation of intracellular free iron content

    Article • BioMetals, March 2022, Springer Science + Business Media

    Professor Huangen Ding

  8. Ferric uptake regulator (Fur) reversibly binds a [2Fe-2S] cluster to sense intracellular iron homeostasis in Escherichia coli

    Article • Journal of Biological Chemistry, November 2020, Elsevier

    Professor Huangen Ding

  9. Light-induced release of nitric oxide from the nitric oxide-bound CDGSH-type [2Fe–2S] clusters in mitochondrial protein Miner2

    Article • Nitric Oxide, August 2019, Elsevier

    Professor Huangen Ding

  10. Zinc Toxicity and Iron-Sulfur Cluster Biogenesis in Escherichia coli

    Article • Applied and Environmental Microbiology, March 2019, ASM Journals

    Professor Huangen Ding

  11. Electron transfer kinetics of the mitochondrial outer membrane protein mitoNEET

    Article • Free Radical Biology and Medicine, June 2018, Elsevier

    Professor Huangen Ding

  12. Anaerobic Copper Toxicity and Iron-Sulfur Cluster Biogenesis in Escherichia coli

    Article • Applied and Environmental Microbiology, June 2017, ASM Journals

    Dr Jianxin Lu, Professor Huangen Ding

  13. The mitochondrial outer membrane protein mitoNEET is a redox enzyme catalyzing electron transfer from FMNH 2 to oxygen or ubiquinone

    Article • Journal of Biological Chemistry, May 2017, American Society for Biochemistry & Molecular Biology (ASBMB)

    Professor Huangen Ding

  14. Binding of nitric oxide in the CDGSH-type [2Fe-2S] clusters of human mitochondrial protein Miner2

    Article • Journal of Biological Chemistry, January 2017, American Society for Biochemistry & Molecular Biology (ASBMB)

    Professor Huangen Ding

  15. Flavin nucleotides act as electron shuttles mediating reduction of the [2Fe-2S] clusters in mitochondrial outer membrane protein mitoNEET

    Article • Free Radical Biology and Medicine, January 2017, Elsevier

    Professor Huangen Ding

  16. Deletion of the Proposed Iron Chaperones IscA/SufA Results in Accumulation of a Red Intermediate Cysteine Desulfurase IscS in Escherichia coli

    Article • Journal of Biological Chemistry, April 2015, American Society for Biochemistry & Molecular Biology (ASBMB)

    Professor Huangen Ding

  17. Reduction of mitochondrial protein mitoNEET [2Fe–2S] clusters by human glutathione reductase

    Article • Free Radical Biology and Medicine, April 2015, Elsevier

    Professor Huangen Ding

  18. Helicase and Its Interacting Factors: Regulation Mechanism, Characterization, Structure, and Application for Drug Design

    Article • BioMed Research International, January 2015, Hindawi Publishing Corporation

    Professor Huangen Ding

  19. Dynamic Metabolism of Iron-Sulfur Proteins in Response to Nitric Oxide in Rat Heart Muscle Cells

    Article • Free Radical Biology and Medicine, November 2014, Elsevier

    Professor Huangen Ding

  20. Redox Control of Mitochondrial Outer Membrane Protein MitoNEET Iron-Sulfur Clusters

    Article • Free Radical Biology and Medicine, November 2014, Elsevier

    Professor Huangen Ding

  21. Copper binding in IscA inhibits iron-sulphur cluster assembly inEscherichia coli

    Article • Molecular Microbiology, July 2014, Wiley

    Professor Huangen Ding

  22. Iron and zinc binding activity of Escherichia coli topoisomerase I homolog YrdD

    Article • BioMetals, January 2014, Springer Science + Business Media

    Professor Huangen Ding

  23. Redox Control of Human Mitochondrial Outer Membrane Protein MitoNEET [2Fe-2S] Clusters by Biological Thiols and Hydrogen Peroxide

    Article • Journal of Biological Chemistry, January 2014, American Society for Biochemistry & Molecular Biology (ASBMB)

    Professor Huangen Ding

  24. The N-Terminal Domain of Human DNA Helicase Rtel1 Contains a Redox Active Iron-Sulfur Cluster

    Article • BioMed Research International, January 2014, Hindawi Publishing Corporation

    Professor Huangen Ding

  25. Regulation of the Mitochondrial Protein mitoNEET [2Fe-2S] Cluster by Nitric Oxide

    Article • Free Radical Biology and Medicine, November 2013, Elsevier

    Professor Huangen Ding

  26. Iron binding activity is essential for the function of IscA in iron–sulphur cluster biogenesis

    Article • Dalton Transactions, January 2013, Royal Society of Chemistry

    Professor Huangen Ding

  27. Stimulation ofEscherichia coliDNA damage inducible DNA helicase DinG by the single-stranded DNA binding protein SSB

    Article • FEBS Letters, October 2012, Wiley

    Professor Huangen Ding

  28. Competition of zinc ion for the [2Fe–2S] cluster binding site in the diabetes drug target protein mitoNEET

    Article • BioMetals, September 2012, Springer Science + Business Media

    Professor Huangen Ding

  29. Iron–sulfur proteins are the major source of protein-bound dinitrosyl iron complexes formed in Escherichia coli cells under nitric oxide stress

    Article • Free Radical Biology and Medicine, June 2011, Elsevier

    Professor Huangen Ding

  30. Escherichia coli topoisomerase I is an iron and zinc binding protein

    Article • BioMetals, February 2011, Springer Science + Business Media

    Professor Huangen Ding

  31. In vivo evidence for the iron-binding activity of an iron–sulfur cluster assembly protein IscA in Escherichia coli

    Article • Biochemical Journal, December 2010, Portland Press Ltd.

    Professor Huangen Ding

  32. Oxygen is required for the l-cysteine-mediated decomposition of protein-bound dinitrosyl–iron complexes

    Article • Free Radical Biology and Medicine, July 2010, Elsevier

    Professor Huangen Ding

  33. Iron-binding activity of human iron–sulfur cluster assembly protein hIscA1

    Article • Biochemical Journal, May 2010, Portland Press Ltd.

    Professor Huangen Ding

  34. Cellular Repair Mechanism for Protein-Bound Dinitrosyl Iron Complexes

    Article • Free Radical Biology and Medicine, January 2010, Elsevier

    Professor Huangen Ding

  35. Ironsulfur Proteins Comprise the Major Source of Protein-bound Dinitrosyl Iron Complexes Formed in Escherichia coli Cells under Nitric Oxide Stress

    Article • Free Radical Biology and Medicine, January 2010, Elsevier

    Professor Huangen Ding

  36. IscA/SufA paralogues are required for the [4Fe-4S] cluster assembly in enzymes of multiple physiological pathways in Escherichia coli under aerobic growth conditions

    Article • Biochemical Journal, June 2009, Portland Press Ltd.

    Professor Huangen Ding

  37. Reactivity of nitric oxide with the [4Fe–4S] cluster of dihydroxyacid dehydratase from Escherichia coli

    Article • Biochemical Journal, February 2009, Portland Press Ltd.

    Professor Huangen Ding

  38. Redox Control of the DNA Damage-inducible Protein DinG Helicase Activity via Its Iron-Sulfur Cluster

    Article • Journal of Biological Chemistry, December 2008, American Society for Biochemistry & Molecular Biology (ASBMB)

    Professor Huangen Ding

  39. Nitric oxide-induced bacteriostasis and modification of iron-sulphur proteins inEscherichia coli

    Article • Molecular Microbiology, November 2008, Wiley

    Professor Huangen Ding

  40. Escherichia coli FtnA acts as an iron buffer for re-assembly of iron–sulfur clusters in response to hydrogen peroxide stress

    Article • BioMetals, July 2008, Springer Science + Business Media

    Professor Huangen Ding

  41. Complementary roles of SufA and IscA in the biogenesis of iron–sulfur clusters in Escherichia coli

    Article • Biochemical Journal, January 2008, Portland Press Ltd.

    Professor Huangen Ding

  42. Distinct Iron Binding Property of Two Putative Iron Donors for the Iron-Sulfur Cluster Assembly: IscA AND THE BACTERIAL FRATAXIN ORTHOLOG CyaY UNDER PHYSIOLOGICAL AND OXIDATIVE STRESS CONDITIONS

    Article • Journal of Biological Chemistry, January 2007, American Society for Biochemistry & Molecular Biology (ASBMB)

    Professor Huangen Ding

  43. Harnessing toxic reactions to signal stress: reactions of nitric oxide with iron–sulfur centers and the informative case of SoxR protein

    Article • January 2007, Elsevier

    Professor Huangen Ding

  44. Interplay of IscA and IscU in Biogenesis of Iron-Sulfur Clusters

    Article • Journal of Biological Chemistry, July 2006, American Society for Biochemistry & Molecular Biology (ASBMB)

    Professor Huangen Ding

  45. Mobilization of the iron centre in IscA for the iron–sulphur cluster assembly in IscU

    Article • Biochemical Journal, August 2005, Portland Press Ltd.

    Professor Huangen Ding

  46. Thioredoxin Reductase System Mediates Iron Binding in IscA and Iron Delivery for the Iron-Sulfur Cluster Assembly in IscU

    Article • Journal of Biological Chemistry, July 2005, American Society for Biochemistry & Molecular Biology (ASBMB)

    Professor Huangen Ding

  47. IscA Mediates Iron Delivery for Assembly of Iron-Sulfur Clusters in IscU under the Limited Accessible Free Iron Conditions

    Article • Journal of Biological Chemistry, July 2004, American Society for Biochemistry & Molecular Biology (ASBMB)

    Professor Huangen Ding

  48. Characterization of iron binding in IscA, an ancient iron-sulphur cluster assembly protein

    Article • Biochemical Journal, April 2004, Portland Press Ltd.

    Professor Huangen Ding

  49. Crystal Structure of the Ancient, Fe−S Scaffold IscA Reveals a Novel Protein Fold †

    Article • Biochemistry, January 2004, American Chemical Society (ACS)

    Professor Huangen Ding

  50. Reversible inactivation of E. coli endonuclease III via modification of its [4Fe-4S] cluster by nitric oxide

    Article • DNA Repair, July 2003, Elsevier

    Professor Huangen Ding

  51. Repair of Nitric Oxide-modified Ferredoxin [2Fe-2S] Cluster by Cysteine Desulfurase (IscS)

    Article • Journal of Biological Chemistry, April 2002, American Society for Biochemistry & Molecular Biology (ASBMB)

    Professor Huangen Ding

  52. [35] Escherichia coli SoxR protein: Sensor/transducer of oxidative stress and nitric oxide

    Article • January 2002, Elsevier

    Professor Huangen Ding

  53. [4] Analyzing cotranslational protein folding and disulfide formation by diagonal sodium dodecyl sulfate-polyacrylamide gel electrophoresis

    Article • January 2002, Elsevier

    Professor Huangen Ding, Maurizio Molinari

  54. L-Cysteine-mediated Destabilization of Dinitrosyl Iron Complexes in Proteins

    Article • Journal of Biological Chemistry, June 2001, American Society for Biochemistry & Molecular Biology (ASBMB)

    Professor Huangen Ding

  55. Direct nitric oxide signal transduction via nitrosylation of iron-sulfur centers in the SoxR transcription activator

    Article • Proceedings of the National Academy of Sciences, May 2000, Proceedings of the National Academy of Sciences

    Professor Huangen Ding

  56. 9. Transcriptional regulation via redox-sensitive iron-sulphur centres in an oxidative stress response

    Article • December 1999, De Gruyter

    Professor Huangen Ding

  57. Thiol-Mediated Disassembly and Reassembly of [2Fe-2S] Clusters in the Redox-Regulated Transcription Factor SoxR †

    Article • Biochemistry, December 1998, American Chemical Society (ACS)

    Professor Huangen Ding

  58. In vivo kinetics of a redox-regulated transcriptional switch

    Article • Proceedings of the National Academy of Sciences, August 1997, Proceedings of the National Academy of Sciences

    Professor Huangen Ding

  59. In vivo kinetics of a redox-regulated transcriptional switch soxR containing [2Fe2S] cluster

    Article • Journal of Inorganic Biochemistry, July 1997, Elsevier

    Professor Huangen Ding

  60. Redox signal transduction via iron-sulfur clusters in the SoxR transcription activator

    Article • Trends in Biochemical Sciences, June 1997, Elsevier

    Professor Huangen Ding

  61. Cysteine-to-Alanine Replacements in the Escherichia Coli SoxR Protein and the Role of the [2Fe-2S] Centers in Transcriptional Activation

    Article • Nucleic Acids Research, April 1997, Oxford University Press (OUP)

    Professor Huangen Ding

  62. Substitutions at position 146 of cytochrome b affect drastically the properties of heme bL and the Qo site of Rhodobacter capsulatus cytochrome bc1 complex

    Article • Biochimica et Biophysica Acta (BBA) - Bioenergetics, March 1997, Elsevier

    Fevzi Daldal, Professor Huangen Ding

  63. Redox Signal Transduction: Mutations Shifting [2Fe-2S] Centers of the SoxR Sensor-Regulator to the Oxidized Form

    Article • Cell, January 1997, Elsevier

    Professor Huangen Ding

  64. The Redox State of the [2Fe-2S] Clusters in SoxR Protein Regulates Its Activity as a Transcription Factor

    Article • Journal of Biological Chemistry, December 1996, American Society for Biochemistry & Molecular Biology (ASBMB)

    Professor Huangen Ding

  65. Glutathione-mediated destabilization in vitro of [2Fe-2S] centers in the SoxR regulatory protein.

    Article • Proceedings of the National Academy of Sciences, September 1996, Proceedings of the National Academy of Sciences

    Professor Huangen Ding

  66. Ion Pair Formation between Basic Residues at 144 of the Cyt b Polypeptide and the Ubiquinones at the Qo Site of the Cyt bc1 Complex

    Article • Biochemistry, December 1995, American Chemical Society (ACS)

    Fevzi Daldal, Professor Huangen Ding

  67. Tyrosine 147 of cytochrome b is required for efficient electron transfer at the ubihydroquinone oxidase site (Qo) of the cytochrome bc1 complex

    Article • Biochemistry, December 1995, American Chemical Society (ACS)

    Fevzi Daldal, Professor Huangen Ding

  68. Ubiquinone Pair in the Qo Site Central to the Primary Energy Conversion Reactions of Cytochrome bc1 Complex

    Article • Biochemistry, December 1995, American Chemical Society (ACS)

    Fevzi Daldal, Professor Huangen Ding

  69. Hydroubiquinone-cytochrome c2 oxidoreductase from Rhodobacter capsulatus: Definition of a minimal, functional isolated preparation

    Article • Biochemistry, February 1993, American Chemical Society (ACS)

    Fevzi Daldal, Professor Huangen Ding

  70. Cytochrome bc1 complex [2Fe-2S] cluster and its interaction with ubiquinone and ubihydroquinone at the Qo site: a double-occupancy Qo site model

    Article • Biochemistry, March 1992, American Chemical Society (ACS)

    Fevzi Daldal, Professor Huangen Ding