All Stories

  1. Mitochondrial DNA Content Modulates Chemosensitivity and Cellular Adaptation in Glioblastoma Cells

    Article • Eurasian Journal of Medicine, April 2026, AVES Publishing Co.

    Professor Hsin-Chen Lee

  2. Integrated stress response-upregulated mitochondrial SLC1A5var enhances glucose dependency in human breast cancer cells in vitro

    Article • The International Journal of Biochemistry & Cell Biology, December 2024, Elsevier

    Professor Hsin-Chen Lee

  3. Mitochondrial dysfunction decreases cisplatin sensitivity in gastric cancer cells through upregulation of integrated stress response and mitokine GDF15

    Article • FEBS Journal, November 2023, Wiley

    Professor Hsin-Chen Lee

  4. Role of mitochondrial alterations in human cancer progression and cancer immunity

    Article • Journal of Biomedical Science, July 2023, Springer Science + Business Media

    Professor Hsin-Chen Lee

  5. Growth differentiation factor 15 induces cisplatin resistance through upregulation of xCT expression and glutathione synthesis in gastric cancer

    Article • Cancer Science, June 2023, Wiley

    Professor Hsin-Chen Lee

  6. The Clinical Benefits of Antiresorptive Agents in Patients with Primary Breast Cancer Receiving Adjuvant Endocrine Therapy: A Systematic Review with Pairwise and Network Meta-analysis

    Article • The Journal of Clinical Endocrinology & Metabolism, May 2023, Endocrine Society

    Professor Hsin-Chen Lee

  7. Effect of co‐medications and potential risk factors of high‐dose methotrexate‐mediated acute hepatotoxicity in patients with osteosarcoma

    Article • Cancer Medicine, April 2023, Wiley

    Professor Hsin-Chen Lee

  8. Cardiovascular Medication Use and Risk of Acute Exacerbation in Patients With Asthma-COPD Overlap (CVACO Study)

    Article • Allergy Asthma and Immunology Research, January 2022, The Korean Academy of Asthma, Allergy and Clinical Immunology and The Korean Academy of Pediatric Al

    Professor Hsin-Chen Lee

  9. Mitochondrial stress adaptation promotes resistance to aromatase inhibitor in human breast cancer cells via ROS/calcium up-regulated amphiregulin–estrogen receptor loop signaling

    Article • Cancer Letters, December 2021, Elsevier

    Professor Hsin-Chen Lee

  10. Salubrinal Enhances Cancer Cell Death during Glucose Deprivation through the Upregulation of xCT and Mitochondrial Oxidative Stress

    Article • Biomedicines, August 2021, MDPI AG

    Professor Hsin-Chen Lee

  11. Significance of Kynurenine 3-Monooxygenase Expression in Colorectal Cancer

    Article • Frontiers in Oncology, April 2021, Frontiers

    Professor Hsin-Chen Lee

  12. Circulating microRNAs Associated With Reversible Cerebral Vasoconstriction Syndrome

    Article • Annals of Neurology, December 2020, Wiley

    Professor Anne Ducros, Professor Hsin-Chen Lee

  13. DNAJA3/Tid1 Is Required for Mitochondrial DNA Maintenance and Regulates Migration and Invasion of Human Gastric Cancer Cells

    Article • Cancers, November 2020, MDPI AG

    Professor Hsin-Chen Lee

  14. Prevalence of mitochondrial DNA common deletion in patients with gliomas and meningiomas: A first report from a Malaysian study group

    Article • Journal of the Chinese Medical Association, July 2020, Wolters Kluwer Health

    Professor Hsin-Chen Lee

  15. Combination of peroxisome proliferator–activated receptor gamma and retinoid X receptor agonists induces sodium/iodide symporter expression and inhibits cell growth of human thyroid cancer cells

    Article • Journal of the Chinese Medical Association, July 2020, Wolters Kluwer Health

    Professor Hsin-Chen Lee

  16. ROS Mediate xCT-Dependent Cell Death in Human Breast Cancer Cells under Glucose Deprivation

    Article • Cells, July 2020, MDPI AG

    Professor Hsin-Chen Lee

  17. Mevalonate Pathway Enzyme HMGCS1 Contributes to Gastric Cancer Progression

    Article • Cancers, April 2020, MDPI AG

    Professor Hsin-Chen Lee

  18. Role of the mitochondrial stress response in human cancer progression

    Article • Experimental Biology and Medicine, April 2020, Frontiers

    Professor Hsin-Chen Lee

  19. Kynurenine 3-monooxygenase upregulates pluripotent genes through β-catenin and promotes triple-negative breast cancer progression

    Article • EBioMedicine, April 2020, Elsevier

    Professor Hsin-Chen Lee

  20. Ash2l interacts with Oct4-stemness circuitry to promote super-enhancer-driven pluripotency network

    Article • Nucleic Acids Research, September 2019, Oxford University Press (OUP)

    Professor Hsin-Chen Lee

  21. Printing a Three‐Dimensional Patient‐Specific Safety Device for Reducing the Potential Risk of Mental Nerve Injury During Transoral Thyroidectomy

    Article • Extremophiles, September 2019, Wiley

    Professor Hsin-Chen Lee

  22. Mucolytic Agents and Statins Use is Associated with a Lower Risk of Acute Exacerbations in Patients with Bronchiectasis-Chronic Obstructive Pulmonary Disease Overlap

    Article • Journal of Clinical Medicine, December 2018, MDPI AG

    Professor Hsin-Chen Lee

  23. Activated Integrated Stress Response Induced by Salubrinal Promotes Cisplatin Resistance in Human Gastric Cancer Cells via Enhanced xCT Expression and Glutathione Biosynthesis

    Article • International Journal of Molecular Sciences, October 2018, MDPI AG

    Professor Hsin-Chen Lee

  24. Generation of two isogenic human induced pluripotent stem cell lines from a 15 year-old female patient with MERRF syndrome and A8344G mutation of mitochondrial DNA

    Article • Stem Cell Research, July 2018, Elsevier

    Professor and Director Yau-Huei Wei, Yau-Huei Wei, Professor Hsin-Chen Lee

  25. MicroRNA‑23a/27a/24‑2 cluster promotes gastric cancer cell proliferation synergistically

    Article • Oncology Letters, June 2018, Spandidos Publications

    Professor Hsin-Chen Lee

  26. Correlation between HGF/c-Met and Notch1 signaling pathways in human gastric cancer cells

    Article • Oncology Reports, May 2018, Spandidos Publications

    Professor Hsin-Chen Lee

  27. Bioactivity and gene expression profiles of hiPSC-generated retinal ganglion cells in MT-ND4 mutated Leber's hereditary optic neuropathy

    Article • Experimental Cell Research, February 2018, Elsevier

    Professor Hsin-Chen Lee

  28. CHAC1 degradation of glutathione enhances cystine-starvation-induced necroptosis and ferroptosis in human triple negative breast cancer cells via the GCN2-eIF2α-ATF4 pathway

    Article • Oncotarget, December 2017, Impact Journals, LLC

    Professor Hsin-Chen Lee

  29. MAOA-a novel decision maker of apoptosis and autophagy in hormone refractory neuroendocrine prostate cancer cells

    Article • Scientific Reports, April 2017, Springer Science + Business Media

    Professor Hsin-Chen Lee

  30. REST is a crucial regulator for acquiring EMT-like and stemness phenotypes in hormone-refractory prostate cancer

    Article • Scientific Reports, March 2017, Springer Science + Business Media

    Professor Hsin-Chen Lee

  31. Notch1-promoted TRPA1 expression in erythroleukemic cells suppresses erythroid but enhances megakaryocyte differentiation

    Article • Scientific Reports, February 2017, Springer Science + Business Media

    Professor Hsin-Chen Lee

  32. ROS and Oxidative Stress in Stem Cells

    Article • Oxidative Medicine and Cellular Longevity, January 2017, Hindawi Publishing Corporation

    Professor and Director Yau-Huei Wei, Professor Hsin-Chen Lee, Magdalena Skonieczna, Yau-Huei Wei

  33. miR-151-3p Targets TWIST1 to Repress Migration of Human Breast Cancer Cells

    Article • PLOS One, December 2016, PLOS

    Professor Hsin-Chen Lee

  34. Mitochondrial dysfunction enhances cisplatin resistance in human gastric cancer cells via the ROS-activated GCN2-eIF2α-ATF4-xCT pathway

    Article • Oncotarget, September 2016, Impact Journals, LLC

    Professor Hsin-Chen Lee

  35. Combined effect of honokiol and rosiglitazone on cell growth inhibition through enhanced G0/G1 phase arrest in hepatoma cells

    Article • Journal of the Chinese Medical Association, August 2016, Wolters Kluwer Health

    Professor Hsin-Chen Lee

  36. Peroxisome Proliferator-Activated Receptor γ Expression Is Inversely Associated with Macroscopic Vascular Invasion in Human Hepatocellular Carcinoma

    Article • International Journal of Molecular Sciences, July 2016, MDPI AG

    Professor Hsin-Chen Lee

  37. Notch1 pathway-mediated microRNA-151-5p promotes gastric cancer progression

    Article • Oncotarget, May 2016, Impact Journals, LLC

    Professor Hsin-Chen Lee

  38. Impaired ROS Scavenging System in Human Induced Pluripotent Stem Cells Generated from Patients with MERRF Syndrome

    Article • Scientific Reports, March 2016, Springer Science + Business Media

    Yau-Huei Wei, Professor Hsin-Chen Lee

  39. Role of mitochondrial dysfunction in cancer progression

    Article • Experimental Biology and Medicine, March 2016, SAGE Publications

    Professor Hsin-Chen Lee

  40. Dysregulation of Mitochondrial Functions and Osteogenic Differentiation in Cisd2-Deficient Murine Induced Pluripotent Stem Cells

    Article • Stem Cells and Development, November 2015, Mary Ann Liebert Inc

    Professor Hsin-Chen Lee

  41. Functional dysconnection in the prefrontal–amygdala circuitry in unaffected siblings of patients with bipolar I disorder

    Article • Bipolar Disorders, August 2015, Wiley

    Professor Hsin-Chen Lee

  42. Energy metabolism determines the sensitivity of human hepatocellular carcinoma cells to mitochondrial inhibitors and biguanide drugs

    Article • Oncology Reports, June 2015, Spandidos Publications

    Professor Hsin-Chen Lee

  43. The reciprocal regulation loop of Notch2 pathway and miR-23b in controlling gastric carcinogenesis

    Article • Oncotarget, May 2015, Impact Journals, LLC

    Professor Hsin-Chen Lee

  44. Krüppel-like factor 4 modulates the migration and invasion of hepatoma cells by suppressing TIMP-1 and TIMP-2

    Article • Oncology Reports, May 2015, Spandidos Publications

    Professor Hsin-Chen Lee

  45. Peripheral and central glucose utilizations modulated by mitochondrial DNA 10398A in bipolar disorder

    Article • Psychoneuroendocrinology, May 2015, Elsevier

    Professor Hsin-Chen Lee

  46. Targeting Aerobic Glycolysis and HIF-1α Expression Enhance Imiquimod-induced Apoptosis in Cancer Cells

    Article • Oncotarget, March 2014, Impact Journals, LLC

    Professor Hsin-Chen Lee

  47. Somatic alterations in mitochondrial DNA and mitochondrial dysfunction in gastric cancer progression

    Article • World Journal of Gastroenterology, January 2014, Baishideng Publishing Group Co., Limited (formerly WJG Press)

    Professor Hsin-Chen Lee

  48. SIRT3 Expression as a Biomarker for Better Prognosis in Gastric Cancer

    Article • Extremophiles, December 2013, Wiley

    Professor Hsin-Chen Lee

  49. Mitochondrial dysfunction represses HIF-1α protein synthesis through AMPK activation in human hepatoma HepG2 cells

    Article • Biochimica et Biophysica Acta (BBA) - General Subjects, October 2013, Elsevier

    Yau-Huei Wei, Professor Hsin-Chen Lee

  50. Downregulation of tumor suppressor MBP-1 by microRNA-363 in gastric carcinogenesis

    Article • Carcinogenesis, August 2013, Oxford University Press (OUP)

    Professor Hsin-Chen Lee

  51. 7-Ketocholesterol induces P-glycoprotein through PI3K/mTOR signaling in hepatoma cells

    Article • Biochemical Pharmacology, August 2013, Elsevier

    Professor Hsin-Chen Lee

  52. Mitochondrial DNA alterations and mitochondrial dysfunction in the progression of hepatocellular carcinoma

    Article • World Journal of Gastroenterology, January 2013, Baishideng Publishing Group Co., Limited (formerly WJG Press)

    Yau-Huei Wei, Professor Hsin-Chen Lee

  53. Regulation of mitochondrial FoF1ATPase activity by Sirt3-catalyzed deacetylation and its deficiency in human cells harboring 4977bp deletion of mitochondrial DNA

    Article • Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease, January 2013, Elsevier

    Yau-Huei Wei, Professor Hsin-Chen Lee

  54. Norcantharidin suppresses cell growth and migration with enhanced anticancer activity of gefitinib and cisplatin in human non-small cell lung cancer cells

    Article • Oncology Reports, October 2012, Spandidos Publications

    Professor Hsin-Chen Lee, Prof. Cheng-Deng Kuo

  55. Suppressor of cytokine signaling 6 (SOCS6) promotes mitochondrial fission via regulating DRP1 translocation

    Article • Cell Death and Differentiation, September 2012, Springer Science + Business Media

    Professor Hsin-Chen Lee

  56. Mitochondrial dysfunction promotes cell migration via reactive oxygen species-enhanced β5-integrin expression in human gastric cancer SC-M1 cells

    Article • Biochimica et Biophysica Acta (BBA) - General Subjects, July 2012, Elsevier

    Professor Hsin-Chen Lee

  57. A novel mechanism of coenzyme Q10 protects against human endothelial cells from oxidative stress-induced injury by modulating NO-related pathways

    Article • The Journal of Nutritional Biochemistry, May 2012, Elsevier

    Professor Hsin-Chen Lee

  58. Curcumin induces the apoptosis of human monocytic leukemia THP-1 cells via the activation of JNK/ERK Pathways

    Article • BMC Complementary and Alternative Medicine, March 2012, Springer Science + Business Media

    Professor Hsin-Chen Lee

  59. Targeting Protective Autophagy Exacerbates UV-Triggered Apoptotic Cell Death

    Article • International Journal of Molecular Sciences, January 2012, MDPI AG

    Professor Hsin-Chen Lee

  60. Melatonin attenuates kainic acid‐induced neurotoxicity in mouse hippocampus via inhibition of autophagy and α‐synuclein aggregation

    Article • Journal of Pineal Research, December 2011, Wiley

    Professor Hsin-Chen Lee

  61. Mitochondria and Aging

    Article • December 2011, Springer Science + Business Media

    Professor and Director Yau-Huei Wei, Professor Hsin-Chen Lee

  62. Enhanced Differentiation of Three-Gene-Reprogrammed Induced Pluripotent Stem Cells into Adipocytes via Adenoviral-Mediated PGC-1α Overexpression

    Article • International Journal of Molecular Sciences, November 2011, MDPI AG

    Professor Hsin-Chen Lee

  63. Ascorbic acid mitigates the myocardial injury after cardiac arrest and electrical shock

    Article • Intensive Care Medicine, September 2011, Springer Science + Business Media

    Professor Tzung-Dau Wang, Professor Hsin-Chen Lee

  64. Gene expression profiling of peripheral blood leukocytes identifies and validates ABCB1 as a novel biomarker for Alzheimer's disease

    Article • Neurobiology of Disease, September 2011, Elsevier

    Professor Hsin-Chen Lee

  65. Somatic mutations of the mitochondrial genome in human breast cancers

    Article • Genes Chromosomes and Cancer, July 2011, Wiley

    Professor Hsin-Chen Lee

  66. Autophagy inhibition enhances apoptosis triggered by BO-1051, an N-mustard derivative, and involves the ATM signaling pathway

    Article • Biochemical Pharmacology, March 2011, Elsevier

    Professor Hsin-Chen Lee

  67. PGC-1α Mediates Differentiation of Mesenchymal Stem Cells to Brown Adipose Cells

    Article • Journal of Atherosclerosis and Thrombosis, January 2011, Japan Atherosclerosis Society

    Professor Hsin-Chen Lee

  68. Somatic mutations of mitochondrial DNA in aging and cancer progression

    Article • Ageing Research Reviews, November 2010, Elsevier

    Professor Hsin-Chen Lee

  69. Role of autophagy in protection afforded by hypoxic preconditioning against MPP+-induced neurotoxicity in SH-SY5Y cells

    Article • Free Radical Biology and Medicine, September 2010, Elsevier

    Professor Hsin-Chen Lee

  70. Mitochondrial DNA Content as a Potential Marker to Predict Response to Anthracycline in Breast Cancer Patients

    Article • The Breast Journal, April 2010, Hindawi Publishing Corporation

    Professor Hsin-Chen Lee

  71. Gly482Ser polymorphism in the peroxisome proliferator–activated receptor γ coactivator–1α gene is associated with oxidative stress and abdominal obesity

    Article • Metabolism, April 2010, Elsevier

    Professor Hsin-Chen Lee

  72. Somatic mutations of mitochondrial genome in hepatocellular carcinoma

    Article • Mitochondrion, March 2010, Elsevier

    Professor and Director Yau-Huei Wei, Professor Hsin-Chen Lee

  73. Somatic mutations in mitochondrial genome and their potential roles in the progression of human gastric cancer

    Article • Biochimica et Biophysica Acta (BBA) - General Subjects, March 2010, Elsevier

    Professor Hsin-Chen Lee

  74. Heteroplasmy of Mitochondrial D310 Mononucleotide Repeat Region in the Blood of Patients with Alzheimer's Disease

    Article • Journal of Alzheimer’s Disease, August 2009, IOS Press

    Professor Hsin-Chen Lee

  75. Association between mitochondrial DNA 4,977 bp deletion and NAD(P)H:quinone oxidoreductase 1 C609T polymorphism in human breast tissues

    Article • Oncology Reports, April 2009, Spandidos Publications

    Professor Hsin-Chen Lee

  76. Mitochondrial dysfunction-induced amphiregulin upregulation mediates chemo-resistance and cell migration in HepG2 cells

    Article • Cellular and Molecular Life Sciences, April 2009, Springer Science + Business Media

    Professor and Director Yau-Huei Wei, Professor Hsin-Chen Lee

  77. Mitochondrial DNA Instability and Metabolic Shift in Human Cancers

    Article • International Journal of Molecular Sciences, February 2009, MDPI AG

    Professor and Director Yau-Huei Wei, Professor Hsin-Chen Lee

  78. MELAS syndrome associated with a tandem duplication in the D-loop of mitochondrial DNA

    Article • Acta Neurologica Scandinavica, January 2009, Wiley

    Associate Professor Cheng-Yoong Pang, Professor Hsin-Chen Lee

  79. CPEO and carnitine deficiency overlapping in MELAS syndrome

    Article • Acta Neurologica Scandinavica, January 2009, Wiley

    Associate Professor Cheng-Yoong Pang, Professor Hsin-Chen Lee

  80. Type IV hyperlipoproteinemia and moderate instability of CAG triplet expansion in the androgen-receptor gene

    Article • Acta Neurologica Scandinavica, January 2009, Wiley

    Associate Professor Cheng-Yoong Pang, Professor Hsin-Chen Lee

  81. MELAS syndrome: correlation between clinical features and molecular genetic analysis

    Article • Acta Neurologica Scandinavica, January 2009, Wiley

    Associate Professor Cheng-Yoong Pang, Professor Hsin-Chen Lee

  82. Peripheral blood mitochondrial DNA content and dysregulation of glucose metabolism

    Article • Diabetes Research and Clinical Practice, January 2009, Elsevier

    Professor and Director Yau-Huei Wei, Professor Hsin-Chen Lee

  83. Involvement of oxidative stress-activated JNK signaling in the methamphetamine-induced cell death of human SH-SY5Y cells

    Article • Toxicology, April 2008, Elsevier

    Professor Hsin-Chen Lee

  84. Peroxisome proliferator‐activated receptor gamma coactivator‐1 alpha (PGC‐1α) upregulated E‐cadherin expression in HepG2 cells

    Article • FEBS Letters, January 2008, Wiley

    Professor Hsin-Chen Lee

  85. Tandem duplication/triplication correlated with poly-cytosine stretch variation in human mitochondrial DNA D-loop region

    Article • Mutagenesis, January 2008, Oxford University Press (OUP)

    Professor Hsin-Chen Lee

  86. Mitochondria Are an Essential Mediator of Nitric Oxide/Cyclic Guanosine 3′,5′-Monophosphate Blocking of Glucose Depletion–Induced Cytotoxicity in Human HepG2 Cells

    Article • Molecular Cancer Research, September 2007, American Association for Cancer Research (AACR)

    Professor Hsin-Chen Lee

  87. Open Reading Frame 8a of the Human Severe Acute Respiratory Syndrome Coronavirus Not Only Promotes Viral Replication but Also Induces Apoptosis

    Article • The Journal of Infectious Diseases, August 2007, Oxford University Press (OUP)

    Professor Hsin-Chen Lee

  88. Enhanced oxidative stress and aberrant mitochondrial biogenesis in human neuroblastoma SH-SY5Y cells during methamphetamine induced apoptosis

    Article • Toxicology and Applied Pharmacology, May 2007, Elsevier

    Professor Hsin-Chen Lee

  89. Heteroplasmic mutation of mitochondrial DNA D-loop and 4977-bp deletion in human cancer cells during mitochondrial DNA depletion

    Article • Mitochondrion, February 2007, Elsevier

    Professor Hsin-Chen Lee

  90. Anticancer effects of low-dose 10-hydroxycamptothecin in human colon cancer

    Article • Oncology Reports, May 2006, Spandidos Publications

    Professor Hsin-Chen Lee

  91. Aberrant methylation of EDNRB and p16 genes in hepatocellular carcinoma (HCC) in Taiwan

    Article • Oncology Reports, February 2006, Spandidos Publications

    Professor Hsin-Chen Lee

  92. Increases of Mitochondrial Mass and Mitochondrial Genome in Association with Enhanced Oxidative Stress in Human Cells Harboring 4,977 BP-Deleted Mitochondrial DNA

    Article • Annals of the New York Academy of Sciences, January 2006, Wiley

    Professor and Director Yau-Huei Wei, Associate Professor Cheng-Yoong Pang, Professor Hsin-Chen Lee

  93. Mitochondrial DNA mutations and mitochondrial DNA depletion in breast cancer

    Article • Genes Chromosomes and Cancer, January 2006, Wiley

    Professor and Director Yau-Huei Wei, Professor Hsin-Chen Lee

  94. Accumulation of mitochondrial DNA with 4977-bp deletion in knee cartilage – an association with idiopathic osteoarthritis

    Article • Osteoarthritis and Cartilage, November 2005, Elsevier

    Professor and Director Yau-Huei Wei, Professor Hsin-Chen Lee

  95. Mitochondrial DNA mutations and mitochondrial DNA depletion in gastric cancer

    Article • Genes Chromosomes and Cancer, May 2005, Wiley

    Professor Hsin-Chen Lee

  96. Mitochondrial Genome Instability and mtDNA Depletion in Human Cancers

    Article • Annals of the New York Academy of Sciences, May 2005, Wiley

    Professor and Director Yau-Huei Wei, Professor Hsin-Chen Lee

  97. Mitochondrial biogenesis and mitochondrial DNA maintenance of mammalian cells under oxidative stress

    Article • The International Journal of Biochemistry & Cell Biology, April 2005, Elsevier

    Professor Hsin-Chen Lee

  98. Polymorphisms of estrogen-metabolizing genes and risk of hepatocellular carcinoma in Taiwan females

    Article • Cancer Letters, August 2004, Elsevier

    Professor Hsin-Chen Lee

  99. Alteration of the copy number and deletion of mitochondrial DNA in human hepatocellular carcinoma

    Article • British Journal of Cancer, May 2004, Springer Science + Business Media

    Professor and Director Yau-Huei Wei, Professor Hsin-Chen Lee

  100. Somatic mutations in the D-loop and decrease in the copy number of mitochondrial DNA in human hepatocellular carcinoma

    Article • Mutation Research/Fundamental and Molecular Mechanisms of Mutagenesis, March 2004, Elsevier

    Professor and Director Yau-Huei Wei, Professor Hsin-Chen Lee

  101. Increased expression of manganese-superoxide dismutase in fibroblasts of patients with CPEO syndrome

    Article • Molecular Genetics and Metabolism, November 2003, Elsevier

    Professor and Director Yau-Huei Wei, Professor Hsin-Chen Lee

  102. Mitochondrial DNA mutations and oxidative stress in mitochondrial diseases

    Article • January 2003, Elsevier

    Professor and Director Yau-Huei Wei, Professor Hsin-Chen Lee

  103. Oxidative Stress, Mitochondrial DNA Mutation, and Impairment of Antioxidant Enzymes in Aging

    Article • Experimental Biology and Medicine, October 2002, SAGE Publications

    Professor and Director Yau-Huei Wei, Professor Hsin-Chen Lee

  104. Increase in mitochondrial mass in human fibroblasts under oxidative stress and during replicative cell senescence

    Article • Journal of Biomedical Science, September 2002, Springer Science + Business Media

    Professor Hsin-Chen Lee

  105. Wernicke’s Encephalopathy in a Patient with Multiple Symmetrical Lipomatosis and the A8344G Mutation of Mitochondrial DNA

    Article • European Neurology, January 2002, Karger Publishers

    Professor and Director Yau-Huei Wei, Professor Hsin-Chen Lee

  106. Enhanced oxidative damage in human cells harboring A3243G mutation of mitochondrial DNA: implication of oxidative stress in the pathogenesis of mitochondrial diabetes

    Article • Diabetes Research and Clinical Practice, December 2001, Elsevier

    Professor and Director Yau-Huei Wei, Associate Professor Cheng-Yoong Pang, Professor Hsin-Chen Lee

  107. Coenzyme Q10 treatment in Leber's hereditary optic neuropathy

    Article • Neuro-Ophthalmology, June 2001, Swets & Zeitlinger Publishers

    Associate Professor Cheng-Yoong Pang, Professor Hsin-Chen Lee

  108. Accumulation of mitochondrial DNA deletions in human oral tissues — effects of betel quid chewing and oral cancer

    Article • Mutation Research/Genetic Toxicology and Environmental Mutagenesis, June 2001, Elsevier

    Professor and Director Yau-Huei Wei, Professor Hsin-Chen Lee

  109. Involvement of nervous system in maternally inherited diabetes and deafness (MIDD) with the A3243G mutation of mitochondrial DNA

    Article • Acta Neurologica Scandinavica, March 2001, Wiley

    Professor and Director Yau-Huei Wei, Professor Hsin-Chen Lee

  110. Article • Biogerontology, January 2001, Springer Science + Business Media

    Professor and Director Yau-Huei Wei, Professor Hsin-Chen Lee

  111. Clinical phenotype and the G11778A mutation of mitochondrial DNA in patients with Leber’s hereditary optic neuropathy in Taiwan

    Article • Neuro-Ophthalmology, January 2001, Swets & Zeitlinger Publishers

    Professor Hsin-Chen Lee

  112. Increase of mitochondria and mitochondrial DNA in response to oxidative stress in human cells

    Article • Biochemical Journal, June 2000, Portland Press Ltd.

    Professor and Director Yau-Huei Wei, Professor Hsin-Chen Lee

  113. Increase of mitochondria and mitochondrial DNA in response to oxidative stress in human cells

    Article • Biochemical Journal, June 2000, Portland Press Ltd.

    Professor and Director Yau-Huei Wei, Professor Hsin-Chen Lee

  114. Mitochondrial role in life and death of the cell

    Article • Journal of Biomedical Science, January 2000, Springer Science + Business Media

    Professor and Director Yau-Huei Wei, Professor Hsin-Chen Lee

  115. Mitochondrial Role in Life and Death of the Cell

    Article • Journal of Biomedical Science, January 2000, Springer Science + Business Media

    Professor Hsin-Chen Lee

  116. Oxidative stress is insignificant in N1S1-transplanted hepatoma despite markedly declined activities of the antioxidant enzymes.

    Article • Oncology Reports, November 1999, Spandidos Publications

    Professor Hsin-Chen Lee

  117. Exclusive Homoplasmic 11778 Mutation in Mitochondrial DNA of Chinese Patients With Leber's Hereditary Optic Neuropathy

    Article • Japanese Journal of Ophthalmology, May 1999, Elsevier

    Professor and Director Yau-Huei Wei, Professor Hsin-Chen Lee

  118. Concurrent Increase of Oxidative DNA Damage and Lipid Peroxidation Together with Mitochondrial DNA Mutation in Human Lung Tissues During Aging—Smoking Enhances Oxidative Stress on the Aged Tissues

    Article • Archives of Biochemistry and Biophysics, February 1999, Elsevier

    Professor and Director Yau-Huei Wei, Professor Hsin-Chen Lee

  119. Oxidative damage elicited by imbalance of free radical scavenging enzymes is associated with large-scale mtDNA deletions in aging human skin

    Article • Mutation Research/Fundamental and Molecular Mechanisms of Mutagenesis, January 1999, Elsevier

    Professor and Director Yau-Huei Wei, Professor Hsin-Chen Lee

  120. Human lung accumulates mitochondrial DNA mutations in aging and in smokers.

    Article • FEBS Letters, December 1998, Wiley

    Professor and Director Yau-Huei Wei, Professor Hsin-Chen Lee

  121. Oxidative Damage and Mutation to Mitochondrial DNA and Age-dependent Decline of Mitochondrial Respiratory Functiona

    Article • Annals of the New York Academy of Sciences, November 1998, Wiley

    Professor and Director Yau-Huei Wei, Associate Professor Cheng-Yoong Pang, Professor Hsin-Chen Lee

  122. Independent occurrence of somatic mutations in mitochondrial DNA of human skin from subjects of various ages

    Article • Human Mutation, January 1998, Wiley

    Professor and Director Yau-Huei Wei, Associate Professor Cheng-Yoong Pang, Professor Hsin-Chen Lee

  123. Decreased cellular respiratory function and mitochondrial DNA mutations in the human heart associated with ageing and disease

    Article • The Asia Pacific Heart Journal, December 1997, Elsevier

    Associate Professor Cheng-Yoong Pang, Professor Hsin-Chen Lee

  124. Role of mitochondria in human aging

    Article • Journal of Biomedical Science, November 1997, Springer Science + Business Media

    Professor and Director Yau-Huei Wei, Professor Hsin-Chen Lee

  125. Simultaneous Increase of Mitochondrial DNA Deletions and Lipid Peroxidation in Human Aging

    Article • Annals of the New York Academy of Sciences, June 1996, Wiley

    Professor and Director Yau-Huei Wei, Professor Hsin-Chen Lee

  126. Tandem Duplications and Large-Scale Deletions of Mitochondrial DNA Are Early Molecular Events of Human Aging Process

    Article • Annals of the New York Academy of Sciences, June 1996, Wiley

    Associate Professor Cheng-Yoong Pang, Professor Hsin-Chen Lee

  127. Compensatory elevation of complex II activity in Leber's hereditary optic neuropathy.

    Article • British Journal of Ophthalmology, January 1996, BMJ

    Professor and Director Yau-Huei Wei, Associate Professor Cheng-Yoong Pang, Professor Hsin-Chen Lee

  128. Photoageing-associated mitochondrial DNA length mutations in human skin

    Article • Archives of Dermatological Research, September 1995, Springer Science + Business Media

    Professor Hsin-Chen Lee

  129. MELAS syndrome associated with diabetes mellitus and hyperthyroidism: a case report from Taiwan

    Article • Clinical Endocrinology, August 1995, Wiley

    Professor Hsin-Chen Lee

  130. Ageing-associated tandem duplications in the D-loop of mitochondrial DNA of human muscle

    Article • FEBS Letters, October 1994, Wiley

    Associate Professor Cheng-Yoong Pang, Professor Hsin-Chen Lee

  131. Human Skin Mitochondrial DNA Deletions Associated with Light Exposure

    Article • Archives of Biochemistry and Biophysics, August 1994, Elsevier

    Professor and Director Yau-Huei Wei, Associate Professor Cheng-Yoong Pang, Professor Hsin-Chen Lee

  132. A specific 4977-bp deletion of mitochondrial DNA in human ageing skin

    Article • Archives of Dermatological Research, August 1994, Springer Science + Business Media

    Professor and Director Yau-Huei Wei, Professor Hsin-Chen Lee

  133. MELAS syndrome with mitochondrial tRNA(Leu(UUR)) gene mutation in a Chinese family.

    Article • Journal of Neurology Neurosurgery & Psychiatry, May 1994, BMJ

    Professor and Director Yau-Huei Wei, Associate Professor Cheng-Yoong Pang, Professor Hsin-Chen Lee

  134. Differential accumulations of 4,977 bp deletion in mitochondrial DNA of various tissues in human ageing

    Article • Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease, April 1994, Elsevier

    Professor and Director Yau-Huei Wei, Associate Professor Cheng-Yoong Pang, Professor Hsin-Chen Lee

  135. Age-dependent increase of mitochondrial DNA deletions together with lipid peroxides and superoxide dismutase in human liver mitochondria

    Article • Free Radical Biology and Medicine, February 1994, Elsevier

    Professor and Director Yau-Huei Wei, Professor Hsin-Chen Lee