All Stories

  1. From pathophysiology to treatment in transthyretin cardiac amyloidosis

    Article • Trends in Molecular Medicine, July 2025, Elsevier

    Dr Henrique Girao

  2. The ins and outs of connexins and pannexins beyond the cell surface

    Article • Trends in Biochemical Sciences, July 2025, Elsevier

    Dr Henrique Girao

  3. Ketogenic diet and ketone salts differentially improve cardiometabolic complications in an HFpEF rat model

    Article • The Journal of Physiology, April 2025, Wiley

    Dr Henrique Girao

  4. Opportunities and challenges for the use of human samples in translational cardiovascular research: a scientific statement of the ESC Working Group on Cellular Biology of the Heart, the ESC Working Group on Cardiovascular Surgery, the ESC Council on Ba...

    Article • Cardiovascular Research, March 2025, Oxford University Press (OUP)

    Dr Henrique Girao

  5. 1,8-Cineole reduces pulmonary vascular remodelling in pulmonary arterial hypertension by restoring intercellular communication and inhibiting angiogenesis

    Article • Phytomedicine, February 2025, Elsevier

    Jorge M. Alves-Silva, Dr Henrique Girao

  6. Unveiling the antitumor mechanism of 7α-acetoxy-6β-hydroxyroyleanone from Plectranthus hadiensis in glioblastoma

    Article • Journal of Ethnopharmacology, December 2024, Elsevier

    Professor Patrícia M Rijo, Mariana Magalhães, Dr Henrique Girao

  7. Should it stay or should it go: gap junction protein GJA1/Cx43 conveys damaged lysosomes to the cell periphery to potentiate exocytosis

    Article • Autophagy, October 2024, Taylor & Francis

    Dr Henrique Girao

  8. Connexin43 promotes exocytosis of damaged lysosomes through actin remodelling

    Article • The EMBO Journal, July 2024, Springer Science + Business Media

    Dr Henrique Girao

  9. Loss of the lysosomal protein CLN3 modifies the lipid content of the nuclear envelope leading to DNA damage and activation of YAP1 pro-apoptotic signaling

    Article • June 2024, Cold Spring Harbor Laboratory Press

    Dr Henrique Girao

  10. Unveiling the Antitumor Mechanism of 7α-Acetoxy-6β-Hydroxyroyleanone from<em> Plectranthus hadiensis</em> in Glioblastoma

    Article • May 2024, MDPI AG

    Professor Patrícia M Rijo, Mariana Magalhães, Dr Henrique Girao

  11. Contribution of extracellular vesicles for the pathogenesis of retinal diseases: shedding light on blood-retinal barrier dysfunction

    Article • Journal of Biomedical Science, May 2024, Springer Science + Business Media

    Dr Henrique Girao

  12. Effect of Blueberry Supplementation on a Diet-Induced Rat Model of Prediabetes—Focus on Hepatic Lipid Deposition, Endoplasmic Stress Response and Autophagy

    Article • Nutrients, February 2024, MDPI AG

    Dr Henrique Girao

  13. Evaluation of the Marginal Adaptation of Two Hydraulic Calcium Silicate Cements Used in Apical Plugs: An In Vitro Study

    Article • Applied Sciences, January 2024, MDPI AG

    Professor Manuel Marques Ferreira, Dr Henrique Girao

  14. Cx43 can form functional channels at the nuclear envelope and modulate gene expression in cardiac cells

    Article • Open Biology, November 2023, Royal Society Publishing

    Dr Henrique Girao

  15. Medical herbarium of the Faculty of Medicine, University of Coimbra: from a 19th century collection to 21st century health literacy

    Article • Planta Medica, November 2023, Thieme Publishing Group

    Dr Henrique Girao

  16. Cx43-mediated hyphal folding counteracts phagosome integrity loss during fungal infection

    Article • Microbiology Spectrum, October 2023, ASM Journals

    Dr Henrique Girao

  17. Aromatic Plant-Based Functional Foods: A Natural Approach to Manage Cardiovascular Diseases

    Article • Molecules, June 2023, MDPI AG

    Dr Henrique Girao

  18. Kazrin promotes dynein/dynactin-dependent traffic from early to recycling endosomes

    Article • eLife, April 2023, eLife

    Dr Henrique Girao

  19. Alvespimycin Inhibits Heat Shock Protein 90 and Overcomes Imatinib Resistance in Chronic Myeloid Leukemia Cell Lines

    Article • Molecules, January 2023, MDPI AG

    Dr Henrique Girao

  20. Plant Nanovesicles for Essential Oil Delivery

    Article • Pharmaceutics, November 2022, MDPI AG

    Dr Henrique Girao

  21. Cardiac fibroblasts and mechanosensation in heart development, health and disease

    Article • Nature Reviews Cardiology, November 2022, Springer Science + Business Media

    Dr Henrique Girao

  22. Osteosarcoma‐Derived Exosomes as Potential PET Imaging Nanocarriers for Lung Metastasis

    Article • Small, October 2022, Wiley

    Dr Henrique Girao

  23. Natural Products in Cardiovascular Diseases: The Potential of Plants from the Allioideae Subfamily (Ex-Alliaceae Family) and Their Sulphur-Containing Compounds

    Article • Plants, July 2022, MDPI AG

    Jorge M. Alves-Silva, Dr Henrique Girao

  24. Long COVID and the cardiovascular system—elucidating causes and cellular mechanisms in order to develop targeted diagnostic and therapeutic strategies: a joint Scientific Statement of the ESC Working Groups on Cellular Biology of the Heart and Myocardi...

    Article • Cardiovascular Research, July 2022, Oxford University Press (OUP)

    Dr Henrique Girao

  25. Cellular and molecular mechanisms underlying plasma membrane functionality and integrity

    Article • Journal of Cell Science, July 2022, The Company of Biologists

    Dr Henrique Girao

  26. Phagolysosomal remodeling to confine Candida albicans in the macrophage

    Article • Trends in Microbiology, June 2022, Elsevier

    Dr Henrique Girao

  27. The Footprint of Exosomes in the Radiation-Induced Bystander Effects

    Article • Bioengineering, May 2022, MDPI AG

    Dr Henrique Girao

  28. Putative Biomarkers in Tears for Diabetic Retinopathy Diagnosis

    Article • Frontiers in Medicine, May 2022, Frontiers

    Dr Henrique Girao

  29. Cx43‐mediated sorting of miRNAs into extracellular vesicles

    Article • EMBO Reports, May 2022, Springer Science + Business Media

    Dr Henrique Girao

  30. The good, the bad and the ugly: the impact of extracellular vesicles on the cardiovascular system

    Article • The Journal of Physiology, April 2022, Wiley

    Dr Henrique Girao

  31. Circadian rhythms in ischaemic heart disease: key aspects for preclinical and translational research: position paper of the ESC working group on cellular biology of the heart

    Article • Cardiovascular Research, September 2021, Oxford University Press (OUP)

    Dr Henrique Girao

  32. COVID-19-related cardiac complications from clinical evidences to basic mechanisms: opinion paper of the ESC Working Group on Cellular Biology of the Heart

    Article • Cardiovascular Research, June 2021, Oxford University Press (OUP)

    Dr Henrique Girao

  33. The Role of Essential Oils and Their Main Compounds in the Management of Cardiovascular Disease Risk Factors

    Article • Molecules, June 2021, MDPI AG

    Jorge M. Alves-Silva, Dr Henrique Girao

  34. Microglial Extracellular Vesicles as Vehicles for Neurodegeneration Spreading

    Article • Biomolecules, May 2021, MDPI AG

    Dr Henrique Girao

  35. Effect of Different Irrigation Solutions on the Diffusion of MTA Cement into the Root Canal Dentin

    Article • Materials, December 2020, MDPI AG

    Professor Manuel Marques Ferreira, Dr Henrique Girao

  36. Cx43 and Associated Cell Signaling Pathways Regulate Tunneling Nanotubes in Breast Cancer Cells

    Article • Cancers, September 2020, MDPI AG

    Dr Henrique Girao

  37. Cx43 and Associated Cell Signaling Pathways Regulate Tunneling Nanotubes in Breast Cancer Cells

    Article • September 2020, MDPI AG

    Dr Henrique Girao

  38. Canonical and Non-Canonical Roles of Connexin43 in Cardioprotection

    Article • Biomolecules, August 2020, MDPI AG

    Dr Henrique Girao

  39. Mitochondrial ion channels as targets for cardioprotection

    Article • Journal of Cellular and Molecular Medicine, June 2020, Wiley

    Dr Henrique Girao

  40. Improving translational research in sex-specific effects of comorbidities and risk factors in ischaemic heart disease and cardioprotection: position paper and recommendations of the ESC Working Group on Cellular Biology of the Heart

    Article • Cardiovascular Research, June 2020, Oxford University Press (OUP)

    Dr Henrique Girao

  41. Targeting mitochondrial fusion and fission proteins for cardioprotection

    Article • Journal of Cellular and Molecular Medicine, May 2020, Wiley

    Dr Henrique Girao

  42. EHD1 Modulates Cx43 Gap Junction Remodeling Associated With Cardiac Diseases

    Article • Circulation Research, May 2020, Wolters Kluwer Health

    Dr Henrique Girao

  43. Caveolin-1 Modulation Increases Efficacy of a Galacto-Conjugated Phthalocyanine in Bladder Cancer Cells Resistant to Photodynamic Therapy

    Article • Molecular Pharmaceutics, April 2020, American Chemical Society (ACS)

    Dr Henrique Girao

  44. A Conserved LIR Motif in Connexins Mediates Ubiquitin-Independent Binding to LC3/GABARAP Proteins

    Article • Cells, April 2020, MDPI AG

    Dr Henrique Girao

  45. RyR2 regulates Cx43 hemichannel intracellular Ca2+-dependent activation in cardiomyocytes

    Article • Cardiovascular Research, December 2019, Oxford University Press (OUP)

    Luc Leybaert, Dr Henrique Girao

  46. Biological Functions of Connexin43 Beyond Intercellular Communication

    Article • Trends in Cell Biology, October 2019, Elsevier

    Dr Henrique Girao

  47. Circulating blood cells and extracellular vesicles in acute cardioprotection

    Article • Cardiovascular Research, December 2018, Oxford University Press (OUP)

    Dr Sean Michael Davidson, Prof. Lucio Barile, Dr. Hector Cabrera-Fuentes, Professor Pasquale Pagliaro, Dr Henrique Girao

  48. Ischaemia alters the effects of cardiomyocyte‐derived extracellular vesicles on macrophage activation

    Article • Journal of Cellular and Molecular Medicine, December 2018, Wiley

    Dr Henrique Girao

  49. Signalling mechanisms that regulate metabolic profile and autophagy of acute myeloid leukaemia cells

    Article • Journal of Cellular and Molecular Medicine, August 2018, Wiley

    Paula Ludovico, Dr Henrique Girao

  50. Intravascular imaging, histopathological analysis, and catecholamine quantification following catheter-based renal denervation in a swine model: the impact of prebifurcation energy delivery

    Article • Hypertension Research, July 2018, Springer Science + Business Media

    Dr Henrique Girao

  51. Disclosing the functional changes of two genetic alterations in a patient with Chronic Progressive External Ophthalmoplegia: Report of the novel mtDNA m.7486G>A variant

    Article • Neuromuscular Disorders, April 2018, Elsevier

    Dr Henrique Girao

  52. Elucidation of the dynamic nature of interactome networks: A practical tutorial

    Article • Journal of Proteomics, January 2018, Elsevier

    Dr Henrique Girao

  53. Molecular control of chaperone-mediated autophagy

    Article • Essays in Biochemistry, December 2017, Portland Press Ltd.

    Dr Henrique Girao

  54. Role of connexin 43 in different forms of intercellular communication – gap junctions, extracellular vesicles and tunnelling nanotubes

    Article • Journal of Cell Science, October 2017, The Company of Biologists

    Dr Henrique Girao

  55. MicroRNA-424(322) as a new marker of disease progression in pulmonary arterial hypertension and its role in right ventricular hypertrophy by targeting SMURF1

    Article • Cardiovascular Research, September 2017, Oxford University Press (OUP)

    Dr Henrique Girao

  56. The Expression of Connexins and SOX2 Reflects the Plasticity of Glioma Stem-Like Cells

    Article • Translational Oncology, August 2017, Elsevier

    Dr Henrique Girao, Professor Fernanda A. Ferreira

  57. Exosomes secreted by cardiomyocytes subjected to ischaemia promote cardiac angiogenesis

    Article • Cardiovascular Research, June 2017, Oxford University Press (OUP)

    Dr Henrique Girao

  58. Characterization of phospholipid nitroxidation by LC-MS in biomimetic models and in H9c2 Myoblast using a lipidomic approach

    Article • Free Radical Biology and Medicine, May 2017, Elsevier

    Dr Henrique Girao

  59. Hyperglycemia-induced degradation of HIF-1α contributes to impaired response of cardiomyocytes to hypoxia

    Article • Revista Portuguesa de Cardiologia, May 2017, Elsevier

    Dr Henrique Girao

  60. Glioblastoma entities express subtle differences in molecular composition and response to treatment

    Article • Oncology Reports, March 2017, Spandidos Publications

    Dr Henrique Girao, Ana Cristina Gonçalves

  61. Cardiac-released extracellular vesicles can activate endothelial cells

    Article • Annals of Translational Medicine, February 2017, AME Publishing Company

    Dr Henrique Girao

  62. Targeted Approach for Proteomic Analysis of a Hidden Membrane Protein

    Article • January 2017, Springer Science + Business Media

    Dr Henrique Girao

  63. Protective Effects of Terpenes on the Cardiovascular System: Current Advances and Future Perspectives

    Article • Current Medicinal Chemistry, December 2016, Bentham Science Publishers

    Dr Henrique Girao, Jorge M. Alves-Silva

  64. The role of galectin-1 in in vitro and in vivo photodynamic therapy with a galactodendritic porphyrin

    Article • European Journal of Cancer, November 2016, Elsevier

    Dr Henrique Girao

  65. Mitochondria-Targeted Photodynamic Therapy with a Galactodendritic Chlorin to Enhance Cell Death in Resistant Bladder Cancer Cells

    Article • Bioconjugate Chemistry, October 2016, American Chemical Society (ACS)

    Dr Henrique Girao

  66. Proteostasis and SUMO in the heart

    Article • The International Journal of Biochemistry & Cell Biology, October 2016, Elsevier

    Dr Henrique Girao

  67. One small step for exosomes, one giant leap for Kawasaki disease

    Article • Revista Portuguesa de Cardiologia, May 2016, Elsevier

    Dr Henrique Girao

  68. One small step for exosomes, one giant leap for Kawasaki disease

    Article • Revista Portuguesa de Cardiologia (English Edition), May 2016, Elsevier

    Dr Henrique Girao

  69. Alteration in Phospholipidome Profile of Myoblast H9c2 Cell Line in a Model of Myocardium Starvation and Ischemia

    Article • Journal of Cellular Physiology, March 2016, Wiley

    Dr Henrique Girao

  70. Acetylated bacterial cellulose coated with urinary bladder matrix as a substrate for retinal pigment epithelium

    Article • Colloids and Surfaces B Biointerfaces, March 2016, Elsevier

    Professor Senentxu Lanceros-Mendez, Dr Henrique Girao, Dr Vitor Sencadas

  71. Presence of Cx43 in extracellular vesicles reduces the cardiotoxicity of the anti-tumour therapeutic approach with doxorubicin

    Article • Journal of Extracellular Vesicles, January 2016, Taylor & Francis

    Dr Henrique Girao

  72. Correction to Bacterial Cellulose As a Support for the Growth of Retinal Pigment Epithelium

    Article • Biomacromolecules, December 2015, American Chemical Society (ACS)

    Professor Senentxu Lanceros-Mendez, Dr Vitor Sencadas, Dr Henrique Girao

  73. Chemical characterization and cytotoxic potential of an ellagitannin-enriched fraction from Fragaria vesca leaves

    Article • Arabian Journal of Chemistry, December 2015, Elsevier

    Dr Henrique Girao, Ana Cristina Gonçalves

  74. New platinum(II)–bipyridyl corrole complexes: Synthesis, characterization and binding studies with DNA and HSA

    Article • Journal of Inorganic Biochemistry, December 2015, Elsevier

    Dr Henrique Girao

  75. Corrigendum: Gap junctional protein Cx43 is involved in the communication between extracellular vesicles and mammalian cells

    Article • Scientific Reports, October 2015, Nature

    Professor Joost PG Sluijter, Sandra I Anjo, Dr Henrique Girao

  76. Interacting Network of the Gap Junction (GJ) Protein Connexin43 (Cx43) is Modulated by Ischemia and Reperfusion in the Heart

    Article • Molecular & Cellular Proteomics, August 2015, American Society for Biochemistry & Molecular Biology (ASBMB)

    Dr Henrique Girao, Sandra I Anjo

  77. Gap junctional protein Cx43 is involved in the communication between extracellular vesicles and mammalian cells

    Article • Scientific Reports, August 2015, Nature

    Professor Joost PG Sluijter, Dr Henrique Girao

  78. The Force at the Tip - Modelling Tension and Proliferation in Sprouting Angiogenesis

    Article • PLoS Computational Biology, August 2015, PLOS

    Dr Henrique Girao

  79. To beat or not to beat: degradation of Cx43 imposes the heart rhythm: Figure 1

    Article • Biochemical Society Transactions, June 2015, Portland Press Ltd.

    Dr Henrique Girao

  80. Connexin 43 ubiquitination determines the fate of gap junctions: restrict to survive: Figure 1

    Article • Biochemical Society Transactions, June 2015, Portland Press Ltd.

    Dr Henrique Girao

  81. K63 linked ubiquitin chain formation is a signal for HIF1A degradation by Chaperone-Mediated Autophagy

    Article • Scientific Reports, May 2015, Nature

    Dr Henrique Girao

  82. Heart ischemia results in connexin43 ubiquitination localized at the intercalated discs

    Article • Biochimie, May 2015, Elsevier

    Dr Henrique Girao

  83. Ischaemia-induced autophagy leads to degradation of gap junction protein connexin43 in cardiomyocytes

    Article • Biochemical Journal, April 2015, Portland Press Ltd.

    Dr Henrique Girao

  84. Bacterial Cellulose As a Support for the Growth of Retinal Pigment Epithelium

    Article • Biomacromolecules, April 2015, American Chemical Society (ACS)

    Dr Vitor Sencadas, Professor Senentxu Lanceros-Mendez, Dr Henrique Girao

  85. Autophagy and Ubiquitination in Cardiovascular Diseases

    Article • DNA and Cell Biology, April 2015, Mary Ann Liebert Inc

    Dr Henrique Girao

  86. Tamoxifen in combination with temozolomide induce a synergistic inhibition of PKC-pan in GBM cell lines

    Article • Biochimica et Biophysica Acta (BBA) - General Subjects, April 2015, Elsevier

    Dr Henrique Girao

  87. Cholinergic stimulation with pyridostigmine protects myocardial infarcted rats against ischemic-induced arrhythmias and preserves connexin43 protein

    Article • AJP Heart and Circulatory Physiology, January 2015, American Physiological Society

    Dr Henrique Girao

  88. Synthesis, characterization and biomolecule-binding properties of novel tetra-platinum(ii)-thiopyridylporphyrins

    Article • Dalton Transactions, January 2015, Royal Society of Chemistry

    Dr Henrique Girao

  89. Bioactivity of Fragaria vesca leaves through inflammation, proteasome and autophagy modulation

    Article • Journal of Ethnopharmacology, December 2014, Elsevier

    Dr Henrique Girao

  90. AMSH-mediated deubiquitination of Cx43 regulates internalization and degradation of gap junctions

    Article • The FASEB Journal, July 2014, Federation of American Societies For Experimental Biology (FASEB)

    Dr Henrique Girao

  91. P145Degradation of gap junction protein Cx43 by autophagy in ischemic heart is determined by the triggering signal: the role of AMPK Vs Beclin1

    Article • Cardiovascular Research, June 2014, European Society of Cardiology

    Dr Henrique Girao

  92. DNAJB4 molecular chaperone distinguishes WT from mutant E-cadherin, determining their fate in vitro and in vivo

    Article • Human Molecular Genetics, November 2013, Oxford University Press (OUP)

    Dr Henrique Girao

  93. STUB1/CHIP is required for HIF1A degradation by chaperone-mediated autophagy

    Article • Autophagy, September 2013, Taylor & Francis

    Dr Henrique Girao

  94. Ubiquitin induces interference in communication: ubiquitination of cx43 leads to gap junction degradation in ischemic heart

    Article • European Heart Journal, August 2013, European Society of Cardiology

    Dr Henrique Girao

  95. To beat or not to beat: detrimental autophagy contributes to gap junctions degradation in ischemic heart

    Article • European Heart Journal, August 2013, European Society of Cardiology

    Dr Henrique Girao

  96. Autophagy modulates dynamics of connexins at the plasma membrane in a ubiquitin-dependent manner

    Article • Molecular Biology of the Cell, April 2012, American Society for Cell Biology (ASCB)

    Dr Henrique Girao

  97. Ubiquitin-mediated internalization of connexin43 is independent of the canonical endocytic tyrosine-sorting signal

    Article • Biochemical Journal, July 2011, Portland Press Ltd.

    Dr Henrique Girao

  98. Eps15 interacts with ubiquitinated Cx43 and mediates its internalization

    Article • Experimental Cell Research, December 2009, Elsevier

    Dr Henrique Girao

  99. Actin in the endocytic pathway: From yeast to mammals

    Article • FEBS Letters, April 2008, Wiley

    Dr Henrique Girao

  100. The proteasome regulates the interaction between Cx43 and ZO-1

    Article • Journal of Cellular Biochemistry, January 2007, Wiley

    Dr Henrique Girao

  101. Subcellular Redistribution of Components of the Ubiquitin–Proteasome Pathway during Lens Differentiation and Maturation

    Article • Investigative Ophthalmology & Visual Science, April 2005, Association for Research in Vision and Ophthalmology (ARVO)

    Dr Henrique Girao

  102. High Glucose Down-regulates Intercellular Communication in Retinal Endothelial Cells by Enhancing Degradation of Connexin 43 by a Proteasome-dependent Mechanism

    Article • Journal of Biological Chemistry, April 2004, American Society for Biochemistry & Molecular Biology (ASBMB)

    Dr Henrique Girao

  103. Article • Cell Communication and Signaling, January 2004, Springer Science + Business Media

    Dr Henrique Girao

  104. Cholesterol oxides mediated changes in cytoskeletal organisation involves Rho GTPases☆☆

    Article • Experimental Cell Research, December 2003, Elsevier

    Dr Henrique Girao

  105. Lens fibers have a fully functional ubiquitin-proteasome pathway

    Article • Experimental Eye Research, May 2003, Elsevier

    Dr Henrique Girao

  106. Cholesterol may act as an antioxidant in lens membranes

    Article • Current Eye Research, January 1999, Taylor & Francis

    Dr Henrique Girao

  107. Cholesterol Oxides Accumulate in Human Cataracts

    Article • Experimental Eye Research, May 1998, Elsevier

    Dr Henrique Girao