Prof. Dr. Haruhiko Fuwa

All Stories

1. 
   Configurational Reassignment of (+)‐Polycitorol A and (−)‐Polycitorol B by Nuclear Magnetic Resonance Spectroscopic Analysis, Theoretical Calculation, and Total Synthesis

   Article • European Journal of Organic Chemistry, April 2026, Wiley

   Prof. Dr. Haruhiko Fuwa

2. 
   Configurational Reassignment of (+)-Polycitorol A and (−)-Polycitorol B by NMR Spectroscopic Analysis, Theoretical Calculation, and Total Synthesis

   Article • February 2026, American Chemical Society (ACS)

   Prof. Dr. Haruhiko Fuwa

3. 
   Late-stage chirality generation strategies for the total synthesis of macrocyclic natural products

   Article • Organic & Biomolecular Chemistry, January 2026, Royal Society of Chemistry

   Prof. Dr. Haruhiko Fuwa

4. 
   Total synthesis and biological evaluation of (−)-enigmazole B

   Article • Bulletin of the Chemical Society of Japan, August 2025, Oxford University Press (OUP)

   Prof. Dr. Haruhiko Fuwa

5. 
   Total Synthesis of (−)-Enigmazole A by the Macrocyclization/Transannular Pyran Cyclization Strategy: Application to Structure–Activity Relationship Investigations

   Article • The Journal of Organic Chemistry, July 2025, American Chemical Society (ACS)

   Prof. Dr. Haruhiko Fuwa

6. 
   Tandem Synthesis of Pyrrolidine and Piperidine Derivatives from Propargylic Alcohols Under Multimetallic Catalysis

   Article • European Journal of Organic Chemistry, May 2025, Wiley

   Prof. Dr. Haruhiko Fuwa

7. 
   Total Synthesis of Exiguolide Stereoisomers: Impact of Stereochemical Permutation on Reactivity, Conformation, and Biological Activity

   Article • The Journal of Organic Chemistry, December 2024, American Chemical Society (ACS)

   Prof. Dr. Haruhiko Fuwa

8. 
   Iriomoteolide-1a and -1b: Structure Elucidation by Integrating NMR Spectroscopic Analysis, Theoretical Calculation, and Total Synthesis

   Article • Journal of the American Chemical Society, October 2024, American Chemical Society (ACS)

   Prof. Dr. Haruhiko Fuwa

9. 
   Total Synthesis of (−)-Fasicularin

   Article • The Journal of Organic Chemistry, July 2024, American Chemical Society (ACS)

   Prof. Dr. Haruhiko Fuwa

10. 
    Total Synthesis of (−)-Enigmazole A by the Macrocyclization/Transannular Pyran Cyclization Strategy

    Article • Organic Letters, February 2024, American Chemical Society (ACS)

    Prof. Dr. Haruhiko Fuwa

11. 
    Atomic-resolution structure analysis inside an adaptable porous framework

    Article • Nature Communications, January 2024, Springer Science + Business Media

    Prof. Dr. Haruhiko Fuwa

12. 
    Pursuing Step Economy in Total Synthesis of Complex Marine Macrolide Natural Products

    Article • January 2024, Springer Science + Business Media

    Prof. Dr. Haruhiko Fuwa

13. 
    Total Synthesis of (−)-Enigmazole B

    Article • Organic Letters, October 2023, American Chemical Society (ACS)

    Prof. Dr. Haruhiko Fuwa

14. 
    Total Synthesis of Marine Macrolide Natural Products by the Macrocyclization/Transannular Pyran Cyclization Strategy

    Article • Synlett, September 2023, Thieme Publishing Group

    Prof. Dr. Haruhiko Fuwa

15. 
    Total Synthesis of (+)-Muricatetrocin B via a Late-Stage Co-Catalyzed Hartung–Mukaiyama Cyclization

    Article • Organic Letters, August 2023, American Chemical Society (ACS)

    Prof. Dr. Haruhiko Fuwa

16. 
    An 11-Step Synthesis of (+)-Neopeltolide by the Macrocyclization/Transannular Pyran Cyclization Strategy

    Article • Bulletin of the Chemical Society of Japan, March 2023, The Chemical Society of Japan

    Prof. Dr. Haruhiko Fuwa

17. 
    Collective Asymmetric Total Synthesis of Cylindricines

    Article • Organic Letters, March 2023, American Chemical Society (ACS)

    Prof. Dr. Haruhiko Fuwa

18. 
    Collective Asymmetric Total Synthesis of Cylindricines

    Article • February 2023, American Chemical Society (ACS)

    Prof. Dr. Haruhiko Fuwa

19. 
    N-Terminal-selective Cu-catalyzed [3+2] cycloaddition for irreversible assembly of two modules with a peptide

    Article • February 2023, American Chemical Society (ACS)

    Prof. Dr. Haruhiko Fuwa

20. 
    Au-catalyzed stereodivergent synthesis of 2,5-disubstituted pyrrolidines: total synthesis of (+)-monomorine I and (+)-indolizidine 195B

    Article • Chemical Communications, January 2023, Royal Society of Chemistry

    Prof. Dr. Haruhiko Fuwa

21. 
    GIAO NMR Calculation-driven Stereochemical Assignment of Marine Macrolide Natural Products: Assessment of the Performance of DP4 and DP4+ Analyses and Assignment of the Relative Configuration of Leptolyngbyalide A–C/Oscillariolide Macrolactone

    Article • Bulletin of the Chemical Society of Japan, November 2022, The Chemical Society of Japan

    Prof. Dr. Haruhiko Fuwa

22. 
    Stereoselective Tandem Synthesis of Pyrrolidine Derivatives under Gold Catalysis: An Asymmetric Synthesis of (−)-Lepadiformine A

    Article • Organic Letters, July 2022, American Chemical Society (ACS)

    Prof. Dr. Haruhiko Fuwa

23. 
    Total Synthesis of (+)-Neopeltolide by the Macrocyclization/Transannular Pyran Cyclization Strategy

    Article • Organic Letters, June 2022, American Chemical Society (ACS)

    Prof. Dr. Haruhiko Fuwa

24. 
    Frontispiece: Tandem Macrolactone Synthesis: Total Synthesis of (−)‐Exiguolide by a Macrocyclization/Transannular Pyran Cyclization Strategy

    Article • Angewandte Chemie, May 2022, Wiley

    Prof. Dr. Haruhiko Fuwa

25. 
    Frontispiz: Tandem Macrolactone Synthesis: Total Synthesis of (−)‐Exiguolide by a Macrocyclization/Transannular Pyran Cyclization Strategy

    Article • Angewandte Chemie, May 2022, Wiley

    Prof. Dr. Haruhiko Fuwa

26. 
    Gambierol Blocks a K+ Current Fraction without Affecting Catecholamine Release in Rat Fetal Adrenomedullary Cultured Chromaffin Cells

    Article • Toxins, April 2022, MDPI AG

    Prof. Dr. Haruhiko Fuwa

27. 
    Tandem Macrolactone Synthesis: Total Synthesis of (−)‐Exiguolide by a Macrocyclization/Transannular Pyran Cyclization Strategy

    Article • Angewandte Chemie, March 2022, Wiley

    Prof. Dr. Haruhiko Fuwa

28. 
    Tandem Macrolactone Synthesis: Total Synthesis of (−)‐Exiguolide by a Macrocyclization/Transannular Pyran Cyclization Strategy

    Article • Angewandte Chemie, March 2022, Wiley

    Prof. Dr. Haruhiko Fuwa

29. 
    Determination of the toxicity equivalency factors for ciguatoxins using human sodium channels

    Article • Food and Chemical Toxicology, February 2022, Elsevier

    Prof. Dr. Haruhiko Fuwa

30. 
    Total Synthesis of (−)-Exiguolide, a Potent Anticancer Marine Macrolide

    Article • Heterocycles, January 2022, Japan Institute of Heterocyclic Chemistry

    Prof. Dr. Haruhiko Fuwa

31. 
    Asymmetric Synthesis of (−)-Atorvastatin Calcium by Tandem Catalysis

    Article • Bulletin of the Chemical Society of Japan, August 2021, The Chemical Society of Japan

    Prof. Dr. Haruhiko Fuwa

32. 
    Synthesis-Driven Stereochemical Assignment of Marine Polycyclic Ether Natural Products

    Article • Marine Drugs, April 2021, MDPI AG

    Prof. Dr. Haruhiko Fuwa

33. 
    Stereoselective Synthesis of the Southern Hemisphere Acyclic Domain of Neaumycin B

    Article • The Journal of Organic Chemistry, April 2021, American Chemical Society (ACS)

    Prof. Dr. Haruhiko Fuwa

34. 
    Ruthenium-Catalyzed Intramolecular Double Hydrofunctionalization of Alkynes. Synthesis of Spirocyclic Hemiaminal Ethers and Their Lewis Acid-Mediated Cleavage/Nucleophilic Addition

    Article • The Journal of Organic Chemistry, April 2021, American Chemical Society (ACS)

    Prof. Dr. Haruhiko Fuwa

35. 
    Cobalt-Catalyzed Hartung–Mukaiyama Cyclization of γ-Hydroxy Olefins: Stereocontrolled Synthesis of the Tetrahydrofuran Moiety of Amphidinolide N

    Article • The Journal of Organic Chemistry, March 2021, American Chemical Society (ACS)

    Prof. Dr. Haruhiko Fuwa

36. 
    Total synthesis and complete configurational assignment of amphirionin-2

    Article • Chemical Science, January 2021, Royal Society of Chemistry

    Prof. Dr. Haruhiko Fuwa

37. 
    Structure determination, correction, and disproof of marine macrolide natural products by chemical synthesis

    Article • Organic Chemistry Frontiers, January 2021, Royal Society of Chemistry

    Prof. Dr. Haruhiko Fuwa

38. 
    Unified Total Synthesis of (−)‐Enigmazole A and (−)‐15‐ O ‐Methylenigmazole A

    Article • Chemistry - An Asian Journal, October 2020, Wiley

    Prof. Dr. Haruhiko Fuwa

39. 
    Tandem Three‐Component Synthesis of syn ‐1,2‐ and syn ‐1,3‐Diol Derivatives

    Article • Chemistry - An Asian Journal, February 2020, Wiley

    Prof. Dr. Haruhiko Fuwa

40. 
    Total Synthesis of a Marine Macrolide Natural Product, Iriomoteolide-2a: The Fundamental Role of Total Synthesis in Natural Product Chemistry

    Article • Journal of Synthetic Organic Chemistry Japan, August 2019, The Society of Synthetic Organic Chemistry, Japan

    Prof. Dr. Haruhiko Fuwa

41. 
    Cover Feature: Total Synthesis, Stereochemical Revision, and Biological Assessment of Iriomoteolide‐2a (Chem. Eur. J. 36/2019)

    Article • Chemistry - A European Journal, May 2019, Wiley

    Prof. Dr. Haruhiko Fuwa

42. 
    Total Synthesis, Stereochemical Revision, and Biological Assessment of Iriomoteolide‐2a

    Article • Chemistry - A European Journal, May 2019, Wiley

    Prof. Dr. Haruhiko Fuwa

43. 
    Stereoselective Tandem Synthesis of syn-1,3-Diol Derivatives by Integrating Olefin Cross-Metathesis, Hemiacetalization, and Intramolecular Oxa-Michael Addition

    Article • Organic Letters, May 2019, American Chemical Society (ACS)

    Prof. Dr. Haruhiko Fuwa

44. 
    Fluorescence-labeled neopeltolide derivatives for subcellular localization imaging

    Article • Organic & Biomolecular Chemistry, January 2019, Royal Society of Chemistry

    Prof. Dr. Haruhiko Fuwa

45. 
    Ruthenium-Catalyzed Intramolecular Double Hydroalkoxylation of Internal Alkynes

    Article • Organic Letters, December 2018, American Chemical Society (ACS)

    Prof. Dr. Haruhiko Fuwa

46. 
    Total Synthesis of (−)-Enigmazole A

    Article • Angewandte Chemie, March 2018, Wiley

    Prof. Dr. Haruhiko Fuwa

47. 
    Total Synthesis of (−)-Enigmazole A

    Article • Angewandte Chemie, March 2018, Wiley

    Prof. Dr. Haruhiko Fuwa

48. 
    Total Synthesis and Stereochemical Revision of Iriomoteolide-2a

    Article • Angewandte Chemie, February 2018, Wiley

    Prof. Dr. Haruhiko Fuwa

49. 
    Total Synthesis and Stereochemical Revision of Iriomoteolide-2a

    Article • Angewandte Chemie, February 2018, Wiley

    Prof. Dr. Haruhiko Fuwa

50. 
    A Synthetic Analogue of Neopeltolide, 8,9-Dehydroneopeltolide, Is a Potent Anti-Austerity Agent against Starved Tumor Cells

    Article • Marine Drugs, October 2017, MDPI AG

    Prof. Dr. Haruhiko Fuwa

51. 
    Tetracyclic Truncated Analogue of the Marine Toxin Gambierol Modifies NMDA, Tau, and Amyloid β Expression in Mice Brains: Implications in AD Pathology

    Article • ACS Chemical Neuroscience, February 2017, American Chemical Society (ACS)

    Prof. Dr. Haruhiko Fuwa

52. 
    Exploiting Ruthenium Carbene-Catalyzed Reactions in Total Synthesis of Marine Oxacyclic Natural Products

    Article • Bulletin of the Chemical Society of Japan, December 2016, The Chemical Society of Japan

    Prof. Dr. Haruhiko Fuwa

53. 
    Diastereoselective Ring-Closing Metathesis as a Means to Construct Medium-Sized Cyclic Ethers: Application to the Synthesis of a Photoactivatable Gambierol Derivative

    Article • The Journal of Organic Chemistry, September 2016, American Chemical Society (ACS)

    Prof. Dr. Haruhiko Fuwa

54. 
    Effect of carbon chain length in acyl coenzyme A on the efficiency of enzymatic transformation of okadaic acid to 7- O -acyl okadaic acid

    Article • Bioorganic & Medicinal Chemistry Letters, July 2016, Elsevier

    Prof. Dr. Haruhiko Fuwa

55. 
    Total Synthesis and Complete Stereostructure of a Marine Macrolide Glycoside, (−)-Lyngbyaloside B

    Article • Chemistry - A European Journal, April 2016, Wiley

    Prof. Dr. Haruhiko Fuwa

56. 
    Toward the Total Synthesis of Amphidinolide N: Synthesis of the C8–C29 Fragment

    Article • Organic Letters, April 2016, American Chemical Society (ACS)

    Prof. Dr. Haruhiko Fuwa

57. 
    Complete Stereochemical Assignment of Campechic Acids A and B

    Article • The Journal of Organic Chemistry, April 2016, American Chemical Society (ACS)

    Prof. Dr. Haruhiko Fuwa

58. 
    Contemporary Strategies for the Synthesis of Tetrahydropyran Derivatives: Application to Total Synthesis of Neopeltolide, a Marine Macrolide Natural Product

    Article • Marine Drugs, March 2016, MDPI AG

    Prof. Dr. Haruhiko Fuwa

59. 
    Progress toward the Total Synthesis of Goniodomin A: Stereocontrolled, Convergent Synthesis of the C12–C36 Fragment

    Article • The Journal of Organic Chemistry, January 2016, American Chemical Society (ACS)

    Prof. Dr. Haruhiko Fuwa

60. 
    Concise synthesis of the C15–C38 fragment of okadaic acid, a specific inhibitor of protein phosphatases 1 and 2A

    Article • Tetrahedron, September 2015, Elsevier

    Prof. Dr. Haruhiko Fuwa

61. 
    Evaluation of gambierol and its analogs for their inhibition of human Kv1.2 and cytotoxicity

    Article • Bioorganic & Medicinal Chemistry Letters, February 2015, Elsevier

    Prof. Dr. Haruhiko Fuwa

62. 
    Concise synthesis of the A/BCD-ring fragment of gambieric acid A

    Article • Frontiers in Chemistry, January 2015, Frontiers

    Prof. Dr. Haruhiko Fuwa

63. 
    Studies toward the Total Synthesis of Amphidinolide N: Stereocontrolled Synthesis of the C13–C29 Segment

    Article • Heterocycles, January 2015, Japan Institute of Heterocyclic Chemistry

    Prof. Dr. Haruhiko Fuwa

64. 
    Concise Synthesis of the C15–C38 Fragment of Okadaic Acid: Application of the Suzuki–Miyaura Reaction to Spiroacetal Synthesis

    Article • Organic Letters, December 2014, American Chemical Society (ACS)

    Prof. Dr. Haruhiko Fuwa

65. 
    Programmed Cell Death Induced by (−)-8,9-Dehydroneopeltolide in Human Promyelocytic Leukemia HL-60 Cells under Energy Stress Conditions

    Article • Marine Drugs, November 2014, MDPI AG

    Prof. Dr. Haruhiko Fuwa

66. 
    Total Synthesis, Stereochemical Reassignment, and Biological Evaluation of (−)-Lyngbyaloside B

    Article • Angewandte Chemie, November 2014, Wiley

    Prof. Dr. Haruhiko Fuwa

67. 
    Potassium currents inhibition by gambierol analogs prevents human T lymphocyte activation

    Article • Archives of Toxicology, August 2014, Springer Science + Business Media

    Prof. Dr. Haruhiko Fuwa

68. 
    Total Synthesis and Complete Structural Assignment of Gambieric Acid A, a Large Polycyclic Ether Marine Natural Product

    Article • The Chemical Record, August 2014, Wiley

    Prof. Dr. Haruhiko Fuwa

69. 
    Synthesis and biological evaluation of (+)-neopeltolide analogues: Importance of the oxazole-containing side chain

    Article • Bioorganic & Medicinal Chemistry Letters, June 2014, Elsevier

    Prof. Dr. Haruhiko Fuwa

70. 
    Stereoselective Synthesis of Medium-Sized Cyclic Ethers: Application of C-Glycosylation Chemistry to Seven- to Nine-Membered Lactone-Derived Thioacetals and Their Sulfone Counterparts

    Article • The Journal of Organic Chemistry, February 2014, American Chemical Society (ACS)

    Prof. Dr. Haruhiko Fuwa

71. 
    Total Synthesis and Structure Revision of Didemnaketal B

    Article • Chemistry - A European Journal, January 2014, Wiley

    Prof. Dr. Haruhiko Fuwa

72. 
    Synthesis and Biological Evaluation of Aspergillide A/Neopeltolide Chimeras

    Article • Chemistry Letters, September 2013, The Chemical Society of Japan

    Prof. Dr. Haruhiko Fuwa

73. 
    Total Synthesis of the Proposed Structure of Didemnaketal B

    Article • Organic Letters, July 2013, American Chemical Society (ACS)

    Prof. Dr. Haruhiko Fuwa

74. 
    Concise Synthesis and Biological Assessment of (+)-Neopeltolide and a 16-Member Stereoisomer Library of 8,9-Dehydroneopeltolide: Identification of Pharmacophoric Elements

    Article • Chemistry - A European Journal, April 2013, Wiley

    Prof. Dr. Haruhiko Fuwa

75. 
    Total Synthesis and Biological Evaluation of (+)-Gambieric Acid A and Its Analogues

    Article • Chemistry - A European Journal, March 2013, Wiley

    Prof. Dr. Haruhiko Fuwa

76. 
    Total Synthesis of 13-Demethyllyngbyaloside B

    Article • Organic Letters, March 2013, American Chemical Society (ACS)

    Prof. Dr. Haruhiko Fuwa

77. 
    Total synthesis and biological evaluation of (−)-exiguolide analogues: importance of the macrocyclic backbone

    Article • Organic & Biomolecular Chemistry, January 2013, Royal Society of Chemistry

    Dr Hiroshi Kubo, Prof. Dr. Haruhiko Fuwa

78. 
    Stereoselective Synthesis of the C1–C16 Fragment of Goniodomin A

    Article • Bulletin of the Chemical Society of Japan, September 2012, The Chemical Society of Japan

    Prof. Dr. Haruhiko Fuwa

79. 
    Effect of Gambierol and Its Tetracyclic and Heptacyclic Analogues in Cultured Cerebellar Neurons: A Structure–Activity Relationships Study

    Article • Chemical Research in Toxicology, August 2012, American Chemical Society (ACS)

    Prof. Dr. Haruhiko Fuwa

80. 
    Total Synthesis and Complete Stereostructure of Gambieric Acid A

    Article • Journal of the American Chemical Society, July 2012, American Chemical Society (ACS)

    Prof. Dr. Haruhiko Fuwa

81. 
    Design and Synthesis of Skeletal Analogues of Gambierol: Attenuation of Amyloid-β and Tau Pathology with Voltage-Gated Potassium Channel andN-Methyl-d-aspartate Receptor Implications

    Article • Journal of the American Chemical Society, April 2012, American Chemical Society (ACS)

    Prof. Dr. Haruhiko Fuwa

82. 
    Tandem catalysis in domino olefin cross-metathesis/intramolecular oxa-conjugate cyclization: concise synthesis of 2,6-cis-substituted tetrahydropyran derivatives

    Article • Organic & Biomolecular Chemistry, January 2012, Royal Society of Chemistry

    Prof. Dr. Haruhiko Fuwa

83. 
    A CONCISE SYNTHESIS OF THE AB-RING FRAGMENT OF (−)-GAMBIEROL

    Article • Heterocycles, January 2012, Japan Institute of Heterocyclic Chemistry

    Prof. Dr. Haruhiko Fuwa

84. 
    Total Synthesis of Tetrahydropyran-Containing Natural Products Exploiting Intramolecular Oxa-Conjugate Cyclization

    Article • Heterocycles, January 2012, Japan Institute of Heterocyclic Chemistry

    Prof. Dr. Haruhiko Fuwa

85. 
    Stereoselective Synthesis of 2,6-Cis-Substituted Tetrahydropyrans: Brønsted Acid-Catalyzed Intramolecular Oxa-Conjugate Cyclization of α,β-Unsaturated Ester Surrogates

    Article • The Journal of Organic Chemistry, December 2011, American Chemical Society (ACS)

    Prof. Dr. Haruhiko Fuwa

86. 
    Total Synthesis of (−)-Brevenal: A Streamlined Strategy for Practical Synthesis of Polycyclic Ethers

    Article • Chemistry - A European Journal, November 2011, Wiley

    Prof. Dr. Haruhiko Fuwa

87. 
    Studies toward the total synthesis of gambieric acids, potent antifungal polycyclic ethers: convergent synthesis of a fully elaborated GHIJ-ring fragment

    Article • Tetrahedron, September 2011, Elsevier

    Prof. Dr. Haruhiko Fuwa

88. 
    A new strategy for the synthesis of substituted dihydropyrones and tetrahydropyrones via palladium-catalyzed coupling of thioesters

    Article • Tetrahedron, July 2011, Elsevier

    Prof. Dr. Haruhiko Fuwa

89. 
    Comparative Cytotoxicity of Gambierol versus Other Marine Neurotoxins

    Article • Chemical Research in Toxicology, June 2011, American Chemical Society (ACS)

    Prof. Dr. Haruhiko Fuwa

90. 
    Biosynthesis-Inspired Intramolecular Oxa-Conjugate Cyclization of α,β-Unsaturated Thioesters: Stereoselective Synthesis of 2,6-cis-Substituted Tetrahydropyrans

    Article • Organic Letters, April 2011, American Chemical Society (ACS)

    Prof. Dr. Haruhiko Fuwa

91. 
    A Convergent Synthesis of the C1−C16 Segment of Goniodomin A via Palladium-Catalyzed Organostannane−Thioester Coupling

    Article • Organic Letters, March 2011, American Chemical Society (ACS)

    Prof. Dr. Haruhiko Fuwa

92. 
    Total Synthesis and Biological Assessment of (−)‐Exiguolide and Analogues

    Article • Chemistry - A European Journal, January 2011, Wiley

    Dr Hiroshi Kubo, Prof. Dr. Haruhiko Fuwa

93. 
    Suppression of Colon Cancer Metastasis by Aes through Inhibition of Notch Signaling

    Article • Cancer Cell, January 2011, Elsevier

    Masanobu Oshima, Prof. Dr. Haruhiko Fuwa, Dr Hiroki Hashida

94. 
    Studies toward the total synthesis of gambieric acids: convergent synthesis of the GHIJ-ring fragment having a side chain

    Article • Tetrahedron Letters, January 2011, Elsevier

    Prof. Dr. Haruhiko Fuwa

95. 
    Synthetic studies on goniodomin A: convergent assembly of the C15–C36 segment via palladium-catalyzed organostannane–thioester coupling

    Article • Tetrahedron, January 2011, Elsevier

    Prof. Dr. Haruhiko Fuwa

96. 
    Total Synthesis of Structurally Complex Marine Oxacyclic Natural Products

    Article • Bulletin of the Chemical Society of Japan, December 2010, The Chemical Society of Japan

    Prof. Dr. Haruhiko Fuwa

97. 
    Palladium-Catalyzed Synthesis of N- and O-Heterocycles Starting from Enol Phosphates

    Article • Synlett, December 2010, Thieme Publishing Group

    Prof. Dr. Haruhiko Fuwa

98. 
    Convergent Assembly of the Spiroacetal Subunit of Didemnaketal B

    Article • Organic Letters, November 2010, American Chemical Society (ACS)

    Prof. Dr. Haruhiko Fuwa

99. 
    The marine polyether gambierol enhances muscle contraction and blocks a transient K+ current in skeletal muscle cells

    Article • Toxicon, October 2010, Elsevier

    Prof. Dr. Haruhiko Fuwa

100. 
     An enantioselective total synthesis of aspergillides A and B

     Article • Tetrahedron, September 2010, Elsevier

     Prof. Dr. Haruhiko Fuwa

101. 
     Studies toward the Total Synthesis of Gambieric Acids: Stereocontrolled Synthesis of a DEFG-Ring Model Compound

     Article • The Journal of Organic Chemistry, August 2010, American Chemical Society (ACS)

     Prof. Dr. Haruhiko Fuwa

102. 
     A Unified Total Synthesis of Aspergillides A and B

     Article • Organic Letters, April 2010, American Chemical Society (ACS)

     Prof. Dr. Haruhiko Fuwa

103. 
     Stereoselective Synthesis of Substituted Tetrahydropyrans via Domino Olefin Cross-Metathesis/Intramolecular Oxa-Conjugate Cyclization

     Article • Organic Letters, April 2010, American Chemical Society (ACS)

     Prof. Dr. Haruhiko Fuwa

104. 
     An Efficient Synthesis of 2,6-Disubstituted 2,3-Dihydro-4H-pyran-4-ones via Sonogashira Coupling of p-Toluenethiol Esters

     Article • Synlett, March 2010, Thieme Publishing Group

     Prof. Dr. Haruhiko Fuwa

105. 
     A Concise Total Synthesis of (+)-Neopeltolide

     Article • Angewandte Chemie, March 2010, Wiley

     Prof. Dr. Haruhiko Fuwa

106. 
     Total Synthesis of (−)-Exiguolide

     Article • Organic Letters, February 2010, American Chemical Society (ACS)

     Prof. Dr. Haruhiko Fuwa

107. 
     Highly efficient synthesis of medium-sized lactones via oxidative lactonization: concise total synthesis of isolaurepan

     Article • Organic & Biomolecular Chemistry, January 2010, Royal Society of Chemistry

     Prof. Dr. Haruhiko Fuwa

108. 
     A Concise Total Synthesis of (±)-Centrolobine

     Article • Heterocycles, January 2010, Japan Institute of Heterocyclic Chemistry

     Prof. Dr. Haruhiko Fuwa

109. 
     Calcium oscillations induced by gambierol in cerebellar granule cells

     Article • Journal of Cellular Biochemistry, January 2010, Wiley

     Prof. Dr. Haruhiko Fuwa

110. 
     Total Synthesis and Biological Evaluation of (+)-Neopeltolide and Its Analogues

     Article • Chemistry - A European Journal, November 2009, Wiley

     Prof. Dr. Haruhiko Fuwa

111. 
     Toward the Total Synthesis of Goniodomin A, An Actin-Targeting Marine Polyether Macrolide: Convergent Synthesis of the C15−C36 Segment

     Article • Organic Letters, November 2009, American Chemical Society (ACS)

     Prof. Dr. Haruhiko Fuwa

112. 
     Stereocontrolled Synthesis of the DEFG-ring Skeleton of Gambieric Acids

     Article • Chemistry Letters, August 2009, The Chemical Society of Japan

     Prof. Dr. Haruhiko Fuwa

113. 
     Proteomic Analysis Reveals Multiple Patterns of Response in Cells Exposed to a Toxin Mixture

     Article • Chemical Research in Toxicology, June 2009, American Chemical Society (ACS)

     Prof. Dr. Haruhiko Fuwa

114. 
     Synthetic Studies on Gambieric Acids, Potent Antifungal Polycyclic Ether Natural Products: Reassignment of the Absolute Configuration of the Nonacyclic Polyether Core by NMR Analysis of Model Compounds

     Article • The Journal of Organic Chemistry, June 2009, American Chemical Society (ACS)

     Prof. Dr. Haruhiko Fuwa

115. 
     Synthesis of 2-Substituted Indoles and Indolines via Suzuki−Miyaura Coupling/5-endo-trigCyclization Strategies

     Article • The Journal of Organic Chemistry, January 2009, American Chemical Society (ACS)

     Prof. Dr. Haruhiko Fuwa

116. 
     A New Method for the Generation of Indole-2,3-quinodimethanes from Allenamides

     Article • Chemistry Letters, September 2008, The Chemical Society of Japan

     Prof. Dr. Haruhiko Fuwa

117. 
     Total Synthesis of (+)-Neopeltolide

     Article • Angewandte Chemie, June 2008, Wiley

     Prof. Dr. Haruhiko Fuwa

118. 
     An Efficient Strategy for the Synthesis of Endocyclic Enol Ethers and Its Application to the Synthesis of Spiroacetals

     Article • Organic Letters, June 2008, American Chemical Society (ACS)

     Prof. Dr. Haruhiko Fuwa

119. 
     Stereocontrolled Synthesis of the A/B-Ring Fragment of Gambieric Acid B: Reassignment of the Absolute Configuration of the Polycyclic Ether Region

     Article • Organic Letters, June 2008, American Chemical Society (ACS)

     Prof. Dr. Haruhiko Fuwa

120. 
     Total Synthesis of (−)-Brevenal: A Concise Synthetic Entry to the Pentacyclic Polyether Core

     Article • Organic Letters, June 2008, American Chemical Society (ACS)

     Prof. Dr. Haruhiko Fuwa

121. 
     Convergent strategies for the total synthesis of polycyclic ether marine metabolites

     Article • Natural Product Reports, January 2008, Royal Society of Chemistry

     Prof. Dr. Haruhiko Fuwa

122. 
     Strategies for the Synthesis of 2-Substituted Indoles and Indolines Starting from Acyclic α-Phosphoryloxy Enecarbamates

     Article • Organic Letters, August 2007, American Chemical Society (ACS)

     Prof. Dr. Haruhiko Fuwa

123. 
     Divergent Synthesis of Multifunctional Molecular Probes To Elucidate the Enzyme Specificity of Dipeptidic γ-Secretase Inhibitors

     Article • ACS Chemical Biology, May 2007, American Chemical Society (ACS)

     Prof. Dr. Haruhiko Fuwa

124. 
     An efficient method for the synthesis of enol ethers and enecarbamates. Total syntheses of isoindolobenzazepine alkaloids, lennoxamine and chilenine

     Article • Organic & Biomolecular Chemistry, January 2007, Royal Society of Chemistry

     Prof. Dr. Haruhiko Fuwa

125. 
     A new method for the generation of indole-2,3-quinodimethanes and 2-(N-alkoxycarbonylamino)-1,3-dienes. Intramolecular Heck/Diels–Alder cycloaddition cascade starting from acyclic α-phosphono enecarbamates

     Article • Chemical Communications, January 2007, Royal Society of Chemistry

     Prof. Dr. Haruhiko Fuwa

126. 
     A strategy for the synthesis of 2,3-disubstituted indoles starting from N-(o-halophenyl)allenamides

     Article • Organic & Biomolecular Chemistry, January 2007, Royal Society of Chemistry

     Prof. Dr. Haruhiko Fuwa

127. 
     Total Synthesis, Structure Revision, and Absolute Configuration of (−)-Brevenal

     Article • Journal of the American Chemical Society, December 2006, American Chemical Society (ACS)

     Prof. Dr. Haruhiko Fuwa

128. 
     Synthesis of biotinylated photoaffinity probes based on arylsulfonamide γ-secretase inhibitors

     Article • Bioorganic & Medicinal Chemistry Letters, August 2006, Elsevier

     Prof. Dr. Haruhiko Fuwa

129. 
     Synthesis of the JK/LM-ring model of prymnesins, potent hemolytic and ichthyotoxic polycyclic ethers isolated from the red tide alga Prymnesium parvum: confirmation of the relative configuration of the K/L-ring juncture

     Article • Tetrahedron Letters, August 2006, Elsevier

     Prof. Dr. Haruhiko Fuwa

130. 
     Total Synthesis of the Proposed Structure of Brevenal

     Article • Journal of the American Chemical Society, August 2006, American Chemical Society (ACS)

     Prof. Dr. Haruhiko Fuwa

131. 
     Novel γ-secretase inhibitors discovered by library screening of in-house synthetic natural product intermediates

     Article • Bioorganic & Medicinal Chemistry Letters, July 2006, Elsevier

     Prof. Dr. Haruhiko Fuwa

132. 
     Effect of Ciguatoxin 3C on Voltage-Gated Na+ and K+ Currents in Mouse Taste Cells

     Article • Chemical Senses, June 2006, Oxford University Press (OUP)

     Prof. Dr. Haruhiko Fuwa

133. 
     C-terminal Fragment of Presenilin Is the Molecular Target of a Dipeptidic γ-Secretase-specific Inhibitor DAPT (N-[N-(3,5-Difluorophenacetyl)-L-alanyl]-S-phenylglycinet-Butyl Ester)

     Article • Journal of Biological Chemistry, March 2006, American Society for Biochemistry & Molecular Biology (ASBMB)

     Prof. Dr. Haruhiko Fuwa

134. 
     Synthetic studies on 3-arylquinazolin-4-ones: intramolecular nucleophilic aromatic substitution reaction of 2-carboxamido-3-arylquinazolin-4-ones and its application to the synthesis of secondary aryl amines

     Article • Tetrahedron, April 2005, Elsevier

     Prof. Dr. Haruhiko Fuwa

135. 
     Inhibition of Voltage-Gated Potassium Currents by Gambierol in Mouse Taste Cells

     Article • Toxicological Sciences, March 2005, Oxford University Press (OUP)

     Prof. Dr. Haruhiko Fuwa

136. 
     Diverted Total Synthesis and Biological Evaluation of Gambierol Analogues: Elucidation of Crucial Structural Elements for Potent Toxicity

     Article • Chemistry - A European Journal, October 2004, Wiley

     Prof. Dr. Haruhiko Fuwa

137. 
     Total Synthesis of Polycyclic Ether Natural Products Based on Suzuki-Miyaura Cross-Coupling

     Article • Synlett, August 2004, Thieme Publishing Group

     Prof. Dr. Haruhiko Fuwa

138. 
     Convergent synthesis of the ABCDE ring fragment of ciguatoxins

     Article • Tetrahedron Letters, June 2004, Elsevier

     Prof. Dr. Haruhiko Fuwa

139. 
     Synthetic studies on antascomicin A: construction of the C18–C34 fragment

     Article • Tetrahedron, June 2004, Elsevier

     Prof. Dr. Haruhiko Fuwa

140. 
     Highly efficient synthesis of medium-sized lactams via intramolecular Staudinger–aza-Wittig reaction of ω-azido pentafluorophenyl ester: synthesis and biological evaluation of LY411575 analogues

     Article • Tetrahedron Letters, March 2004, Elsevier

     Prof. Dr. Haruhiko Fuwa

141. 
     Pathological effects on mice by gambierol, possibly one of the ciguatera toxins

     Article • Toxicon, December 2003, Elsevier

     Prof. Dr. Haruhiko Fuwa

142. 
     Synthesis and biological evaluation of gambierol analogues

     Article • Bioorganic & Medicinal Chemistry Letters, August 2003, Elsevier

     Prof. Dr. Haruhiko Fuwa

143. 
     Total Synthesis of (−)-Gambierol

     Article • Journal of the American Chemical Society, December 2002, American Chemical Society (ACS)

     Prof. Dr. Haruhiko Fuwa

144. 
     Synthetic Studies toward Gambierol. Convergent Synthesis of the Octacyclic Polyether Core

     Article • Organic Letters, November 2001, American Chemical Society (ACS)

     Prof. Dr. Haruhiko Fuwa