All Stories

  1. Fitness Landscapes of APOBEC3G Antagonism by HIV-1 Vif proteins
  2. The Sindbis virus nsP3 opal codon protects viral RNA and fitness by maintaining replication spherule integrity
  3. Molecular exaptation by the integrin αI domain
  4. The viral arms race: an interview with Harmit Malik
  5. Yellow Fever Virus Interactomes Reveal Common and Divergent Strategies of Replication and Evolution for Mosquito-borne Flaviviruses
  6. Heterozygous and generalist MxA super-restrictors overcome breadth-specificity trade-offs in antiviral restriction
  7. A conserved opal termination codon optimizes a temperature-dependent trade-off between protein production and processing in alphaviruses
  8. Antiviral Mx proteins have an ancient origin and widespread distribution among eukaryotes
  9. Heterozygous and generalist MxA super-restrictors overcome breadth-specificity tradeoffs in antiviral restriction
  10. TheDrosophilamaternal-effect geneabnormal oocyte(ao) does not repress histone gene expression
  11. Antiviral Mx proteins have an ancient origin and widespread distribution among eukaryotes
  12. Widespread fungal–bacterial competition for magnesium lowers bacterial susceptibility to polymyxin antibiotics
  13. Indels allow antiviral proteins to evolve functional novelty inaccessible by missense mutations
  14. The diverse evolutionary histories of domesticated metaviral capsid genes in mammals
  15. Evolutionary origin and structural ligand mimicry by the inserted domain of alpha-integrin proteins
  16. Expansion and loss of sperm nuclear basic protein genes in Drosophila correspond with genetic conflicts between sex chromosomes
  17. Driving lessons: a brief (personal) history of centromere drive
  18. Recurrent but short-lived duplications of centromeric proteins in holocentric Caenorhabditis species
  19. Genetic conflicts between sex chromosomes drive expansion and loss of sperm nuclear basic protein genes in Drosophila
  20. Recurrent but short-lived duplications of centromeric proteins in holocentric Caenorhabditis species
  21. Novel Classes and Evolutionary Turnover of Histone H2B Variants in the Mammalian Germline
  22. The novel anti-CRISPR AcrIIA22 relieves DNA torsion in target plasmids and impairs SpyCas9 activity
  23. Novel classes and evolutionary turnover of histone H2B variants in the mammalian germline
  24. An actin-related protein that is most highly expressed in Drosophila testes is critical for embryonic development
  25. Gametic specialization of centromeric histone paralogs in Drosophila virilis
  26. Putting the brakes on centromere drive in Mimulus
  27. A balancing act between primate lentiviruses and their receptor
  28. Biparental contributions of the H2A.B histone variant control embryonic development in mice
  29. Innovation of heterochromatin functions drives rapid evolution of essential ZAD-ZNF genes in Drosophila
  30. A natural variant of the essential host gene MMS21 restricts the parasitic 2-micron plasmid in Saccharomyces cerevisiae
  31. AcrIIA22 is a novel anti-CRISPR that impairs SpyCas9 activity by relieving DNA torsion of target plasmids
  32. A rapidly evolving actin mediates fertility and developmental tradeoffs in Drosophila
  33. Mutational resilience of antiviral restriction favors primate TRIM5α in host-virus evolutionary arms races
  34. Innovation of heterochromatin functions drives rapid evolution of essential ZAD-ZNF genes in Drosophila
  35. Natural variation in an essential host gene contributes to parasitic plasmid resistance in Saccharomyces cerevisiae
  36. Ancient Coretention of Paralogs of Cid Centromeric Histones and Cal1 Chaperones in Mosquito Species
  37. Dynamic Evolution of De Novo DNA Methyltransferases in Rodent and Primate Genomes
  38. Hybridization promotes asexual reproduction in Caenorhabditis nematodes
  39. A Burst of Genetic Innovation in Drosophila Actin-Related Proteins for Testis-Specific Function
  40. Combinatorial mutagenesis of rapidly evolving residues yields super-restrictor antiviral proteins
  41. Dynamic evolution of de novo DNA methyltransferases in rodent and primate genomes
  42. Functional metagenomics-guided discovery of potent Cas9 inhibitors in the human microbiome
  43. A burst of genetic innovation in actin-related proteins (Arps) for testis-specific function in a Drosophila lineage
  44. Density-dependent resistance protects Legionella pneumophila from its own antimicrobial metabolite, HGA
  45. Cryptic asexual reproduction in Caenorhabditis nematodes revealed by interspecies hybridization
  46. Functional metagenomics-guided discovery of potent Cas9 inhibitors in the human microbiome
  47. Evolution-guided design of super-restrictor antiviral proteins reveals a breadth-versus-specificity tradeoff
  48. Gametic specialization of centromeric histone paralogs in Drosophila virilis
  49. Density-dependent resistance protects Legionella pneumophila from its own antimicrobial metabolite, HGA
  50. Evolutionary origins and diversification of testis-specific short histone H2A variants in mammals
  51. Culture shock
  52. Evolutionary origins and diversification of testis-specific short histone H2A variants in mammals
  53. The gene drive bubble: New realities
  54. wtf genes are prolific dual poison-antidote meiotic drivers
  55. Recurrent Gene Duplication Leads to Diverse Repertoires of Centromeric Histones in Drosophila Species
  56. Genetic conflicts: the usual suspects and beyond
  57. The piggyBac transposon-derived genes TPB1 and TPB6 mediate essential transposon-like excision during the developmental rearrangement of key genes in Tetrahymena thermophila ...
  58. Recurrent gene duplication leads to diverse repertoires of centromeric histones in Drosophila species
  59. A mitochondrial DNA hypomorph of cytochrome oxidase specifically impairs male fertility inDrosophila melanogaster
  60. Evolution-guided functional analyses reveal diverse antiviral specificities encoded by IFIT1 genes in mammals
  61. Evolution of a transcriptional regulator from a transmembrane nucleoporin
  62. Conservation and Innovation of APOBEC3A Restriction Functions during Primate Evolution
  63. Hide and seek: how chromatin-based pathways silence retroelements in the mammalian germline
  64. Recurrent gene duplication diversifies genome defense repertoire in Drosophila
  65. Evolutionary Turnover of Kinetochore Proteins: A Ship of Theseus?
  66. An essential cell cycle regulation gene causes hybrid inviability in Drosophila
  67. Evolutionary Analyses Suggest a Function of MxB Immunity Proteins Beyond Lentivirus Restriction
  68. Chromosome Segregation: Human Female Meiosis Breaks All the Rules
  69. LINE-1 Retroelements Get ZAPped!
  70. Mitotic fidelity requires transgenerational action of a testis-restricted HP1
  71. R2d2 and Hyperdrive Mechanisms (in Mouse Meiosis)
  72. Speciation via Autoimmunity: A Dangerous Mix
  73. Transferred interbacterial antagonism genes augment eukaryotic innate immune function
  74. Genetic Conflicts: Stronger Centromeres Win Tug-of-War in Female Meiosis
  75. Recurrent loss of CenH3 is associated with independent transitions to holocentricity in insects
  76. How a Virus Blocks a Cellular Emergency Access Lane to the Nucleus, STAT!
  77. Genome rearrangements and pervasive meiotic drive cause hybrid infertility in fission yeast
  78. Rapid Evolution of PARP Genes Suggests a Broad Role for ADP-Ribosylation in Host-Virus Conflicts
  79. Molecular Basis for Specific Recognition of Bacterial Ligands by NAIP/NLRC4 Inflammasomes
  80. Mobile DNA: an evolving field
  81. Mobile genetic elements and genome evolution 2014
  82. An Evolutionary Screen Highlights Canonical and Noncanonical Candidate Antiviral Genes within the Primate TRIM Gene Family
  83. Host gene evolution traces the evolutionary history of ancient primate lentiviruses
  84. An evolutionary perspective on the broad antiviral specificity of MxA
  85. A rapidly evolving genomic toolkit forDrosophilaheterochromatin
  86. Identification of an overprinting gene in Merkel cell polyomavirus provides evolutionary insight into the birth of viral genes
  87. Stepwise Evolution of Essential Centromere Function in a Drosophila Neogene
  88. Birth, decay, and reconstruction of an ancient TRIMCyp gene fusion in primate genomes
  89. Rules of Engagement: Molecular Insights from Host-Virus Arms Races
  90. Extensive evolutionary and functional diversity among mammalian AIM2-like receptors
  91. Evolution-Guided Identification of Antiviral Specificity Determinants in the Broadly Acting Interferon-Induced Innate Immunity Factor MxA
  92. Poxviruses Deploy Genomic Accordions to Adapt Rapidly against Host Antiviral Defenses
  93. Rapid evolution of centromeres and centromeric/kinetochore proteins
  94. The function and evolution of the restriction factor viperin in primates was not driven by lentiviruses
  95. Phylogenomic Analysis Reveals Dynamic Evolutionary History of the Drosophila Heterochromatin Protein 1 (HP1) Gene Family
  96. A unified phylogeny-based nomenclature for histone variants
  97. Convergent Evolution of Escape from Hepaciviral Antagonism in Primates
  98. The Ability of Primate Lentiviruses to Degrade the Monocyte Restriction Factor SAMHD1 Preceded the Birth of the Viral Accessory Protein Vpx
  99. Retroviruses push the envelope for mammalian placentation
  100. Birth, Death, and Replacement of Karyopherins in Drosophila
  101. Learning to Protect Your Genome on the Fly
  102. Adaptive Evolution of Centromeric Proteins
  103. Paleovirology—ghosts and gifts of viruses past
  104. The Breadth of Antiviral Activity of Apobec3DE in Chimpanzees Has Been Driven by Positive Selection
  105. Absence of Positive Selection on Centromeric Histones in Tetrahymena Suggests Unsuppressed Centromere-Drive in Lineages Lacking Male Meiosis
  106. Ancient Adaptive Evolution of Tetherin Shaped the Functions of Vpu and Nef in Human Immunodeficiency Virus and Primate Lentiviruses
  107. Paleovirology—Modern Consequences of Ancient Viruses
  108. Diversifying selection and functional analysis of interleukin-4 suggests antagonism-driven evolution at receptor-binding interfaces
  109. Accelerated Evolution of the Prdm9 Speciation Gene across Diverse Metazoan Taxa
  110. Multiple Roles for Heterochromatin Protein 1 Genes inDrosophila
  111. Diamonds and rust: how transposable elements influence mammalian genomes
  112. Altered Heterochromatin Binding by a Hybrid Sterility Protein in Drosophila Sibling Species
  113. The evolutionary conundrum of pathogen mimicry
  114. Major Evolutionary Transitions in Centromere Complexity
  115. Evolution of TRIM antiviral genes in primate genomes
  116. A Surrogate Approach to Study the Evolution of Noncoding DNA Elements That Organize Eukaryotic Genomes
  117. The apolipoprotein L family of programmed cell death and immunity genes rapidly evolved in primates at discrete sites of host-pathogen interactions
  118. An expanded clade of rodent Trim5 genes
  119. The Centromere-Drive Hypothesis: A Simple Basis for Centromere Complexity
  120. Protein kinase R reveals an evolutionary model for defeating viral mimicry
  121. Guidelines for Naming Nonprimate APOBEC3 Genes and Proteins
  122. Antiretroelement Activity of APOBEC3H Was Lost Twice in Recent Human Evolution
  123. The Evolution of Centromeric DNA Sequences
  124. Positive Selection and Increased Antiviral Activity Associated with the PARP-Containing Isoform of Human Zinc-Finger Antiviral Protein
  125. Discordant Evolution of the Adjacent Antiretroviral Genes TRIM22 and TRIM5 in Mammals
  126. Species-specific positive selection of the male-specific lethal complex that participates in dosage compensation in Drosophila
  127. Restriction of an Extinct Retrovirus by the Human TRIM5  Antiviral Protein
  128. Molecular Evolution of Drosophilacdc6, an Essential DNA Replication-Licensing Gene, Suggests an Adaptive Choice of Replication Origins
  129. Genes get diabolical
  130. Positive selection of yeast nonhomologous end-joining genes and a retrotransposon conflict hypothesis
  131. A hitchhiker's guide to survival finally makes CENs
  132. Genetic conflicts during meiosis and the evolutionary origins of centromere complexity: Figure 1
  133. Adaptive Evolution and Antiviral Activity of the Conserved Mammalian Cytidine Deaminase APOBEC3H
  134. High-Frequency Persistence of an Impaired Allele of the Retroviral Defense Gene TRIM5α in Humans
  135. The CNA1 Histone of the Ciliate Tetrahymena thermophila Is Essential for Chromosome Segregation in the Germline Micronucleus
  136. finds centromeres in the driver's seat
  137. Positive selection of primate TRIM5 α identifies a critical species-specific retroviral restriction domain
  138. Ribonuclease H evolution in retrotransposable elements
  139. Positive Selection of Iris, a Retroviral Envelope–Derived Host Gene in Drosophila melanogaster
  140. Positive Selection Drives the Evolution of rhino, a Member of the Heterochromatin Protein 1 Family in Drosophila
  141. Ancient Adaptive Evolution of the Primate Antiviral DNA-Editing Enzyme APOBEC3G
  142. Phylogenomics of the nucleosome
  143. Identification of the yeast gene encoding the tRNA m1G methyltransferase responsible for modification at position 9
  144. Conflict begets complexity: the evolution of centromeres
  145. Centromeres: Selfish drivers
  146. Recurrent evolution of DNA-binding motifs in the Drosophila centromeric histone
  147. Origins and Evolution of Retrotransposons
  148. Speciation and Centromere Evolution
  149. The Centromere Paradox: Stable Inheritance with Rapidly Evolving DNA
  150. Phylogenetic Analysis of Ribonuclease H Domains Suggests a Late, Chimeric Origin of LTR Retrotransposable Elements and Retroviruses
  151. Ten-Kilodalton Domain in Ty3 Gag3-Pol3p between PR and RT Is Dispensable for Ty3 Transposition
  152. Dual recognition–incision enzymes might be involved in mismatch repair and meiosis
  153. Poised for Contagion: Evolutionary Origins of the Infectious Abilities of Invertebrate Retroviruses
  154. Putative telomerase catalytic subunits from Giardia lamblia and Caenorhabditis elegans
  155. A functional homolog of a yeast tRNA splicing enzyme is conserved in higher eukaryotes and in Escherichia coli
  156. Are retrotransposons long-term hitchhikers?
  157. Evolutionary specialization of the nuclear targeting apparatus