All Stories

  1. Rapid protamine evolution suppresses meiotic drive in Drosophila
  2. Retention of a single Cenp-C gene in different syntenic locations in the montium group of Drosophila species
  3. Structural modeling and experimental validation define the MxA-Thogotovirus nucleoprotein interface that drives restriction and escape
  4. Strain-specific epistasis shapes fitness landscapes of APOBEC3G antagonism by HIV-1 Vif proteins
  5. Remote homology and functional genetics unmask deeply preserved Scm3/HJURP orthologs in metazoans
  6. A conserved in-frame stop codon acts as a multipotent defense mechanism in alphaviruses
  7. Remote homology and functional genetics unmask deeply preserved Scm3/HJURP orthologs in metazoans
  8. Magnesium depletion by Candida albicans unleashes two unusual modes of colistin resistance in Pseudomonas aeruginosa with different fitness costs
  9. The Drosophila maternal-effect gene abnormal oocyte ( ao ) does not repress histone gene expression
  10. Retention of a single Cenp-C gene in different syntenic locations in the montium group of Drosophila species
  11. Dynamic evolution of EZHIP, an inhibitor of the Polycomb Repressive Complex 2 in mammals
  12. Fitness Landscapes of APOBEC3G Antagonism by HIV-1 Vif proteins
  13. The Sindbis virus nsP3 opal codon protects viral RNA and fitness by maintaining replication spherule integrity
  14. Molecular exaptation by the integrin αI domain
  15. Rapid protamine evolution suppresses meiotic drive in Drosophila
  16. The viral arms race: an interview with Harmit Malik
  17. Yellow Fever Virus Interactomes Reveal Common and Divergent Strategies of Replication and Evolution for Mosquito-borne Flaviviruses
  18. Indels allow antiviral proteins to evolve functional novelty inaccessible by missense mutations
  19. Heterozygous and generalist MxA super-restrictors overcome breadth-specificity trade-offs in antiviral restriction
  20. A conserved opal termination codon optimizes a temperature-dependent trade-off between protein production and processing in alphaviruses
  21. Antiviral Mx proteins have an ancient origin and widespread distribution among eukaryotes
  22. Magnesium depletion unleashes two unusual modes of colistin resistance with different fitness costs
  23. Heterozygous and generalist MxA super-restrictors overcome breadth-specificity tradeoffs in antiviral restriction
  24. Recognition of phylogenetically diverse pathogens through enzymatically amplified recruitment of RNF213
  25. TheDrosophilamaternal-effect geneabnormal oocyte(ao) does not repress histone gene expression
  26. A conserved opal termination codon optimizes a temperature-dependent tradeoff between protein production and processing in alphaviruses
  27. Antiviral Mx proteins have an ancient origin and widespread distribution among eukaryotes
  28. Widespread fungal–bacterial competition for magnesium lowers bacterial susceptibility to polymyxin antibiotics
  29. Indels allow antiviral proteins to evolve functional novelty inaccessible by missense mutations
  30. The diverse evolutionary histories of domesticated metaviral capsid genes in mammals
  31. Evolutionary origin and structural ligand mimicry by the inserted domain of alpha-integrin proteins
  32. Expansion and loss of sperm nuclear basic protein genes in Drosophila correspond with genetic conflicts between sex chromosomes
  33. Driving lessons: a brief (personal) history of centromere drive
  34. Recurrent but short-lived duplications of centromeric proteins in holocentric Caenorhabditis species
  35. Genetic conflicts between sex chromosomes drive expansion and loss of sperm nuclear basic protein genes in Drosophila
  36. Recurrent but short-lived duplications of centromeric proteins in holocentric Caenorhabditis species
  37. Novel Classes and Evolutionary Turnover of Histone H2B Variants in the Mammalian Germline
  38. The novel anti-CRISPR AcrIIA22 relieves DNA torsion in target plasmids and impairs SpyCas9 activity
  39. Novel classes and evolutionary turnover of histone H2B variants in the mammalian germline
  40. An actin-related protein that is most highly expressed in Drosophila testes is critical for embryonic development
  41. Gametic specialization of centromeric histone paralogs in Drosophila virilis
  42. Putting the brakes on centromere drive in Mimulus
  43. A balancing act between primate lentiviruses and their receptor
  44. Biparental contributions of the H2A.B histone variant control embryonic development in mice
  45. Innovation of heterochromatin functions drives rapid evolution of essential ZAD-ZNF genes in Drosophila
  46. A natural variant of the essential host gene MMS21 restricts the parasitic 2-micron plasmid in Saccharomyces cerevisiae
  47. AcrIIA22 is a novel anti-CRISPR that impairs SpyCas9 activity by relieving DNA torsion of target plasmids
  48. A rapidly evolving actin mediates fertility and developmental tradeoffs in Drosophila
  49. Mutational resilience of antiviral restriction favors primate TRIM5α in host-virus evolutionary arms races
  50. Innovation of heterochromatin functions drives rapid evolution of essential ZAD-ZNF genes in Drosophila
  51. Natural variation in an essential host gene contributes to parasitic plasmid resistance in Saccharomyces cerevisiae
  52. Ancient Coretention of Paralogs of Cid Centromeric Histones and Cal1 Chaperones in Mosquito Species
  53. Dynamic Evolution of De Novo DNA Methyltransferases in Rodent and Primate Genomes
  54. Hybridization promotes asexual reproduction in Caenorhabditis nematodes
  55. Meiosis: How Gambling Chromosomes Beat the Rules
  56. A Burst of Genetic Innovation in Drosophila Actin-Related Proteins for Testis-Specific Function
  57. Combinatorial mutagenesis of rapidly evolving residues yields super-restrictor antiviral proteins
  58. Dynamic evolution of de novo DNA methyltransferases in rodent and primate genomes
  59. Functional metagenomics-guided discovery of potent Cas9 inhibitors in the human microbiome
  60. A burst of genetic innovation in actin-related proteins (Arps) for testis-specific function in a Drosophila lineage
  61. Density-dependent resistance protects Legionella pneumophila from its own antimicrobial metabolite, HGA
  62. Cryptic asexual reproduction in Caenorhabditis nematodes revealed by interspecies hybridization
  63. Functional metagenomics-guided discovery of potent Cas9 inhibitors in the human microbiome
  64. Evolution-guided design of super-restrictor antiviral proteins reveals a breadth-versus-specificity tradeoff
  65. Gametic specialization of centromeric histone paralogs in Drosophila virilis
  66. Density-dependent resistance protects Legionella pneumophila from its own antimicrobial metabolite, HGA
  67. The cellular mechanisms and consequences of centromere drive
  68. Kindr Motors Drive in Meiosis
  69. Evolutionary origins and diversification of testis-specific short histone H2A variants in mammals
  70. Culture shock
  71. Evolutionary origins and diversification of testis-specific short histone H2A variants in mammals
  72. The gene drive bubble: New realities
  73. wtf genes are prolific dual poison-antidote meiotic drivers
  74. Recurrent Gene Duplication Leads to Diverse Repertoires of Centromeric Histones in Drosophila Species
  75. Genetic conflicts: the usual suspects and beyond
  76. The piggyBac transposon-derived genes TPB1 and TPB6 mediate essential transposon-like excision during the developmental rearrangement of key genes in Tetrahymena thermophila ...
  77. Recurrent gene duplication leads to diverse repertoires of centromeric histones in Drosophila species
  78. Did a Single Amino Acid Change Make Ebola Virus More Virulent?
  79. A mitochondrial DNA hypomorph of cytochrome oxidase specifically impairs male fertility inDrosophila melanogaster
  80. Evolution-guided functional analyses reveal diverse antiviral specificities encoded by IFIT1 genes in mammals
  81. Evolution of a transcriptional regulator from a transmembrane nucleoporin
  82. Conservation and Innovation of APOBEC3A Restriction Functions during Primate Evolution
  83. Hide and seek: how chromatin-based pathways silence retroelements in the mammalian germline
  84. Recurrent gene duplication diversifies genome defense repertoire in Drosophila
  85. Evolutionary Turnover of Kinetochore Proteins: A Ship of Theseus?
  86. An essential cell cycle regulation gene causes hybrid inviability in Drosophila
  87. Evolutionary Analyses Suggest a Function of MxB Immunity Proteins Beyond Lentivirus Restriction
  88. Chromosome Segregation: Human Female Meiosis Breaks All the Rules
  89. LINE-1 Retroelements Get ZAPped!
  90. Mitotic fidelity requires transgenerational action of a testis-restricted HP1
  91. R2d2 and Hyperdrive Mechanisms (in Mouse Meiosis)
  92. Speciation via Autoimmunity: A Dangerous Mix
  93. Transferred interbacterial antagonism genes augment eukaryotic innate immune function
  94. Genetic Conflicts: Stronger Centromeres Win Tug-of-War in Female Meiosis
  95. Recurrent loss of CenH3 is associated with independent transitions to holocentricity in insects
  96. How a Virus Blocks a Cellular Emergency Access Lane to the Nucleus, STAT!
  97. Genome rearrangements and pervasive meiotic drive cause hybrid infertility in fission yeast
  98. Rapid Evolution of PARP Genes Suggests a Broad Role for ADP-Ribosylation in Host-Virus Conflicts
  99. Molecular Basis for Specific Recognition of Bacterial Ligands by NAIP/NLRC4 Inflammasomes
  100. Mobile DNA: an evolving field
  101. Mobile genetic elements and genome evolution 2014
  102. An Evolutionary Screen Highlights Canonical and Noncanonical Candidate Antiviral Genes within the Primate TRIM Gene Family
  103. Host gene evolution traces the evolutionary history of ancient primate lentiviruses
  104. An evolutionary perspective on the broad antiviral specificity of MxA
  105. A rapidly evolving genomic toolkit forDrosophilaheterochromatin
  106. Identification of an overprinting gene in Merkel cell polyomavirus provides evolutionary insight into the birth of viral genes
  107. Stepwise Evolution of Essential Centromere Function in a Drosophila Neogene
  108. Birth, decay, and reconstruction of an ancient TRIMCyp gene fusion in primate genomes
  109. Rules of Engagement: Molecular Insights from Host-Virus Arms Races
  110. Extensive evolutionary and functional diversity among mammalian AIM2-like receptors
  111. Evolution-Guided Identification of Antiviral Specificity Determinants in the Broadly Acting Interferon-Induced Innate Immunity Factor MxA
  112. Poxviruses Deploy Genomic Accordions to Adapt Rapidly against Host Antiviral Defenses
  113. Rapid evolution of centromeres and centromeric/kinetochore proteins
  114. The function and evolution of the restriction factor viperin in primates was not driven by lentiviruses
  115. Phylogenomic Analysis Reveals Dynamic Evolutionary History of the Drosophila Heterochromatin Protein 1 (HP1) Gene Family
  116. A unified phylogeny-based nomenclature for histone variants
  117. Convergent Evolution of Escape from Hepaciviral Antagonism in Primates
  118. The Ability of Primate Lentiviruses to Degrade the Monocyte Restriction Factor SAMHD1 Preceded the Birth of the Viral Accessory Protein Vpx
  119. Retroviruses push the envelope for mammalian placentation
  120. Birth, Death, and Replacement of Karyopherins in Drosophila
  121. Learning to Protect Your Genome on the Fly
  122. Adaptive Evolution of Centromeric Proteins
  123. Paleovirology—ghosts and gifts of viruses past
  124. The Breadth of Antiviral Activity of Apobec3DE in Chimpanzees Has Been Driven by Positive Selection
  125. Absence of Positive Selection on Centromeric Histones in Tetrahymena Suggests Unsuppressed Centromere-Drive in Lineages Lacking Male Meiosis
  126. Ancient Adaptive Evolution of Tetherin Shaped the Functions of Vpu and Nef in Human Immunodeficiency Virus and Primate Lentiviruses
  127. Paleovirology—Modern Consequences of Ancient Viruses
  128. Diversifying selection and functional analysis of interleukin-4 suggests antagonism-driven evolution at receptor-binding interfaces
  129. Accelerated Evolution of the Prdm9 Speciation Gene across Diverse Metazoan Taxa
  130. Multiple Roles for Heterochromatin Protein 1 Genes inDrosophila
  131. Diamonds and rust: how transposable elements influence mammalian genomes
  132. Altered Heterochromatin Binding by a Hybrid Sterility Protein in Drosophila Sibling Species
  133. The evolutionary conundrum of pathogen mimicry
  134. Major Evolutionary Transitions in Centromere Complexity
  135. Evolution of TRIM antiviral genes in primate genomes
  136. A Surrogate Approach to Study the Evolution of Noncoding DNA Elements That Organize Eukaryotic Genomes
  137. The apolipoprotein L family of programmed cell death and immunity genes rapidly evolved in primates at discrete sites of host-pathogen interactions
  138. An expanded clade of rodent Trim5 genes
  139. The Centromere-Drive Hypothesis: A Simple Basis for Centromere Complexity
  140. Protein kinase R reveals an evolutionary model for defeating viral mimicry
  141. Guidelines for Naming Nonprimate APOBEC3 Genes and Proteins
  142. Antiretroelement Activity of APOBEC3H Was Lost Twice in Recent Human Evolution
  143. The Evolution of Centromeric DNA Sequences
  144. Positive Selection and Increased Antiviral Activity Associated with the PARP-Containing Isoform of Human Zinc-Finger Antiviral Protein
  145. Discordant Evolution of the Adjacent Antiretroviral Genes TRIM22 and TRIM5 in Mammals
  146. Species-specific positive selection of the male-specific lethal complex that participates in dosage compensation in Drosophila
  147. Restriction of an Extinct Retrovirus by the Human TRIM5  Antiviral Protein
  148. Molecular Evolution of Drosophilacdc6, an Essential DNA Replication-Licensing Gene, Suggests an Adaptive Choice of Replication Origins
  149. Genes get diabolical
  150. Positive selection of yeast nonhomologous end-joining genes and a retrotransposon conflict hypothesis
  151. A hitchhiker's guide to survival finally makes CENs
  152. Genetic conflicts during meiosis and the evolutionary origins of centromere complexity: Figure 1
  153. Adaptive Evolution and Antiviral Activity of the Conserved Mammalian Cytidine Deaminase APOBEC3H
  154. High-Frequency Persistence of an Impaired Allele of the Retroviral Defense Gene TRIM5α in Humans
  155. The CNA1 Histone of the Ciliate Tetrahymena thermophila Is Essential for Chromosome Segregation in the Germline Micronucleus
  156. finds centromeres in the driver's seat
  157. Positive selection of primate TRIM5 α identifies a critical species-specific retroviral restriction domain
  158. Ribonuclease H evolution in retrotransposable elements
  159. Positive Selection of Iris, a Retroviral Envelope–Derived Host Gene in Drosophila melanogaster
  160. Positive Selection Drives the Evolution of rhino, a Member of the Heterochromatin Protein 1 Family in Drosophila
  161. Ancient Adaptive Evolution of the Primate Antiviral DNA-Editing Enzyme APOBEC3G
  162. Phylogenomics of the nucleosome
  163. Identification of the yeast gene encoding the tRNA m1G methyltransferase responsible for modification at position 9
  164. Conflict begets complexity: the evolution of centromeres
  165. Centromeres: Selfish drivers
  166. Recurrent evolution of DNA-binding motifs in the Drosophila centromeric histone
  167. Origins and Evolution of Retrotransposons
  168. Speciation and Centromere Evolution
  169. The Centromere Paradox: Stable Inheritance with Rapidly Evolving DNA
  170. Phylogenetic Analysis of Ribonuclease H Domains Suggests a Late, Chimeric Origin of LTR Retrotransposable Elements and Retroviruses
  171. Ten-Kilodalton Domain in Ty3 Gag3-Pol3p between PR and RT Is Dispensable for Ty3 Transposition
  172. Dual recognition–incision enzymes might be involved in mismatch repair and meiosis
  173. Poised for Contagion: Evolutionary Origins of the Infectious Abilities of Invertebrate Retroviruses
  174. Putative telomerase catalytic subunits from Giardia lamblia and Caenorhabditis elegans
  175. A functional homolog of a yeast tRNA splicing enzyme is conserved in higher eukaryotes and in Escherichia coli
  176. Are retrotransposons long-term hitchhikers?
  177. Evolutionary specialization of the nuclear targeting apparatus