All Stories

  1. Repeatability, interocular correlation and agreement of optic nerve head vessel density in healthy eyes: a swept-source optical coherence tomographic angiography study

    Article • International Journal of Ophthalmology, May 2024, Tsinghua University Press

    Haoyu Chen

  2. Different effect of media opacity on automated and manual measurement of foveal avascular zone of optical coherence tomography angiographies

    Article • British Journal of Ophthalmology, July 2020, BMJ

    Haoyu Chen

  3. Ellipsoid zone optical intensity reduction as an early biomarker for retinitis pigmentosa

    Article • Acta Ophthalmologica, July 2020, Wiley

    Haoyu Chen

  4. The Healing Process and Functional Recovery of Neuroretina after Idiopathic Macular Hole Surgery without Internal Limiting Membrane Reversal Tamponade

    Article • Journal of Ophthalmology, May 2020, Hindawi Publishing Corporation

    Haoyu Chen

  5. Reduced photoreceptor outer segment layer thickness in mild commotio retinae without ellipsoid zone disruption

    Article • Graefe s Archive for Clinical and Experimental Ophthalmology, April 2020, Springer Science + Business Media

    Haoyu Chen

  6. Identification of TIE2 as a susceptibility gene for neovascular age-related macular degeneration and polypoidal choroidal vasculopathy

    Article • British Journal of Ophthalmology, March 2020, BMJ

    Haoyu Chen

  7. Reliability of foveal avascular zone metrics automatically measured by Cirrus optical coherence tomography angiography in healthy subjects

    Article • International Ophthalmology, December 2019, Springer Science + Business Media

    Haoyu Chen

  8. Response to Comment on: Quantification of anterior chamber reaction after intravitreal injections of conbercept and ranibizumab: a pilot study

    Article • Eye, October 2019, Springer Science + Business Media

    Haoyu Chen

  9. Prognostic factors associated with visual outcome of salvageable eyes with posttraumatic endophthalmitis

    Article • Scientific Reports, September 2019, Springer Science + Business Media

    Haoyu Chen

  10. Quantification of anterior chamber reaction after intravitreal injections of conbercept and ranibizumab: a pilot study

    Article • Eye, July 2019, Springer Science + Business Media

    Haoyu Chen

  11. Whole exome sequencing identifies novel USH2A mutations and confirms Usher syndrome 2 diagnosis in Chinese retinitis pigmentosa patients

    Article • Scientific Reports, April 2019, Springer Science + Business Media

    Prof. Tsz Kin Ng, Haoyu Chen

  12. Intravitreal Injection of Hydrogen Peroxide Induces Acute Retinal Degeneration, Apoptosis, and Oxidative Stress in Mice

    Article • Oxidative Medicine and Cellular Longevity, November 2018, Hindawi Publishing Corporation

    Haoyu Chen, Prof. Tsz Kin Ng

  13. Macular Pigment Optical Density Measured by a Single Wavelength Reflection Photometry with and without Mydriasis

    Article • Current Eye Research, October 2018, Taylor & Francis

    Haoyu Chen

  14. Tractional Descemet’s membrane detachment after ocular alkali burns: case reports and review of literature

    Article • BMC Ophthalmology, September 2018, Springer Science + Business Media

    Haoyu Chen

  15. Association of coding and UTR variants in the known regions with wet age-related macular degeneration in Han Chinese population

    Article • Journal of Human Genetics, July 2018, Springer Science + Business Media

    Haoyu Chen

  16. Relationship between Optical Intensity on Optical Coherence Tomography and Retinal Ischemia in Branch Retinal Vein Occlusion

    Article • Scientific Reports, June 2018, Springer Science + Business Media

    Haoyu Chen

  17. Prevalence and risk factors for diabetic retinopathy in China: a multi-hospital-based cross-sectional study

    Article • British Journal of Ophthalmology, August 2017, BMJ

    Haoyu Chen

  18. Automated framework for intraretinal cystoid macular edema segmentation in three-dimensional optical coherence tomography images with macular hole

    Article • Journal of Biomedical Optics, July 2017, SPIE

    Haoyu Chen

  19. Reply

    Article • Retina, May 2017, Wolters Kluwer Health

    Haoyu Chen

  20. Automated boundary segmentation and wound analysis for longitudinal corneal OCT images

    Article • March 2017, SPIE

    Haoyu Chen

  21. Longitudinal Evaluation of Wound Healing after Penetrating Corneal Injury: Anterior Segment Optical Coherence Tomography Study

    Article • Current Eye Research, February 2017, Taylor & Francis

    Haoyu Chen

  22. Graph search: active appearance model based automated segmentation of retinal layers for optic nerve head centered OCT images

    Article • February 2017, SPIE

    Haoyu Chen

  23. Nonrigid registration of 3D longitudinal optical coherence tomography volumes with choroidal neovascularization

    Article • February 2017, SPIE

    Haoyu Chen, Professor Dehui Xiang

  24. Identification of ANGPT2 as a New Gene for Neovascular Age-Related Macular Degeneration and Polypoidal Choroidal Vasculopathy in the Chinese and Japanese Populations

    Article • Investigative Ophthalmology & Visual Science, February 2017, Association for Research in Vision and Ophthalmology (ARVO)

    Haoyu Chen

  25. 3D Choroid Neovascularization Growth Prediction with Combined Hyperelastic Biomechanical Model and Reaction-Diffusion Model

    Article • January 2017, Springer Science + Business Media

    Haoyu Chen

  26. Choroid Neovascularization Growth Prediction with Treatment Based on Reaction-Diffusion Model in 3D OCT Images

    Article • IEEE Journal of Biomedical and Health Informatics, January 2017, Institute of Electrical & Electronics Engineers (IEEE)

    Haoyu Chen

  27. A Framework for Classification and Segmentation of Branch Retinal Artery Occlusion in SD-OCT

    Article • IEEE Transactions on Image Processing, January 2017, Institute of Electrical & Electronics Engineers (IEEE)

    Haoyu Chen

  28. Reduced Macular Vascular Density in Myopic Eyes

    Article • Chinese Medical Journal, January 2017, Medknow

    Haoyu Chen

  29. Change in flash visual evoked potentials in New Zealand albino rabbits after sub-tenon’s anesthesia

    Article • Cutaneous and Ocular Toxicology, December 2016, Taylor & Francis

    Haoyu Chen

  30. Protective effects of an HTRA1 insertion–deletion variant against age-related macular degeneration in the Chinese populations

    Article • Laboratory Investigation, November 2016, Nature

    Haoyu Chen, Prof. Tsz Kin Ng

  31. Severe Traumatic Eyes with No Light Perception

    Article • November 2016, Springer Science + Business Media

    Haoyu Chen

  32. Association of ABCG1 With Neovascular Age-Related Macular Degeneration and Polypoidal Choroidal Vasculopathy in Chinese and Japanese

    Article • Investigative Ophthalmology & Visual Science, October 2016, Association for Research in Vision and Ophthalmology (ARVO)

    Haoyu Chen

  33. Repeatability, reproducibility and agreement of intraocular pressure measurement in rabbits by the TonoVet and Tono-Pen

    Article • Scientific Reports, October 2016, Nature

    Haoyu Chen

  34. CORRELATION OF OPTICAL INTENSITY ON OPTICAL COHERENCE TOMOGRAPHY AND VISUAL OUTCOME IN CENTRAL RETINAL ARTERY OCCLUSION

    Article • Retina, October 2016, Wolters Kluwer Health

    Haoyu Chen

  35. Change of Optical Intensity during Healing Process of Corneal Wound on Anterior Segment Optical Coherence Tomography

    Article • Scientific Reports, August 2016, Nature

    Haoyu Chen

  36. HTRA1 promoter variant differentiates polypoidal choroidal vasculopathy from exudative age-related macular degeneration

    Article • Scientific Reports, June 2016, Nature

    Haoyu Chen, Prof. Tsz Kin Ng

  37. Risk factors for endophthalmitis requiring evisceration or enucleation

    Article • Scientific Reports, June 2016, Nature

    Haoyu Chen

  38. Mutations of RagA GTPase in mTORC1 Pathway Are Associated with Autosomal Dominant Cataracts

    Article • PLoS Genetics, June 2016, PLOS

    Haoyu Chen, Prof. Tsz Kin Ng

  39. Automatic Three-dimensional Detection of Photoreceptor Ellipsoid Zone Disruption Caused by Trauma in the OCT

    Article • Scientific Reports, May 2016, Nature

    Haoyu Chen

  40. A missense variant in FGD6 confers increased risk of polypoidal choroidal vasculopathy

    Article • Nature Genetics, April 2016, Nature

    Haoyu Chen

  41. Identification ofPGFas a New Gene for Neovascular Age-Related Macular Degeneration in a Chinese Population

    Article • Investigative Ophthalmology & Visual Science, April 2016, Association for Research in Vision and Ophthalmology (ARVO)

    Haoyu Chen

  42. 3D choroid neovascularization growth prediction based on reaction-diffusion model

    Article • March 2016, SPIE

    Haoyu Chen

  43. A framework for classification and segmentation of branch retinal artery occlusion in SD-OCT

    Article • March 2016, SPIE

    Haoyu Chen

  44. An automated framework for 3D serous pigment epithelium detachment segmentation in SD-OCT images

    Article • Scientific Reports, February 2016, Nature

    Professor Dehui Xiang, Haoyu Chen

  45. Optical Intensities of Different Compartments of Subretinal Fluid in Acute Vogt-Koyanagi-Harada Disease

    Article • PLOS One, February 2016, PLOS

    Haoyu Chen

  46. Profile and Determinants of Retinal Optical Intensity in Normal Eyes with Spectral Domain Optical Coherence Tomography

    Article • PLOS One, February 2016, PLOS

    Professor Dehui Xiang, Haoyu Chen

  47. Association of Genetic Variants with Polypoidal Choroidal Vasculopathy

    Article • Ophthalmology, September 2015, Elsevier

    Haoyu Chen

  48. Prediction of spontaneous closure of traumatic macular hole with spectral domain optical coherence tomography

    Article • Scientific Reports, July 2015, Nature

    Haoyu Chen

  49. Comparison of Retinal Thickness Measurements between the Topcon Algorithm and a Graph-Based Algorithm in Normal and Glaucoma Eyes

    Article • PLOS One, June 2015, PLOS

    Professor Dehui Xiang, Haoyu Chen

  50. Automated segmentation of intraretinal cystoid macular edema for retinal 3D OCT images with macular hole

    Article • April 2015, Institute of Electrical & Electronics Engineers (IEEE)

    Haoyu Chen

  51. Association of PEDF polymorphisms with age-related macular degeneration and polypoidal choroidal vasculopathy: a systematic review and meta-analysis

    Article • Scientific Reports, March 2015, Nature

    Haoyu Chen

  52. Corrigendum: New loci and coding variants confer risk for age-related macular degeneration in East Asians

    Article • Nature Communications, March 2015, Nature

    Haoyu Chen

  53. Automated segmentation of serous pigment epithelium detachment in SD-OCT images

    Article • March 2015, SPIE

    Professor Dehui Xiang, Haoyu Chen

  54. Automatic choroid cells segmentation and counting based on approximate convexity and concavity of chain code in fluorescence microscopic image

    Article • March 2015, SPIE

    Haoyu Chen

  55. Quantitative analysis of retinal layers' optical intensities on 3D optical coherence tomography for central retinal artery occlusion

    Article • Scientific Reports, March 2015, Nature

    Professor Dehui Xiang, Haoyu Chen

  56. Automated 3-D Retinal Layer Segmentation of Macular Optical Coherence Tomography Images With Serous Pigment Epithelial Detachments

    Article • IEEE Transactions on Medical Imaging, February 2015, Institute of Electrical & Electronics Engineers (IEEE)

    Professor Dehui Xiang, Haoyu Chen

  57. New loci and coding variants confer risk for age-related macular degeneration in East Asians

    Article • Nature Communications, January 2015, Nature

    Haoyu Chen

  58. Antagonist of GH-releasing hormone receptors alleviates experimental ocular inflammation

    Article • Proceedings of the National Academy of Sciences, December 2014, Proceedings of the National Academy of Sciences

    Haoyu Chen, Prof. Tsz Kin Ng

  59. Association of HLA-DR4/HLA-DRB1*04 with Vogt-Koyanagi-Harada disease: A Systematic Review and Meta-analysis

    Article • Scientific Reports, November 2014, Nature

    Haoyu Chen

  60. Rapid and cost-effective molecular diagnosis using exome sequencing of one proband with autosomal dominant congenital cataract

    Article • Eye, October 2014, Nature

    Haoyu Chen

  61. Comparison of retinal thickness measurements of normal eyes between topcon algorithm and a graph based algorithm

    Article • September 2014, The University of Iowa

    Haoyu Chen

  62. Serological Association of Chlamydia pneumoniae Infection with Age-Related Macular Degeneration: A Systematic Review and Meta-Analysis

    Article • PLOS One, July 2014, PLOS

    Haoyu Chen

  63. Comparison of the optical coherence tomographic characters between acute Vogt-Koyanagi-Harada disease and acute central serous chorioretinopathy

    Article • BMC Ophthalmology, June 2014, Springer Science + Business Media

    Haoyu Chen

  64. A framework for retinal layer intensity analysis for retinal artery occlusion patient based on 3D OCT

    Article • March 2014, SPIE

    Haoyu Chen

  65. Support vector machine based IS/OS disruption detection from SD-OCT images

    Article • March 2014, SPIE

    Professor Dehui Xiang, Haoyu Chen

  66. Multimodal retinal imaging in a Chinese kindred with familial amyloid polyneuropathy secondary to transthyretin Ile107Met mutation

    Article • Eye, January 2014, Nature

    Haoyu Chen

  67. Quantitative Analysis of Retinal Layer Optical Intensities on Three-Dimensional Optical Coherence Tomography

    Article • Investigative Ophthalmology & Visual Science, October 2013, Association for Research in Vision and Ophthalmology (ARVO)

    Haoyu Chen

  68. Publication Times, Impact Factors, and Advance Online Publication in Ophthalmology Journals

    Article • Ophthalmology, August 2013, Elsevier

    Haoyu Chen

  69. PREDICTION OF VISUAL PROGNOSIS WITH SPECTRAL-DOMAIN OPTICAL COHERENCE TOMOGRAPHY IN OUTER RETINAL ATROPHY SECONDARY TO CLOSED GLOBE TRAUMA

    Article • Retina, June 2013, Wolters Kluwer Health

    Haoyu Chen

  70. A genome-wide meta-analysis identifies two novel loci associated with high myopia in the Han Chinese population

    Article • Human Molecular Genetics, February 2013, Oxford University Press (OUP)

    Haoyu Chen

  71. Comparison of Pterygium Recurrence Rates After Limbal Conjunctival Autograft Transplantation and Other Techniques

    Article • Cornea, December 2012, Wolters Kluwer Health

    Haoyu Chen

  72. Survey of systematic reviews and meta-analyses published in ophthalmology

    Article • British Journal of Ophthalmology, March 2012, BMJ

    Haoyu Chen

  73. Interactive Effects ofATOH7andRFTN1in Association with Adult-Onset Primary Open-Angle Glaucoma

    Article • Investigative Ophthalmology & Visual Science, February 2012, Association for Research in Vision and Ophthalmology (ARVO)

    Haoyu Chen

  74. MIDTERM RESULTS OF LOW-DOSE INTRAVITREAL TRIAMCINOLONE AS ADJUNCTIVE TREATMENT FOR PROLIFERATIVE VITREORETINOPATHY

    Article • Retina, June 2011, Wolters Kluwer Health

    Haoyu Chen

  75. Interactive Expressions of HtrA1 and VEGF in Human Vitreous Humors and Fetal RPE Cells

    Article • Investigative Ophthalmology & Visual Science, May 2011, Association for Research in Vision and Ophthalmology (ARVO)

    Haoyu Chen, Prof. Tsz Kin Ng

  76. Imaging inadvertent Desçemet's membrane break secondary to cataract surgery

    Article • Clinical and Experimental Optometry, September 2010, Wiley

    Haoyu Chen

  77. Genetic and Functional Dissection of HTRA1 and LOC387715 in Age-Related Macular Degeneration

    Article • PLoS Genetics, February 2010, PLOS

    Professor Ruifu Yang, Haoyu Chen

  78. Slit-Robo Signaling in Ocular Angiogenesis

    Article • December 2009, Springer Science + Business Media

    Haoyu Chen

  79. Slit2–Robo4 signalling promotes vascular stability by blocking Arf6 activity

    Article • Nature, October 2009, Nature

    Haoyu Chen

  80. Common variants on chromosome 2 and risk of primary open-angle glaucoma in the Afro-Caribbean population of Barbados

    Article • Proceedings of the National Academy of Sciences, October 2009, Proceedings of the National Academy of Sciences

    Haoyu Chen

  81. Mutant prominin 1 found in patients with macular degeneration disrupts photoreceptor disk morphogenesis in mice

    Article • Journal of Clinical Investigation, May 2009, American Society for Clinical Investigation

    Haoyu Chen

  82. Toll-like Receptor 3 and Geographic Atrophy in Age-Related Macular Degeneration

    Article • The New England Journal of Medicine and Surgery and the Collateral Branches of Science, October 2008, New England Journal of Medicine (NEJM/MMS)

    Haoyu Chen

  83. Genetic susceptibility of diabetic retinopathy

    Article • Current Diabetes Reports, August 2008, Springer Science + Business Media

    Haoyu Chen

  84. Mutant prominin 1 found in patients with macular degeneration disrupts photoreceptor disk morphogenesis in mice

    Article • Journal of Clinical Investigation, July 2008, American Society for Clinical Investigation

    Haoyu Chen, Professor David M Hunt

  85. Promoter polymorphism of the erythropoietin gene in severe diabetic eye and kidney complications

    Article • Proceedings of the National Academy of Sciences, May 2008, Proceedings of the National Academy of Sciences

    Dr Rola N Hamam, Haoyu Chen

  86. Corrigendum: Robo4 stabilizes the vascular network by inhibiting pathologic angiogenesis and endothelial hyperpermeability

    Article • Nature Medicine, May 2008, Nature

    Haoyu Chen

  87. Robo4 stabilizes the vascular network by inhibiting pathologic angiogenesis and endothelial hyperpermeability

    Article • Nature Medicine, March 2008, Nature

    Haoyu Chen

  88. Genetic association of LOXL1 gene variants and exfoliation glaucoma in a Utah cohort

    Article • Cell Cycle, February 2008, Taylor & Francis

    Haoyu Chen

  89. Further mapping of 10q26 supports strong association of HTRA1 polymorphisms with age-related macular degeneration

    Article • Vision Research, February 2008, Elsevier

    Haoyu Chen

  90. Familial aggregation of age-related macular degeneration in the Utah population

    Article • Vision Research, February 2008, Elsevier

    Haoyu Chen

  91. Association of HTRA1 polymorphism and bilaterality in advanced age-related macular degeneration

    Article • Vision Research, February 2008, Elsevier

    Haoyu Chen

  92. 10q26 Is Associated with Increased Risk of Age-Related Macular Degeneration in the Utah Population

    Article • January 2008, Springer Science + Business Media

    Haoyu Chen

  93. HTRA1 Variant Confers Similar Risks to Geographic Atrophy and Neovascular Age-related Macular Degeneration

    Article • Cell Cycle, May 2007, Taylor & Francis

    Haoyu Chen

  94. Elovl4 haploinsufficiency does not induce early onset retinal degeneration in mice

    Article • Vision Research, March 2007, Elsevier

    Haoyu Chen

  95. Essential role of Elovl4 in very long chain fatty acid synthesis, skin permeability barrier function, and neonatal survival

    Article • International Journal of Biological Sciences, January 2007, Ivyspring International Publisher

    Haoyu Chen

  96. A Variant of the HTRA1 Gene Increases Susceptibility to Age-Related Macular Degeneration

    Article • Science, November 2006, American Association for the Advancement of Science

    Haoyu Chen