All Stories

  1. Recent advances in understanding neuropathic pain: glia, sex differences, and epigenetics

    Article • F1000Research, November 2016, Faculty of 1000, Ltd.

    Prof Halina Machelska

  2. Adoptive transfer of M2 macrophages reduces neuropathic pain via opioid peptides

    Article • Journal of Neuroinflammation, October 2016, Springer Science + Business Media

    Prof Halina Machelska

  3. Leukocyte opioid receptors mediate analgesia via Ca2+-regulated release of opioid peptides

    Article • Brain Behavior and Immunity, October 2016, Elsevier

    Prof Halina Machelska

  4. Distinct roles of exogenous opioid agonists and endogenous opioid peptides in the peripheral control of neuropathy-triggered heat pain

    Article • Scientific Reports, September 2016, Nature

    Prof Halina Machelska

  5. Opioids and TRPV1 in the peripheral control of neuropathic pain – Defining a target site in the injured nerve

    Article • Neuropharmacology, February 2016, Elsevier

    Prof Halina Machelska

  6. Immunohistochemical Analysis of Opioid Receptors in Peripheral Tissues

    Article • September 2014, Springer Science + Business Media

    Prof Halina Machelska

  7. Electrophysiological Patch Clamp Assay to Monitor the Action of Opioid Receptors

    Article • September 2014, Springer Science + Business Media

    Prof Halina Machelska

  8. Analysis of Potassium and Calcium Imaging to Assay the Function of Opioid Receptors

    Article • September 2014, Springer Science + Business Media

    Prof Halina Machelska

  9. Skin–Nerve Preparation to Assay the Function of Opioid Receptors in Peripheral Endings of Sensory Neurons

    Article • September 2014, Springer Science + Business Media

    Prof Halina Machelska

  10. Peripheral Neuroimmune Interactions and Neuropathic Pain

    Article • January 2014, Springer Science + Business Media

    Prof Halina Machelska

  11. μ-Opioid Receptor Antibody Reveals Tissue-Dependent Specific Staining and Increased Neuronal μ-Receptor Immunoreactivity at the Injured Nerve Trunk in Mice

    Article • PLoS ONE, November 2013, PLOS

    Prof Halina Machelska

  12. Endogene Opioide: Ihre Wirkung kann man deutlich verstärken - Nachgehakt bei Prof. Dr. Halina Machelska und Prof. Dr. Christoph Stein

    Article • Journal Club Schmerzmedizin, July 2013, Thieme Publishing Group

    Prof Halina Machelska

  13. Stronger Antinociceptive Efficacy of Opioids at the Injured Nerve Trunk Than at Its Peripheral Terminals in Neuropathic Pain

    Article • Journal of Pharmacology and Experimental Therapeutics, July 2013, American Society for Pharmacology & Experimental Therapeutics (ASPET)

    Prof Halina Machelska

  14. Neuroimmune interactions after nerve injury and opioid-mediated pain control

    Article • Brain Behavior and Immunity, February 2013, Elsevier

    Prof Halina Machelska

  15. Impaired Nociception and Peripheral Opioid Antinociception in Mice Lacking Both Kinin B1 and B2 Receptors

    Article • Anesthesiology, February 2012, Wolters Kluwer Health

    Prof Halina Machelska

  16. Cutaneous nociceptors lack sensitisation, but reveal μ-opioid receptor-mediated reduction in excitability to mechanical stimulation in neuropathy

    Article • Molecular Pain, January 2012, SAGE Publications

    Prof Halina Machelska

  17. Modulation of Peripheral Sensory Neurons by the Immune System: Implications for Pain Therapy

    Article • Pharmacological Reviews, October 2011, American Society for Pharmacology & Experimental Therapeutics (ASPET)

    Prof Halina Machelska

  18. Control of Neuropathic Pain by Immune Cells and Opioids

    Article • CNS & Neurological Disorders - Drug Targets, August 2011, Bentham Science Publishers

    Prof Halina Machelska

  19. Dual Peripheral Actions of Immune Cells in Neuropathic Pain

    Article • Archivum Immunologiae et Therapiae Experimentalis, January 2011, Springer Science + Business Media

    Prof Halina Machelska

  20. Analgesic effects of immune cells in neuropathic pain

    Article • Pharmacological Reports, January 2011, Elsevier

    Prof Halina Machelska

  21. Activation of opioid receptors in injured nerves is required for efficient analgesia in neuropathic pain

    Article • Pharmacological Reports, January 2011, Elsevier

    Prof Halina Machelska

  22. T lymphocytes containing β-endorphin ameliorate mechanical hypersensitivity following nerve injury

    Article • Brain Behavior and Immunity, October 2010, Elsevier

    Prof Halina Machelska

  23. Peripheral antinociceptive effects of MC4 receptor antagonists in a rat model of neuropathic pain – a biochemical and behavioral study

    Article • Pharmacological Reports, November 2009, Elsevier

    Prof Halina Machelska

  24. 105 T CELL-DERIVED AND EXOGENOUS OPIOIDS ACTING AT PERIPHERAL OPIOID RECEPTORS CONTROL NEUROPATHIC PAIN

    Article • European Journal of Pain, September 2009, Wiley

    Prof Halina Machelska

  25. 286 PAIN CONTROL BY PREVENTION OF OPIOID PEPTIDE DEGRADATION IN PERIPHERAL INFLAMED TISSUE

    Article • European Journal of Pain, September 2009, Wiley

    Prof Halina Machelska

  26. Immune cell–derived opioids protect against neuropathic pain in mice

    Article • Journal of Clinical Investigation, April 2009, American Society for Clinical Investigation

    Prof Halina Machelska

  27. Immune cell–derived opioids protect against neuropathic pain in mice

    Article • Journal of Clinical Investigation, April 2009, American Society for Clinical Investigation

    Prof Halina Machelska

  28. Peripheral non-viral MIDGE vector-driven delivery of β-endorphin in inflammatory pain

    Article • Molecular Pain, January 2009, SAGE Publications

    Prof Halina Machelska

  29. Immune cells-mediated opioid release controls inflammatory pain

    Article • European Journal of Anaesthesiology, May 2008, Wolters Kluwer Health

    Prof Halina Machelska

  30. Immune System, Pain and Analgesia

    Article • January 2008, Elsevier

    Prof Halina Machelska

  31. Targeting of opioid-producing leukocytes for pain control

    Article • Neuropeptides, December 2007, Elsevier

    Prof Halina Machelska

  32. Relative contribution of peripheral versus central opioid receptors to antinociception

    Article • Brain Research, July 2007, Elsevier

    Prof Halina Machelska

  33. 292 T LYMPHOCYTES CONTRIBUTE TO OPIOID PAIN CONTROL IN NEURITIS

    Article • European Journal of Pain, June 2007, Wiley

    Prof Halina Machelska

  34. 279 LEUKOCYTE-DERIVED OPIOIDS PRODUCE PERIPHERAL ANTINOCICEPTION IN NEUROPATHIC PAIN

    Article • European Journal of Pain, June 2007, Wiley

    Prof Halina Machelska

  35. 291 EXPRESSION OF PERIPHERAL OPIOID RECEPTORS AND PEPTIDES IN A NEUROPATHIC PAIN MODEL

    Article • European Journal of Pain, June 2007, Wiley

    Prof Halina Machelska

  36. Immune-derived Opioids: Production and Function in Inflammatory Pain

    Article • January 2007, Elsevier

    Prof Halina Machelska

  37. A stomatin-domain protein essential for touch sensation in the mouse

    Article • Nature, December 2006, Nature

    Prof Halina Machelska, Gary Lewin

  38. 275 LEUKOCYTE-DERIVED OPIOIDS INHIBIT NEUROPATHIC PAIN BY ACTIVATING PERIPHERAL OPIOID RECEPTORS

    Article • European Journal of Pain, September 2006, Wiley

    Prof Halina Machelska

  39. Leukocyte-Derived Opioid Peptides and Inhibition of Pain

    Article • Journal of Neuroimmune Pharmacology, February 2006, Springer Science + Business Media

    Prof Halina Machelska

  40. Control of inflammatory pain by chemokine-mediated recruitment of opioid-containing polymorphonuclear cells

    Article • Pain, December 2004, Wolters Kluwer Health

    Prof Halina Machelska

  41. Tissue Monocytes/Macrophages in Inflammation

    Article • Anesthesiology, July 2004, Wolters Kluwer Health

    Prof Halina Machelska

  42. Selectins and integrins but not platelet-endothelial cell adhesion molecule-1 regulate opioid inhibition of inflammatory pain

    Article • British Journal of Pharmacology, June 2004, Wiley

    Prof Halina Machelska

  43. Endogenous peripheral antinociception in early inflammation is not limited by the number of opioid-containing leukocytes but by opioid receptor expression

    Article • Pain, March 2004, Wolters Kluwer Health

    Prof Halina Machelska

  44. Mobilization of Opioid-containing Polymorphonuclear Cells by Hematopoietic Growth Factors and Influence on Inflammatory Pain

    Article • Anesthesiology, January 2004, Wolters Kluwer Health

    Prof Halina Machelska

  45. Breaking the pain barrier

    Article • Nature Medicine, November 2003, Nature

    Prof Halina Machelska

  46. Attacking pain at its source: new perspectives on opioids

    Article • Nature Medicine, August 2003, Nature

    Prof Halina Machelska

  47. Different mechanisms of intrinsic pain inhibition in early and late inflammation

    Article • Journal of Neuroimmunology, August 2003, Elsevier

    Prof Halina Machelska

  48. Peripheral Opioid Analgesia Neuroimmune Interactions and Therapeutic Implications

    Article • May 2003, Taylor & Francis

    Prof Halina Machelska

  49. Peripheral analgesic and anti-inflammatory effects of opioids — neuro-immune crosstalk

    Article • January 2003, Springer Science + Business Media

    Prof Halina Machelska

  50. Immune Mechanisms in Pain Control

    Article • Anesthesia & Analgesia, October 2002, Wolters Kluwer Health

    Prof Halina Machelska

  51. Immune Mechanisms in Pain Control

    Article • Anesthesia & Analgesia, October 2002, Wolters Kluwer Health

    Prof Halina Machelska

  52. Immunohistochemical localization of endomorphin-1 and endomorphin-2 in immune cells and spinal cord in a model of inflammatory pain

    Article • Journal of Neuroimmunology, May 2002, Elsevier

    Prof Halina Machelska

  53. Peripheral analgesic and antiinflammatory effects of opioids

    Article • Zeitschrift für Rheumatologie, December 2001, Springer Science + Business Media

    Prof Halina Machelska

  54. Opioid Peptide–expressing Leukocytes

    Article • Anesthesiology, August 2001, Wolters Kluwer Health

    Prof Halina Machelska

  55. Analgesic and Antiinflammatory Effects of Two Novel κ-Opioid Peptides

    Article • Anesthesiology, June 2001, Wolters Kluwer Health

    Prof Halina Machelska

  56. Why is morphine not the ultimate analgesic and what can be done to improve it?

    Article • Journal of Pain, September 2000, Elsevier

    Prof Halina Machelska

  57. Room B, 10/16/2000 2: 00 PM - 4: 00 PM (PS) Quantitative PCR of Opioid Peptide mRNAs Correlates with Stress-Induced Analgesia

    Article • Anesthesiology, September 2000, Wolters Kluwer Health

    Prof Halina Machelska

  58. Room B, 10/16/2000 2: 00 PM - 4: 00 PM (PS) Granulocytes Mediate Endogenous Analgesia in Early Inflammatory Pain

    Article • Anesthesiology, September 2000, Wolters Kluwer Health

    Prof Halina Machelska

  59. Co-expression of β-endorphin with adhesion molecules in a model of inflammatory pain

    Article • Journal of Neuroimmunology, August 2000, Elsevier

    Prof Halina Machelska

  60. Pain Control by Immune-Derived Opioids

    Article • Clinical and Experimental Pharmacology and Physiology, July 2000, Wiley

    Prof Halina Machelska

  61. Pain control and the immune system

    Article • Current Opinion in Anaesthesiology, October 1999, Wolters Kluwer Health

    Prof Halina Machelska

  62. Selectins promote pain control

    Article • Biomedicine & Pharmacotherapy, September 1999, Elsevier

    Prof Halina Machelska

  63. Antinociception after both peripheral and intrathecal injection of oxotremorine is modulated by spinal nitric oxide

    Article • European Neuropsychopharmacology, March 1999, Elsevier

    Prof Halina Machelska

  64. Pain control in inflammation governed by selectins

    Article • Nature Medicine, December 1998, Nature

    Prof Halina Machelska

  65. Peripheral nociceptive integration

    Article • Pain Forum, June 1998, Elsevier

    Prof Halina Machelska

  66. Effects of pentylenetetrazol kindling on glutamate receptor genes expression in the rat hippocampus

    Article • Brain Research, March 1998, Elsevier

    Prof Halina Machelska

  67. Chronic morphine increases biosynthesis of nitric oxide synthase in the rat spinal cord

    Article • Neuroreport, August 1997, Wolters Kluwer Health

    Prof Halina Machelska

  68. Effects of pilocarpine and kainate-induced seizures on N-methyl-d-aspartate receptor gene expression in the rat hippocampus

    Article • Neuroscience, April 1997, Elsevier

    Prof Halina Machelska

  69. Nitric oxide synthase inhibitor l-name prevents amphetamine-induced prodynorphin gene expression in the rat

    Article • Progress in Neuro-Psychopharmacology and Biological Psychiatry, October 1996, Elsevier

    Prof Halina Machelska

  70. Intracerebroventricular galanin and N-terminal galanin fragment enhance the morphine-induced analgesia in the rat

    Article • Journal of Neural Transmission, October 1995, Springer Science + Business Media

    Prof Halina Machelska

  71. Kappa opioid receptor agonists suppress absence seizures in WAG/Rij rats

    Article • Neuroscience Letters, February 1995, Elsevier

    Prof Halina Machelska

  72. Kappa opioid receptor agonists inhibit the pilocarpine-induced seizures and toxicity in the mouse

    Article • European Neuropsychopharmacology, December 1994, Elsevier

    Prof Halina Machelska

  73. Modulation of morphine and cocaine effects by inhibition of nitric oxide synthase

    Article • Regulatory Peptides, November 1994, Elsevier

    Prof Halina Machelska

  74. The role of the nitric oxide pathway in the morphine- and cocaine-induced behavioral sensitization and proenkephalin gene expression

    Article • Neuropeptides, April 1994, Elsevier

    Prof Halina Machelska

  75. Involvement of the nitric oxide pathway in nociceptive processes in the central nervous system in rats

    Article • Regulatory Peptides, February 1994, Elsevier

    Prof Halina Machelska

  76. L-Nitroarginine methyl ester attenuates the development of morphine tolerance and dependence in mice

    Article • Regulatory Peptides, February 1994, Elsevier

    Prof Halina Machelska

  77. Inhibition of nitric oxide synthase attenuates the development of morphine tolerance and dependence in mice

    Article • Neuropharmacology, February 1994, Elsevier

    Prof Halina Machelska

  78. Inhibition of nitric oxide synthase enhances morphine antinociception in the rat spinal cord

    Article • Life Sciences, January 1993, Elsevier

    Prof Halina Machelska

  79. Local burn injury profoundly enhances endogenous opioid systems activity in rats

    Article • Pharmacological Research, May 1992, Elsevier

    Prof Halina Machelska

  80. Faculty of 1000 evaluation for Case Report: Neuropathic pain in a patient with congenital insensitivity to pain.

    Article • Faculty of 1000, Ltd.

    Prof Halina Machelska

  81. Faculty of 1000 evaluation for Case Report: Neuropathic pain in a patient with congenital insensitivity to pain

    Article • Faculty of 1000, Ltd.

    Prof Halina Machelska

  82. Faculty of 1000 evaluation for Cortical astrocytes rewire somatosensory cortical circuits for peripheral neuropathic pain.

    Article • Faculty of 1000, Ltd.

    Prof Halina Machelska

  83. Faculty of 1000 evaluation for Injured sensory neuron-derived CSF1 induces microglial proliferation and DAP12-dependent pain.

    Article • Faculty of 1000, Ltd.

    Prof Halina Machelska

  84. Faculty of 1000 evaluation for TMEM16F Regulates Spinal Microglial Function in Neuropathic Pain States.

    Article • Faculty of 1000, Ltd.

    Prof Halina Machelska

  85. Faculty of 1000 evaluation for Differential methylation of the TRPA1 promoter in pain sensitivity.

    Article • Faculty of 1000, Ltd.

    Prof Halina Machelska

  86. Faculty of 1000 evaluation for Persistent Alterations in Microglial Enhancers in a Model of Chronic Pain.

    Article • Faculty of 1000, Ltd.

    Prof Halina Machelska

  87. Faculty of 1000 evaluation for Mindfulness Meditation for Chronic Pain: Systematic Review and Meta-analysis.

    Article • Faculty of 1000, Ltd.

    Prof Halina Machelska

  88. Faculty of 1000 evaluation for EULAR revised recommendations for the management of fibromyalgia.

    Article • Faculty of 1000, Ltd.

    Prof Halina Machelska

  89. Faculty of 1000 evaluation for An industry perspective on the role and utility of animal models of pain in drug discovery.

    Article • Faculty of 1000, Ltd.

    Prof Halina Machelska

  90. Faculty of 1000 evaluation for Inhibition of mechanical allodynia in neuropathic pain by TLR5-mediated A-fiber blockade.

    Article • Faculty of 1000, Ltd.

    Prof Halina Machelska

  91. Faculty of 1000 evaluation for Dorsal Horn Parvalbumin Neurons Are Gate-Keepers of Touch-Evoked Pain after Nerve Injury.

    Article • Faculty of 1000, Ltd.

    Prof Halina Machelska

  92. Faculty of 1000 evaluation for Macrophage-Colony Stimulating Factor Derived from Injured Primary Afferent Induces Proliferation of Spinal Microglia and Neuropathic Pain in Rats.

    Article • Faculty of 1000, Ltd.

    Prof Halina Machelska

  93. Faculty of 1000 evaluation for Oligodendrocyte ablation triggers central pain independently of innate or adaptive immune responses in mice.

    Article • Faculty of 1000, Ltd.

    Prof Halina Machelska

  94. Faculty of 1000 evaluation for Connexin-43 induces chemokine release from spinal cord astrocytes to maintain late-phase neuropathic pain in mice.

    Article • Faculty of 1000, Ltd.

    Prof Halina Machelska

  95. Faculty of 1000 evaluation for Bone marrow-derived cells in the population of spinal microglia after peripheral nerve injury.

    Article • Faculty of 1000, Ltd.

    Prof Halina Machelska

  96. Faculty of 1000 evaluation for G9a is essential for epigenetic silencing of K(+) channel genes in acute-to-chronic pain transition.

    Article • Faculty of 1000, Ltd.

    Prof Halina Machelska

  97. Faculty of 1000 evaluation for Promoted Interaction of Nuclear Factor-κB With Demethylated Purinergic P2X3 Receptor Gene Contributes to Neuropathic Pain in Rats With Diabetes.

    Article • Faculty of 1000, Ltd.

    Prof Halina Machelska

  98. Faculty of 1000 evaluation for Overlapping signatures of chronic pain in the DNA methylation landscape of prefrontal cortex and peripheral T cells.

    Article • Faculty of 1000, Ltd.

    Prof Halina Machelska

  99. Faculty of 1000 evaluation for Correlation Between DNA Methylation of TRPA1 and Chronic Pain States in Human Whole Blood Cells.

    Article • Faculty of 1000, Ltd.

    Prof Halina Machelska

  100. Faculty of 1000 evaluation for Nerve Injury Diminishes Opioid Analgesia through Lysine Methyltransferase-mediated Transcriptional Repression of μ-Opioid Receptors in Primary Sensory Neurons.

    Article • Faculty of 1000, Ltd.

    Prof Halina Machelska

  101. Faculty of 1000 evaluation for Suppression of Peripheral Pain by Blockade of Voltage-Gated Calcium 2.2 Channels in Nociceptors Induces RANKL and Impairs Recovery From Inflammatory Arthritis in a Mouse Model.

    Article • Faculty of 1000, Ltd.

    Prof Halina Machelska

  102. Faculty of 1000 evaluation for Effect of Mindfulness-Based Stress Reduction vs Cognitive Behavioral Therapy or Usual Care on Back Pain and Functional Limitations in Adults With Chronic Low Back Pain: A Randomized Clinical Trial.

    Article • Faculty of 1000, Ltd.

    Prof Halina Machelska