All Stories

  1. Development of Chemical Tools to Monitor Human Kallikrein 13 (KLK13) Activity

    Article • International Journal of Molecular Sciences, March 2019, MDPI AG

    PhD Grzegorz Dubin

  2. Development of a novel, high-affinity ssDNA trypsin inhibitor

    Article • Journal of Enzyme Inhibition and Medicinal Chemistry, January 2019, Taylor & Francis

    PhD Grzegorz Dubin

  3. Crystal structure of the FAS1 domain of the hyaluronic acid receptor stabilin-2

    Article • Acta Crystallographica Section D Structural Biology, June 2018, International Union of Crystallography

    PhD Grzegorz Dubin

  4. Structural basis for ADP-dependent glucokinase inhibition by 8-bromo–substituted adenosine nucleotide

    Article • Journal of Biological Chemistry, May 2018, American Society for Biochemistry & Molecular Biology (ASBMB)

    PhD Grzegorz Dubin

  5. Identification of small-molecule inhibitors of USP2a

    Article • European Journal of Medicinal Chemistry, April 2018, Elsevier

    PhD Grzegorz Dubin

  6. Unique Substrate Specificity of SplE Serine Protease from Staphylococcus aureus

    Article • Structure, April 2018, Elsevier

    PhD Grzegorz Dubin

  7. A novel, dual pan-PIM/FLT3 inhibitor SEL24 exhibits broad therapeutic potential in acute myeloid leukemia

    Article • Oncotarget, March 2018, Impact Journals, LLC

    PhD Grzegorz Dubin

  8. Crystal structure of ADP-dependent glucokinase from Methanocaldococcus jannaschii in complex with 5-iodotubercidin reveals phosphoryl transfer mechanism

    Article • Protein Science, February 2018, Wiley

    PhD Grzegorz Dubin

  9. Spatial attributes of the four-helix bundle group of bacteriocins – The high-resolution structure of BacSp222 in solution

    Article • International Journal of Biological Macromolecules, February 2018, Elsevier

    PhD Grzegorz Dubin

  10. Modular endolysin of Burkholderia AP3 phage has the largest lysozyme-like catalytic subunit discovered to date and no catalytic aspartate residue

    Article • Scientific Reports, November 2017, Springer Science + Business Media

    PhD Grzegorz Dubin

  11. Identification of novel mazEF/pemIK family toxin-antitoxin loci and their distribution in the Staphylococcus genus

    Article • Scientific Reports, October 2017, Springer Science + Business Media

    PhD Grzegorz Dubin

  12. Structural analysis of PIM1 kinase complexes with ATP-competitive inhibitors

    Article • Scientific Reports, October 2017, Springer Science + Business Media

    PhD Grzegorz Dubin

  13. Staphylococcus Aureus V8 protease disrupts the integrity of the airway epithelial barrier and impairs IL-6 production in vitro

    Article • The Laryngoscope, October 2017, Wiley

    Dr Sarah Vreugde, PhD Grzegorz Dubin

  14. Properties of halogenated and sulfonated porphyrins relevant for the selection of photosensitizers in anticancer and antimicrobial therapies

    Article • PLoS ONE, October 2017, PLOS

    PhD Grzegorz Dubin

  15. Bioactive Macrocyclic Inhibitors of the PD-1/PD-L1 Immune Checkpoint

    Article • Angewandte Chemie International Edition, September 2017, Wiley

    Łukasz Berlicki, PhD Grzegorz Dubin

  16. Small-molecule inhibitors of PD-1/PD-L1 immune checkpoint alleviate the PD-L1-induced exhaustion of T-cells

    Article • Oncotarget, August 2017, Impact Journals, LLC

    PhD Grzegorz Dubin

  17. Structural Biology of the Immune Checkpoint Receptor PD-1 and Its Ligands PD-L1/PD-L2

    Article • Structure, August 2017, Elsevier

    PhD Grzegorz Dubin

  18. Crystal structure of a low molecular weight activator Blm-pep with yeast 20S proteasome – insights into the enzyme activation mechanism

    Article • Scientific Reports, July 2017, Nature

    PhD Grzegorz Dubin

  19. Small-Molecule Inhibitors of the Programmed Cell Death-1/Programmed Death-Ligand 1 (PD-1/PD-L1) Interaction via Transiently Induced Protein States and Dimerization of PD-L1

    Article • Journal of Medicinal Chemistry, June 2017, American Chemical Society (ACS)

    PhD Grzegorz Dubin

  20. Malassezia globosa Mg MDL2 lipase: Crystal structure and rational modification of substrate specificity

    Article • Biochemical and Biophysical Research Communications, June 2017, Elsevier

    PhD Grzegorz Dubin, Dr. Faez Iqbal Khan

  21. 1,4,5-Trisubstituted Imidazole-Based p53–MDM2/MDMX Antagonists with Aliphatic Linkers for Conjugation with Biological Carriers

    Article • Journal of Medicinal Chemistry, May 2017, American Chemical Society (ACS)

    PhD Grzegorz Dubin

  22. Lithocholic Acid Hydroxyamide Destabilizes Cyclin D1 and Induces G 0 /G 1 Arrest by Inhibiting Deubiquitinase USP2a

    Article • Cell Chemical Biology, April 2017, Elsevier

    PhD Grzegorz Dubin

  23. Structural Characterization of Human Coronavirus NL63 N Protein

    Article • Journal of Virology, March 2017, ASM Journals

    PhD Grzegorz Dubin

  24. Rational design and synthesis of 1,5-disubstituted tetrazoles as potent inhibitors of the MDM2-p53 interaction

    Article • European Journal of Medicinal Chemistry, January 2017, Elsevier

    PhD Grzegorz Dubin

  25. A Unique Mdm2-Binding Mode of the 3-Pyrrolin-2-one- and 2-Furanone-Based Antagonists of the p53-Mdm2 Interaction

    Article • ACS Chemical Biology, December 2016, American Chemical Society (ACS)

    PhD Grzegorz Dubin

  26. Distinct 3D Architecture and Dynamics of the Human HtrA2(Omi) Protease and Its Mutated Variants

    Article • PLoS ONE, August 2016, PLOS

    PhD Grzegorz Dubin

  27. Inhibitors of programmed cell death 1 (PD-1): a patent review (2010-2015)

    Article • Expert Opinion on Therapeutic Patents, July 2016, Taylor & Francis

    PhD Grzegorz Dubin

  28. Visualization of kallikreins in thyroid epithelial and carcinoma cells

    Article • Endocrine Abstracts, May 2016, Bioscientifica

    PhD Grzegorz Dubin

  29. Identification of Secreted Exoproteome Fingerprints of Highly-Virulent and Non-Virulent Staphylococcus aureus Strains

    Article • Frontiers in Cellular and Infection Microbiology, May 2016, Frontiers

    PhD Grzegorz Dubin

  30. Structure of human Programmed cell death 1 ligand 1 (PD-L1) with low molecular mass inhibitor

    Article • April 2016, Protein Data Bank, Rutgers University

    PhD Grzegorz Dubin

  31. Structure of human Programmed cell death 1 ligand 1 (PD-L1) with low molecular mass inhibitor

    Article • April 2016, Protein Data Bank, Rutgers University

    PhD Grzegorz Dubin

  32. Structural basis for small molecule targeting of the programmed death ligand 1 (PD-L1)

    Article • Oncotarget, April 2016, Impact Journals, LLC

    PhD Grzegorz Dubin

  33. The outer-membrane export signal of Porphyromonas gingivalis type IX secretion system (T9SS) is a conserved C-terminal β-sandwich domain

    Article • Scientific Reports, March 2016, Nature

    PhD Grzegorz Dubin

  34. Structure of the Complex of Human Programmed Death 1, PD-1, and Its Ligand PD-L1

    Article • Structure, December 2015, Elsevier

    PhD Grzegorz Dubin

  35. PD-1 binding domain from human PD-L1

    Article • November 2015, Protein Data Bank, Rutgers University

    PhD Grzegorz Dubin

  36. Structure of the complex of human programmed death-1 (PD-1) and its ligand PD-L1.

    Article • November 2015, Protein Data Bank, Rutgers University

    PhD Grzegorz Dubin

  37. Investigation of Serine-Proteinase-Catalyzed Peptide Splicing in Analogues of Sunflower Trypsin Inhibitor 1 (SFTI-1)

    Article • ChemBioChem, August 2015, Wiley

    PhD Grzegorz Dubin

  38. Structural Basis of GD2 Ganglioside and Mimetic Peptide Recognition by 14G2a Antibody

    Article • Molecular & Cellular Proteomics, July 2015, American Society for Biochemistry & Molecular Biology (ASBMB)

    PhD Grzegorz Dubin

  39. The Nucleocapsid Protein of Human Coronavirus NL63

    Article • PLoS ONE, February 2015, PLOS

    PhD Grzegorz Dubin

  40. Atomic resolution crystal structure of HV-BBI protease inhibitor from amphibian skin in complex with bovine trypsin

    Article • Proteins Structure Function and Bioinformatics, January 2015, Wiley

    PhD Grzegorz Dubin

  41. A systematic investigation of the stability of green fluorescent protein fusion proteins

    Article • Acta Biochimica Polonica, January 2015, Polskie Towarzystwo Biochemiczne (Polish Biochemical Society)

    PhD Grzegorz Dubin

  42. Staphylococcal SplB Serine Protease Utilizes a Novel Molecular Mechanism of Activation

    Article • Journal of Biological Chemistry, April 2014, American Society for Biochemistry & Molecular Biology (ASBMB)

    PhD Grzegorz Dubin

  43. Staphylococcal Proteases Aid in Evasion of the Human Complement System

    Article • Journal of Innate Immunity, January 2014, Karger Publishers

    PhD Grzegorz Dubin

  44. Development and binding characteristics of phosphonate inhibitors of SplA protease from Staphylococcus aureus

    Article • Protein Science, December 2013, Wiley

    PhD Grzegorz Dubin

  45. Biochemical and Structural Characterization of SplD Protease from Staphylococcus aureus

    Article • PLoS ONE, October 2013, PLOS

    PhD Grzegorz Dubin

  46. A regulatory role for Staphylococcus aureus toxin–antitoxin system PemIKSa

    Article • Nature Communications, June 2013, Nature

    PhD Grzegorz Dubin

  47. Structural phase transition and related electronic properties in quasi-one-dimensional (NbSe4)10/3I

    Article • Acta Crystallographica Section B Structural Science Crystal Engineering and Materials, May 2013, International Union of Crystallography

    PhD Grzegorz Dubin

  48. Insights into eukaryotic Rubisco assembly — Crystal structures of RbcX chaperones from Arabidopsis thaliana

    Article • Biochimica et Biophysica Acta (BBA) - General Subjects, April 2013, Elsevier

    PhD Grzegorz Dubin

  49. Mdm2 and MdmX inhibitors for the treatment of cancer: a patent review (2011 – present)

    Article • Expert Opinion on Therapeutic Patents, February 2013, Informa Healthcare

    PhD Grzegorz Dubin

  50. Bacterial Proteases in Disease – Role in Intracellular Survival, Evasion of Coagulation/ Fibrinolysis Innate Defenses, Toxicoses and Viral Infections

    Article • Current Pharmaceutical Design, December 2012, Bentham Science Publishers

    PhD Grzegorz Dubin

  51. Bacterial Proteases in Disease – Role in Intracellular Survival, Evasion of Coagulation/ Fibrinolysis Innate Defenses, Toxicoses and Viral Infections

    Article • Current Pharmaceutical Design, December 2012, Bentham Science Publishers

    PhD Grzegorz Dubin

  52. Isolation, biochemical characterization, and cloning of a bacteriocin from the poultry-associated Staphylococcus aureus strain CH-91

    Article • Applied Microbiology and Biotechnology, November 2012, Springer Science + Business Media

    PhD Grzegorz Dubin

  53. Staphylococcal proteases aid evasion of human complement system

    Article • Immunobiology, November 2012, Elsevier

    PhD Grzegorz Dubin

  54. Prevalence of genes encoding extracellular proteases inStaphylococcus aureus— important targets triggering immune responsein vivo

    Article • FEMS Immunology & Medical Microbiology, November 2012, Oxford University Press (OUP)

    PhD Grzegorz Dubin

  55. The virulence of Staphylococcus aureus correlates with strain genotype in a chicken embryo model but not a nematode model

    Article • Microbes and Infection, November 2012, Elsevier

    PhD Grzegorz Dubin

  56. The development of first Staphylococcus aureus SplB protease inhibitors: Phosphonic analogues of glutamine

    Article • Bioorganic & Medicinal Chemistry Letters, September 2012, Elsevier

    PhD Grzegorz Dubin

  57. On the Mechanism of Action of SJ-172550 in Inhibiting the Interaction of MDM4 and p53

    Article • PLoS ONE, June 2012, PLOS

    PhD Grzegorz Dubin

  58. Substrate specificity of Staphylococcus aureus cysteine proteases – Staphopains A, B and C

    Article • Biochimie, February 2012, Elsevier

    PhD Grzegorz Dubin

  59. α1-Antichymotrypsin inactivates staphylococcal cysteine protease in cross-class inhibition

    Article • Biochimie, May 2011, Elsevier

    PhD Grzegorz Dubin

  60. Activation mechanism of thiol protease precursor from broiler chicken specific Staphylococcus aureus strain CH-91

    Article • Veterinary Microbiology, January 2011, Elsevier

    PhD Grzegorz Dubin

  61. Interaction of regulators Mdm2 and Mdmx with transcription factors p53, p63 and p73

    Article • Cell Cycle, November 2010, Taylor & Francis

    PhD Grzegorz Dubin

  62. Exfoliative Toxins of Staphylococcus aureus

    Article • Toxins, May 2010, MDPI AG

    PhD Grzegorz Dubin

  63. A novel matrix metalloprotease-like enzyme (karilysin) of the periodontal pathogen Tannerella forsythia ATCC 43037

    Article • Biological Chemistry, January 2010, De Gruyter

    PhD Grzegorz Dubin

  64. Structural and functional characterization of SplA, an exclusively specific protease of Staphylococcus aureus

    Article • Biochemical Journal, May 2009, Portland Press Ltd.

    PhD Grzegorz Dubin

  65. High affinity interaction of the p53 peptide-analogue with human Mdm2 and Mdmx

    Article • Cell Cycle, April 2009, Taylor & Francis

    PhD Grzegorz Dubin

  66. Elafin is specifically inactivated by RgpB from Porphyromonas gingivalis by distinct proteolytic cleavage

    Article • Biological Chemistry, January 2009, De Gruyter

    PhD Grzegorz Dubin

  67. Enzymatic Activity of the Staphylococcus aureus SplB Serine Protease is Induced by Substrates Containing the Sequence Trp-Glu-Leu-Gln

    Article • Journal of Molecular Biology, May 2008, Elsevier

    PhD Grzegorz Dubin

  68. Staphylococcus aureusinfection triggers production of neutralizing, V8 protease-specific antibodies

    Article • FEMS Immunology & Medical Microbiology, March 2008, Oxford University Press (OUP)

    PhD Grzegorz Dubin

  69. The human fibrinolytic system is a target for the staphylococcal metalloprotease aureolysin

    Article • Biochemical Journal, February 2008, Portland Press Ltd.

    PhD Grzegorz Dubin

  70. Staphylococcus aureus-Derived Staphopain B, a Potent Cysteine Protease Activator of Plasma Chemerin

    Article • The Journal of Immunology, March 2007, The American Association of Immunologists

    PhD Grzegorz Dubin

  71. The staphostatin family of cysteine protease inhibitors in the genus Staphylococcus as an example of parallel evolution of protease and inhibitor specificity

    Article • Biological Chemistry, January 2007, De Gruyter

    PhD Grzegorz Dubin

  72. Functional and Structural Characterization of Spl Proteases from Staphylococcus aureus

    Article • Journal of Molecular Biology, April 2006, Elsevier

    PhD Grzegorz Dubin

  73. Article • Molecular Medicine, January 2006, The Feinstein Institute for Medical Research (North Shore LIJ Research Institute)

    PhD Grzegorz Dubin

  74. Proteinaceous cysteine protease inhibitors

    Article • Cellular and Molecular Life Sciences, March 2005, Springer Science + Business Media

    PhD Grzegorz Dubin

  75. Letter to the Editor: 1 H, 15 N and 13 C NMR Resonance Assignments of Staphostatin A, a Specific Staphylococcus Aureus Cysteine Proteinase Inhibitor

    Article • Journal of Biomolecular NMR, March 2004, Springer Science + Business Media

    PhD Grzegorz Dubin

  76. Characterisation of a highly specific, endogenous inhibitor of cysteine protease from Staphylococcus epidermidis, a new member of the staphostatin family

    Article • Biological Chemistry, January 2004, De Gruyter

    PhD Grzegorz Dubin

  77. A Novel Class of Cysteine Protease Inhibitors:  Solution Structure of Staphostatin A fromStaphylococcus aureus†

    Article • Biochemistry, November 2003, American Chemical Society (ACS)

    PhD Grzegorz Dubin

  78. Extracellular Proteases of Staphylococcus spp.

    Article • Biological Chemistry, January 2002, De Gruyter

    PhD Grzegorz Dubin

  79. Molecular Cloning and Biochemical Characterisation of Proteases from Staphylococcus epidermidis

    Article • Biological Chemistry, January 2001, De Gruyter

    PhD Grzegorz Dubin