All Stories

  1. Development of Chemical Tools to Monitor Human Kallikrein 13 (KLK13) Activity
  2. Development of a novel, high-affinity ssDNA trypsin inhibitor
  3. Crystal structure of the FAS1 domain of the hyaluronic acid receptor stabilin-2
  4. Structural basis for ADP-dependent glucokinase inhibition by 8-bromo–substituted adenosine nucleotide
  5. Identification of small-molecule inhibitors of USP2a
  6. Unique Substrate Specificity of SplE Serine Protease from Staphylococcus aureus
  7. A novel, dual pan-PIM/FLT3 inhibitor SEL24 exhibits broad therapeutic potential in acute myeloid leukemia
  8. Crystal structure of ADP-dependent glucokinase from Methanocaldococcus jannaschii in complex with 5-iodotubercidin reveals phosphoryl transfer mechanism
  9. Spatial attributes of the four-helix bundle group of bacteriocins – The high-resolution structure of BacSp222 in solution
  10. Modular endolysin of Burkholderia AP3 phage has the largest lysozyme-like catalytic subunit discovered to date and no catalytic aspartate residue
  11. Identification of novel mazEF/pemIK family toxin-antitoxin loci and their distribution in the Staphylococcus genus
  12. Structural analysis of PIM1 kinase complexes with ATP-competitive inhibitors
  13. Staphylococcus Aureus V8 protease disrupts the integrity of the airway epithelial barrier and impairs IL-6 production in vitro
  14. Properties of halogenated and sulfonated porphyrins relevant for the selection of photosensitizers in anticancer and antimicrobial therapies
  15. Bioactive Macrocyclic Inhibitors of the PD-1/PD-L1 Immune Checkpoint
  16. Small-molecule inhibitors of PD-1/PD-L1 immune checkpoint alleviate the PD-L1-induced exhaustion of T-cells
  17. Structural Biology of the Immune Checkpoint Receptor PD-1 and Its Ligands PD-L1/PD-L2
  18. Crystal structure of a low molecular weight activator Blm-pep with yeast 20S proteasome – insights into the enzyme activation mechanism
  19. Small-Molecule Inhibitors of the Programmed Cell Death-1/Programmed Death-Ligand 1 (PD-1/PD-L1) Interaction via Transiently Induced Protein States and Dimerization of PD-L1
  20. Malassezia globosa Mg MDL2 lipase: Crystal structure and rational modification of substrate specificity
  21. 1,4,5-Trisubstituted Imidazole-Based p53–MDM2/MDMX Antagonists with Aliphatic Linkers for Conjugation with Biological Carriers
  22. Lithocholic Acid Hydroxyamide Destabilizes Cyclin D1 and Induces G 0 /G 1 Arrest by Inhibiting Deubiquitinase USP2a
  23. Structural Characterization of Human Coronavirus NL63 N Protein
  24. Rational design and synthesis of 1,5-disubstituted tetrazoles as potent inhibitors of the MDM2-p53 interaction
  25. A Unique Mdm2-Binding Mode of the 3-Pyrrolin-2-one- and 2-Furanone-Based Antagonists of the p53-Mdm2 Interaction
  26. Distinct 3D Architecture and Dynamics of the Human HtrA2(Omi) Protease and Its Mutated Variants
  27. Inhibitors of programmed cell death 1 (PD-1): a patent review (2010-2015)
  28. Visualization of kallikreins in thyroid epithelial and carcinoma cells
  29. Identification of Secreted Exoproteome Fingerprints of Highly-Virulent and Non-Virulent Staphylococcus aureus Strains
  30. Structure of human Programmed cell death 1 ligand 1 (PD-L1) with low molecular mass inhibitor
  31. Structure of human Programmed cell death 1 ligand 1 (PD-L1) with low molecular mass inhibitor
  32. Structural basis for small molecule targeting of the programmed death ligand 1 (PD-L1)
  33. The outer-membrane export signal of Porphyromonas gingivalis type IX secretion system (T9SS) is a conserved C-terminal β-sandwich domain
  34. Structure of the Complex of Human Programmed Death 1, PD-1, and Its Ligand PD-L1
  35. PD-1 binding domain from human PD-L1
  36. Structure of the complex of human programmed death-1 (PD-1) and its ligand PD-L1.
  37. Investigation of Serine-Proteinase-Catalyzed Peptide Splicing in Analogues of Sunflower Trypsin Inhibitor 1 (SFTI-1)
  38. Structural Basis of GD2 Ganglioside and Mimetic Peptide Recognition by 14G2a Antibody
  39. The Nucleocapsid Protein of Human Coronavirus NL63
  40. Atomic resolution crystal structure of HV-BBI protease inhibitor from amphibian skin in complex with bovine trypsin
  41. A systematic investigation of the stability of green fluorescent protein fusion proteins
  42. Staphylococcal SplB Serine Protease Utilizes a Novel Molecular Mechanism of Activation
  43. Staphylococcal Proteases Aid in Evasion of the Human Complement System
  44. Development and binding characteristics of phosphonate inhibitors of SplA protease from Staphylococcus aureus
  45. Biochemical and Structural Characterization of SplD Protease from Staphylococcus aureus
  46. A regulatory role for Staphylococcus aureus toxin–antitoxin system PemIKSa
  47. Structural phase transition and related electronic properties in quasi-one-dimensional (NbSe4)10/3I
  48. Insights into eukaryotic Rubisco assembly — Crystal structures of RbcX chaperones from Arabidopsis thaliana
  49. Mdm2 and MdmX inhibitors for the treatment of cancer: a patent review (2011 – present)
  50. Bacterial Proteases in Disease – Role in Intracellular Survival, Evasion of Coagulation/ Fibrinolysis Innate Defenses, Toxicoses and Viral Infections
  51. Bacterial Proteases in Disease – Role in Intracellular Survival, Evasion of Coagulation/ Fibrinolysis Innate Defenses, Toxicoses and Viral Infections
  52. Isolation, biochemical characterization, and cloning of a bacteriocin from the poultry-associated Staphylococcus aureus strain CH-91
  53. Staphylococcal proteases aid evasion of human complement system
  54. Prevalence of genes encoding extracellular proteases inStaphylococcus aureus— important targets triggering immune responsein vivo
  55. The virulence of Staphylococcus aureus correlates with strain genotype in a chicken embryo model but not a nematode model
  56. The development of first Staphylococcus aureus SplB protease inhibitors: Phosphonic analogues of glutamine
  57. On the Mechanism of Action of SJ-172550 in Inhibiting the Interaction of MDM4 and p53
  58. Substrate specificity of Staphylococcus aureus cysteine proteases – Staphopains A, B and C
  59. α1-Antichymotrypsin inactivates staphylococcal cysteine protease in cross-class inhibition
  60. Activation mechanism of thiol protease precursor from broiler chicken specific Staphylococcus aureus strain CH-91
  61. Interaction of regulators Mdm2 and Mdmx with transcription factors p53, p63 and p73
  62. Exfoliative Toxins of Staphylococcus aureus
  63. A novel matrix metalloprotease-like enzyme (karilysin) of the periodontal pathogen Tannerella forsythia ATCC 43037
  64. Structural and functional characterization of SplA, an exclusively specific protease of Staphylococcus aureus
  65. High affinity interaction of the p53 peptide-analogue with human Mdm2 and Mdmx
  66. Elafin is specifically inactivated by RgpB from Porphyromonas gingivalis by distinct proteolytic cleavage
  67. Enzymatic Activity of the Staphylococcus aureus SplB Serine Protease is Induced by Substrates Containing the Sequence Trp-Glu-Leu-Gln
  68. Staphylococcus aureusinfection triggers production of neutralizing, V8 protease-specific antibodies
  69. The human fibrinolytic system is a target for the staphylococcal metalloprotease aureolysin
  70. Staphylococcus aureus-Derived Staphopain B, a Potent Cysteine Protease Activator of Plasma Chemerin
  71. The staphostatin family of cysteine protease inhibitors in the genus Staphylococcus as an example of parallel evolution of protease and inhibitor specificity
  72. Functional and Structural Characterization of Spl Proteases from Staphylococcus aureus
  73. Proteinaceous cysteine protease inhibitors
  74. Letter to the Editor: 1 H, 15 N and 13 C NMR Resonance Assignments of Staphostatin A, a Specific Staphylococcus Aureus Cysteine Proteinase Inhibitor
  75. Characterisation of a highly specific, endogenous inhibitor of cysteine protease from Staphylococcus epidermidis, a new member of the staphostatin family
  76. A Novel Class of Cysteine Protease Inhibitors:  Solution Structure of Staphostatin A fromStaphylococcus aureus†
  77. Extracellular Proteases of Staphylococcus spp.
  78. Molecular Cloning and Biochemical Characterisation of Proteases from Staphylococcus epidermidis