All Stories

  1. Image-based analysis of living mammalian cells using label-free 3D refractive index maps reveals new organelle dynamics and dry mass flux

    Article • PLoS Biology, December 2019, PLOS

    Prof. Gisou van der Goot

  2. Converging physiological roles of the anthrax toxin receptors

    Article • F1000Research, August 2019, Faculty of 1000, Ltd.

    Prof. Gisou van der Goot

  3. The molecular era of protein S-acylation: spotlight on structure, mechanisms, and dynamics

    Article • Critical Reviews in Biochemistry and Molecular Biology, July 2018, Taylor & Francis

    Prof. Gisou van der Goot

  4. Revealing Assembly of a Pore-Forming Complex Using Single-Cell Kinetic Analysis and Modeling

    Article • Biophysical Journal, April 2016, Elsevier

    Prof. Gisou van der Goot

  5. Staphylococcus aureus alpha toxin can bind to cholesterol-sensitive phosphatidyl choline head group arrangements

    Article • February 2016, Sciencematters

    Prof. Gisou van der Goot

  6. Why publish single observations? Because Science Matters.

    Article • February 2016, Sciencematters

    Prof. Gisou van der Goot, Prof. Iva M Tolić

  7. Model-Driven Understanding of Palmitoylation Dynamics: Regulated Acylation of the Endoplasmic Reticulum Chaperone Calnexin

    Article • PLoS Computational Biology, February 2016, PLOS

    Prof. Gisou van der Goot

  8. New Insight into the Catalytic and Inhibition Mechanism of the Human Acyl Protein Thioesterase

    Article • Biophysical Journal, February 2016, Elsevier

    Prof. Gisou van der Goot

  9. Cytoplasmic Ubiquitin-Specific Protease 19 (USP19) Modulates Aggregation of Polyglutamine-Expanded Ataxin-3 and Huntingtin through the HSP90 Chaperone

    Article • PLoS ONE, January 2016, PLOS

    Prof. Gisou van der Goot

  10. Pore-forming toxins: ancient, but never really out of fashion

    Article • Nature Reviews Microbiology, December 2015, Nature

    Prof. Gisou van der Goot

  11. is your protein of interest palmitoylated ?

    Article • F1000Research, July 2015, Faculty of 1000, Ltd.

    Prof. Gisou van der Goot, dr laurence abrami, Dr Mathieu Blanc

  12. Kicking Out Pathogens in Exosomes

    Article • Cell, June 2015, Elsevier

    Prof. Gisou van der Goot

  13. The SwissLipids knowledgebase for lipid biology

    Article • Bioinformatics, May 2015, Oxford University Press (OUP)

    Prof. Gisou van der Goot

  14. How many lives does CLIMP-63 have?

    Article • Biochemical Society Transactions, April 2015, Portland Press Ltd.

    Prof. Gisou van der Goot

  15. Differential Dependence on N-Glycosylation of Anthrax Toxin Receptors CMG2 and TEM8

    Article • PLoS ONE, March 2015, PLOS

    Prof. Gisou van der Goot

  16. Aerolysin and Related Aeromonas Toxins

    Article • January 2015, Elsevier

    Prof. Gisou van der Goot

  17. Live-cell multiplane three-dimensional super-resolution optical fluctuation imaging

    Article • Nature Communications, December 2014, Nature

    Prof. Gisou van der Goot

  18. Close Encounter of the Third Kind: The ER Meets Endosomes at Fission Sites

    Article • Developmental Cell, December 2014, Elsevier

    Prof. Gisou van der Goot

  19. Mechanistic effects of protein palmitoylation and the cellular consequences thereof

    Article • Chemistry and Physics of Lipids, May 2014, Elsevier

    Prof. Gisou van der Goot

  20. Membrane-Damaging Toxins: Pore Formation

    Article • April 2014, ASM Journals

    Prof. Gisou van der Goot

  21. Introduction: Brief Historical Overview

    Article • January 2014, Springer Science + Business Media

    Prof. Gisou van der Goot

  22. Hijacking Multivesicular Bodies Enables Long-Term and Exosome-Mediated Long-Distance Action of Anthrax Toxin

    Article • Cell Reports, November 2013, Elsevier

    Prof. Gisou van der Goot

  23. Molecular assembly of the aerolysin pore reveals a swirling membrane-insertion mechanism

    Article • Nature Methods, August 2013, Nature

    Prof. Gisou van der Goot

  24. Calnexin Controls the STAT3-Mediated Transcriptional Response to EGF

    Article • Molecular Cell, August 2013, Elsevier

    Prof. Gisou van der Goot

  25. Did Cholera Toxin Finally Get Caught?

    Article • Cell Host & Microbe, May 2013, Elsevier

    Prof. Gisou van der Goot

  26. In-Depth Analysis of Hyaline Fibromatosis Syndrome Frameshift Mutations at the Same Site Reveal the Necessity of Personalized Therapy

    Article • Human Mutation, April 2013, Wiley

    Prof. Gisou van der Goot

  27. What does S-palmitoylation do to membrane proteins?

    Article • FEBS Journal, April 2013, Wiley

    Prof. Gisou van der Goot

  28. Palmitoylation, pathogens and their host: Table 1

    Article • Biochemical Society Transactions, February 2013, Portland Press Ltd.

    Prof. Gisou van der Goot

  29. The Molecular Assembly of the Aerolysin Pore Reveals a Unique Swirling Membrane-Insertion Mechanism

    Article • Biophysical Journal, January 2013, Elsevier

    Prof. Gisou van der Goot

  30. Biochemical Membrane Lipidomics during Drosophila Development

    Article • Developmental Cell, January 2013, Elsevier

    Prof. Gisou van der Goot, Dr. Xueli Guan

  31. Pathogenic Pore-Forming Proteins: Function and Host Response

    Article • Cell Host & Microbe, September 2012, Elsevier

    Prof. Gisou van der Goot

  32. Caspase-2 is an initiator caspase responsible for pore-forming toxin-mediated apoptosis

    Article • The EMBO Journal, April 2012, Wiley

    Prof. Gisou van der Goot

  33. Binding of Lassa virus perturbs extracellular matrix-induced signal transduction via dystroglycan

    Article • Cellular Microbiology, April 2012, Wiley

    Prof. Gisou van der Goot

  34. Palmitoylated calnexin is a key component of the ribosome-translocon complex

    Article • The EMBO Journal, February 2012, Wiley

    Prof. Gisou van der Goot

  35. Unraveling the Assembly of Large Macromolecular Machines by Integrating Computational Techniques with Experimental Data

    Article • Biophysical Journal, January 2012, Elsevier

    Prof. Gisou van der Goot

  36. 5.9 Pore-Forming Toxins

    Article • January 2012, Elsevier

    Prof. Gisou van der Goot

  37. The dark sides of capillary morphogenesis gene 2

    Article • The EMBO Journal, December 2011, Wiley

    Prof. Gisou van der Goot

  38. Monalysin, a Novel ß-Pore-Forming Toxin from the Drosophila Pathogen Pseudomonas entomophila, Contributes to Host Intestinal Damage and Lethality

    Article • PLoS Pathogens, September 2011, PLOS

    Prof. Gisou van der Goot

  39. Dual Chaperone Role of the C-Terminal Propeptide in Folding and Oligomerization of the Pore-Forming Toxin Aerolysin

    Article • PLoS Pathogens, July 2011, PLOS

    Prof. Gisou van der Goot

  40. Pore-forming toxins induce multiple cellular responses promoting survival

    Article • Cellular Microbiology, April 2011, Wiley

    Prof. Gisou van der Goot

  41. Dynamics of Unfolded Protein Transport through an Aerolysin Pore

    Article • Journal of the American Chemical Society, March 2011, American Chemical Society (ACS)

    Prof. Gisou van der Goot

  42. When cells and microbes meet in Krakow

    Article • EMBO Reports, February 2011, EMBO

    Prof. Gisou van der Goot

  43. Assembly and Function of Pore-Forming Toxin Aerolysin from Aeromonas Hydrophila

    Article • Biophysical Journal, February 2011, Elsevier

    Prof. Gisou van der Goot

  44. Preliminary crystallographic analysis of two oligomerization-deficient mutants of the aerolysin toxin, H132D and H132N, in their proteolyzed forms

    Article • Acta Crystallographica Section F Structural Biology and Crystallization Communications, November 2010, International Union of Crystallography

    Prof. Gisou van der Goot

  45. Endocytosis of the Anthrax Toxin Is Mediated by Clathrin, Actin and Unconventional Adaptors

    Article • PLoS Pathogens, March 2010, PLOS

    Prof. Gisou van der Goot

  46. The 2DX robot: A membrane protein 2D crystallization Swiss Army knife

    Article • Journal of Structural Biology, March 2010, Elsevier

    Prof. Gisou van der Goot

  47. Anthrax toxin triggers the activation of src -like kinases to mediate its own uptake

    Article • Proceedings of the National Academy of Sciences, January 2010, Proceedings of the National Academy of Sciences

    Prof. Gisou van der Goot

  48. Getting the Opportunity to Fly on your own

    Article • CHIMIA International Journal for Chemistry, December 2009, Swiss Chemical Society

    Prof. Gisou van der Goot

  49. Receptors of anthrax toxin and cell entry

    Article • Molecular Aspects of Medicine, December 2009, Elsevier

    Prof. Gisou van der Goot

  50. Membrane injury by pore-forming proteins

    Article • Current Opinion in Cell Biology, August 2009, Elsevier

    Prof. Gisou van der Goot

  51. Novel ubiquitin-dependent quality control in the endoplasmic reticulum

    Article • Trends in Cell Biology, August 2009, Elsevier

    Prof. Gisou van der Goot

  52. Shigella Phagocytic Vacuolar Membrane Remnants Participate in the Cellular Response to Pathogen Invasion and Are Regulated by Autophagy

    Article • Cell Host & Microbe, August 2009, Elsevier

    Prof. Gisou van der Goot

  53. Systemic hyalinosis mutations in the CMG2 ectodomain leading to loss of function through retention in the endoplasmic reticulum

    Article • Human Mutation, April 2009, Wiley

    Prof. Gisou van der Goot

  54. Palmitoylation of membrane proteins (Review)

    Article • Molecular Membrane Biology, January 2009, Taylor & Francis

    Prof. Gisou van der Goot

  55. Functional interactions between anthrax toxin receptors and the WNT signalling protein LRP6

    Article • Cellular Microbiology, December 2008, Hindawi Publishing Corporation

    Dr Gary Davidson, Prof. Gisou van der Goot

  56. Activation of the Unfolded Protein Response Is Required for Defenses against Bacterial Pore-Forming Toxin In Vivo

    Article • PLoS Pathogens, October 2008, PLOS

    Prof. Gisou van der Goot

  57. Hrs and SNX3 Functions in Sorting and Membrane Invagination within Multivesicular Bodies

    Article • PLoS Biology, September 2008, PLOS

    Prof. Gisou van der Goot

  58. Regulation of the V-ATPase along the Endocytic Pathway Occurs through Reversible Subunit Association and Membrane Localization

    Article • PLoS ONE, July 2008, PLOS

    Prof. Gisou van der Goot

  59. Pore formation: An ancient yet complex form of attack

    Article • Biochimica et Biophysica Acta (BBA) - Biomembranes, July 2008, Elsevier

    Prof. Gisou van der Goot

  60. Maturation modulates caspase-1-independent responses of dendritic cells to Anthrax Lethal Toxin

    Article • Cellular Microbiology, May 2008, Wiley

    Prof. Gisou van der Goot

  61. Elastic Membrane Heterogeneity of Living Cells Revealed by Stiff Nanoscale Membrane Domains

    Article • Biophysical Journal, February 2008, Elsevier

    Prof. Gisou van der Goot

  62. Exotoxin Secretion: Getting Out to Find the Way In

    Article • Cell Host & Microbe, January 2008, Elsevier

    Prof. Gisou van der Goot

  63. Late Endosomal Cholesterol Accumulation Leads to Impaired Intra-Endosomal Trafficking

    Article • PLoS ONE, September 2007, PLOS

    Prof. Gisou van der Goot

  64. The role of the inflammasome in cellular responses to toxins and bacterial effectors

    Article • Seminars in Immunopathology, September 2007, Springer Science + Business Media

    Prof. Gisou van der Goot

  65. Diversity of Raft-Like Domains in Late Endosomes

    Article • PLoS ONE, April 2007, PLOS

    Prof. Gisou van der Goot

  66. Editorial Overview

    Article • Current Opinion in Microbiology, February 2007, Elsevier

    Prof. Gisou van der Goot

  67. Intra-endosomal membrane traffic

    Article • Trends in Cell Biology, October 2006, Elsevier

    Prof. Gisou van der Goot

  68. Caspase-1 Activation of Lipid Metabolic Pathways in Response to Bacterial Pore-Forming Toxins Promotes Cell Survival

    Article • Cell, September 2006, Elsevier

    Prof. Gisou van der Goot

  69. About lipids and toxins

    Article • FEBS Letters, August 2006, Wiley

    Prof. Gisou van der Goot

  70. Mechanisms of pathogen entry through the endosomal compartments

    Article • Nature Reviews Molecular Cell Biology, June 2006, Nature

    Prof. Gisou van der Goot

  71. Toxoplasma: Guess Who's Coming to Dinner

    Article • Cell, April 2006, Elsevier

    Prof. Gisou van der Goot

  72. Dynamics of GPI-anchored proteins on the surface of living cells

    Article • Nanomedicine Nanotechnology Biology and Medicine, March 2006, Elsevier

    Prof. Gisou van der Goot

  73. A rivet model for channel formation by aerolysin-like pore-forming toxins

    Article • The EMBO Journal, January 2006, Wiley

    Prof. Gisou van der Goot

  74. Receptor palmitoylation and ubiquitination regulate anthrax toxin endocytosis

    Article • The Journal of Cell Biology, January 2006, Rockefeller University Press

    Prof. Gisou van der Goot

  75. Toxins in the Endosomes

    Article • January 2006, Springer Science + Business Media

    Prof. Gisou van der Goot

  76. Aerolysin and related Aeromonas toxins

    Article • January 2006, Elsevier

    Prof. Gisou van der Goot

  77. Bacterial invasion via lipid rafts

    Article • Cellular Microbiology, March 2005, Wiley

    Prof. Gisou van der Goot

  78. Oiling the key hole

    Article • Molecular Microbiology, February 2005, Wiley

    Prof. Gisou van der Goot

  79. Anthrax toxin: the long and winding road that leads to the kill

    Article • Trends in Microbiology, February 2005, Elsevier

    Prof. Gisou van der Goot

  80. A bacterial big-MAC attack

    Article • Nature Structural & Molecular Biology, December 2004, Nature

    Prof. Gisou van der Goot

  81. Membrane insertion of anthrax protective antigen and cytoplasmic delivery of lethal factor occur at different stages of the endocytic pathway

    Article • The Journal of Cell Biology, August 2004, Rockefeller University Press

    Prof. Gisou van der Goot

  82. Sliding doors: clathrin-coated pits or caveolae?

    Article • Nature, May 2003, Nature

    Prof. Gisou van der Goot

  83. Anthrax toxin triggers endocytosis of its receptor via a lipid raft–mediated clathrin-dependent process

    Article • The Journal of Cell Biology, January 2003, Rockefeller University Press

    Prof. Gisou van der Goot

  84. Eukaryotic cells and microbial pathogens: a familiar couple take centre stage

    Article • Nature, January 2003, Nature

    Prof. Gisou van der Goot

  85. Oiling the wheels of the endocytic pathway

    Article • Trends in Cell Biology, July 2002, Elsevier

    Prof. Gisou van der Goot

  86. The glycan core of GPI-anchored proteins modulates aerolysin binding but is not sufficient: the polypeptide moiety is required for the toxin-receptor interaction

    Article • FEBS Letters, January 2002, Wiley

    Prof. Gisou van der Goot

  87. La vie sans cavéoles

    Article • médecine/sciences, January 2002, EDP Sciences

    Prof. Gisou van der Goot

  88. Not as simple as just punching a hole

    Article • Toxicon, November 2001, Elsevier

    Prof. Gisou van der Goot

  89. The bacterial toxin toolkit

    Article • Nature Reviews Molecular Cell Biology, July 2001, Nature

    Prof. Gisou van der Goot

  90. Pore-Forming Toxins

    Article • January 2001

    Prof. Gisou van der Goot

  91. Analysis of glycosyl phosphatidylinositol-anchored proteins by two-dimensional gel electrophoresis

    Article • Electrophoresis, October 2000, Wiley

    Prof. Gisou van der Goot

  92. Increased Stability upon Heptamerization of the Pore-forming Toxin Aerolysin

    Article • Journal of Biological Chemistry, December 1999, American Society for Biochemistry & Molecular Biology (ASBMB)

    Prof. Gisou van der Goot

  93. Plasma Membrane Microdomains Act as Concentration Platforms to Facilitate Intoxication by Aerolysin

    Article • The Journal of Cell Biology, October 1999, Rockefeller University Press

    Prof. Gisou van der Goot

  94. The lectin-like domain of tumor necrosis factor-α increases membrane conductance in microvascular endothelial cells and peritoneal macrophages

    Article • European Journal of Immunology, October 1999, Wiley

    Prof. Gisou van der Goot

  95. The lectin-like domain of tumor necrosis factor-α increases membrane conductance in microvascular endothelial cells and peritoneal macrophages

    Article • European Journal of Immunology, October 1999, Wiley

    Prof. Gisou van der Goot

  96. The Staphylococcal α-Toxin Pore Has a Flexible Conformation †

    Article • Biochemistry, April 1999, American Chemical Society (ACS)

    Prof. Gisou van der Goot

  97. Aerolysin—A Paradigm for Membrane Insertion of Beta-Sheet Protein Toxins?

    Article • Journal of Structural Biology, January 1998, Elsevier

    Prof. Gisou van der Goot

  98. Movement of a Loop in Domain 3 of Aerolysin Is Required for Channel Formation †

    Article • Biochemistry, January 1998, American Chemical Society (ACS)

    Prof. Gisou van der Goot

  99. A pore-forming toxin leads to vacuolation of the endoplasmic reticulum

    Article • Biology of the Cell, January 1998, Wiley

    Prof. Gisou van der Goot

  100. Conformational Changes in Aerolysin during the Transition from the Water-Soluble Protoxin to the Membrane Channel †

    Article • Biochemistry, December 1997, American Chemical Society (ACS)

    Prof. Gisou van der Goot

  101. Matrix-assisted laser desorption-ionization time-of-flight mass spectrometry in the subunit stoichiometry study of high-mass non-covalent complexes

    Article • International Journal of Mass Spectrometry and Ion Processes, December 1997, Elsevier

    Prof. Gisou van der Goot

  102. Separation of early steps in endocytic membrane transport

    Article • Electrophoresis, January 1997, Wiley

    Prof. Gisou van der Goot

  103. Membrane insertion: The strategies of toxins (Review)

    Article • Molecular Membrane Biology, January 1997, Taylor & Francis

    Prof. Gisou van der Goot

  104. Characterisation of the heptameric pore-forming complex of theAeromonastoxin aerolysin using MALDI-TOF mass spectrometry

    Article • FEBS Letters, April 1996, Wiley

    Prof. Gisou van der Goot

  105. Structure and Assembly of the Channel-Forming Aeromonas Toxin Aerolysin

    Article • January 1996, Springer Science + Business Media

    Prof. Gisou van der Goot

  106. Aerolysin - the ins and outs of a model channel-forming toxin

    Article • Molecular Microbiology, January 1996, Wiley

    Prof. Gisou van der Goot

  107. Protonation of Histidine-132 Promotes Oligomerization of the Channel-Forming Toxin Aerolysin

    Article • Biochemistry, December 1995, American Chemical Society (ACS)

    Prof. Gisou van der Goot

  108. All in the family: the toxic activity of pore-forming colicins

    Article • Toxicology, February 1994, Elsevier

    Prof. Gisou van der Goot

  109. The cytolytic toxin aerolysin: from the soluble form to the transmembrane channel

    Article • Toxicology, February 1994, Elsevier

    Prof. Gisou van der Goot

  110. The Pore-Forming Toxin Aerolysin: From the Soluble to a Transmembrane Form

    Article • January 1994, Springer Science + Business Media

    Prof. Gisou van der Goot

  111. Oligomerization of the channel-forming toxin aerolysin precedes insertion into lipid bilayers

    Article • Biochemistry, March 1993, American Chemical Society (ACS)

    Prof. Gisou van der Goot

  112. Modèle d'étude de l'insertion des protéines membranaires

    Article • médecine/sciences, January 1993, INIST-CNRS

    Prof. Gisou van der Goot

  113. The molten globule intermediate for protein insertion or translocation through membranes

    Article • Trends in Cell Biology, November 1992, Elsevier

    Prof. Gisou van der Goot

  114. Spectroscopic study of the activation and oligomerization of the channel-forming toxin aerolysin: identification of the site of proteolytic activation

    Article • Biochemistry, September 1992, American Chemical Society (ACS)

    Prof. Gisou van der Goot

  115. The membrane insertion of colicins

    Article • FEBS Letters, July 1992, Wiley

    Prof. Gisou van der Goot

  116. Flow cytometry and sorting of amphibian bladder endocytic vesicles containing ADH-sensitive water channels

    Article • The Journal of Membrane Biology, June 1992, Springer Science + Business Media

    Prof. Gisou van der Goot

  117. Puncturing Cell Membranes: Comparison of Colicin A and Aerolysin

    Article • January 1992, Springer Science + Business Media

    Prof. Gisou van der Goot

  118. A 'molten-globule' membrane-insertion intermediate of the pore-forming domain of colicin A

    Article • Nature, December 1991, Nature

    Prof. Gisou van der Goot

  119. Evidence for permanent water channels in the basolateral membrane of an ADH-sensitive epithelium

    Article • The Journal of Membrane Biology, February 1991, Springer Science + Business Media

    Prof. Gisou van der Goot

  120. Water permeabilities and salt reflection coefficients of luminal, basolateral and intracellular membrane vesicles isolated from rabbit kidney proximal tubule

    Article • Biochimica et Biophysica Acta (BBA) - Biomembranes, November 1989, Elsevier

    Prof. Gisou van der Goot

  121. Determination of solute reflection coefficients in kidney brush-border membrane vesicles by light scattering: influence of the refractive index

    Article • Biochimica et Biophysica Acta (BBA) - Biomembranes, February 1989, Elsevier

    Prof. Gisou van der Goot

  122. Faculty of 1000 evaluation for Membrane lipid saturation activates endoplasmic reticulum unfolded protein response transducers through their transmembrane domains.

    Article • Faculty of 1000, Ltd.

    Prof. Gisou van der Goot