All Stories

  1. Lack of glutathione peroxidase-8 in the ER impacts on lipid composition of HeLa cells microsomal membranes

    Article • Free Radical Biology and Medicine, February 2020, Elsevier

    Giorgio Cozza

  2. Insight into the mechanism of ferroptosis inhibition by ferrostatin-1

    Article • Redox Biology, January 2020, Elsevier

    Giorgio Cozza

  3. Biochemical and cellular mechanism of protein kinase CK2 inhibition by deceptive curcumin

    Article • FEBS Journal, November 2019, Wiley

    Giorgio Cozza

  4. Inactivation of the glutathione peroxidase GPx4 by the ferroptosis‐inducing molecule RSL3 requires the adaptor protein 14‐3‐3ε

    Article • FEBS Letters, October 2019, Wiley

    Giorgio Cozza

  5. Benextramine and derivatives as novel human monoamine oxidases inhibitors: an integrated approach

    Article • FEBS Journal, July 2019, Wiley

    Giorgio Cozza

  6. Pharmacophore-guided discovery of CDC25 inhibitors causing cell cycle arrest and tumor regression

    Article • Scientific Reports, February 2019, Springer Science + Business Media

    Giorgio Cozza

  7. Stealth Iron Oxide Nanoparticles for Organotropic Drug Targeting

    Article • Biomacromolecules, January 2019, American Chemical Society (ACS)

    Giorgio Cozza, PhD Fabio Vianello

  8. A pathogenic role for cystic fibrosis transmembrane conductance regulator in celiac disease

    Article • The EMBO Journal, November 2018, EMBO

    Giorgio Cozza

  9. The Golgi ‘casein kinase’ Fam20C is a genuine ‘phosvitin kinase’ and phosphorylates polyserine stretches devoid of the canonical consensus

    Article • FEBS Journal, November 2018, Wiley

    Giorgio Cozza

  10. Hydrophobic Derivatives of Glycopeptide Antibiotics as Inhibitors of Protein Kinases

    Article • Biochemistry (Moscow), October 2018, Pleiades Publishing Ltd

    Giorgio Cozza

  11. Development of a yeast-based system to identify new hBRAFV600E functional interactors

    Article • Oncogene, September 2018, Springer Science + Business Media

    Giorgio Cozza

  12. Developmental phosphoproteomics identifies the kinase CK2 as a driver of Hedgehog signaling and a therapeutic target in medulloblastoma

    Article • Science Signaling, September 2018, American Association for the Advancement of Science

    Giorgio Cozza

  13. The Acidophilic Kinases PLK2 and PLK3: Structure, Substrate Targeting and Inhibition

    Article • Current Protein and Peptide Science, June 2018, Bentham Science Publishers

    Giorgio Cozza

  14. TG2 regulates the heat‐shock response by the post‐translational modification of HSF1

    Article • EMBO Reports, May 2018, EMBO

    Giorgio Cozza

  15. The importance of negative determinants as modulators of CK2 targeting. The lesson of Akt2 S131

    Article • PLoS ONE, March 2018, PLOS

    Giorgio Cozza

  16. Covalently bound DNA on naked iron oxide nanoparticles: Intelligent colloidal nano-vector for cell transfection

    Article • Biochimica et Biophysica Acta (BBA) - General Subjects, November 2017, Elsevier

    Giorgio Cozza, PhD Fabio Vianello

  17. Glutathione peroxidase 4-catalyzed reduction of lipid hydroperoxides in membranes: The polar head of membrane phospholipids binds the enzyme and addresses the fatty acid hydroperoxide group toward the redox center

    Article • Free Radical Biology and Medicine, November 2017, Elsevier

    Giorgio Cozza

  18. The landscape of BRAF transcript and protein variants in human cancer

    Article • Molecular Cancer, April 2017, Springer Science + Business Media

    Giorgio Cozza

  19. Fam20C is under the control of sphingolipid signaling in human cell lines

    Article • FEBS Journal, March 2017, Wiley

    Giorgio Cozza

  20. The Development of CK2 Inhibitors: From Traditional Pharmacology to in Silico Rational Drug Design

    Article • Pharmaceuticals, February 2017, MDPI AG

    Giorgio Cozza

  21. Role of Interaction and Nucleoside Diphosphate Kinase B in Regulation of the Cystic Fibrosis Transmembrane Conductance Regulator Function by cAMP-Dependent Protein Kinase A

    Article • PLoS ONE, March 2016, PLOS

    Dr Richmond Muimo, Giorgio Cozza

  22. Casein kinases as potential therapeutic targets

    Article • Expert Opinion on Therapeutic Targets, November 2015, Informa Healthcare

    Giorgio Cozza

  23. A new role for sphingosine: Up-regulation of Fam20C, the genuine casein kinase that phosphorylates secreted proteins

    Article • Biochimica et Biophysica Acta (BBA) - Proteins and Proteomics, October 2015, Elsevier

    Giorgio Cozza

  24. Chimeric peptides as modulators of CK2-dependent signaling: Mechanism of action and off-target effects

    Article • Biochimica et Biophysica Acta (BBA) - Proteins and Proteomics, October 2015, Elsevier

    Giorgio Cozza

  25. “Genuine” Casein Kinase (Fam20C): The Mother of the Phosphosecretome

    Article • September 2015, Wiley

    Giorgio Cozza

  26. Design, validation and efficacy of bisubstrate inhibitors specifically affecting ecto-CK2 kinase activity

    Article • Biochemical Journal, September 2015, Portland Press Ltd.

    Giorgio Cozza

  27. A chemogenomic screening identifies CK2 as a target for pro-senescence therapy in PTEN-deficient tumours

    Article • Nature Communications, June 2015, Springer Science + Business Media

    Giorgio Cozza

  28. Understanding mammalian glutathione peroxidase 7 in the light of its homologs

    Article • Free Radical Biology and Medicine, June 2015, Elsevier

    Giorgio Cozza

  29. Casein kinase 2 (CK2) phosphorylates the deubiquitylase OTUB1 at Ser16to trigger its nuclear localization

    Article • Science Signaling, April 2015, American Association for the Advancement of Science

    Giorgio Cozza

  30. ALK Kinase Domain Mutations in Primary Anaplastic Large Cell Lymphoma: Consequences on NPM-ALK Activity and Sensitivity to Tyrosine Kinase Inhibitors

    Article • PLoS ONE, April 2015, PLOS

    Giorgio Cozza

  31. The Selectivity of CK2 Inhibitor Quinalizarin: A Reevaluation

    Article • BioMed Research International, January 2015, Hindawi Publishing Corporation

    Giorgio Cozza

  32. “Genuine” Casein Kinase: The False Sister of CK2 That Phosphorylates Secreted Proteins at S-x-E/pS Motifs

    Article • January 2015, Springer Science + Business Media

    Giorgio Cozza

  33. The lysine-specific demethylase 1 is a novel substrate of protein kinase CK2

    Article • Biochimica et Biophysica Acta (BBA) - Proteins and Proteomics, April 2014, Elsevier

    Giorgio Cozza

  34. Synthesis and Properties of a Selective Inhibitor of Homeodomain–Interacting Protein Kinase 2 (HIPK2)

    Article • PLoS ONE, February 2014, PLOS

    Giorgio Cozza

  35. Cell-permeable dual inhibitors of protein kinases CK2 and PIM-1: structural features and pharmacological potential

    Article • Cellular and Molecular Life Sciences, January 2014, Springer Science + Business Media

    Giorgio Cozza

  36. Novel polyamine analogues: From substrates towards potential inhibitors of monoamine oxidases

    Article • European Journal of Medicinal Chemistry, December 2013, Elsevier

    Giorgio Cozza

  37. Detection of Phospho-Sites Generated by Protein Kinase CK2 in CFTR: Mechanistic Aspects of Thr1471 Phosphorylation

    Article • PLoS ONE, September 2013, PLOS

    Giorgio Cozza

  38. Exploiting the repertoire of CK2 inhibitors to target DYRK and PIM kinases

    Article • Biochimica et Biophysica Acta (BBA) - Proteins and Proteomics, July 2013, Elsevier

    Giorgio Cozza

  39. Protein disulfide isomerase and glutathione are alternative substrates in the one Cys catalytic cycle of glutathione peroxidase 7

    Article • Biochimica et Biophysica Acta (BBA) - General Subjects, June 2013, Elsevier

    Giorgio Cozza

  40. Kinase CK2 Inhibition: An Update

    Article • Current Medicinal Chemistry, January 2013, Bentham Science Publishers

    Giorgio Cozza

  41. Investigation on PLK2 and PLK3 substrate recognition

    Article • Biochimica et Biophysica Acta (BBA) - Proteins and Proteomics, December 2012, Elsevier

    Giorgio Cozza

  42. Protein kinase CK2 inhibitors: a patent review

    Article • Expert Opinion on Therapeutic Patents, August 2012, Informa Healthcare

    Giorgio Cozza

  43. Inhibition of Protein Kinase CK2 by Flavonoids and Tyrphostins. A Structural Insight

    Article • Biochemistry, July 2012, American Chemical Society (ACS)

    Giorgio Cozza

  44. Tools to discriminate between targets of CK2 vs PLK2/PLK3 acidophilic kinases

    Article • BioTechniques, July 2012, Informa UK (Informa Life Sciences)

    Giorgio Cozza

  45. Casein hydrolysate for uterine infection treatment: a patent evaluation (WO2011132191)

    Article • Expert Opinion on Therapeutic Patents, March 2012, Informa Healthcare

    Giorgio Cozza

  46. Urolithin as a Converging Scaffold Linking Ellagic acid and Coumarin Analogues: Design of Potent Protein Kinase CK2 Inhibitors

    Article • ChemMedChem, October 2011, Wiley

    Giorgio Cozza

  47. Unprecedented Selectivity and Structural Determinants of a New Class of Protein Kinase CK2 Inhibitors in Clinical Trials for the Treatment of Cancer

    Article • Biochemistry, October 2011, American Chemical Society (ACS)

    Giorgio Cozza

  48. A Comparison of Thiol Peroxidase Mechanisms

    Article • Antioxidants & Redox Signaling, August 2011, Mary Ann Liebert Inc

    Giorgio Cozza

  49. Structural features underlying the selectivity of the kinase inhibitors NBC and dNBC: role of a nitro group that discriminates between CK2 and DYRK1A

    Article • Cellular and Molecular Life Sciences, July 2011, Springer Science + Business Media

    Giorgio Cozza

  50. The Dark Side of Protein Kinase CK2 Inhibition

    Article • Current Medicinal Chemistry, June 2011, Bentham Science Publishers

    Giorgio Cozza

  51. The Role of the N-Terminal Domain in the Regulation of the “Constitutively Active” Conformation of Protein Kinase CK2α: Insight from a Molecular Dynamics Investigation

    Article • ChemMedChem, May 2011, Wiley

    Giorgio Cozza

  52. 8-Hydroxynaphthalene-1,4-dione derivative as novel compound for glioma treatment

    Article • Bioorganic & Medicinal Chemistry Letters, April 2011, Elsevier

    Giorgio Cozza

  53. Erratum to: Isoform specific phosphorylation of p53 by protein kinase CK1

    Article • Cellular and Molecular Life Sciences, January 2011, Springer Science + Business Media

    Giorgio Cozza

  54. Glutathione Peroxidase-4

    Article • January 2011, Springer Science + Business Media

    Giorgio Cozza

  55. A novel glucosyltransferase from Catharanthus roseus cell suspensions

    Article • Process Biochemistry, May 2010, Elsevier

    Giorgio Cozza

  56. Cystic fibrosis transmembrane regulator fragments with the Phe 508 deletion exert a dual allosteric control over the master kinase CK2

    Article • Biochemical Journal, February 2010, Portland Press Ltd.

    Giorgio Cozza

  57. Isoform specific phosphorylation of p53 by protein kinase CK1

    Article • Cellular and Molecular Life Sciences, December 2009, Springer Science + Business Media

    Giorgio Cozza

  58. Tetraiodobenzimidazoles are potent inhibitors of protein kinase CK2

    Article • Bioorganic & Medicinal Chemistry, October 2009, Elsevier

    Giorgio Cozza

  59. ATP Non-Competitive Ser/Thr Kinase Inhibitors as Potential Anticancer Agents

    Article • Anti-Cancer Agents in Medicinal Chemistry, September 2009, Bentham Science Publishers

    Giorgio Cozza

  60. Quinalizarin as a potent, selective and cell-permeable inhibitor of protein kinase CK2

    Article • Biochemical Journal, August 2009, Portland Press Ltd.

    Giorgio Cozza

  61. A novel splicing variant encoding putative catalytic α subunit of maize protein kinase CK2

    Article • Physiologia Plantarum, July 2009, Wiley

    Giorgio Cozza

  62. How druggable is protein kinase CK2?

    Article • Medicinal Research Reviews, June 2009, Wiley

    Giorgio Cozza

  63. Medicinal Chemistry and the Molecular Operating Environment (MOE): Application of QSAR and Molecular Docking to Drug Discovery

    Article • Current Topics in Medicinal Chemistry, December 2008, Bentham Science Publishers

    Giorgio Cozza

  64. The selectivity of inhibitors of protein kinase CK2: an update

    Article • Biochemical Journal, November 2008, Portland Press Ltd.

    Giorgio Cozza

  65. Identification of novel protein kinase CK1 delta (CK1δ) inhibitors through structure-based virtual screening

    Article • Bioorganic & Medicinal Chemistry Letters, October 2008, Elsevier

    Giorgio Cozza

  66. The Regulatory β Subunit of Protein Kinase CK2 Contributes to the Recognition of the Substrate Consensus Sequence. A Study with an eIF2β-Derived Peptide†

    Article • Biochemistry, August 2008, American Chemical Society (ACS)

    Giorgio Cozza

  67. Coumarin as Attractive Casein Kinase 2 (CK2) Inhibitor Scaffold: An Integrate Approach To Elucidate the Putative Binding Motif and Explain Structure–Activity Relationships

    Article • Journal of Medicinal Chemistry, February 2008, American Chemical Society (ACS)

    Giorgio Cozza

  68. Elucidation of the ribonuclease a aggregation process mediated by 3D domain swapping: A computational approach reveals possible new multimeric structures

    Article • Biopolymers, January 2008, Wiley

    Giorgio Cozza

  69. Tetrabromocinnamic Acid (TBCA) and Related Compounds Represent a New Class of Specific Protein Kinase CK2 Inhibitors

    Article • ChemBioChem, January 2007, Wiley

    Giorgio Cozza

  70. Pyrazoloquinazoline Tricyclic System as Novel Scaffold to Design New Kinase CK2 Inhibitors

    Article • Letters in Drug Design & Discovery, May 2006, Bentham Science Publishers

    Giorgio Cozza

  71. Identification of Ellagic Acid as Potent Inhibitor of Protein Kinase CK2:  A Successful Example of a Virtual Screening Application

    Article • Journal of Medicinal Chemistry, April 2006, American Chemical Society (ACS)

    Giorgio Cozza

  72. Autophosphorylation at the regulatory β subunit reflects the supramolecular organization of protein kinase CK2

    Article • Molecular and Cellular Biochemistry, June 2005, Springer Science + Business Media

    Giorgio Cozza

  73. Inhibition of Protein Kinase CK2 by Condensed Polyphenolic Derivatives. An in Vitro and in Vivo Study†

    Article • Biochemistry, October 2004, American Chemical Society (ACS)

    Giorgio Cozza