All Stories

  1. The Molecular Landscape of Inflammation in Inflammatory Bowel Disease (IBD): Targets for Precision Medicine

    Article • Biomedicines, November 2025, MDPI AG

    Gianluca Costa

  2. Tailoring the Management of Colonic Lipomas: A 10-Year Experience of Surgical and Endoscopic Resection

    Article • Journal of Personalized Medicine, November 2025, MDPI AG

    Gianluca Costa

  3. A Focus on Inflammatory and Bacterial Biomarkers in Secondary Peritonitis

    Article • Cells, October 2025, MDPI AG

    Gianluca Costa

  4. Non-Operative Management (NOM) in Rectal Cancer: Current Evidence and Future Directions

    Article • Encyclopedia, October 2025, MDPI AG

    Gianluca Costa

  5. Liver Robotic Surgery: A Review of Current Use and Future Perspectives

    Article • Journal of Clinical Medicine, October 2025, MDPI AG

    Gianluca Costa

  6. Chronic Groin Pain After Hernia Surgery: What Are We Missing?

    Article • Journal of Clinical Medicine, August 2025, MDPI AG

    Gianluca Costa

  7. Clinical Safety and Feasibility of Minimally Invasive Colectomy Under Neuraxial Anesthesia in Frail Patients: Preliminary Case Series

    Article • Journal of Clinical Medicine, August 2025, MDPI AG

    Gianluca Costa

  8. Chronic Groin Pain After Hernia Surgery: What Are We Missing?

    Article • August 2025, MDPI AG

    Gianluca Costa

  9. Radiomics Beyond Radiology: Literature Review on Prediction of Future Liver Remnant Volume and Function Before Hepatic Surgery

    Article • Journal of Clinical Medicine, July 2025, MDPI AG

    Gianluca Costa

  10. Comparison of Laparoscopic and Robotic Lateral Lymph Node Dissection for Rectal Cancer: A Systematic Review and Meta-analysis of Short- and Long-term Outcomes

    Article • Annali Italiani di Chirurgia, June 2025, Annali Italiani di Chirurgia

    Gianluca Costa

  11. Machine Learning for Predicting the Low Risk of Postoperative Pancreatic Fistula After Pancreaticoduodenectomy: Toward a Dynamic and Personalized Postoperative Management Strategy

    Article • Cancers, May 2025, MDPI AG

    Gianluca Costa

  12. Radiological Assessment After Pancreaticoduodenectomy for a Precision Approach to Managing Complications: A Narrative Review

    Article • Journal of Personalized Medicine, May 2025, MDPI AG

    Gianluca Costa

  13. A Comparison of Machine Learning-Based Models and a Simple Clinical Bedside Tool to Predict Morbidity and Mortality After Gastrointestinal Cancer Surgery in the Elderly

    Article • Bioengineering, May 2025, MDPI AG

    Gianluca Costa

  14. Epidemiological analysis of intra-abdominal infections in Italy from the Italian register of complicated intra-abdominal infections—the IRIS study: a prospective observational nationwide study

    Article • World Journal of Emergency Surgery, March 2025, Springer Science + Business Media

    Gianluca Costa

  15. Management of high-surgical risk patients with acute cholecystitis following percutaneous cholecystostomy. results of an international Delphi consensus study

    Article • International Journal of Surgery, March 2025, Wolters Kluwer Health

    Gianluca Costa

  16. Machine Learning Approaches for the Prediction of Postoperative Major Complications in Patients Undergoing Surgery for Bowel Obstruction

    Article • Journal of Personalized Medicine, October 2024, MDPI AG

    Gianluca Costa

  17. Reducing water use in the operating room: a single-center retrospective analysis

    Article • Chirurgia, September 2024, Edizioni Minerva Medica

    Gianluca Costa

  18. Quadruple Assessment of Colorectal Anastomosis after Laparoscopic Rectal Resection: A Retrospective Analysis of a Propensity-Matched Cohort

    Article • Journal of Clinical Medicine, August 2024, MDPI AG

    Gianluca Costa

  19. A Green Lantern for the Surgeon: A Review on the Use of Indocyanine Green (ICG) in Minimally Invasive Surgery

    Article • Journal of Clinical Medicine, August 2024, MDPI AG

    Gianluca Costa

  20. Evaluation of Short-Term Effects on Colorectal Surgery Elective Patients after Implementing a Patient Blood Management Program: A Multicenter Retrospective Analysis

    Article • Journal of Clinical Medicine, July 2024, MDPI AG

    Gianluca Costa

  21. Radiomics in Oesogastric Cancer: Staging and Prediction of Preoperative Treatment Response: A Narrative Review and the Results of Personal Experience

    Article • Cancers, July 2024, MDPI AG

    Gianluca Costa

  22. Machine Learning Approaches for the Prediction of Postoperative Major Complications in Patients Undergoing Surgery for Bowel Obstruction

    Article • July 2024, MDPI AG

    Gianluca Costa

  23. Current Management of Acute Severe Ulcerative Colitis: New Insights on the Surgical Approaches

    Article • Journal of Personalized Medicine, May 2024, MDPI AG

    Gianluca Costa

  24. Comparison of purse-string technique vs linear suture for skin closure after ileostomy reversal. A randomized controlled trial

    Article • Langenbeck s Archives of Surgery, April 2024, Springer Science + Business Media

    Gianluca Costa

  25. Beyond acute appendicitis: a single-institution experience of unexpected pathology findings after 989 consecutive emergency appendectomy

    Article • Langenbeck s Archives of Surgery, March 2024, Springer Science + Business Media

    Gianluca Costa

  26. Laparoscopic Treatment of Perforated Peptic Ulcer: A Propensity Score-Matched Comparison of Interrupted Stitches Repair versus Knotless Barbed Suture

    Article • Journal of Clinical Medicine, February 2024, MDPI AG

    Gianluca Costa

  27. Acute cholecystitis management in high-risk, critically ill, and unfit-for-surgery patients: the Italian Society of Emergency Surgery and Trauma (SICUT) guidelines

    Article • Updates in Surgery, December 2023, Springer Science + Business Media

    Gianluca Costa

  28. Application of fluorescence-guided surgery in the acute care setting: a systematic literature review

    Article • Langenbeck s Archives of Surgery, September 2023, Springer Science + Business Media

    Gianluca Costa

  29. Percutaneous cholecystostomy as bridge to surgery vs surgery in unfit patients with acute calculous cholecystitis: A systematic review and meta-analysis

    Article • The Surgeon, August 2023, Elsevier

    Gianluca Costa

  30. Management of Acute Cholecystitis in High-Risk Patients: Percutaneous Gallbladder Drainage as a Definitive Treatment vs. Emergency Cholecystectomy—Systematic Review and Meta-Analysis

    Article • Journal of Clinical Medicine, July 2023, MDPI AG

    Gianluca Costa

  31. Editorial: Surgical outcomes in acute care surgery: should we introduce the concept of time-critical condition?

    Article • Frontiers in Surgery, July 2023, Frontiers

    Gianluca Costa

  32. The unrestricted global effort to complete the COOL trial

    Article • World Journal of Emergency Surgery, May 2023, Springer Science + Business Media

    Gianluca Costa

  33. Colorectal neoplastic emergencies in immunocompromised patients: preliminary result from the Web-based International Register of Emergency Surgery and Trauma (WIRES-T trial)

    Article • Updates in Surgery, May 2023, Springer Science + Business Media

    Gianluca Costa

  34. Perforated peptic ulcer (PPU) treatment: an Italian nationwide propensity score-matched cohort study investigating laparoscopic vs open approach

    Article • Surgical Endoscopy, March 2023, Springer Science + Business Media

    Gianluca Costa

  35. Tumor regression grade (TRG) for gastric cancer and radiological methods on predicting response to perioperative chemotherapy: a narrative review

    Article • Digestive Medicine Research, March 2023, AME Publishing Company

    Gianluca Costa

  36. The Unrestricted Global effort to complete the Closed Or Open after Source Control Laparotomy for Severe Complicated Intra-Abdominal Sepsis (COOL) Trial

    Article • February 2023, Research Square

    Gianluca Costa

  37. Acute diverticulitis in immunocompromised patients: evidence from an international multicenter observational registry (Web-based International Register of Emergency Surgery and Trauma, Wires-T)

    Article • Techniques in Coloproctology, February 2023, Springer Science + Business Media

    Gianluca Costa, Evgeni Dimitrov

  38. Emergency Surgery in a Large Urban Area Community Hospital During SARS-CoV-2 Pandemic: An Analysis on Acute Appendicitis

    Article • Il Giornale di Chirurgia - Journal of Surgery, November 2022, Wolters Kluwer Health

    Gianluca Costa

  39. Laparoscopic extended right colectomy with complete mesocolic excision with central vascular ligation – a video vignette

    Article • Colorectal Disease, November 2022, Wiley

    Gianluca Costa

  40. Patients with an Open Abdomen in Asian, American and European Continents: A Comparative Analysis from the International Register of Open Abdomen (IROA)

    Article • Extremophiles, November 2022, Springer Science + Business Media

    Gianluca Costa

  41. Study and validation of an explainable machine learning-based mortality prediction following emergency surgery in the elderly: A prospective observational study

    Article • International Journal of Surgery, November 2022, Wolters Kluwer Health

    Gianluca Costa

  42. Gastro-intestinal emergency surgery: Evaluation of morbidity and mortality. Protocol of a prospective, multicenter study in Italy for evaluating the burden of abdominal emergency surgery in different age groups. (The GESEMM study)

    Article • Frontiers in Surgery, September 2022, Frontiers

    Gianluca Costa

  43. Oncological outcomes of rectal cancer patients with anastomotic leakage: A multicenter case-control study

    Article • Frontiers in Surgery, September 2022, Frontiers

    Gianluca Costa

  44. Laparoscopic versus Open Surgery for Gastric Cancer in Western Countries: A Systematic Review and Meta-Analysis of Short- and Long-Term Outcomes

    Article • Journal of Clinical Medicine, June 2022, MDPI AG

    Gianluca Costa

  45. Metabolic Syndrome (MetS), Systemic Inflammatory Response Syndrome (SIRS), and Frailty: Is There any Room for Good Outcome in the Elderly Undergoing Emergency Surgery?

    Article • Frontiers in Surgery, June 2022, Frontiers

    Gianluca Costa

  46. Revisional One Anastomosis Gastric Bypass with a 150-cm Biliopancreatic Limb After Failure of Adjustable Gastric Banding: Mid-Term Outcomes and Comparison Between One- and Two-Stage Approaches

    Article • Obesity Surgery, October 2021, Springer Science + Business Media

    Gianluca Costa

  47. Robotic surgery for colorectal liver metastases resection: A systematic review

    Article • International Journal of Medical Robotics and Computer Assisted Surgery, September 2021, Wiley

    Gianluca Costa

  48. Minimally Invasive Approach to Gastric GISTs: Analysis of a Multicenter Robotic and Laparoscopic Experience with Literature Review

    Article • Cancers, August 2021, MDPI AG

    Gianluca Costa

  49. 2D vs 3D laparoscopic right colectomy: A propensity score-matching comparison of personal experience with systematic review and meta-analysis

    Article • World Journal of Gastrointestinal Surgery, June 2021, Baishideng Publishing Group Co., Limited (formerly WJG Press)

    Gianluca Costa

  50. Laparoscopic splenectomy after trauma

    Article • Journal of Minimal Access Surgery, April 2021, Medknow

    Gianluca Costa

  51. Clinical-pathological features and treatment of acute appendicitis in the very elderly: an interim analysis of the FRAILESEL Italian multicentre prospective study

    Article • European Journal of Trauma and Emergency Surgery, March 2021, Springer Science + Business Media

    Gianluca Costa

  52. Laparoscopic versus open rectal resection: a 1:2 propensity score–matched analysis of oncological adequateness, short- and long-term outcomes

    Article • International Journal of Colorectal Disease, January 2021, Springer Science + Business Media

    Gianluca Costa

  53. Colorectal cancer: Greater neo-angiogenesis, less perforation, worst oncological outcomes

    Article • Medical Hypotheses, January 2021, Elsevier

    Gianluca Costa

  54. How to Define an Elderly and Frail Patient?

    Article • January 2021, Springer Science + Business Media

    Gianluca Costa

  55. Redo-laparoscopy in the management of complications after laparoscopic colorectal surgery: a systematic review and meta-analysis of surgical outcomes

    Article • Techniques in Coloproctology, November 2020, Springer Science + Business Media

    Gianluca Costa

  56. The Emergency Surgery Frailty Index (EmSFI): development and internal validation of a novel simple bedside risk score for elderly patients undergoing emergency surgery

    Article • Aging Clinical and Experimental Research, November 2020, Springer Science + Business Media

    Gianluca Costa

  57. Robotic versus open oncological gastric surgery in the elderly: a propensity score-matched analysis

    Article • Journal of Robotic Surgery, November 2020, Springer Science + Business Media

    Gianluca Costa

  58. Open abdomen management for severe peritonitis in elderly. Results from the prospective International Register of Open Abdomen (IROA): Cohort study

    Article • International Journal of Surgery, October 2020, Elsevier

    Gianluca Costa

  59. Open Abdomen and Fluid Instillation in the Septic Abdomen: Results from the IROA Study

    Article • Extremophiles, August 2020, Springer Science + Business Media

    Gianluca Costa

  60. Laparoscopic versus open distal gastrectomy for locally advanced gastric cancer in middle–low-volume centers in Western countries: a propensity score matching analysis

    Article • Langenbeck s Archives of Surgery, August 2020, Springer Science + Business Media

    Gianluca Costa

  61. Emergency hernia repair in the elderly: multivariate analysis of morbidity and mortality from an Italian registry

    Article • Hernia, July 2020, Springer Science + Business Media

    Gianluca Costa

  62. Laparoscopic Repair of Perforated Peptic Ulcer in the Elderly: An Interim Analysis of the FRAILESEL Italian Multicenter Prospective Cohort Study

    Article • Surgical Laparoscopy Endoscopy & Percutaneous Techniques, July 2020, Wolters Kluwer Health

    Gianluca Costa

  63. Minimally invasive laparoscopic and robot-assisted emergency treatment of strangulated giant hiatal hernias: report of five cases and literature review

    Article • World Journal of Emergency Surgery, June 2020, Springer Science + Business Media

    Gianluca Costa

  64. Robotic or three-dimensional (3D) laparoscopy for right colectomy with complete mesocolic excision (CME) and intracorporeal anastomosis? A propensity score-matching study comparison

    Article • Surgical Endoscopy, May 2020, Springer Science + Business Media

    Gianluca Costa

  65. Acute care surgery and post‐operative COVID ‐19 pneumonia: a surgical and environmental challenge

    Article • Australian and New Zealand Journal of Surgery, May 2020, Wiley

    Gianluca Costa

  66. Differences between computed tomoghaphy and surgical findings in acute complicated diverticulitis

    Article • Asian Journal of Surgery, March 2020, Elsevier

    Gianluca Costa

  67. The use of emergency laparoscopy for acute abdomen in the elderly: the FRAILESEL Italian Multicenter Prospective Cohort Study

    Article • Updates in Surgery, February 2020, Springer Science + Business Media

    Gianluca Costa

  68. Challenging case of blunt vascular liver trauma: hematoma of the hepatic artery

    Article • Pan African Medical Journal, January 2020, Pan African Medical Journal

    Gianluca Costa

  69. Trends in open abdomen management in Italy: a subgroup analysis from the IROA project

    Article • Updates in Surgery, October 2019, Springer Science + Business Media

    Gianluca Costa

  70. Open Abdomen in Obese Patients: Pay Attention! New Evidences from IROA, the International Register of Open Abdomen

    Article • Extremophiles, October 2019, Springer Science + Business Media

    Gianluca Costa

  71. Clinico-pathological features of colon cancer patients undergoing emergency surgery: a comparison between elderly and non-elderly patients

    Article • Open Medicine, October 2019, De Gruyter

    Gianluca Costa

  72. EMSFI (Emergency Surgery Frailty Index): A New Validated Score in the Elderly Undergoing Emergency Surgery

    Article • Journal of the American College of Surgeons, October 2019, Wolters Kluwer Health

    Gianluca Costa

  73. Risk factors for postoperative morbidity following appendectomy in the elderly: a nationwide prospective cohort study

    Article • European Journal of Trauma and Emergency Surgery, July 2019, Springer Science + Business Media

    Gianluca Costa

  74. Management of complications of first instance of hepatic trauma in a liver surgery unit: Portal vein ligation as a conservative therapeutic strategy

    Article • Open Medicine, May 2019, De Gruyter

    Gianluca Costa

  75. Surgical Training in South Africa: An Overview and Attempt to Assess the Training System from the Perspective of Foreign Trainees

    Article • Extremophiles, May 2019, Springer Science + Business Media

    Gianluca Costa, Dr Timothy Craig Hardcastle

  76. Damage control surgery for perforated diverticulitis with diffuse peritonitis: saves lives and reduces ostomy

    Article • World Journal of Emergency Surgery, April 2019, Springer Science + Business Media

    Gianluca Costa

  77. 2017 WSES and SICG guidelines on acute calcolous cholecystitis in elderly population

    Article • World Journal of Emergency Surgery, March 2019, Springer Science + Business Media

    Gianluca Costa, Dr Salomone Di Saverio

  78. Non-operative management of blunt splenic injury: is it really so extensively feasible? a critical appraisal of a single-center experience

    Article • Pan African Medical Journal, January 2019, Pan African Medical Journal

    Gianluca Costa

  79. Open abdomen and entero-atmospheric fistulae: An interim analysis from the International Register of Open Abdomen (IROA)

    Article • Injury, January 2019, Elsevier

    Gianluca Costa

  80. Frailty and emergency surgery in the elderly: protocol of a prospective, multicenter study in Italy for evaluating perioperative outcome (The FRAILESEL Study)

    Article • Updates in Surgery, January 2018, Springer Science + Business Media

    Gianluca Costa

  81. Hollow viscus injuries: predictors of outcome and role of diagnostic delay

    Article • Therapeutics and Clinical Risk Management, August 2017, Dove Medical Press

    Gianluca Costa, Andrea Mingoli

  82. Emergency surgery for colorectal cancer does not affect nodal harvest comparing elective procedures: a propensity score-matched analysis

    Article • International Journal of Colorectal Disease, July 2017, Springer Science + Business Media

    Gianluca Costa

  83. Frailty and emergency surgery in the elderly: Protocol of a prospective, multicenter study in Italy for evaluating perioperative outcome (The FRAILESEL Study)

    Article • F1000Research, July 2017, Faculty of 1000, Ltd.

    Gianluca Costa, Professor Giuseppe Nigri, Dr Mauro Zago, PIERGASPARE PALUMBO

  84. Erratum to: IROA: International Register of Open Abdomen, preliminary results

    Article • World Journal of Emergency Surgery, March 2017, Springer Science + Business Media

    Gianluca Costa

  85. IROA: International Register of Open Abdomen, preliminary results

    Article • World Journal of Emergency Surgery, February 2017, Springer Science + Business Media

    Gianluca Costa, Andras Vereczkei

  86. The impact of frailty syndrome and risk scores on emergency cholecystectomy patients

    Article • Surgery Today, May 2016, Springer Science + Business Media

    Gianluca Costa

  87. Emergency presentation of cystic lymphangioma of the colon: A case report and literature review

    Article • International Journal of Surgery Case Reports, January 2016, Elsevier

    Gianluca Costa

  88. Changes in the Surgical Approach to Colonic Emergencies during a 15-Year Period

    Article • Digestive Surgery, January 2014, Karger Publishers

    Gianluca Costa

  89. Colorectal cancer in pregnancy: one disease, two patients

    Article • Australian and New Zealand Journal of Surgery, July 2013, Wiley

    Gianluca Costa

  90. Emergency abdominal surgery in the elderly: a ten-year experience

    Article • BMC Geriatrics, April 2009, Springer Science + Business Media

    Gianluca Costa

  91. Total Mesorectal Excision and Low Rectal Anastomosis for the Treatment of Rectal Cancer and Prevention of Pelvic Recurrences

    Article • Archives of Surgery, February 2001, American Medical Association (AMA)

    Gianluca Costa

  92. Prospective evaluation of omentoplasty in preventing leakage of colorectal anastomosis

    Article • Diseases of the Colon & Rectum, July 2000, Wolters Kluwer Health

    Gianluca Costa

  93. Management of Benign Biliary Strictures

    Article • Archives of Surgery, February 2000, American Medical Association (AMA)

    Gianluca Costa

  94. The Need for Antibiotic Prophylaxis in Elective Laparoscopic Cholecystectomy

    Article • Archives of Surgery, January 2000, American Medical Association (AMA)

    Gianluca Costa

  95. Rectal cancer and inguinal metastases

    Article • Diseases of the Colon & Rectum, November 1999, Wolters Kluwer Health

    Gianluca Costa

  96. The role of serum and gastric juice levels of carcinoembryonic antigen, CA19.9 and CA72.4 in patients with gastric cancer

    Article • Journal of Cancer Research and Clinical Oncology, August 1998, Springer Science + Business Media

    Gianluca Costa

  97. Comparison of four minimally invasive methods of laparoscopic vagotomy in a porcine model

    Article • Surgical Endoscopy, May 1998, Springer Science + Business Media

    Gianluca Costa

  98. The Long-Term Outcome of Hepaticojejunostomy in the Treatment of Benign Bile Duct Strictures

    Article • Annals of Surgery, August 1996, Wolters Kluwer Health

    Gianluca Costa

  99. Is there a causal connection between bile acids and colorectal cancer?

    Article • Surgery Today, January 1996, Springer Science + Business Media

    Gianluca Costa