All Stories

  1. Leukocytes and Endothelial Cells Participate in the Pathogenesis of Alzheimer’s Disease: Identifying New Biomarkers Mirroring Metabolic Alterations
  2. Translational Aspects of Cardiovascular Biology: From Bench to Bedside
  3. A machine learning model identifies a functional connectome signature that predicts blood pressure levels: imaging insights from a large population of 35882 patients
  4. A novel urinary proteomic classifier predicts the risk of coronary artery disease
  5. COVID-19 Causes Ferroptosis and Oxidative Stress in Human Endothelial Cells
  6. Endothelial Dysfunction Drives CRTd Outcome at 1-Year Follow-Up: A Novel Role as Biomarker for miR-130a-5p
  7. Hyperglycemia drives the transition from pre-frailty to frailty: The Monteforte study
  8. Linking lifestyle factors to cardiovascular risk through metabolomics: Insights from a large population of diabetic patients followed-up for 11 years
  9. Istaroxime and Beyond: New Therapeutic Strategies to Specifically Activate SERCA and Treat Heart Failure
  10. Non-Coding RNAs in Clinical Practice: From Biomarkers to Therapeutic Tools
  11. Targeting Cardiovascular and Metabolic Disorders Through Annual Nationwide Screening and Lifestyle Intervention: Insights from a Cohort of 5,819,041 Subjects with a 4-year Follow-up
  12. Efficacy of the New Inotropic Agent Istaroxime in Acute Heart Failure
  13. High HDL (High-Density Lipoprotein) Cholesterol Increases Cardiovascular Risk in Hypertensive Patients
  14. Empagliflozin and Cognitive Impairment in Frail Older Adults with Type 2 Diabetes and Heart Failure
  15. miR-142 Targets TIM-1 in Human Endothelial Cells: Potential Implications for Stroke, COVID-19, Zika, Ebola, Dengue, and Other Viral Infections
  16. SGLT2 Inhibition via Empagliflozin Improves Endothelial Function and Reduces Mitochondrial Oxidative Stress: Insights From Frail Hypertensive and Diabetic Patients
  17. Parkin Controls Cardiac Function in Obesity by Regulating Mitochondrial Calcium Uptake
  18. Mitochondrial microRNAs are dysregulated in patients with Fabry Disease
  19. The Non-Coding RNA Journal Club: Highlights on Recent Papers—11
  20. Bioengineering Strategies to Create 3D Cardiac Constructs from Human Induced Pluripotent Stem Cells
  21. Empagliflozin Improves Cognitive Impairment in Frail Older Adults With Type 2 Diabetes and Heart Failure With Preserved Ejection Fraction
  22. Functional Role of microRNAs in Regulating Cardiomyocyte Death
  23. Exosome-Mediated Angiogenesis Underlies LVAD-Induced Bleeding in Patients With End-Stage Heart Failure
  24. IP3 receptor orchestrates maladaptive vascular responses in heart failure
  25. Epidemiology of obstructive sleep apnea: What is the contribution of hypertension and arterial stiffness?
  26. Sortilin drives hypertension by modulating sphingolipid/ceramide homeostasis and by triggering oxidative stress
  27. OUP accepted manuscript
  28. Heart failure in diabetes
  29. Glycation of Ryanodine Receptor in Circulating Lymphocytes Predicts the Response to Cardiac Resynchronization Therapy
  30. Aspirin, NOACs, Warfarin: which is the best choice to tackle cognitive decline in elderly patients? Insights from the GIRAF and ASCEND-Dementia trials presented at the AHA 2021
  31. l-Arginine and COVID-19: An Update
  32. Effects of adding L-arginine orally to standard therapy in patients with COVID-19: A randomized, double-blind, placebo-controlled, parallel-group trial. Results of the first interim analysis
  33. Hyperglycemia Drives Stent Restenosis in STEMI Patients
  34. Advances in the understanding of excitation-contraction coupling: the pulsing quest for drugs against heart failure and arrhythmias
  35. Role of endothelial miR-24 in COVID-19 cerebrovascular events
  36. Cognitive Impairment in Frail Hypertensive Elderly Patients: Role of Hyperglycemia
  37. Functional Role of miR-155 in the Pathogenesis of Diabetes Mellitus and Its Complications
  38. Cognitive dysfunction correlates with physical impairment in frail patients with acute myocardial infarction
  39. SGLT2 inhibitors in cardiovascular medicine
  40. Targeting the phenotypic switch of vascular smooth muscle cells to tackle atherosclerosis
  41. Impact of thrombus aspiration in frail STEMI patients
  42. Effects of Chronic Supplementation of L-Arginine on Physical Fitness in Water Polo Players
  43. Inclisiran: a new milestone on the PCSK9 road to tackle cardiovascular risk
  44. miR-24 Targets the Transmembrane Glycoprotein Neuropilin-1 in Human Brain Microvascular Endothelial Cells
  45. miR-24 targets SARS-CoV-2 co-factor Neuropilin-1 in human brain microvascular endothelial cells: Insights for COVID-19 neurological manifestations
  46. Chronic kidney disease: Definition, updated epidemiology, staging, and mechanisms of increased cardiovascular risk
  47. The discovery and development of IP3 receptor modulators: an update
  48. In patients with early AF and CV conditions, early rhythm-control therapy vs. usual care reduced CV events at 5 years
  49. What is linking COVID-19 and endothelial dysfunction? Updates on nanomedicine and bioengineering from the 2020 AHA Scientific Sessions
  50. Thyroid hormones regulate both cardiovascular and renal mechanisms underlying hypertension
  51. Vitamin C and Cardiovascular Disease: An Update
  52. Exploiting GRK2 Inhibition as a Therapeutic Option in Experimental Cancer Treatment: Role of p53-Induced Mitochondrial Apoptosis
  53. miR-98 Regulates TMPRSS2 Expression in Human Endothelial Cells: Key Implications for COVID-19
  54. Genetics of adrenergic signaling drives coronary artery calcification
  55. Metabolic Flexibility of Mitochondria Plays a Key Role in Balancing Glucose and Fatty Acid Metabolism in the Diabetic Heart
  56. Role of Endothelial G Protein-Coupled Receptor Kinase 2 in Angioedema
  57. Arginine and Endothelial Function
  58. miR-7 Regulates GLP-1-Mediated Insulin Release by Targeting β-Arrestin 1
  59. Standardizing translational microbiome studies and metagenomic analyses
  60. Cardiac BIN1 Replacement Therapy Ameliorates Inotropy and Lusitropy in Heart Failure by Regulating Calcium Handling
  61. Hypertension, Thrombosis, Kidney Failure, and Diabetes: Is COVID-19 an Endothelial Disease? A Comprehensive Evaluation of Clinical and Basic Evidence
  62. Is COVID-19 an Endothelial Disease? Clinical and Basic Evidence
  63. Inositol 1,4,5-Trisphosphate Receptors in Human Disease: A Comprehensive Update
  64. Modulation of SERCA in Patients with Persistent Atrial Fibrillation Treated by Epicardial Thoracoscopic Ablation: The CAMAF Study
  65. Cardiomyocyte‐derived exosomal microRNA‐92a mediates post‐ischemic myofibroblast activation both in vitro and ex vivo
  66. Modulation of SERCA in Patients with Persistent Atrial Fibrillation Treated by Epicardial Thoracoscopic Ablation: The CAMAF Study
  67. Pathophysiological mechanisms underlying the beneficial effects of physical activity in hypertension
  68. Calcium supplements: Good for the bone, bad for the heart? A systematic updated appraisal
  69. Cardiosomal microRNAs Are Essential in Post-Infarction Myofibroblast Phenoconversion
  70. We are What We Eat: Impact of Food from Short Supply Chain on Metabolic Syndrome
  71. Pre-eclampsia and future cardiovascular diseases: How to assess the risk?
  72. Functional role of gut microbiota and PCSK9 in the pathogenesis of diabetes mellitus and cardiovascular disease
  73. The Non-Coding RNA Journal Club: Highlights on Recent Papers—7
  74. Diabetes Mellitus and Its Cardiovascular Complications: New Insights into an Old Disease
  75. Heparanase in health and disease: The neglected housekeeper of the cell?
  76. Why is chronic obstructive pulmonary disease linked to atrial fibrillation? A systematic overview of the underlying mechanisms
  77. Diabetes, body fat, skeletal muscle, and hypertension: The ominous chiasmus?
  78. The Non-Coding RNA Journal Club: Highlights on Recent Papers—6
  79. Update on peripheral artery disease: Epidemiology and evidence-based facts
  80. The Amino-Terminal Domain of GRK5 Inhibits Cardiac Hypertrophy through the Regulation of Calcium-Calmodulin Dependent Transcription Factors
  81. Effectiveness of new generation drug-eluting stents in ostial right coronary artery lesions
  82. Sirolimus induces depletion of intracellular calcium stores and mitochondrial dysfunction in pancreatic beta cells
  83. Impaired mitochondrial calcium uptake caused by tacrolimus underlies beta-cell failure
  84. Physiology and pathophysiology of excitation–contraction coupling: the functional role of ryanodine receptor
  85. The Non-Coding RNA Journal Club: Highlights on Recent Papers—5
  86. Intracellular calcium release channels: an update
  87. Quit smoking to outsmart atherogenesis: Molecular mechanisms underlying clinical evidence
  88. Mechanistic Role of Kinases in the Regulation of Mitochondrial Fitness
  89. Functional Role of Mitochondria in Arrhythmogenesis
  90. Childhood obesity and education
  91. Adrenergic signaling in heart failure and cardiovascular aging
  92. Dietary Components and Metabolic Dysfunction: Translating Preclinical Studies into Clinical Practice
  93. Integrating diet and inflammation to calculate cardiovascular risk
  94. Erratum: The Non-Coding RNA Journal Club: Highlights on Recent Papers—4. Non-Coding RNA 2016, 2, 9
  95. The Non-Coding RNA Journal Club: Highlights on Recent Papers—4
  96. Leaky ryanodine receptors contribute to diaphragmatic weakness during mechanical ventilation
  97. Maintenance of normal blood pressure is dependent on IP3R1-mediated regulation of eNOS
  98. Telemonitoring in heart failure patients treated by cardiac resynchronisation therapy with defibrillator (CRT-D): the TELECART Study
  99. MicroRNAs and Endothelial (Dys) Function
  100. The Non-Coding RNA Journal Club: Highlights on Recent Papers—3
  101. GRK2 induces cardiac hypertrophy through the regulation of NFκB activity
  102. Calcium release channel RyR2 regulates insulin release and glucose homeostasis
  103. Review of "Phosphoinositide 3-kinase: friend and foe in cardiovascular disease"
  104. Review of "Getting to the Heart of the Matter: An Overview of Cardiac Toxicity Related to Cancer Therapy"
  105. Review of "KMUP-1 Attenuates Endothelin-1-Induced Cardiomyocyte Hypertrophy through Activation of Heme Oxygenase-1 and Suppression of the Akt/GSK-3β, Calcineurin/NFATc4 and RhoA/ROCK Pathways"
  106. Essential Roles of Intracellular Calcium Release Channels in Muscle, Brain, Metabolism, and Aging
  107. Integrating GRK2 and NFkappaB in the Pathophysiology of Cardiac Hypertrophy
  108. Mitochondrial calcium overload is a key determinant in heart failure
  109. Mitochondrial oxidative stress promotes atrial fibrillation
  110. Calcium release channel RyR2 regulates insulin release and glucose homeostasis
  111. β-Blockers in Diabetic Patients With Heart Failure
  112. Effects of Low-Carbohydrate and Low-Fat Diets
  113. A Fleeting Glimpse Inside microRNA, Epigenetics, and Micropeptidomics
  114. Exploiting microRNA Specificity and Selectivity: Paving a Sustainable Path Towards Precision Medicine
  115. microRNAs Distinctively Regulate Vascular Smooth Muscle and Endothelial Cells: Functional Implications in Angiogenesis, Atherosclerosis, and In-Stent Restenosis
  116. Mechanistic Role of MicroRNAs in Coupling Lipid Metabolism and Atherosclerosis
  117. Circulating microRNAs: The Future of Biomarkers in Anti-doping Field
  118. Computational Prediction of microRNA Targets
  119. Essential Role of microRNA in Skin Physiology and Disease
  120. Insights into the Role of microRNAs in Pancreatic Cancer Pathogenesis: Potential for Diagnosis, Prognosis, and Therapy
  121. microRNA: Basic Science
  122. microRNA: Cancer
  123. microRNA: Medical Evidence
  124. Functional Role of Calstabin2 in Age-related Cardiac Alterations
  125. Metabolic syndrome is associated with a poor outcome in patients affected by outflow tract premature ventricular contractions treated by catheter ablation
  126. Application of microRNAs in diagnosis and treatment of cardiovascular disease
  127. Genetically enhancing mitochondrial antioxidant activity improves muscle function in aging
  128. CaMKII protects MKP-1 from proteasome degradation in endothelial cells
  129. A selective microRNA-based strategy inhibits restenosis while preserving endothelial function
  130. Chest Pain, Panic Disorder and Coronary Artery Disease: A Systematic Review
  131. Functional role of miRNA in cardiac resynchronization therapy
  132. Impact of Diabetes Mellitus on the Clinical Response to Cardiac Resynchronization Therapy in Elderly People
  133. Atrial fibrillation and microRNAs
  134. Angiopoietin-Like Proteins: A Comprehensive Look
  135. Myocardial Perfusion Imaging Study of CO2-Induced Panic Attack
  136. Adrenal Signaling in Heart Failure: Something More Than a Distant Ship's Smoke on the Horizon
  137. Imaging atrial arrhythmic intracellular calcium in intact heart
  138. Tailoring mTOR-based therapy: molecular evidence and clinical challenges
  139. G-Protein-Coupled Receptor Kinase 2 and Hypertension
  140. Adrenergic receptors and metabolism: role in development of cardiovascular disease
  141. Physical activity ameliorates cardiovascular health in elderly subjects: the functional role of the β adrenergic system
  142. Pinpointing beta adrenergic receptor in ageing pathophysiology: victim or executioner? Evidence from crime scenes
  143. CaMK4 Gene Deletion Induces Hypertension
  144. Endothelial Cells Are Able to Synthesize and Release Catecholamines Both In Vitro and In Vivo
  145. Role of cardiac resynchronization therapy in the development of new-onset atrial fibrillation: A single-center prospective study.
  146. Role of cardiac resynchronization therapy in the development of new-onset atrial fibrillation: A single-center prospective study.
  147. Regarding the impact of left ventricular size on response to cardiac resynchronization therapy
  148. Coronary Heart Disease Risk Factors and Mortality
  149. Thrombolysis Outcomes in Acute Ischemic Stroke Patients With Prior Stroke and Diabetes Mellitu
  150. Development of Atrial Fibrillation in Recipients of Cardiac Resynchronization Therapy: The Role of Atrial Reverse Remodelling
  151. Atrial remodelling in echocardiographic super-responders to cardiac resynchronization therapy
  152. Age-Related Impairment in Insulin Release: The Essential Role of  2-Adrenergic Receptor
  153. Mitochondrial localization unveils a novel role for GRK2 in organelle biogenesis
  154. Atrial Function in Patients Undergoing CRT
  155. Cardiac resynchronisation therapy response predicts occurrence of atrial fibrillation in non-ischaemic dilated cardiomyopathy
  156. In patients affected by nonischemic dilated cardiomyopathy, cardiac resynchronization therapy response predicts occurrence of atrial fibrillation
  157. G Protein-Coupled Receptor Kinase 2 in Patients With Acute Myocardial Infarction
  158. Integrating Cardiac PIP3 and cAMP Signaling through a PKA Anchoring Function of p110γ
  159. Impaired neoangiogenesis in β2-adrenoceptor gene-deficient mice: restoration by intravascular human β2-adrenoceptor gene transfer and role of NFκB and CREB transcription factors
  160. Evaluation of the anti-angiogenic properties of the new selective αVβ3 integrin antagonist RGDechiHCit
  161. The GPIIIA PlA2 polymorphism is associated with an increased risk of cardiovascular adverse events
  162. Intracardiac Injection of AdGRK5-NT Reduces Left Ventricular Hypertrophy by Inhibiting NF- B-Dependent Hypertrophic Gene Expression
  163. Advanced algorithms can lead to electrocardiographic misinterpretations
  164. Overproduction of phosphoprotein enriched in diabetes (PED) induces mesangial expansion and upregulates protein kinase C-β activity and TGF-β1 expression
  165. The G protein coupled receptor kinase 2 plays an essential role in beta-adrenergic receptor-induced insulin resistance
  166. In vivo properties of the proangiogenic peptide QK
  167. Endothelial α1-adrenoceptors regulate neo-angiogenesis
  168. A new synthetic protein, TAT-RH, inhibits tumor growth through the regulation of NFκB activity
  169. Enhanced GRK2 Expression and Desensitization of βAR Vasodilatation in Hypertensive Patients
  170. The G-protein-coupled receptor kinase 5 inhibits NFκB transcriptional activity by inducing nuclear accumulation of IκBα
  171. Endothelial β2 adrenergic signaling to AKT: Role of Gi and SRC
  172. G protein-coupled receptor kinases 2 (GRK2) and acute myocardial infarction
  173. GRK5 regulates NFkB transcription activity in endothelial cells
  174. The PlA1/A2 polymorphism of glycoprotein IIIa and cerebrovascular events in hypertension: increased risk of ischemic stroke in high-risk patients
  175. G Protein-Coupled Receptor Kinases and Hypertension
  176. Ischemic Neoangiogenesis Enhanced by  2-Adrenergic Receptor Overexpression: A Novel Role for the Endothelial Adrenergic System
  177. AKT Participates in Endothelial Dysfunction in Hypertension