All Stories

  1. Protective Effects of Extracts from Green Leaves and Rhizomes of Posidonia oceanica (L.) Delile on an In Vitro Model of the Human Blood–Brain Barrier
  2. 25-Hydroxycholesterol attenuates tumor necrosis factor alpha-induced blood-brain barrier breakdown in vitro
  3. Erratum to “CD31 orchestrates metabolic regulation in autophagy pathways of rheumatoid arthritis” [Pharmacol. Res. 207 (2024) 107346]
  4. CD31 orchestrates metabolic regulation in autophagy pathways of rheumatoid arthritis
  5. Secretome of brain microvascular endothelial cells promotes endothelial barrier tightness and protects against hypoxia-induced vascular leakage
  6. Enterovirus A71 crosses a human blood–brain barrier model through infected immune cells
  7. Synergistic induction of blood–brain barrier properties
  8. Retraction Note: Secretome of endothelial progenitor cells from stroke patients promotes endothelial barrier tightness and protects against hypoxia-induced vascular leakage
  9. Enhancing Oral Delivery of Biologics: A Non-Competitive and Cross-Reactive Anti-Leptin Receptor Nanofitin Demonstrates a Gut-Crossing Capacity in an Ex Vivo Porcine Intestinal Model
  10. 25-Hydroxycholesterol in health and diseases
  11. BrainBike peptidomimetic enables efficient transport of proteins across brain endothelium
  12. Vesicular Trafficking, a Mechanism Controlled by Cascade Activation of Rab Proteins: Focus on Rab27
  13. ProNGF promotes brain metastasis through TrkA/EphA2 induced Src activation in triple negative breast cancer cells
  14. Discovery, Structure–Activity Relationships, and In Vivo Activity of Dihydropyridone Agonists of the Bile Acid Receptor TGR5
  15. High levels of endothelial ICAM-1 prohibit natalizumab mediated abrogation of CD4+ T cell arrest on the inflamed BBB under flow in vitro
  16. Differential Blood–Brain Barrier Transport and Cell Uptake of Cyclic Peptides In Vivo and In Vitro
  17. Challenges and Opportunities in the Oral Delivery of Recombinant Biologics
  18. Highlighting In Vitro the Role of Brain-like Endothelial Cells on the Maturation and Metabolism of Brain Pericytes by SWATH Proteomics
  19. Impact of Pesticide Residues on the Gut-Microbiota–Blood–Brain Barrier Axis: A Narrative Review
  20. TNFα Activates the Liver X Receptor Signaling Pathway and Promotes Cholesterol Efflux from Human Brain Pericytes Independently of ABCA1
  21. Synergistic induction of blood-brain barrier properties
  22. Quantitative Targeted Absolute Proteomics for Better Characterization of an In Vitro Human Blood–Brain Barrier Model Derived from Hematopoietic Stem Cells
  23. Pioglitazone Attenuates the Effects of Peripheral Inflammation in a Human In Vitro Blood–Brain Barrier Model
  24. Challenges and opportunities in the use of transcriptomic characterization of human iPSC-derived BBB models
  25. TNF-α and IL-1β Modulate Blood-Brain Barrier Permeability and Decrease Amyloid-β Peptide Efflux in a Human Blood-Brain Barrier Model
  26. Antimalarial Drug Discovery: From Quinine to the Most Recent Promising Clinical Drug Candidates
  27. Interaction of surfactant coated PLGA nanoparticles with in vitro human brain-like endothelial cells
  28. Direct interaction of TrkA/CD44v3 is essential for NGF-promoted aggressiveness of breast cancer cells
  29. A New Class of Bi- and Trifunctional Sugar Oximes as Antidotes against Organophosphorus Poisoning
  30. An In Vitro Human Blood–Brain Barrier Model to Study Breast Cancer Brain Metastasis
  31. The Blood–Brain Barrier, an Evolving Concept Based on Technological Advances and Cell–Cell Communications
  32. A Triple Culture Cell System Modeling the Human Blood-Brain Barrier
  33. RETRACTED ARTICLE: Secretome of endothelial progenitor cells from stroke patients promotes endothelial barrier tightness and protects against hypoxia-induced vascular leakage
  34. Transport study of interleukin-1 inhibitors using a human in vitro model of the blood-brain barrier
  35. Potential neurotoxicity of titanium implants: Prospective, in-vivo and in-vitro study
  36. SARS-CoV-2 Poorly Replicates in Cells of the Human Blood-Brain Barrier Without Associated Deleterious Effects
  37. Miniaturization and Automation of a Human In Vitro Blood–Brain Barrier Model for the High-Throughput Screening of Compounds in the Early Stage of Drug Discovery
  38. Evaluation of a human iPSC-derived BBB model for repeated dose toxicity testing with cyclosporine A as model compound
  39. Role of ABCA7 in Human Health and in Alzheimer’s Disease
  40. Discovery of pyrazolo-thieno[3,2-d]pyrimidinylamino-phenyl acetamides as type-II pan-tropomyosin receptor kinase (TRK) inhibitors: Design, synthesis, and biological evaluation
  41. Central nervous system delivery of molecules across the blood-brain barrier
  42. Endothelial Iron Homeostasis Regulates Blood-Brain Barrier Integrity via the HIF2α—Ve-Cadherin Pathway
  43. Correction to: Differential neurovirulence of Usutu viruslineages in mice and neuronal cells
  44. Flow induces barrier and glycocalyx-related genes and negative surface charge in a lab-on-a-chip human blood-brain barrier model
  45. Time-Dependent Internalization of Polymer-Coated Silica Nanoparticles in Brain Endothelial Cells and Morphological and Functional Effects on the Blood-Brain Barrier
  46. Beyond the Rule of 5: Impact of PEGylation with Various Polymer Sizes on Pharmacokinetic Properties, Structure–Properties Relationships of mPEGylated Small Agonists of TGR5 Receptor
  47. Differential neurovirulence of Usutu virus lineages in mice and neuronal cells
  48. Correction: PLGA protein nanocarriers with tailor-made fluorescence/MRI/PET imaging modalities
  49. Advancing human induced pluripotent stem cell‐derived blood‐brain barrier models for studying immune cell interactions
  50. Endothelial iron homeostasis regulates BBB integrity via the HIF2α – Ve-cadherin pathway
  51. Naphthoquinone–Dopamine Hybrids Inhibit α‐Synuclein Aggregation, Disrupt Preformed Fibrils, and Attenuate Aggregate‐Induced Toxicity
  52. Chemoselective Hydrogenation of 6‐Alkynyl‐3‐fluoro‐2‐pyridinaldoximes: Access to First‐in‐Class 6‐Alkyl‐3‐Fluoro‐2‐pyridinaldoxime Scaffolds as New Reactivators of Sarin‐Inhibited Human Acetylcholinesterase with Increased Blood–Brain Barrier Permeability
  53. Caspase-1 has a critical role in blood-brain barrier injury and its inhibition contributes to multifaceted repair
  54. First step to the improvement of the blood brain barrier passage of atazanavir encapsulated in sustainable bioorganic vesicles
  55. Zika Virus Infection Promotes Local Inflammation, Cell Adhesion Molecule Upregulation, and Leukocyte Recruitment at the Blood-Brain Barrier
  56. Contribution of brain pericytes in blood–brain barrier formation and maintenance: a transcriptomic study of cocultured human endothelial cells derived from hematopoietic stem cells
  57. Homology Modeling of the Human P-glycoprotein (ABCB1) and Insights into Ligand Binding through Molecular Docking Studies
  58. The Effect of Sodium Bicarbonate, a Beneficial Adjuvant Molecule in Cystic Fibrosis, on Bronchial Epithelial Cells Expressing a Wild-Type or Mutant CFTR Channel
  59. Efficacy Assessment of an Uncharged Reactivator of NOP-Inhibited Acetylcholinesterase Based on Tetrahydroacridine Pyridine-Aldoxime Hybrid in Mouse Compared to Pralidoxime
  60. Development of a human in vitro blood–brain tumor barrier model of diffuse intrinsic pontine glioma to better understand the chemoresistance
  61. Study of Usutu virus neuropathogenicity in mice and human cellular models
  62. Serum-derived factors of breast cancer patients with brain metastases alter permeability of a human blood–brain barrier model
  63. GM1 Oligosaccharide Crosses the Human Blood–Brain Barrier In Vitro by a Paracellular Route
  64. Targeting and Crossing the Blood-Brain Barrier with Extracellular Vesicles
  65. New Lipidyl-Cyclodextrins Obtained by Ring Opening of Methyl Oleate Epoxide Using Ball Milling
  66. Human CD4+ T cell subsets differ in their abilities to cross endothelial and epithelial brain barriers in vitro
  67. Ketone Bodies Promote Amyloid-β1–40 Clearance in a Human in Vitro Blood–Brain Barrier Model
  68. Nonionotropic Action of Endothelial NMDA Receptors on Blood–Brain Barrier Permeability via Rho/ROCK-Mediated Phosphorylation of Myosin
  69. A High Output Method to Isolate Cerebral Pericytes from Mouse
  70. Transport Studies Using Blood-Brain Barrier In Vitro Models: A Critical Review and Guidelines
  71. PLGA protein nanocarriers with tailor-made fluorescence/MRI/PET imaging modalities
  72. A Miniaturized Pump Out Method for Characterizing Molecule Interaction with ABC Transporters
  73. Granisetron Alleviates Alzheimer’s Disease Pathology in TgSwDI Mice Through Calmodulin-Dependent Protein Kinase II/cAMP-Response Element Binding Protein Pathway
  74. Purpurin modulates Tau-derived VQIVYK fibrillization and ameliorates Alzheimer’s disease-like symptoms in animal model
  75. Oxysterols and the NeuroVascular Unit (NVU): A far true love with bright and dark sides
  76. PECAM-1 Stabilizes Blood-Brain Barrier Integrity and Favors Paracellular T-Cell Diapedesis Across the Blood-Brain Barrier During Neuroinflammation
  77. Transient blood–brain barrier disruption is induced by low pulsed electrical fields in vitro: an analysis of permeability and trans-endothelial electric resistivity
  78. A silicon nanomembrane platform for the visualization of immune cell trafficking across the human blood–brain barrier under flow
  79. Corrigendum to “Mimicking brain tissue binding in an in vitro model of the blood-brain barrier illustrates differences between in vitro and in vivo methods for assessing the rate of brain penetration” [Eur. J. Pharm. Biopharm. 127 (2018) 453–461]
  80. Blood-Brain Barrier Cellular Responses Toward Organophosphates: Natural Compensatory Processes and Exogenous Interventions to Rescue Barrier Properties
  81. Exploring in vitro the potential effects of repeated drug treatment on the distribution of other xenobiotics at the human blood-brain barrier (BBB)
  82. HIV Neuroinfection and Alzheimer’s Disease: Similarities and Potential Links?
  83. ABCA7 Downregulation Modifies Cellular Cholesterol Homeostasis and Decreases Amyloid-β Peptide Efflux in an in vitro Model of the Blood-Brain Barrier
  84. Receptor-mediated PLGA nanoparticles for glioblastoma multiforme treatment
  85. Sodium Transporters Are Involved in Lithium Influx in Brain Endothelial Cells
  86. Mimicking brain tissue binding in an in vitro model of the blood-brain barrier illustrates differences between in vitro and in vivo methods for assessing the rate of brain penetration
  87. Food-Derived Hemorphins Cross Intestinal and Blood–Brain Barriers In Vitro
  88. Petits mais costauds
  89. Abstracts from the 20th International Symposium on Signal Transduction at the Blood-Brain Barriers
  90. Brain tissue binding explains discrepancy between in vitro and in vivo methods for assessing blood–brain barrier permeability of chemicals
  91. Disease-Induced Alterations in Brain Drug Transporters in Animal Models of Alzheimer’s Disease
  92. Topical Intestinal Aminoimidazole Agonists of G-Protein-Coupled Bile Acid Receptor 1 Promote Glucagon Like Peptide-1 Secretion and Improve Glucose Tolerance
  93. Modélisation in vitro de la barrière hémato-encéphalique
  94. Resveratrol and Grape Extract-loaded Solid Lipid Nanoparticles for the Treatment of Alzheimer’s Disease
  95. Cyclodextrins as Emerging Therapeutic Tools in the Treatment of Cholesterol-Associated Vascular and Neurodegenerative Diseases
  96. ALCAM (CD166) is involved in extravasation of monocytes rather than T cells across the blood–brain barrier
  97. ST6GALNAC5 Expression Decreases the Interactions between Breast Cancer Cells and the Human Blood-Brain Barrier
  98. Modulation of Amyloid-β1–40 Transport by ApoA1 and ApoJ Across an in vitro Model of the Blood-Brain Barrier
  99. In vitro blood–brain barrier permeability predictions for GABA A receptor modulating piperine analogs
  100. β-Cyclodextrins Decrease Cholesterol Release and ABC-Associated Transporter Expression in Smooth Muscle Cells and Aortic Endothelial Cells
  101. Pharmacokinetics and In Vitro Blood-Brain Barrier Screening of the Plant-Derived Alkaloid Tryptanthrin
  102. Selection of a Relevant In Vitro Blood-Brain Barrier Model to Investigate Pro-Metastatic Features of Human Breast Cancer Cell Lines
  103. Adapting coculture in vitro models of the blood–brain barrier for use in cancer research: maintaining an appropriate endothelial monolayer for the assessment of transendothelial migration
  104. Evaluation of drug-induced neurotoxicity based on metabolomics, proteomics and electrical activity measurements in complementary CNS in vitro models
  105. Bexarotene Promotes Cholesterol Efflux and Restricts Apical-to-Basolateral Transport of Amyloid-β Peptides in an In Vitro Model of the Human Blood-Brain Barrier
  106. Efficient Docosahexaenoic Acid Uptake by the Brain from a Structured Phospholipid
  107. In vitro discrimination of the role of LRP1 at the BBB cellular level: Focus on brain capillary endothelial cells and brain pericytes
  108. Blood–Brain Barrier Proteomics: Towards the Understanding of Neurodegenerative Diseases
  109. Effects of oxysterols on the blood–brain barrier: Implications for Alzheimer’s disease
  110. Amyloid-β Peptides, Alzheimer's Disease and the Blood-brain Barrier
  111. Oxysterols decrease apical-to-basolateral transport of Aß peptides via an ABCB1-mediated process in an in vitro Blood-brain barrier model constituted of bovine brain capillary endothelial cells
  112. Truncated thioredoxin (Trx‐80) promotes pro‐inflammatory macrophages of the M1 phenotype and enhances atherosclerosis
  113. The LXR/RXR Approaches in Alzheimer’s Disease: Is the Blood-Bra in Barrier the Forgotten Partner?
  114. Apolipoprotéine E et intégrité de la barrière hémato-encéphalique
  115. Brain Pericytes ABCA1 Expression Mediates Cholesterol Efflux but not Cellular Amyloid-β Peptide Accumulation
  116. Brain pericytes from stress-susceptible pigs increase blood-brain barrier permeability in vitro
  117. A differential proteomic approach identifies structural and functional components that contribute to the differentiation of brain capillary endothelial cells
  118. Modelling the Neurovascular Unit and the Blood-Brain Barrier with the Unique Function of Pericytes
  119. La barrière hémato-encéphalique
  120. Erratum
  121. The Mysterious Link between Cholesterol and Alzheimer?s Disease: Is the Blood-Brain Barrier a Suspect?
  122. Apical-to-Basolateral Transport of Amyloid-β Peptides through Blood-Brain Barrier Cells is Mediated by the Receptor for Advanced Glycation End-Products and is Restricted by P-Glycoprotein
  123. Transcriptional profiles of receptors and transporters involved in brain cholesterol homeostasis at the blood–brain barrier: Use of an in vitro model
  124. Physiological Pathway for Low-Density Lipoproteins across the Blood-Brain Barrier: Transcytosis through Brain Capillary Endothelial Cells In Vitro
  125. BMP2 and BMP6 control p57Kip2 expression and cell growth arrest/terminal differentiation in normal primary human epidermal keratinocytes
  126. UVB-induced mutations in human key gatekeeper genes governing signalling pathways and consequences for skin tumourigenesis