All Stories

  1. The SARS-CoV-2 main protease Mpro causes microvascular brain pathology by cleaving NEMO in brain endothelial cells

    Article • Nature Neuroscience, October 2021, Springer Science + Business Media

    Dr Markus Krohn

  2. The trophoblast clock controls transport across placenta in mice

    Article • Development, April 2021, The Company of Biologists

    Dr Markus Krohn

  3. Brain Distribution of Dual ABCB1/ABCG2 Substrates Is Unaltered in a Beta-Amyloidosis Mouse Model

    Article • International Journal of Molecular Sciences, November 2020, MDPI AG

    Dr Markus Krohn

  4. Generation and Characterization of an Abcc1 Humanized Mouse Model (hABCC1flx/flx) with Knockout Capability

    Article • Molecular Pharmacology, June 2019, American Society for Pharmacology & Experimental Therapeutics (ASPET)

    Dr Markus Krohn

  5. French maritime pine bark treatment decelerates plaque development and improves spatial memory in Alzheimer's disease mice

    Article • Phytomedicine, April 2019, Elsevier

    Dr Markus Krohn

  6. ABCA7 Downregulation Modifies Cellular Cholesterol Homeostasis and Decreases Amyloid-β Peptide Efflux in an in vitro Model of the Blood-Brain Barrier

    Article • Journal of Alzheimer’s Disease, July 2018, IOS Press

    Pr. Fabien Gosselet, Dr Markus Krohn

  7. Humanization of the blood–brain barrier transporter ABCB1 in mice disrupts genomic locus — lessons from three unsuccessful approaches

    Article • July 2018, Akademiai Kiado

    Dr Markus Krohn

  8. Improved method for cannula fixation for long-term intracerebral brain infusion

    Article • Journal of Neuroscience Methods, October 2017, Elsevier

    Dr Markus Krohn

  9. Expression of endogenous mouse APP modulates β-amyloid deposition in hAPP-transgenic mice

    Article • Acta Neuropathologica Communications, June 2017, Springer Science + Business Media

    Dr Markus Krohn

  10. Revisiting rodent models: Octodon degus as Alzheimer’s disease model?

    Article • Acta Neuropathologica Communications, August 2016, Springer Science + Business Media

    Dr Markus Krohn

  11. Sideritis spp. Extracts Enhance Memory and Learning in Alzheimer’s β-Amyloidosis Mouse Models and Aged C57Bl/6 Mice

    Article • Journal of Alzheimer’s Disease, August 2016, IOS Press

    Dr Markus Krohn

  12. Chronic Toxoplasma gondii infection enhances β-amyloid phagocytosis and clearance by recruited monocytes

    Article • Acta Neuropathologica Communications, March 2016, Springer Science + Business Media

    Dr Markus Krohn, Dirk Montag

  13. Activation of Mitochondrial Complex II-Dependent Respiration Is Beneficial for α-Synucleinopathies

    Article • Molecular Neurobiology, August 2015, Springer Science + Business Media

    Dr Markus Krohn

  14. Accumulation of murine amyloid-β mimics early Alzheimer’s disease

    Article • Brain, May 2015, Oxford University Press (OUP)

    Oliver von Bohlen und Halbach, Dr Markus Krohn

  15. Alzheimer’s and ABC transporters — new opportunities for diagnostics and treatment

    Article • Neurobiology of Disease, December 2014, Elsevier

    Dr Markus Krohn

  16. Vascular and extravascular distribution of the ATP-binding cassette transporters ABCB1 and ABCC1 in aged human brain and pituitary

    Article • Mechanisms of Ageing and Development, November 2014, Elsevier

    Dr Markus Krohn

  17. Cerebral ABC Transporter-common Mechanisms May Modulate Neurodegenerative Diseases and Depression in Elderly Subjects

    Article • Archives of Medical Research, November 2014, Elsevier

    Dr Markus Krohn

  18. Reduced Alzheimer’s Disease Pathology by St. John’s Wort Treatment is Independent of Hyperforin and Facilitated by ABCC1 and Microglia Activation in Mice

    Article • Current Alzheimer Research, December 2013, Bentham Science Publishers

    Dr Markus Krohn

  19. Impaired mitochondrial energy production and ABC transporter function—A crucial interconnection in dementing proteopathies of the brain

    Article • Mechanisms of Ageing and Development, October 2013, Elsevier

    Dr Markus Krohn

  20. Genomic background-related activation of microglia and reduced β-amyloidosis in a mouse model of Alzheimer's disease

    Article • European Journal of Microbiology and Immunology, March 2013, Akademiai Kiado

    Dr Markus Krohn

  21. Neprilysin/ABC-transporter-deficient mice are a new physiologic model of Alzheimer's disease

    Article • Alzheimer s & Dementia, July 2012, Elsevier

    Dr Markus Krohn

  22. A new pathogenic pathway and causative treatment option for Alzheimer's disease: From aging to mitochondrial and ABC transporter dysfunction

    Article • Alzheimer s & Dementia, July 2012, Elsevier

    Dr Markus Krohn

  23. ABC Transporters B1, C1 and G2 Differentially Regulate Neuroregeneration in Mice

    Article • PLOS One, April 2012, PLOS

    Dr Markus Krohn

  24. Mitochondrial DNA polymorphisms specifically modify cerebral β-amyloid proteostasis

    Article • Acta Neuropathologica, April 2012, Springer Science + Business Media

    Oliver von Bohlen und Halbach, Dr Markus Krohn

  25. Determination of Spatial and Temporal Distribution of Microglia by 230nm-High-Resolution, High-Throughput Automated Analysis Reveals Different Amyloid Plaque Populations in an APP/PS1 Mouse Model of Alzheimers Disease

    Article • Current Alzheimer Research, November 2011, Bentham Science Publishers

    Dr Markus Krohn

  26. Cerebral amyloid-β proteostasis is regulated by the membrane transport protein ABCC1 in mice

    Article • Journal of Clinical Investigation, October 2011, American Society for Clinical Investigation

    Dr Markus Krohn

  27. Automated Detection of Amyloid-β-Related Cortical and Subcortical Signal Changes in a Transgenic Model of Alzheimer's Disease using High-Field MRI

    Article • Journal of Alzheimer’s Disease, February 2011, IOS Press

    Professor Martin Lotze, Dr Markus Krohn

  28. Die Funktion der Blut-Hirn-Schranke für die Pathogenese der Alzheimer-Demenz – Implikationen für immunologische Therapien zur Plaqueauflösung

    Article • Fortschritte der Neurologie · Psychiatrie, August 2009, Thieme Publishing Group

    Dr Markus Krohn

  29. Alzheimer's disease and blood–brain barrier function—Why have anti-β-amyloid therapies failed to prevent dementia progression?

    Article • Neuroscience & Biobehavioral Reviews, July 2009, Elsevier

    Dr Markus Krohn

  30. Clinico-Pathologic Function of Cerebral ABC Transporters – Implications for the Pathogenesis of Alzheimers Disease

    Article • Current Alzheimer Research, August 2008, Bentham Science Publishers

    Dr Markus Krohn

  31. MDR1‐P‐Glycoprotein (ABCB1) Mediates Transport of Alzheimer’s Amyloid‐β Peptides—Implications for the Mechanisms of Aβ Clearance at the Blood–Brain Barrier

    Article • Brain Pathology, October 2007, Wiley

    Dr Markus Krohn