All Stories

  1. Why the Assay Matters in Model-Informed Precision Dosing: An Example of Ustekinumab in Crohn’s Disease
  2. Response to Shen et al
  3. Systematic review and scoring‐based selection of pharmacokinetic models for precision dosing of vancomycin in neonates and children
  4. High Doses of Antidepressants and Long-term Treatment of Obsessive-compulsive Disorder: Another Barrier to Accessing Deep Brain Stimulation?
  5. A fluconazole population pharmacokinetics study to improve target attainment in critically ill patients
  6. Infliximab and Ustekinumab Clearance Better Predict Endoscopic Outcomes Than Trough Concentrations in Crohn’s Disease
  7. Optimizing the switch from escalated intravenous to subcutaneous infliximab: a population pharmacokinetics–pharmacodynamics study
  8. The Gravity of a Unique Subcutaneous Anti-IL23 Induction Regimen
  9. Response to Dai et al.
  10. Population pharmacokinetics of edoxaban in geriatric patients with atrial fibrillation
  11. A Multiple Imputation Workflow for Handling Missing Covariate Data in Pharmacometrics Modeling
  12. A Risk Stratification Tool for Relapse After Intravenous-To-Subcutaneous Switching of Infliximab in Patients With Inflammatory Bowel Diseases
  13. Ustekinumab Drug Clearance Is Better Associated with Disease Control than Serum Trough Concentrations in a Prospective Cohort of Inflammatory Bowel Disease
  14. Intensified infliximab induction therapy for steroid-refractory acute severe ulcerative colitis
  15. Model-informed precision dosing in inflammatory bowel diseases
  16. Tracking the journey: Gastrointestinal transit and intraluminal pH dynamics in aging populations using wireless motility capsule
  17. Anidulafungin exposure and population pharmacokinetics in critically ill patients with invasive candidiasis
  18. Dose Optimization of Amikacin in the Emergency Department: A Population Pharmacokinetics Simulation Study
  19. Model-informed precision dosing: State of the art and future perspectives
  20. Human serum albumin: prediction model and reference values for preterm and term neonates
  21. Correction: Model-Informed Precision Dosing of Tacrolimus: A Systematic Review of Population Pharmacokinetic Models and a Benchmark Study of Software Tools
  22. Model-Informed Precision Dosing of Tacrolimus: A Systematic Review of Population Pharmacokinetic Models and a Benchmark Study of Software Tools
  23. Decreased Kidney Function Explains Higher Vancomycin Exposure in Older Adults
  24. Ixekizumab trough concentrations in psoriasis: Paving the way towards personalised therapy: A cohort study
  25. The PPP2R1A cancer hotspot mutant p.R183W increases clofarabine resistance in uterine serous carcinoma cells by a gain-of-function mechanism
  26. Dosing of IV posaconazole to treat critically ill patients with invasive pulmonary aspergillosis: a population pharmacokinetics modelling and simulation study
  27. Forecasted infliximab concentrations during induction predict time to remission and sustained disease control of inflammatory bowel disease
  28. Exposure–response relationship of guselkumab and the potential of serum proteomics in identifying predictive biomarker candidates in psoriasis
  29. Best Practice for Therapeutic Drug Monitoring of Infliximab: Position Statement from the International Association of Therapeutic Drug Monitoring and Clinical Toxicology
  30. The PPP2R1A cancer hotspot mutant p.R183W increases clofarabine resistance in uterine serous carcinoma cells by a gain-of-function mechanism
  31. Personalized Antifungal Therapy Through Model-Informed Precision Dosing of Posaconazole
  32. Do we perceive sensations inside and outside of our body differently? Perceptual, emotional, and behavioral differences between visceral and somatic sensation, discomfort, and pain
  33. Agreement Between a Colorimetric Assay and Ultra-Performance Liquid Chromatography-Tandem Mass Spectrometry for Quantifying Paracetamol Plasma Concentrations
  34. Therapeutic drug monitoring of monoclonal antibodies in chronic inflammatory diseases: A snapshot of laboratories and applications across Europe
  35. Identifying risk factors of anti‐TNF induced skin lesions and other adverse events in paediatric patients with inflammatory bowel disease
  36. Therapeutic Drug Monitoring Can Guide the Intravenous-to-Subcutaneous Switch of Infliximab and Vedolizumab: A Simulation Study
  37. TRPA1 Antagonist LY3526318 Inhibits the Cinnamaldehyde‐Evoked Dermal Blood Flow Increase: Translational Proof of Pharmacology
  38. Therapeutic Drug Monitoring 2.0: Time to Assemble the Puzzle
  39. Drug Repurposing for Targeting Myeloid-Derived Suppressor-Cell-Generated Immunosuppression in Ovarian Cancer: A Literature Review of Potential Candidates
  40. Isavuconazole Exposure in Critically Ill Patients Treated with Extracorporeal Membrane Oxygenation: Two Case Reports and a Narrative Literature Review
  41. A personalised taper-to-target strategy with adalimumab in Crohn's disease
  42. Insights into the Pharmacokinetics and Pharmacodynamics of Direct Oral Anticoagulants in Older Adults with Atrial Fibrillation: A Structured Narrative Review
  43. A Model-Based Tool for Guiding Infliximab Induction Dosing to Maximize Long-term Deep Remission in Children with Inflammatory Bowel Diseases
  44. Erratum to: Introduction of Subcutaneous Infliximab CT-P13 and Vedolizumab in Clinical Practice: A Multi-Stakeholder Position Statement Highlighting the Need for Post-Marketing Studies
  45. Liposomal amphotericin B exposure in critically ill patients: a prospective pharmacokinetic study
  46. Systematic Comparison of Hospital-Wide Standard and Model-Based Therapeutic Drug Monitoring of Vancomycin in Adults
  47. Ceftriaxone dosing based on the predicted probability of augmented renal clearance in critically ill patients with pneumonia
  48. Multi‐model averaging improves the performance of model‐guided infliximab dosing in patients with inflammatory bowel diseases
  49. Clinical Significance of Serum Albumin and Implications of FcRn Inhibitor Treatment in IgG-Mediated Autoimmune Disorders
  50. Editorial: Therapeutic Drug Monitoring (TDM): A Useful Tool for Pediatric Pharmacology Applied to Routine Clinical Practice
  51. Exposure to intravenous posaconazole in critically ill patients with influenza: A pharmacokinetic analysis of the POSA‐FLU study
  52. Therapeutic drug monitoring in dermatology: the way towards dose optimization of secukinumab in chronic plaque psoriasis
  53. The TARGET trial as a plea for model-informed precision dosing of piperacillin/tazobactam in patients with sepsis
  54. Introduction of Subcutaneous Infliximab CT-P13 and Vedolizumab in Clinical Practice: A Multi-Stakeholder Position Statement Highlighting the Need for Post-Marketing Studies
  55. Prospective assessment of breakthrough infections and neurotoxicity and their association with cefepime trough concentrations in patients with febrile neutropenia
  56. Meropenem Target Attainment and Population Pharmacokinetics in Critically Ill Septic Patients with Preserved or Increased Renal Function
  57. Infliximab Concentrations during Induction Are Predictive for Endoscopic Remission in Pediatric Patients with Inflammatory Bowel Disease under Combination Therapy
  58. Recent advances in clearance monitoring of monoclonal antibodies in patients with inflammatory bowel diseases
  59. Corrigendum to: Pharmacokinetic-Pharmacodynamic Model of Vedolizumab for Targeting Endoscopic Remission in Patients with Crohn Disease: Posthoc Analysis of the LOVE-CD Study
  60. Model-Informed Precision Dosing during Infliximab Induction Therapy Reduces Variability in Exposure and Endoscopic Improvement between Patients with Ulcerative Colitis
  61. Bosentan Alters Endo- and Exogenous Bile Salt Disposition in Sandwich-Cultured Human Hepatocytes
  62. Ustekinumab Dosing Individualization in Crohn’s Disease Guided by a Population Pharmacokinetic–Pharmacodynamic Model
  63. Population pharmacokinetics of cefazolin in maternal and umbilical cord plasma, and simulated exposure in term neonates
  64. New Tools for Therapeutic Drug Monitoring: Making Big Things out of Small Pieces
  65. A Population Pharmacokinetic Modeling and Simulation Study of Posaconazole Oral Suspension in Immunocompromised Pediatric Patients: A Short Communication
  66. Quantification and Explanation of the Variability of First-Dose Amikacin Concentrations in Critically Ill Patients Admitted to the Emergency Department: A Population Pharmacokinetic Analysis
  67. Population pharmacokinetic‐pharmacodynamic model‐based exploration of alternative ustekinumab dosage regimens for patients with Crohn's disease
  68. Monocyte-driven atypical cytokine storm and aberrant neutrophil activation as key mediators of COVID-19 disease severity
  69. Corrigendum to “itraconazole for COVID-19: Preclinical studies and a proof-of-concept randomized clinical trial Laurens”
  70. Pharmacokinetic-Pharmacodynamic Model of Vedolizumab for Targeting Endoscopic Remission in Patients With Crohn Disease: Posthoc Analysis of the LOVE-CD Study
  71. Meropenem Pharmacokinetics and Target Attainment in Critically Ill Patients Are Not Affected by Extracorporeal Membrane Oxygenation: A Matched Cohort Analysis
  72. Concomitant use of isavuconazole and CYP3A4/5 inducers: Where pharmacogenetics meets pharmacokinetics
  73. Pharmacokinetic/Pharmacodynamic Target Attainment Based on Measured versus Predicted Unbound Ceftriaxone Concentrations in Critically Ill Patients with Pneumonia: An Observational Cohort Study
  74. P344 Effectiveness and safety of switching patients with inflammatory bowel disease from originator infliximab to CT-P13: systematic review and meta-analysis
  75. Infliximab Exposure Associates With Radiologic Evidence of Healing in Patients With Crohn’s Disease
  76. P280 Introduction of subcutaneous infliximab CT-P13 and vedolizumab in daily clinical practice: outstanding questions demonstrate the need for post-marketing studies
  77. P307 Modelling of the relationship between ustekinumab exposure, faecal calprotectin and endoscopic outcomes in patients with Crohn’s disease
  78. P304 Rational infliximab induction dosing to achieve long-term deep remission in children with Inflammatory Bowel Diseases
  79. Itraconazole for COVID-19: preclinical studies and a proof-of-concept randomized clinical trial
  80. The effect of aging on infliximab exposure and response in patients with inflammatory bowel diseases
  81. Pharmacokinetics and target attainment of intravenous posaconazole in critically ill patients during extracorporeal membrane oxygenation
  82. Therapeutic drug monitoring of anti-tumor necrosis factor agents: lessons learned and remaining issues
  83. Monocyte-driven atypical cytokine storm and aberrant neutrophil activation as key mediators of COVID-19 disease severity
  84. Saliva for Precision Dosing of Antifungal Drugs: Saliva Population PK Model for Voriconazole Based on a Systematic Review.
  85. Modelling of the relationship between infliximab exposure, faecal calprotectin and endoscopic remission in patients with Crohn's disease
  86. Software Tools for Model-Informed Precision Dosing: How Well Do They Satisfy the Needs?
  87. Reply
  88. Monitoring a Combination of Calprotectin and Infliximab Identifies Patients With Mucosal Healing of Crohn’s Disease
  89. Peak Concentrations of Ustekinumab After Intravenous Induction Therapy Identify Patients With Crohn’s Disease Likely to Achieve Endoscopic and Biochemical Remission
  90. Reply
  91. Monocyte-Driven Atypical Cytokine Storm and Aberrant Neutrophil Activation as Key Mediators of COVID19 Disease Severity
  92. Itraconazole for COVID-19: Preclinical Studies and a Proof-of-Concept Pilot Clinical Study
  93. How, When, and For Whom Should We Perform Therapeutic Drug Monitoring?
  94. Influence of Drug Exposure on Vedolizumab-Induced Endoscopic Remission in Anti-Tumour Necrosis Factor [TNF] Naïve and Anti-TNF Exposed IBD Patients
  95. A Population Pharmacokinetic and Exposure–Response Model of Golimumab for Targeting Endoscopic Remission in Patients With Ulcerative Colitis
  96. Adequate Infliximab Exposure During Induction Predicts Remission in Paediatric Patients With Inflammatory Bowel Disease
  97. Efficacy, Pharmacokinetics, and Immunogenicity is Not Affected by Switching From Infliximab Originator to a Biosimilar in Pediatric Patients With Inflammatory Bowel Disease
  98. Pharmacodynamic Monitoring of Biological Therapies in Chronic Inflammatory Diseases
  99. Subcutaneous Absorption Contributes to Observed Interindividual Variability in Adalimumab Serum Concentrations in Crohn’s Disease: A Prospective Multicentre Study
  100. Optimising infliximab induction dosing for patients with ulcerative colitis
  101. Ustekinumab Exposure-outcome Analysis in Crohn’s Disease Only in Part Explains Limited Endoscopic Remission Rates
  102. P589 A population pharmacokinetic model to improve mucosal healing upon golimumab induction therapy in patients with ulcerative colitis
  103. P342 A population pharmacokinetic model to support therapeutic drug monitoring during vedolizumab therapy
  104. P265 Pharmacokinetic and pharmacodynamic evaluation of radiological healing in Crohn’s disease patients treated with Infliximab: a TAILORIX MRE substudy
  105. P408 Switching from infliximab originator to a biosimilar does not affect efficacy, pharmacokinetics and immunogenicity in paediatric patients with inflammatory bowel disease
  106. OP25 Targeting endoscopic outcomes through combined pharmacokinetic and pharmacodynamic monitoring of infliximab therapy in patients with Crohn’s disease
  107. Evidence to Support Monitoring of Vedolizumab Trough Concentrations in Patients With Inflammatory Bowel Diseases
  108. Letter: overcoming secondary loss of response to infliximab-it is not the drug, it is how you use it! Authors’ reply
  109. Higher Infliximab Trough Levels Are Associated With Better Outcome in Paediatric Patients With Inflammatory Bowel Disease
  110. Effectiveness and safety of switching IBD patients from the originator to the biosimilar infliximab
  111. Pharmacokinetic Modeling and Simulation of Biologicals in Inflammatory Bowel Disease: The Dawning of a New Era for Personalized Treatment
  112. Anti-infliximab antibody concentrations can guide treatment intensification in patients with Crohn's disease who lose clinical response
  113. Antibodies Toward Vedolizumab Appear from the First Infusion Onward and Disappear Over Time
  114. Practical recommendations for the use of therapeutic drug monitoring of biopharmaceuticals in inflammatory diseases
  115. Current Practices for Therapeutic Drug Monitoring of Biopharmaceuticals in Pediatrics
  116. Therapeutic Drug Monitoring of Biopharmaceuticals May Benefit From Pharmacokinetic and Pharmacokinetic–Pharmacodynamic Modeling
  117. Anti-Infliximab Antibody Concentrations Guide Therapeutic Decision-Making in Patients with Crohn's Disease Losing Clinical Response
  118. Antibodies Towards Vedolizumab Appear from Week 2 Onwards and Disappear upon Treatment
  119. Recent Anti-TNF Exposure Predicts Lower Vedolizumab Trough Concentrations in Patients with Crohn Disease
  120. Blocking α4β7 Integrin Through Vedolizumab: Necessary but not Sufficient?
  121. A Genetic Variation in the Neonatal Fc-Receptor Affects Anti-TNF Drug Concentrations in Inflammatory Bowel Disease
  122. Harmonization of Infliximab and Anti-Infliximab Assays Facilitates the Comparison Between Originators and Biosimilars in Clinical Samples
  123. Sa1943 Variability in Vedolizumab Exposure Between Patients With Inflammatory Bowel Disease
  124. Variability in Golimumab Exposure: A ‘Real-Life’ Observational Study in Active Ulcerative Colitis
  125. Neutralisation of Soluble Tumor Necrosis Factor