All Stories

  1. High Doses of Antidepressants and Long-term Treatment of Obsessive-compulsive Disorder: Another Barrier to Accessing Deep Brain Stimulation?
  2. A fluconazole population pharmacokinetics study to improve target attainment in critically ill patients
  3. Infliximab and Ustekinumab Clearance Better Predict Endoscopic Outcomes Than Trough Concentrations in Crohn’s Disease
  4. Optimizing the switch from escalated intravenous to subcutaneous infliximab: a population pharmacokinetics–pharmacodynamics study
  5. The Gravity of a Unique Subcutaneous Anti-IL23 Induction Regimen
  6. Response to Dai et al.
  7. Population pharmacokinetics of edoxaban in geriatric patients with atrial fibrillation
  8. A Multiple Imputation Workflow for Handling Missing Covariate Data in Pharmacometrics Modeling
  9. A Risk Stratification Tool for Relapse After Intravenous-To-Subcutaneous Switching of Infliximab in Patients With Inflammatory Bowel Diseases
  10. Ustekinumab Drug Clearance Is Better Associated with Disease Control than Serum Trough Concentrations in a Prospective Cohort of Inflammatory Bowel Disease
  11. Intensified infliximab induction therapy for steroid-refractory acute severe ulcerative colitis
  12. Model-informed precision dosing in inflammatory bowel diseases
  13. Tracking the journey: Gastrointestinal transit and intraluminal pH dynamics in aging populations using wireless motility capsule
  14. Anidulafungin exposure and population pharmacokinetics in critically ill patients with invasive candidiasis
  15. Dose Optimization of Amikacin in the Emergency Department: A Population Pharmacokinetics Simulation Study
  16. Model-informed precision dosing: State of the art and future perspectives
  17. Human serum albumin: prediction model and reference values for preterm and term neonates
  18. Correction: Model-Informed Precision Dosing of Tacrolimus: A Systematic Review of Population Pharmacokinetic Models and a Benchmark Study of Software Tools
  19. Model-Informed Precision Dosing of Tacrolimus: A Systematic Review of Population Pharmacokinetic Models and a Benchmark Study of Software Tools
  20. Decreased Kidney Function Explains Higher Vancomycin Exposure in Older Adults
  21. Ixekizumab trough concentrations in psoriasis: Paving the way towards personalised therapy: A cohort study
  22. The PPP2R1A cancer hotspot mutant p.R183W increases clofarabine resistance in uterine serous carcinoma cells by a gain-of-function mechanism
  23. Dosing of IV posaconazole to treat critically ill patients with invasive pulmonary aspergillosis: a population pharmacokinetics modelling and simulation study
  24. Forecasted infliximab concentrations during induction predict time to remission and sustained disease control of inflammatory bowel disease
  25. Exposure–response relationship of guselkumab and the potential of serum proteomics in identifying predictive biomarker candidates in psoriasis
  26. Best Practice for Therapeutic Drug Monitoring of Infliximab: Position Statement from the International Association of Therapeutic Drug Monitoring and Clinical Toxicology
  27. The PPP2R1A cancer hotspot mutant p.R183W increases clofarabine resistance in uterine serous carcinoma cells by a gain-of-function mechanism
  28. Personalized Antifungal Therapy Through Model-Informed Precision Dosing of Posaconazole
  29. Do we perceive sensations inside and outside of our body differently? Perceptual, emotional, and behavioral differences between visceral and somatic sensation, discomfort, and pain
  30. Agreement Between a Colorimetric Assay and Ultra-Performance Liquid Chromatography-Tandem Mass Spectrometry for Quantifying Paracetamol Plasma Concentrations
  31. Therapeutic drug monitoring of monoclonal antibodies in chronic inflammatory diseases: A snapshot of laboratories and applications across Europe
  32. Identifying risk factors of anti‐TNF induced skin lesions and other adverse events in paediatric patients with inflammatory bowel disease
  33. Therapeutic Drug Monitoring Can Guide the Intravenous-to-Subcutaneous Switch of Infliximab and Vedolizumab: A Simulation Study
  34. TRPA1 Antagonist LY3526318 Inhibits the Cinnamaldehyde‐Evoked Dermal Blood Flow Increase: Translational Proof of Pharmacology
  35. Therapeutic Drug Monitoring 2.0: Time to Assemble the Puzzle
  36. Drug Repurposing for Targeting Myeloid-Derived Suppressor-Cell-Generated Immunosuppression in Ovarian Cancer: A Literature Review of Potential Candidates
  37. Isavuconazole Exposure in Critically Ill Patients Treated with Extracorporeal Membrane Oxygenation: Two Case Reports and a Narrative Literature Review
  38. A personalised taper-to-target strategy with adalimumab in Crohn's disease
  39. Insights into the Pharmacokinetics and Pharmacodynamics of Direct Oral Anticoagulants in Older Adults with Atrial Fibrillation: A Structured Narrative Review
  40. A Model-Based Tool for Guiding Infliximab Induction Dosing to Maximize Long-term Deep Remission in Children with Inflammatory Bowel Diseases
  41. Erratum to: Introduction of Subcutaneous Infliximab CT-P13 and Vedolizumab in Clinical Practice: A Multi-Stakeholder Position Statement Highlighting the Need for Post-Marketing Studies
  42. Liposomal amphotericin B exposure in critically ill patients: a prospective pharmacokinetic study
  43. Systematic Comparison of Hospital-Wide Standard and Model-Based Therapeutic Drug Monitoring of Vancomycin in Adults
  44. Ceftriaxone dosing based on the predicted probability of augmented renal clearance in critically ill patients with pneumonia
  45. Multi‐model averaging improves the performance of model‐guided infliximab dosing in patients with inflammatory bowel diseases
  46. Clinical Significance of Serum Albumin and Implications of FcRn Inhibitor Treatment in IgG-Mediated Autoimmune Disorders
  47. Editorial: Therapeutic Drug Monitoring (TDM): A Useful Tool for Pediatric Pharmacology Applied to Routine Clinical Practice
  48. Exposure to intravenous posaconazole in critically ill patients with influenza: A pharmacokinetic analysis of the POSA‐FLU study
  49. Therapeutic drug monitoring in dermatology: the way towards dose optimization of secukinumab in chronic plaque psoriasis
  50. The TARGET trial as a plea for model-informed precision dosing of piperacillin/tazobactam in patients with sepsis
  51. Introduction of Subcutaneous Infliximab CT-P13 and Vedolizumab in Clinical Practice: A Multi-Stakeholder Position Statement Highlighting the Need for Post-Marketing Studies
  52. Prospective assessment of breakthrough infections and neurotoxicity and their association with cefepime trough concentrations in patients with febrile neutropenia
  53. Meropenem Target Attainment and Population Pharmacokinetics in Critically Ill Septic Patients with Preserved or Increased Renal Function
  54. Infliximab Concentrations during Induction Are Predictive for Endoscopic Remission in Pediatric Patients with Inflammatory Bowel Disease under Combination Therapy
  55. Recent advances in clearance monitoring of monoclonal antibodies in patients with inflammatory bowel diseases
  56. Corrigendum to: Pharmacokinetic-Pharmacodynamic Model of Vedolizumab for Targeting Endoscopic Remission in Patients with Crohn Disease: Posthoc Analysis of the LOVE-CD Study
  57. Model-Informed Precision Dosing during Infliximab Induction Therapy Reduces Variability in Exposure and Endoscopic Improvement between Patients with Ulcerative Colitis
  58. Bosentan Alters Endo- and Exogenous Bile Salt Disposition in Sandwich-Cultured Human Hepatocytes
  59. Ustekinumab Dosing Individualization in Crohn’s Disease Guided by a Population Pharmacokinetic–Pharmacodynamic Model
  60. Population pharmacokinetics of cefazolin in maternal and umbilical cord plasma, and simulated exposure in term neonates
  61. New Tools for Therapeutic Drug Monitoring: Making Big Things out of Small Pieces
  62. A Population Pharmacokinetic Modeling and Simulation Study of Posaconazole Oral Suspension in Immunocompromised Pediatric Patients: A Short Communication
  63. Quantification and Explanation of the Variability of First-Dose Amikacin Concentrations in Critically Ill Patients Admitted to the Emergency Department: A Population Pharmacokinetic Analysis
  64. Population pharmacokinetic‐pharmacodynamic model‐based exploration of alternative ustekinumab dosage regimens for patients with Crohn's disease
  65. Monocyte-driven atypical cytokine storm and aberrant neutrophil activation as key mediators of COVID-19 disease severity
  66. Corrigendum to “itraconazole for COVID-19: Preclinical studies and a proof-of-concept randomized clinical trial Laurens”
  67. Pharmacokinetic-Pharmacodynamic Model of Vedolizumab for Targeting Endoscopic Remission in Patients With Crohn Disease: Posthoc Analysis of the LOVE-CD Study
  68. Meropenem Pharmacokinetics and Target Attainment in Critically Ill Patients Are Not Affected by Extracorporeal Membrane Oxygenation: A Matched Cohort Analysis
  69. Concomitant use of isavuconazole and CYP3A4/5 inducers: Where pharmacogenetics meets pharmacokinetics
  70. Pharmacokinetic/Pharmacodynamic Target Attainment Based on Measured versus Predicted Unbound Ceftriaxone Concentrations in Critically Ill Patients with Pneumonia: An Observational Cohort Study
  71. P344 Effectiveness and safety of switching patients with inflammatory bowel disease from originator infliximab to CT-P13: systematic review and meta-analysis
  72. Infliximab Exposure Associates With Radiologic Evidence of Healing in Patients With Crohn’s Disease
  73. P280 Introduction of subcutaneous infliximab CT-P13 and vedolizumab in daily clinical practice: outstanding questions demonstrate the need for post-marketing studies
  74. P307 Modelling of the relationship between ustekinumab exposure, faecal calprotectin and endoscopic outcomes in patients with Crohn’s disease
  75. P304 Rational infliximab induction dosing to achieve long-term deep remission in children with Inflammatory Bowel Diseases
  76. Itraconazole for COVID-19: preclinical studies and a proof-of-concept randomized clinical trial
  77. The effect of aging on infliximab exposure and response in patients with inflammatory bowel diseases
  78. Pharmacokinetics and target attainment of intravenous posaconazole in critically ill patients during extracorporeal membrane oxygenation
  79. Therapeutic drug monitoring of anti-tumor necrosis factor agents: lessons learned and remaining issues
  80. Monocyte-driven atypical cytokine storm and aberrant neutrophil activation as key mediators of COVID-19 disease severity
  81. Saliva for Precision Dosing of Antifungal Drugs: Saliva Population PK Model for Voriconazole Based on a Systematic Review.
  82. Modelling of the relationship between infliximab exposure, faecal calprotectin and endoscopic remission in patients with Crohn's disease
  83. Software Tools for Model-Informed Precision Dosing: How Well Do They Satisfy the Needs?
  84. Reply
  85. Monitoring a Combination of Calprotectin and Infliximab Identifies Patients With Mucosal Healing of Crohn’s Disease
  86. Peak Concentrations of Ustekinumab After Intravenous Induction Therapy Identify Patients With Crohn’s Disease Likely to Achieve Endoscopic and Biochemical Remission
  87. Reply
  88. Monocyte-Driven Atypical Cytokine Storm and Aberrant Neutrophil Activation as Key Mediators of COVID19 Disease Severity
  89. Itraconazole for COVID-19: Preclinical Studies and a Proof-of-Concept Pilot Clinical Study
  90. How, When, and For Whom Should We Perform Therapeutic Drug Monitoring?
  91. Influence of Drug Exposure on Vedolizumab-Induced Endoscopic Remission in Anti-Tumour Necrosis Factor [TNF] Naïve and Anti-TNF Exposed IBD Patients
  92. A Population Pharmacokinetic and Exposure–Response Model of Golimumab for Targeting Endoscopic Remission in Patients With Ulcerative Colitis
  93. Adequate Infliximab Exposure During Induction Predicts Remission in Paediatric Patients With Inflammatory Bowel Disease
  94. Efficacy, Pharmacokinetics, and Immunogenicity is Not Affected by Switching From Infliximab Originator to a Biosimilar in Pediatric Patients With Inflammatory Bowel Disease
  95. Pharmacodynamic Monitoring of Biological Therapies in Chronic Inflammatory Diseases
  96. Subcutaneous Absorption Contributes to Observed Interindividual Variability in Adalimumab Serum Concentrations in Crohn’s Disease: A Prospective Multicentre Study
  97. Optimising infliximab induction dosing for patients with ulcerative colitis
  98. Ustekinumab Exposure-outcome Analysis in Crohn’s Disease Only in Part Explains Limited Endoscopic Remission Rates
  99. P589 A population pharmacokinetic model to improve mucosal healing upon golimumab induction therapy in patients with ulcerative colitis
  100. P342 A population pharmacokinetic model to support therapeutic drug monitoring during vedolizumab therapy
  101. P265 Pharmacokinetic and pharmacodynamic evaluation of radiological healing in Crohn’s disease patients treated with Infliximab: a TAILORIX MRE substudy
  102. P408 Switching from infliximab originator to a biosimilar does not affect efficacy, pharmacokinetics and immunogenicity in paediatric patients with inflammatory bowel disease
  103. OP25 Targeting endoscopic outcomes through combined pharmacokinetic and pharmacodynamic monitoring of infliximab therapy in patients with Crohn’s disease
  104. Evidence to Support Monitoring of Vedolizumab Trough Concentrations in Patients With Inflammatory Bowel Diseases
  105. Letter: overcoming secondary loss of response to infliximab-it is not the drug, it is how you use it! Authors’ reply
  106. Higher Infliximab Trough Levels Are Associated With Better Outcome in Paediatric Patients With Inflammatory Bowel Disease
  107. Effectiveness and safety of switching IBD patients from the originator to the biosimilar infliximab
  108. Pharmacokinetic Modeling and Simulation of Biologicals in Inflammatory Bowel Disease: The Dawning of a New Era for Personalized Treatment
  109. Anti-infliximab antibody concentrations can guide treatment intensification in patients with Crohn's disease who lose clinical response
  110. Antibodies Toward Vedolizumab Appear from the First Infusion Onward and Disappear Over Time
  111. Practical recommendations for the use of therapeutic drug monitoring of biopharmaceuticals in inflammatory diseases
  112. Current Practices for Therapeutic Drug Monitoring of Biopharmaceuticals in Pediatrics
  113. Therapeutic Drug Monitoring of Biopharmaceuticals May Benefit From Pharmacokinetic and Pharmacokinetic–Pharmacodynamic Modeling
  114. Anti-Infliximab Antibody Concentrations Guide Therapeutic Decision-Making in Patients with Crohn's Disease Losing Clinical Response
  115. Antibodies Towards Vedolizumab Appear from Week 2 Onwards and Disappear upon Treatment
  116. Recent Anti-TNF Exposure Predicts Lower Vedolizumab Trough Concentrations in Patients with Crohn Disease
  117. Blocking α4β7 Integrin Through Vedolizumab: Necessary but not Sufficient?
  118. A Genetic Variation in the Neonatal Fc-Receptor Affects Anti-TNF Drug Concentrations in Inflammatory Bowel Disease
  119. Harmonization of Infliximab and Anti-Infliximab Assays Facilitates the Comparison Between Originators and Biosimilars in Clinical Samples
  120. Sa1943 Variability in Vedolizumab Exposure Between Patients With Inflammatory Bowel Disease
  121. Variability in Golimumab Exposure: A ‘Real-Life’ Observational Study in Active Ulcerative Colitis
  122. Neutralisation of Soluble Tumor Necrosis Factor