All Stories

  1. Plasma Levels of MicroRNA Let-7c-5p May Predict Risk of Acute Chest Syndrome in Patients with Sickle Cell Disease
  2. Connexin channels and hemichannels are modulated differently by charge reversal at residues forming the intracellular pocket
  3. A crystallin mutant cataract with mineral deposits
  4. Pediatric cataracts of different etiologies contain insoluble, calcified particles
  5. Editorial: Ion channels, pumps, and transporters in lens physiology and disease
  6. Loss of fiber cell communication may contribute to the development of cataracts of many different etiologies
  7. Levels and Modifications of Both Lens Fiber Cell Connexins Are Affected in Connexin Mutant Mice
  8. Connexin Mutants Cause Cataracts Through Deposition of Apatite
  9. Cataract-linked serine mutations in the gap junction protein connexin50 expose a sorting signal that promotes its lysosomal degradation
  10. Circulating Small Extracellular Vesicles May Contribute to Vaso-Occlusive Crises in Sickle Cell Disease
  11. Molecular mechanisms underlying enhanced hemichannel function of a cataract-associated Cx50 mutant
  12. Insights image for “Circulating extracellular vesicles from patients with acute chest syndrome disrupt adherens junctions between endothelial cells”
  13. Gap Junctions between Endothelial Cells Are Disrupted by Circulating Extracellular Vesicles from Sickle Cell Patients with Acute Chest Syndrome
  14. Do Connexin Mutants Cause Cataracts by Perturbing Glutathione Levels and Redox Metabolism in the Lens?
  15. Circulating Extracellular Vesicles and Endothelial Damage in Sickle Cell Disease
  16. Connexin Mutants Compromise the Lens Circulation and Cause Cataracts through Biomineralization
  17. ZO-1 Regulates Intercalated Disc Composition and Atrioventricular Node Conduction
  18. Circulating extracellular vesicles from patients with acute chest syndrome disrupt adherens junctions between endothelial cells
  19. The Connexin50D47A Mutant Causes Cataracts by Calcium Precipitation
  20. Connecting Exosomes and Connexins
  21. Chemical chaperone treatment improves levels and distributions of connexins in Cx50D47A mouse lenses
  22. Disruption of the lens circulation causes calcium accumulation and precipitates in connexin mutant mice
  23. Gap junction gene and protein families: Connexins, innexins, and pannexins
  24. Connexins in Cardiovascular and Neurovascular Health and Disease: Pharmacological Implications
  25. Physiological and Optical Alterations Precede the Appearance of Cataracts in Cx46fs380 Mice
  26. Characterization of a variant of gap junction protein α8 identified in a family with hereditary cataract
  27. Mono-Heteromeric Configurations of Gap Junction Channels Formed by Connexin43 and Connexin45 Reduce Unitary Conductance and Determine both Voltage Gating and Metabolic Flux Asymmetry
  28. Exosomes contribute to endothelial integrity and acute chest syndrome risk: Preliminary findings
  29. Gap junction structure: unraveled, but not fully revealed
  30. Intermittent hypoxia causes NOX2-dependent remodeling of atrial connexins
  31. The Cataract-linked Mutant Connexin50D47A Causes Endoplasmic Reticulum Stress in Mouse Lenses
  32. Connexin23 deletion does not affect lens transparency
  33. Are these connexins compatible and does it matter?
  34. The Connexin46 Mutant, Cx46T19M, Causes Loss of Gap Junction Function and Alters Hemi-channel Gating
  35. Connexin40 abnormalities and atrial fibrillation in the human heart
  36. Connexin46fs380 Causes Progressive Cataracts
  37. Degradation of a connexin40 mutant linked to atrial fibrillation is accelerated
  38. Gap Junction Protein Connexin43 Exacerbates Lung Vascular Permeability
  39. Faculty Opinions recommendation of Mix and match: investigating heteromeric and heterotypic gap junction channels in model systems and native tissues.
  40. c-Src Kinase Inhibition Reduces Arrhythmia Inducibility and Connexin43 Dysregulation After Myocardial Infarction
  41. Atrial fibrillation-associated Connexin40 mutants make hemichannels and synergistically form gap junction channels with novel properties
  42. Roles and regulation of lens epithelial cell connexins
  43. Connexin hemichannels in the lens
  44. Connexin50D47A Decreases Levels of Fiber Cell Connexins and Impairs Lens Fiber Cell Differentiation
  45. Faculty Opinions recommendation of Gap junctions and connexin hemichannels underpin hemostasis and thrombosis.
  46. Faculty Opinions recommendation of Connexin 37 limits thrombus propensity by downregulating platelet reactivity.
  47. Faculty Opinions recommendation of Oligomeric structure and functional characterization of Caenorhabditis elegans Innexin-6 gap junction protein.
  48. Faculty Opinions recommendation of Structural and functional similarities of calcium homeostasis modulator 1 (CALHM1) ion channel with connexins, pannexins, and innexins.
  49. A Connexin50 Mutant, CX50fs, That Causes Cataracts Is Unstable, but Is Rescued by a Proteasomal Inhibitor
  50. An MIP/AQP0 mutation with impaired trafficking and function underlies an autosomal dominant congenital lamellar cataract
  51. Connexin Mutants and Cataracts
  52. Interfering amino terminal peptides and functional implications for heteromeric gap junction formation
  53. Erratum: Interfering amino terminal peptides and functional implications for heteromeric gap junction formation
  54. c-Jun N-terminal kinase activation contributes to reduced connexin43 and development of atrial arrhythmias
  55. Faculty Opinions recommendation of Autophagy modulates dynamics of connexins at the plasma membrane in a ubiquitin-dependent manner.
  56. Faculty Opinions recommendation of Internalized gap junctions are degraded by autophagy.
  57. Faculty Opinions recommendation of Lens intracellular hydrostatic pressure is generated by the circulation of sodium and modulated by gap junction coupling.
  58. Faculty Opinions recommendation of LRRC8 proteins share a common ancestor with pannexins, and may form hexameric channels involved in cell-cell communication.
  59. Critical role of the first transmembrane domain of Cx26 in regulating oligomerization and function
  60. Structural organization of intercellular channels II. Amino terminal domain of the connexins: sequence, functional roles, and structure
  61. Cytoplasmic Amino Acids within the Membrane Interface Region Influence Connexin Oligomerization
  62. Inducible Coexpression of Connexin37 or Connexin40 with Connexin43 Selectively Affects Intercellular Molecular Transfer
  63. Faculty Opinions recommendation of Trafficking of gap junction channels at a vertebrate electrical synapse in vivo.
  64. Faculty Opinions recommendation of Cx50 requires an intact PDZ-binding motif and ZO-1 for the formation of functional intercellular channels.
  65. Faculty Opinions recommendation of Molecular dynamics simulations of the Cx26 hemichannel: evaluation of structural models with Brownian dynamics.
  66. Faculty Opinions recommendation of ATP and glutamate released via astroglial connexin 43 hemichannels mediate neuronal death through activation of pannexin 1 hemichannels.
  67. Faculty Opinions recommendation of Phosphatase-resistant gap junctions inhibit pathological remodeling and prevent arrhythmias.
  68. Faculty Opinions recommendation of Nε-lysine acetylation determines dissociation from GAP junctions and lateralization of connexin 43 in normal and dystrophic heart.
  69. Atomic Force Microscopy of Connexin40 Gap Junction Hemichannels Reveals Calcium-dependent Three-dimensional Molecular Topography and Open-Closed Conformations of Both the Extracellular and Cytoplasmic Faces
  70. Different domains are critical for oligomerization compatibility of different connexins
  71. Different consequences of cataract-associated mutations at adjacent positions in the first extracellular boundary of connexin50
  72. Autophagy: a pathway that contributes to connexin degradation
  73. Faculty Opinions recommendation of Thrombin promotes release of ATP from lung epithelial cells through coordinated activation of rho- and Ca2+-dependent signaling pathways.
  74. Faculty Opinions recommendation of Substitution of connexin40 with connexin45 prevents hyperreninemia and attenuates hypertension.
  75. Faculty Opinions recommendation of GJC2 missense mutations cause human lymphedema.
  76. Faculty Opinions recommendation of Ubiquitin-independent proteasomal degradation of endoplasmic reticulum-localized connexin43 mediated by CIP75.
  77. Faculty Opinions recommendation of Ultrastructure and regulation of lateralized connexin43 in the failing heart.
  78. Faculty Opinions recommendation of The carboxyl-terminal domain of connexin43 is a negative modulator of neuronal differentiation.
  79. Faculty Opinions recommendation of Intramolecular loop/tail interactions are essential for connexin 43-hemichannel activity.
  80. Faculty Opinions recommendation of MicroRNA-208a is a regulator of cardiac hypertrophy and conduction in mice.
  81. Faculty Opinions recommendation of A gap junction connexin is required in the vertebrate left-right organizer.
  82. Faculty Opinions recommendation of Gap junction protein Cx37 interacts with endothelial nitric oxide synthase in endothelial cells.
  83. Connexin40 and connexin43 determine gating properties of atrial gap junction channels
  84. A Mutant Connexin50 with Enhanced Hemichannel Function Leads to Cell Death
  85. Faculty Opinions recommendation of Gap junction turnover is achieved by the internalization of small endocytic double-membrane vesicles.
  86. The N Terminus of Connexin37 Contains an α-Helix That Is Required for Channel Function
  87. Faculty Opinions recommendation of ERp29 restricts Connexin43 oligomerization in the endoplasmic reticulum.
  88. Faculty Opinions recommendation of Structure of the connexin 26 gap junction channel at 3.5 A resolution.
  89. The cytoplasmic accumulations of the cataract-associated mutant, Connexin50P88S, are long-lived and form in the endoplasmic reticulum
  90. Oxidative Stress, Lens Gap Junctions, and Cataracts
  91. The Family of Connexin Genes
  92. An intact connexin N-terminus is required for function but not gap junction formation
  93. Faculty Opinions recommendation of Endothelial adherens junctions control tight junctions by VE-cadherin-mediated upregulation of claudin-5.
  94. Cataracts Are Caused by Alterations of a Critical N-Terminal Positive Charge in Connexin50
  95. Faculty Opinions recommendation of Prediction of membrane-protein topology from first principles.
  96. Faculty Opinions recommendation of Enhancement of ventricular gap-junction coupling by rotigaptide.
  97. Cx30.2 can form heteromeric gap junction channels with other cardiac connexins
  98. Faculty Opinions recommendation of Mutation in a novel connexin-like gene (Gjf1) in the mouse affects early lens development and causes a variable small-eye phenotype.
  99. Faculty Opinions recommendation of Gap junction channels exhibit connexin-specific permeability to cyclic nucleotides.
  100. Faculty Opinions recommendation of Gap junction adhesion is necessary for radial migration in the neocortex.
  101. Faculty Opinions recommendation of Analysis of Connexin43 phosphorylated at S325, S328 and S330 in normoxic and ischemic heart.
  102. Faculty Opinions recommendation of Translocation of connexin 43 to the inner mitochondrial membrane of cardiomyocytes through the heat shock protein 90-dependent TOM pathway and its importance for cardioprotection.
  103. Faculty Opinions recommendation of A Gja1 missense mutation in a mouse model of oculodentodigital dysplasia.
  104. Faculty Opinions recommendation of The conditional connexin43G138R mouse mutant represents a new model of hereditary oculodentodigital dysplasia in humans.
  105. A novel connexin50 mutation associated with congenital nuclear pulverulent cataracts
  106. Faculty Opinions recommendation of The muscle-specific microRNA miR-1 regulates cardiac arrhythmogenic potential by targeting GJA1 and KCNJ2.
  107. Faculty Opinions recommendation of Relative contributions of connexins 40 and 43 to atrial impulse propagation in synthetic strands of neonatal and fetal murine cardiomyocytes.
  108. Transgenic overexpression of connexin50 induces cataracts
  109. Connexin43 increases the sensitivity of prostate cancer cells to TNFα-induced apoptosis
  110. Faculty Opinions recommendation of Pannexin 1 in erythrocytes: function without a gap.
  111. Faculty Opinions recommendation of Pannexin-1 mediates large pore formation and interleukin-1beta release by the ATP-gated P2X7 receptor.
  112. Faculty Opinions recommendation of Somatic mutations in the connexin 40 gene (GJA5) in atrial fibrillation.
  113. Faculty Opinions recommendation of Mefloquine effects on the lens suggest cooperative gating of gap junction channels.
  114. Faculty Opinions recommendation of Coupling between A-type horizontal cells is mediated by connexin 50 gap junctions in the rabbit retina.
  115. Faculty Opinions recommendation of Structural determinants for the differences in voltage gating of chicken Cx56 and Cx45.6 gap-junctional hemichannels.
  116. Faculty Opinions recommendation of Ischemia opens neuronal gap junction hemichannels.
  117. N-terminal residues in Cx43 and Cx40 determine physiological properties of gap junction channels, but do not influence heteromeric assembly with each other or with Cx26
  118. Faculty Opinions recommendation of Connexin30.2 containing gap junction channels decelerate impulse propagation through the atrioventricular node.
  119. An Aberrant Sequence in a Connexin46 Mutant Underlies Congenital Cataracts
  120. Faculty Opinions recommendation of Connexin-specific cell-to-cell transfer of short interfering RNA by gap junctions.
  121. Faculty Opinions recommendation of Cross-presentation by intercellular peptide transfer through gap junctions.
  122. Connexin43 with a cytoplasmic loop deletion inhibits the function of several connexins
  123. A novel GJA8 mutation is associated with autosomal dominant lamellar pulverulent cataract: further evidence for gap junction dysfunction in human cataract
  124. Faculty Opinions recommendation of Impaired permeability to Ins(1,4,5)P3 in a mutant connexin underlies recessive hereditary deafness.
  125. Faculty Opinions recommendation of Defining a minimal motif required to prevent connexin oligomerization in the endoplasmic reticulum.
  126. Dynamic model for ventricular junctional conductance during the cardiac action potential
  127. Transcriptional regulation of the murine promoter by cardiac factors Nkx2-5, GATA4 and Tbx5
  128. Polyvalent Cations Constitute the Voltage Gating Particle in Human Connexin37 Hemichannels
  129. Faculty Opinions recommendation of A Calpha model for the transmembrane alpha helices of gap junction intercellular channels.
  130. Faculty Opinions recommendation of The novel mouse connexin39 gene is expressed in developing striated muscle fibers.
  131. Faculty Opinions recommendation of Defective epidermal barrier in neonatal mice lacking the C-terminal region of connexin43.
  132. Highly restricted pattern of connexin36 expression in chick somite development
  133. Faculty Opinions recommendation of CCN3 (NOV) interacts with connexin43 in C6 glioma cells: possible mechanism of connexin-mediated growth suppression.
  134. Adenoviral delivery of human connexin37 induces endothelial cell death through apoptosis
  135. Amino terminal glutamate residues confer spermine sensitivity and affect voltage gating and channel conductance of rat connexin40 gap junctions
  136. Connexin43 and connexin26 form gap junctions, but not heteromeric channels in co-expressing cells
  137. Pathways for degradation of connexins and gap junctions
  138. Faculty Opinions recommendation of Gap junction channel protein innexin 2 is essential for epithelial morphogenesis in the Drosophila embryo.
  139. Faculty Opinions recommendation of Drebrin is a novel connexin-43 binding partner that links gap junctions to the submembrane cytoskeleton.
  140. Faculty Opinions recommendation of A transient diffusion model yields unitary gap junctional permeabilities from images of cell-to-cell fluorescent dye transfer between Xenopus oocytes.
  141. Faculty Opinions recommendation of Single-channel SCAM identifies pore-lining residues in the first extracellular loop and first transmembrane domains of Cx46 hemichannels.
  142. Faculty Opinions recommendation of A tyrosine-based sorting signal is involved in connexin43 stability and gap junction turnover.
  143. Faculty Opinions recommendation of Replacement of connexin40 by connexin45 in the mouse: impact on cardiac electrical conduction.
  144. Faculty Opinions recommendation of Pharmacological modulation of cardiac gap junctions to enhance cardiac conduction: evidence supporting a novel target for antiarrhythmic therapy.
  145. Faculty Opinions recommendation of Molecular basis of calcium regulation in connexin-32 hemichannels.
  146. Faculty Opinions recommendation of Pannexins, a family of gap junction proteins expressed in brain.
  147. Homomeric and Heteromeric Gap Junctions
  148. Plasma Membrane Channels Formed by Connexins: Their Regulation and Functions
  149. Faculty Opinions recommendation of Impulse propagation in synthetic strands of neonatal cardiac myocytes with genetically reduced levels of connexin43.
  150. Faculty Opinions recommendation of Expression of genes involved in vascular development and angiogenesis in endothelial cells of adult lung.
  151. A Carboxyl Terminal Domain of Connexin43 Is Critical for Gap Junction Plaque Formation but not for Homo- or Hetero-Oligomerization
  152. Loss of function and impaired degradation of a cataract-associated mutant connexin50
  153. Faculty Opinions recommendation of Connexin43 phosphorylation at S368 is acute during S and G2/M and in response to protein kinase C activation.
  154. New Developments in the Gap Junction Field: Report from the 2002 ASCB Meeting
  155. A Carboxyl Terminal Domain of Connexin43 Is Critical for Gap Junction Plaque Formation but not for Homo- or Hetero-Oligomerization
  156. Gap Junction Synthesis and Degradation as Therapeutic Targets
  157. Cardiac Gap Junction Channels Show Quantitative Differences in Selectivity
  158. Connexin43 and Connexin45 Form Heteromeric Gap Junction Channels in Which Individual Components Determine Permeability and Regulation
  159. Functional Role of the Carboxyl Terminal Domain of Human Connexin 50 in Gap Junctional Channels
  160. Redistribution of connexin45 in gap junctions of connexin43-deficient hearts
  161. Cardiovascular Connexins: Molecular Composition and Biochemical Regulation
  162. Heterotypic Docking of Cx43 and Cx45 Connexons Blocks Fast Voltage Gating of Cx43
  163. Heteromeric Mixing of Connexins: Compatibility of Partners and Functional Consequences
  164. Mouse Connexin 45: Genomic Cloning and Exon Usage
  165. Functional Expression and Biophysical Properties of Polymorphic Variants of the Human Gap Junction Protein Connexin37
  166. Mouse connexin37: gene structure and promoter analysis
  167. Gap junctions in the chicken pineal gland
  168. Connexin and Gap Junction Degradation
  169. Functional Expression and Biochemical Characterization of an Epitope-Tagged Connexin37
  170. Gap junction genes and their regulation
  171. Heterogeneous Localization of Connexin40 in the Renal Vasculature
  172. Cultured Chicken Embryo Lens Cells Resemble Differentiating Fiber Cells in vivo and Contain Two Kinetic Pools of Connexin56
  173. Chapter 2: Degradation of Gap Junctions and Connexins
  174. Effects of angiotensin II on expression of the gap junction channel protein connexin43 in neonatal rat ventricular myocytes
  175. Proteolysis of connexin43-containing gap junctions in normal and heat-stressed cardiac myocytes
  176. Cardiovascular Gap Junction Proteins: Molecular Characterization and Biochemical Regulation
  177. Regulation of connexin43 expression and function by prostaglandin E2 (PGE2) and parathyroid hormone (PTH) in osteoblastic cells
  178. Degradation of Connexin43 Gap Junctions Involves both the Proteasome and the Lysosome
  179. Mouse Connexin40: Gene Structure and Promoter Analysis
  180. The Gap-Junction Protein Connexin 56 is Phosphorylated in the Intracellular Loop and the Carboxy-Terminal Region
  181. Rat uterine myometrium contains the gap junction protein connexin45, which has a differing temporal expression pattern from connexin43
  182. Expression of Zebrafish connexin43.4 in the Notochord and Tail Bud of Wild-Type and Mutant no tail Embryos
  183. Reply to the Editor
  184. The extent of heterocellular communication mediated by gap junctions is predictive of bystander tumor cytotoxicity in vitro.
  185. The Gap Junction Protein Connexin43 Is Degraded via the Ubiquitin Proteasome Pathway
  186. Gap Junction Protein Phenotypes of the Human Heart and Conduction System
  187. Transfected connexin45 alters gap junction permeability in cells expressing endogenous connexin43.
  188. Structural and molecular determinants of intercellular coupling in cardiac myocytes
  189. The Molecular Basis of Anisotropy: Role of Gap Junctions
  190. Modulation of Connexin43 Expression:.
  191. Localization and distribution of gap junctions in normal and cardiomyopathic hamster heart
  192. Distinct gap junction protein phenotypes in cardiac tissues with disparate conduction properties
  193. Molecular Cloning of Two Human Cardiac Gap Junction Proteins, Connexin40 and Connexin45
  194. Expression patterns of mRNAs for the gap junction proteins connexin43 and connexin42 suggest their involvement in chick limb morphogenesis and specification of the arterial vasculature
  195. Differential expression of gap junction connexins in endocrine and exocrine glands.
  196. Differential expression of gap junction connexins in endocrine and exocrine glands
  197. Molecular and biophysical properties of the connexins from developing chick heart
  198. Connexins, gap-junction proteins, and ATP-induced pores in macrophages
  199. Expression of multiple connexins by cells of the cardiovascular system and lens
  200. Distribution of gap junctions in dog and rat ventricle studied with a double-label technique
  201. Molecular cloning and expression of rat connexin40, a gap junction protein expressed in vascular smooth muscle
  202. Cardiac myocyte interconnections at gap junctions
  203. Zygotic expression of the connexin43 gene supplies subunits for gap junction assembly during mouse preimplantation development
  204. In vivo modulation of connexin 43 gene expression and junctional coupling of pancreatic B-cells
  205. Connexin family of gap junction proteins
  206. Expression of the gap junction protein connexin43 in embryonic chick lens: Molecular cloning, ultrastructural localization, and post-translational phosphorylation
  207. Phosphorylation of connexin43 gap junction protein in uninfected and Rous sarcoma virus-transformed mammalian fibroblasts.
  208. Differential expression of three gap junction proteins in developing and mature brain tissues.
  209. Formation of gap junctions by expression of connexins in Xenopus oocyte pairs
  210. Normal long-term survival with α-thalassemia
  211. Monocyte bone degradation: In vitro analysis of monocyte activity in patients with juvenile rheumatoid arthritis
  212. Endogenous lectins in chickens and slime molds: Transfer from intracellular to extracellular sites
  213. Lectins from chicken tissues are mitogenic for Thy-1 negative murine spleen cells
  214. Chicken tissue binding sites for a purified chicken lectin
  215. Muscle development in vitro following X irradiation
  216. Developmentally regulated lectins from chick muscle, brain, and liver have similar chemical and immunological properties