All Stories

  1. Dural ectopic lymphatic structures accumulate during aging and exhibit dysregulation in neurodegenerative diseases

    Article • Proceedings of the National Academy of Sciences, August 2025, Proceedings of the National Academy of Sciences

    Dr. Eitan Okun

  2. Intermittent Fasting Reprograms Chromatin Accessibility to Modulate Gene Expression in Brain and Muscle

    Article • February 2025, Cold Spring Harbor Laboratory Press

    Dr. Eitan Okun

  3. CD8+ T cells exacerbate AD-like symptoms in mouse model of amyloidosis

    Article • Brain Behavior and Immunity, November 2024, Elsevier

    Dr. Eitan Okun

  4. Unbiased analysis of spatial learning strategies in a modified Barnes maze using convolutional neural networks

    Article • Scientific Reports, July 2024, Springer Science + Business Media

    Dr. Eitan Okun

  5. Unraveling the molecular basis of cannabidiolic acid methyl Ester's anti-depressive effects in a rat model of treatment-resistant depression

    Article • Journal of Psychiatric Research, July 2024, Elsevier

    Dr. Eitan Okun

  6. Neuronal deletion of Gtf2i results in developmental microglial alterations in a mouse model related to Williams syndrome

    Article • Glia, March 2024, Wiley

    Dr. Eitan Okun

  7. Neural correlates of subjective cognitive decline in adults at high risk for Alzheimer’s disease

    Article • Frontiers in Aging Neuroscience, February 2023, Frontiers

    Dr. Eitan Okun

  8. Early diagnosis and treatment of Alzheimer’s disease by targeting toxic soluble Aβ oligomers

    Article • Proceedings of the National Academy of Sciences, November 2022, Proceedings of the National Academy of Sciences

    Prof. Shai Rahimipour, Dr. Eitan Okun

  9. Corrigendum to “Physiology and pharmacology of amyloid precursor protein” [Pharmacology & Therapeutics Volume 235(2022) 108122

    Article • Pharmacology & Therapeutics, October 2022, Elsevier

    Dr. Eitan Okun

  10. Sleeve Gastrectomy Reduces Glycemia but Does Not Affect Cognitive Impairment in Lean 5xFAD Mice

    Article • Frontiers in Neuroscience, August 2022, Frontiers

    Dr. Eitan Okun

  11. Physiology and pharmacology of amyloid precursor protein

    Article • Pharmacology & Therapeutics, July 2022, Elsevier

    Dr. Eitan Okun

  12. HCAR1-Mediated l-Lactate Signaling Suppresses Microglial Phagocytosis

    Article • NeuroMolecular Medicine, April 2022, Springer Science + Business Media

    Dr. Eitan Okun

  13. Integrative epigenomic and transcriptomic analyses reveal metabolic switching by intermittent fasting in brain

    Article • GeroScience, March 2022, Springer Science + Business Media

    Dr. Eitan Okun

  14. COVID-19 Vaccination of Individuals with Down Syndrome—Data from the Trisomy 21 Research Society Survey on Safety, Efficacy, and Factors Associated with the Decision to Be Vaccinated

    Article • Vaccines, March 2022, MDPI AG

    Brian Chicoine, Dr. Eitan Okun

  15. Induction of an effective anti-Amyloid-β humoral response in aged mice

    Article • Vaccine, August 2021, Elsevier

    Dr. Eitan Okun

  16. Immune Dysregulation and the Increased Risk of Complications and Mortality Following Respiratory Tract Infections in Adults With Down Syndrome

    Article • Frontiers in Immunology, June 2021, Frontiers

    Dr. Eitan Okun

  17. Correction to: Specific Susceptibility to COVID-19 in Adults with Down Syndrome

    Article • NeuroMolecular Medicine, May 2021, Springer Science + Business Media

    Dr. Eitan Okun

  18. Adult Hippocampal Neurogenesis: One Lactate to Rule Them All

    Article • NeuroMolecular Medicine, April 2021, Springer Science + Business Media

    Dr. Eitan Okun

  19. Therapeutic B-cell depletion reverses progression of Alzheimer’s disease

    Article • Nature Communications, April 2021, Springer Science + Business Media

    Dr. Eitan Okun

  20. Maternal antibodies facilitate Amyloid-β clearance by activating Fc-receptor-Syk-mediated phagocytosis

    Article • Communications Biology, March 2021, Springer Science + Business Media

    Dr. Eitan Okun

  21. Specific Susceptibility to COVID-19 in Adults with Down Syndrome

    Article • NeuroMolecular Medicine, March 2021, Springer Science + Business Media

    Dr. Eitan Okun

  22. High-Intensity Functional Training: Molecular Mechanisms and Benefits

    Article • NeuroMolecular Medicine, January 2021, Springer Science + Business Media

    Dr. Eitan Okun

  23. Mild Physical Activity Does Not Improve Spatial Learning in a Virtual Environment

    Article • Frontiers in Behavioral Neuroscience, November 2020, Frontiers

    Dr. Eitan Okun

  24. Designed proteinoid polymers and nanoparticles encapsulating risperidone for enhanced antipsychotic activity

    Article • Journal of Nanobiotechnology, October 2020, Springer Science + Business Media

    Dr. Eitan Okun

  25. The Effects of High-intensity Functional Training (HIFT) on Spatial Learning, Visual Pattern Separation and Attention Span in Adolescents

    Article • Frontiers in Behavioral Neuroscience, September 2020, Frontiers

    Dr. Eitan Okun

  26. A Tellurium-Based Small Immunomodulatory Molecule Ameliorates Depression-Like Behavior in Two Distinct Rat Models

    Article • NeuroMolecular Medicine, July 2020, Springer Science + Business Media

    Dr. Eitan Okun

  27. Food and Age: It Takes Two to Degenerate

    Article • Frontiers in Aging Neuroscience, June 2020, Frontiers

    Dr. Eitan Okun

  28. A modified Barnes maze for an accurate assessment of spatial learning in mice

    Article • Journal of Neuroscience Methods, January 2020, Elsevier

    Dr. Eitan Okun

  29. L-Lactate Promotes Adult Hippocampal Neurogenesis

    Article • Frontiers in Neuroscience, May 2019, Frontiers

    Dr. Eitan Okun

  30. Extracellular DAMPs in Plants and Mammals: Immunity, Tissue Damage and Repair

    Article • Trends in Immunology, November 2018, Elsevier

    Dr. Eitan Okun

  31. The Toll Pathway in the Central Nervous System of Flies and Mammals

    Article • NeuroMolecular Medicine, October 2018, Springer Science + Business Media

    Dr. Eitan Okun

  32. Restoring microglial and astroglial homeostasis using DNA immunization in a Down Syndrome mouse model

    Article • Brain Behavior and Immunity, October 2018, Elsevier

    Dr. Eitan Okun

  33. Dopamine receptors in the rat entopeduncular nucleus

    Article • Brain Structure and Function, March 2018, Springer Science + Business Media

    Dr. Eitan Okun

  34. Deficiency of Toll-like receptors 2, 3 or 4 extends life expectancy in Huntington’s disease mice

    Article • Heliyon, January 2018, Elsevier

    Dr. Eitan Okun

  35. A protocol for quantitative analysis of murine and human amyloid-β1-40 and 1-42

    Article • Journal of Neuroscience Methods, November 2017, Elsevier

    Dr. Eitan Okun

  36. Dopaminergic Modulation of Synaptic Integration and Firing Patterns in the Rat Entopeduncular Nucleus

    Article • Journal of Neuroscience, June 2017, Society for Neuroscience

    Dr. Eitan Okun

  37. Sirt6 alters adult hippocampal neurogenesis

    Article • PLOS One, June 2017, PLOS

    Dr. Eitan Okun

  38. The Effect of Nanoparticle Size on the Ability to Cross the Blood–Brain Barrier: An In Vivo Study

    Article • Nanomedicine, June 2017, Taylor & Francis

    Dr. Eitan Okun

  39. Toll-like receptor 3 deficiency decreases epileptogenesis in a pilocarpine model of SE-induced epilepsy in mice

    Article • Epilepsia, February 2017, Wiley

    Dr. Eitan Okun

  40. Unbiased classification of spatial strategies in the Barnes maze

    Article • Bioinformatics, July 2016, Oxford University Press (OUP)

    Dr. Eitan Okun

  41. Inflammation, Lifestyle and Chronic Diseases

    Article • April 2016, Taylor & Francis

    Dr. Eitan Okun

  42. Unraveling cognitive traits using the Morris water maze unbiased strategy classification (MUST-C) algorithm

    Article • Brain Behavior and Immunity, February 2016, Elsevier

    Dr. Eitan Okun

  43. Corrigendum to “Unraveling cognitive traits using the Morris water maze unbiased strategy classification (MUST-C) algorithm” [Brain Behav. Immun. 52C (2016) 132–144]

    Article • Brain Behavior and Immunity, February 2016, Elsevier

    Dr. Eitan Okun

  44. DAMPs as mediators of sterile inflammation in aging-related pathologies

    Article • Ageing Research Reviews, November 2015, Elsevier

    Dr. Eitan Okun

  45. Postnatal TLR2 activation impairs learning and memory in adulthood

    Article • Brain Behavior and Immunity, August 2015, Elsevier

    Dr. Eitan Okun

  46. No ECSIT-stential evidence for a link with Alzheimer's disease yet (retrospective on DOI 10.1002/bies.201100193)

    Article • BioEssays, November 2014, Wiley

    Dr. Eitan Okun

  47. Cardiovascular Fitness and Cognitive Spatial Learning in Rodents and in Humans

    Article • The Journals of Gerontology Series A, September 2014, Oxford University Press (OUP)

    Dr. Eitan Okun

  48. Toll-like receptors as developmental tools that regulate neurogenesis during development: an update

    Article • Frontiers in Neuroscience, August 2014, Frontiers

    Dr. Eitan Okun

  49. Pancreatic polypeptide inhibits somatostatin secretion

    Article • FEBS Letters, July 2014, Wiley

    Dr. Eitan Okun

  50. A heavy toll on the outcome of ischemic brain stroke

    Article • Experimental Neurology, April 2014, Elsevier

    Dr. Eitan Okun

  51. Toll-like receptors 2 and 4 modulate autonomic control of heart rate and energy metabolism

    Article • Brain Behavior and Immunity, February 2014, Elsevier

    Dr. Eitan Okun, Professor Stuart Maudsley

  52. Evidence that collaboration between HIF-1α and Notch-1 promotes neuronal cell death in ischemic stroke

    Article • Neurobiology of Disease, February 2014, Elsevier

    Dr. Eitan Okun

  53. Tellurium Compound AS101 Ameliorates Experimental Autoimmune Encephalomyelitis by VLA-4 Inhibition and Suppression of Monocyte and T Cell Infiltration into the CNS

    Article • NeuroMolecular Medicine, November 2013, Springer Science + Business Media

    Dr. Eitan Okun

  54. Opposing actions of environmental enrichment and Alzheimer’s disease on the expression of hippocampal microRNAs in mouse models

    Article • Translational Psychiatry, September 2013, Nature

    Dr. Eitan Okun

  55. A ketone ester diet exhibits anxiolytic and cognition-sparing properties, and lessens amyloid and tau pathologies in a mouse model of Alzheimer's disease

    Article • Neurobiology of Aging, June 2013, Elsevier

    Dr. Eitan Okun

  56. Neuron-Specific Expression of Tomosyn1 in the Mouse Hippocampal Dentate Gyrus Impairs Spatial Learning and Memory

    Article • NeuroMolecular Medicine, March 2013, Springer Science + Business Media

    Dr. Eitan Okun

  57. Dietary energy intake modifies brainstem autonomic dysfunction caused by mutant α-synuclein

    Article • Neurobiology of Aging, March 2013, Elsevier

    Dr. Eitan Okun

  58. Effects of cerium oxide nanoparticles on the growth of keratinocytes, fibroblasts and vascular endothelial cells in cutaneous wound healing

    Article • Biomaterials, March 2013, Elsevier

    Dr. Eitan Okun

  59. Involvement of PGC-1α in the formation and maintenance of neuronal dendritic spines

    Article • Nature Communications, December 2012, Nature

    Dr. Eitan Okun

  60. Evidence for a Developmental Role for TLR4 in Learning and Memory

    Article • PLOS One, October 2012, PLOS

    Dr. Eitan Okun

  61. Aberrant heart rate and brainstem brain-derived neurotrophic factor (BDNF) signaling in a mouse model of Huntington's disease

    Article • Neurobiology of Aging, July 2012, Elsevier

    Dr. Eitan Okun

  62. The Tellurium compound, AS101, increases SIRT1 level and activity and prevents type 2 diabetes

    Article • Aging, June 2012, Impact Journals, LLC

    Dr. Eitan Okun

  63. DNA immunization with HBsAg-based particles expressing a B cell epitope of amyloid β-peptide attenuates disease progression and prolongs survival in a mouse model of Alzheimer's disease

    Article • Vaccine, February 2012, Elsevier

    Dr. Eitan Okun

  64. Roles of Innate Immunity and Inflammation in the Aging Brain

    Article • July 2011, Taylor & Francis

    Dr. Eitan Okun

  65. Toll-like receptor signaling in neural plasticity and disease

    Article • Trends in Neurosciences, May 2011, Elsevier

    Dr. Eitan Okun

  66. Evidence for Altered Numb Isoform Levels in Alzheimer's Disease Patients and a Triple Transgenic Mouse Model

    Article • Journal of Alzheimer’s Disease, April 2011, IOS Press

    Dr. Eitan Okun

  67. Electroconvulsive shock ameliorates disease processes and extends survival in huntingtin mutant mice

    Article • Human Molecular Genetics, March 2011, Oxford University Press (OUP)

    Dr. Eitan Okun

  68. Electroconvulsive shock ameliorates disease processes and extends survival in huntingtin mutant mice

    Article • Human Molecular Genetics, November 2010, Oxford University Press (OUP)

    Dr. Eitan Okun

  69. GLP-1 receptor stimulation depresses heart rate variability and inhibits neurotransmission to cardiac vagal neurons

    Article • Cardiovascular Research, August 2010, European Society of Cardiology

    Dr. Eitan Okun

  70. Toll-like receptor 3 inhibits memory retention and constrains adult hippocampal neurogenesis

    Article • Proceedings of the National Academy of Sciences, August 2010, Proceedings of the National Academy of Sciences

    Dr. Eitan Okun

  71. Evidence that adiponectin receptor 1 activation exacerbates ischemic neuronal death

    Article • Experimental & Translational Stroke Medicine, August 2010, Springer Science + Business Media

    Dr. Eitan Okun

  72. TLR2 activation inhibits embryonic neural progenitor cell proliferation

    Article • Journal of Neurochemistry, June 2010, Wiley

    Dr. Eitan Okun

  73. Tomosyn Expression Pattern in the Mouse Hippocampus Suggests Both Presynaptic and Postsynaptic Functions

    Article • Frontiers in Neuroanatomy, January 2010, Frontiers

    Dr. Eitan Okun

  74. Involvement of Fc Receptors in Disorders of the Central Nervous System

    Article • NeuroMolecular Medicine, October 2009, Springer Science + Business Media

    Dr. Eitan Okun

  75. The Therapeutic Potential of microRNAs in Nervous System Damage, Degeneration, and Repair

    Article • NeuroMolecular Medicine, September 2009, Springer Science + Business Media

    Dr. Eitan Okun

  76. Adhesion- and migration-related side effects of phosphothioated CpG oligodeoxynucleotides

    Article • Cell Adhesion & Migration, July 2009, Taylor & Francis

    Dr. Eitan Okun

  77. TOLL-LIKE RECEPTORS IN ISCHEMIA-REPERFUSION INJURY

    Article • Shock, July 2009, Wolters Kluwer Health

    Dr. Eitan Okun

  78. Toll-like receptors in neurodegeneration

    Article • Brain Research Reviews, March 2009, Elsevier

    Dr. Eitan Okun

  79. Phosphothioated oligodeoxynucleotides induce nonspecific effects on neuronal cell adhesion in a growth substrate‐dependent manner

    Article • Journal of Neuroscience Research, January 2009, Wiley

    Dr. Eitan Okun

  80. Neuronal Vulnerability to Oxidative Damage in Aging

    Article • January 2009, Springer Science + Business Media

    Dr. Eitan Okun

  81. Basis of Ionic Dysregulation in Cerebral Ischemia

    Article • January 2009, Springer Science + Business Media

    Dr. Eitan Okun

  82. Rapamycin and curcumin induce apoptosis in primary resting B chronic lymphocytic leukemia cells

    Article • Leukemia & Lymphoma, January 2009, Taylor & Francis

    Dr. Eitan Okun

  83. The organotellurium compound ammonium trichloro(dioxoethylene‐o,o′)tellurate reacts with homocysteine to form homocystine and decreases homocysteine levels in hyperhomocysteinemic mice

    Article • European Journal of Biochemistry, May 2007, Wiley

    Dr. Eitan Okun

  84. The organotellurium compound ammonium trichloro(dioxoethylene‐0,0′) tellurate enhances neuronal survival and improves functional outcome in an ischemic stroke model in mice

    Article • Journal of Neurochemistry, March 2007, Wiley

    Dr. Eitan Okun

  85. Novel Involvement of the Immunomodulator AS101 in IL‐10 Signaling, via the Tyrosine Kinase Fer

    Article • Annals of the New York Academy of Sciences, January 2007, Wiley

    Dr. Eitan Okun

  86. Gamma secretase–mediated Notch signaling worsens brain damage and functional outcome in ischemic stroke

    Article • Nature Reports Stem Cells, May 2006, Nature

    Dr. Eitan Okun

  87. Experimental handling stress as infection-facilitating factor for the goldfish ulcerative disease

    Article • Veterinary Immunology and Immunopathology, February 2006, Elsevier

    Dr. Eitan Okun

  88. Upregulation of carp GDNF mRNA by the immunomodulator AS101

    Article • Developmental & Comparative Immunology, January 2006, Elsevier

    Dr. Eitan Okun