All Stories

  1. 4-Phenylbutyrate protects against atherosclerotic lesion growth by increasing the expression of HSP25 in macrophages and in the circulation of Apoe−/− mice

    Article • The FASEB Journal, July 2019, Federation of American Societies For Experimental Biology (FASEB)

    Dr Ed O'Brien

  2. Characterization of heat shock protein 27 in extracellular vesicles: a potential anti-inflammatory therapy

    Article • The FASEB Journal, February 2019, Federation of American Societies For Experimental Biology (FASEB)

    Dr Ed O'Brien

  3. Heat shock protein-27 and sex-selective regulation of muscarinic and proteinase-activated receptor 2-mediated vasodilatation: differential sensitivity to endothelial NOS inhibition

    Article • British Journal of Pharmacology, April 2018, Wiley

    Dr Vivek Krishna Pulakazhi Venu, Dr Ed O'Brien

  4. Recombinant heat shock protein 27 (HSP27/HSPB1) protects against cadmium-induced oxidative stress and toxicity in human cervical cancer cells

    Article • Cell Stress and Chaperones, March 2017, Springer Science + Business Media

    Dr Ed O'Brien

  5. Reverse Cholesterol Transport is increased by Heat Shock Protein 27

    Article • The FASEB Journal, February 2017, Federation of American Societies For Experimental Biology (FASEB)

    Dr Ed O'Brien, Dr Vivek Krishna Pulakazhi Venu

  6. Extracellular Release and Signaling by Heat Shock Protein 27: Role in Modifying Vascular Inflammation

    Article • Frontiers in Immunology, July 2016, Frontiers

    Dr Ed O'Brien

  7. Impact of Center Experience on Patient Radiation Exposure During Transradial Coronary Angiography and Percutaneous Intervention: A Patient‐Level, International, Collaborative, Multi‐Center Analysis

    Article • Journal of the American Heart Association, May 2016, Wolters Kluwer Health

    Dr Ed O'Brien

  8. Platelet reactivity following high loading doses of clopidogrel in patients undergoing primary percutaneous coronary angioplasty: A pilot study

    Article • Clinical Trials and Regulatory Science in Cardiology, October 2015, Elsevier

    Dr Ed O'Brien

  9. Clinical outcomes among patients with extreme obesity undergoing elective coronary revascularization: Evaluation of major complications in contemporary practice

    Article • International Journal of Cardiology, May 2015, Elsevier

    Dr Ed O'Brien

  10. The Effects of Knockdown of Rho-Associated Kinase 1 and Zipper-Interacting Protein Kinase on Gene Expression and Function in Cultured Human Arterial Smooth Muscle Cells

    Article • PLoS ONE, February 2015, PLOS

    Dr Ed O'Brien

  11. Recommendations concerning the new U.S. National Institutes of Health initiative to balance the sex of cells and animals in preclinical research

    Article • The FASEB Journal, February 2015, Federation of American Societies For Experimental Biology (FASEB)

    Dr Ed O'Brien, Executive Director, The Hormel Institute Robert Clarke

  12. Role of Mutation and Pharmacologic Block of Human KCNH2 in Vasculogenesis and Fetal Mortality: Partial Rescue by Transforming Growth Factor- 

    Article • Circulation Arrhythmia and Electrophysiology, February 2015, Wolters Kluwer Health

    Dr Ed O'Brien

  13. Granulocyte colony-stimulating factor therapy for stem cell mobilization following anterior wall myocardial infarction: the CAPITAL STEM MI randomized trial

    Article • Canadian Medical Association Journal, June 2014, Canadian Medical Association (CMA)

    Dr Ed O'Brien

  14. A Novel Stretching Platform for Applications in Cell and Tissue Mechanobiology

    Article • Journal of Visualized Experiments, June 2014, MyJove Corporation

    Dr Ed O'Brien

  15. Circulating Endothelial Progenitor Cells and In-Stent Restenosis: Friend, Foe, or None of the Above?

    Article • Canadian Journal of Cardiology, January 2014, Elsevier

    Dr Ed O'Brien

  16. Giant Saphenous Vein Graft Aneurysm Presenting as ST-Elevation Myocardial Infarction

    Article • Circulation Journal, January 2014, Japanese Circulation Society

    Dr Ed O'Brien

  17. The Evolution of Coronary Stents: A Brief Review

    Article • Canadian Journal of Cardiology, January 2014, Elsevier

    Dr Ed O'Brien

  18. Glycogen Synthase Kinase-3  Inhibition Augments Diabetic Endothelial Progenitor Cell Abundance and Functionality via Cathepsin B: A Novel Therapeutic Opportunity for Arterial Repair

    Article • Diabetes, December 2013, American Diabetes Association

    Dr Ed O'Brien

  19. Heat shock protein-27 attenuates foam cell formation and atherogenesis by down-regulating scavenger receptor-A expression via NF-κB signaling

    Article • Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids, December 2013, Elsevier

    Dr Ed O'Brien

  20. The Effect of Statins on Circulating Endothelial Progenitor Cells in Humans

    Article • Journal of Cardiovascular Pharmacology, November 2013, Wolters Kluwer Health

    Dr Ed O'Brien

  21. Heat shock protein 27 attenuates neointima formation and accelerates reendothelialization after arterial injury and stent implantation: importance of vascular endothelial growth factor up-regulation

    Article • The FASEB Journal, October 2013, Federation of American Societies For Experimental Biology (FASEB)

    Dr Ed O'Brien

  22. Serum Heat Shock Protein 27 Levels Represent a Potential Therapeutic Target for Atherosclerosis

    Article • Journal of the American College of Cardiology, October 2013, Elsevier

    Dr Ed O'Brien

  23. Circulating endothelial progenitor cells in HIV infection: A systematic review

    Article • Trends in Cardiovascular Medicine, August 2013, Elsevier

    Dr Ed O'Brien

  24. Percutaneous coronary intervention with or without on-site coronary artery bypass surgery: A systematic review and meta-analysis

    Article • International Journal of Cardiology, July 2013, Elsevier

    Dr Ed O'Brien

  25. Response to Letter Regarding Article, "Bivalirudin for Primary Percutaneous Coronary Interventions: Outcome Assessment in the Ottawa STEMI Registry"

    Article • Circulation Cardiovascular Interventions, April 2013, Wolters Kluwer Health

    Dr Ed O'Brien

  26. Neuroimmune Guidance Cue Semaphorin 3E Is Expressed in Atherosclerotic Plaques and Regulates Macrophage Retention

    Article • Arteriosclerosis Thrombosis and Vascular Biology, February 2013, Wolters Kluwer Health

    Dr Ed O'Brien

  27. Chronic Over-Expression of Heat Shock Protein 27 Attenuates Atherogenesis and Enhances Plaque Remodeling: A Combined Histological and Mechanical Assessment of Aortic Lesions

    Article • PLoS ONE, February 2013, PLOS

    Dr Ed O'Brien

  28. Bivalirudin for Primary Percutaneous Coronary Interventions: Outcome Assessment in the Ottawa STEMI Registry

    Article • Circulation Cardiovascular Interventions, November 2012, Wolters Kluwer Health

    Dr Ed O'Brien

  29. Natural History and Management of Aortocoronary Saphenous Vein Graft Aneurysms: A Systematic Review of Published Cases

    Article • Circulation, October 2012, Wolters Kluwer Health

    Dr Ed O'Brien

  30. Reduction in Mortality as a Result of Direct Transport From the Field to a Receiving Center for Primary Percutaneous Coronary Intervention

    Article • Journal of the American College of Cardiology, October 2012, Elsevier

    Dr Michel Robert Le May, Dr Ed O'Brien

  31. Reply to: Cardiovascular Disease Risk in HIV Infection and Endothelial Progenitor Cells

    Article • The Journal of Infectious Diseases, August 2012, Oxford University Press (OUP)

    Dr Ed O'Brien

  32. Transradial Versus Transfemoral Artery Approach for Coronary Angiography and Percutaneous Coronary Intervention in the Extremely Obese

    Article • JACC Cardiovascular Interventions, August 2012, Elsevier

    Dr Michel Robert Le May, Dr Ed O'Brien

  33. Extracellular HSP27 acts as a signaling molecule to activate NF-κB in macrophages

    Article • Cell Stress and Chaperones, August 2012, Springer Science + Business Media

    Dr Ed O'Brien

  34. Infective Endocarditis Presenting as ST-Elevation Myocardial Infarction: An Angiographic Diagnosis

    Article • Canadian Journal of Cardiology, July 2012, Elsevier

    Dr Ed O'Brien

  35. Transbrachial insertion of an intra-aortic balloon pump for high-risk percutaneous coronary intervention

    Article • Clinical Research in Cardiology, May 2012, Springer Science + Business Media

    Dr Ed O'Brien

  36. RACER renal stents for large diameter left main coronary artery intervention

    Article • International Journal of Cardiology, May 2012, Elsevier

    Dr Ed O'Brien

  37. Circulating Endothelial Progenitor Cell Levels Are Not Reduced in HIV-Infected Men

    Article • The Journal of Infectious Diseases, January 2012, Oxford University Press (OUP)

    Dr Ed O'Brien

  38. Unprotected left main coronary artery stenting with zotarolimus (Endeavor) drug‐eluting stents

    Article • Catheterization and Cardiovascular Interventions, January 2012, Wiley

    Dr Michel Robert Le May, Dr Ed O'Brien

  39. Attenuation of Atherogenesis via the Anti-inflammatory Effects of the Selective Estrogen Receptor Beta Modulator 8β-VE2

    Article • Journal of Cardiovascular Pharmacology, October 2011, Wolters Kluwer Health

    Dr Ed O'Brien

  40. Endothelial Progenitors and Repair of Cardiovascular Disease

    Article • September 2011, Springer Science + Business Media

    Dr Ed O'Brien

  41. Coronary stent fracture

    Article • Canadian Medical Association Journal, March 2011, Canadian Medical Association (CMA)

    Dr Ed O'Brien

  42. Pre-Procedural Atorvastatin Mobilizes Endothelial Progenitor Cells: Clues to the Salutary Effects of Statins on Healing of Stented Human Arteries

    Article • PLoS ONE, January 2011, PLOS

    Dr Ed O'Brien

  43. Usefulness of Mean Platelet Volume as a Biomarker for Long-Term Outcomes After Percutaneous Coronary Intervention

    Article • The American Journal of Cardiology, January 2011, Elsevier

    Dr Michel Robert Le May, Dr Ed O'Brien

  44. Gene Dosage of the Common Variant 9p21 Predicts Severity of Coronary Artery Disease

    Article • Journal of the American College of Cardiology, August 2010, Elsevier

    Dr Ed O'Brien

  45. Delayed re-endothelialization with rapamycin-coated stents is rescued by the addition of a glycogen synthase kinase-3β inhibitor

    Article • Cardiovascular Research, February 2010, European Society of Cardiology

    Dr Ed O'Brien

  46. Heat Shock Protein 27: Clue to Understanding Estrogen-Mediated Atheroprotection?

    Article • Trends in Cardiovascular Medicine, February 2010, Elsevier

    Dr Ed O'Brien

  47. Heat Shock Protein 27 Protects Against Atherogenesis via an Estrogen-Dependent Mechanism: Role of Selective Estrogen Receptor Beta Modulation

    Article • Arteriosclerosis Thrombosis and Vascular Biology, September 2009, Wolters Kluwer Health

    Dr Ed O'Brien

  48. Primary Percutaneous Coronary Angioplasty With and Without Eptifibatide in ST-Segment Elevation Myocardial Infarction: A Safety and Efficacy Study of Integrilin-Facilitated Versus Primary Percutaneous Coronary Intervention in ST-Segment Elevation Myoca...

    Article • Circulation Cardiovascular Interventions, August 2009, Wolters Kluwer Health

    Dr Ed O'Brien

  49. Inhibition of endothelial progenitor cell glycogen synthase kinase-3β results in attenuated neointima formation and enhanced re-endothelialization after arterial injury

    Article • Cardiovascular Research, July 2009, European Society of Cardiology

    Dr Ed O'Brien

  50. Extracellular Release of the Atheroprotective Heat Shock Protein 27 Is Mediated by Estrogen and Competitively Inhibits acLDL Binding to Scavenger Receptor-A

    Article • Circulation Research, July 2008, Wolters Kluwer Health

    Dr Ed O'Brien

  51. Letter by Hibbert et al Regarding Article, "Smooth Muscle Cells Healing Atherosclerotic Plaque Disruptions Are of Local, Not Blood, Origin in Apolipoprotein E Knockout Mice"

    Article • Circulation, March 2008, Wolters Kluwer Health

    Dr Ed O'Brien

  52. Contribution of Recipient-Derived Cells in Allograft Neointima Formation and the Response to Stent Implantation

    Article • PLoS ONE, March 2008, PLOS

    Dr Ed O'Brien

  53. A Citywide Protocol for Primary PCI in ST-Segment Elevation Myocardial Infarction

    Article • New England Journal of Medicine, January 2008, New England Journal of Medicine (NEJM/MMS)

    Dr Michel Robert Le May, Dr Ed O'Brien

  54. Discovery of NM23-H2 as an estrogen receptor β-associated protein: Role in estrogen-induced gene transcription and cell migration

    Article • The Journal of Steroid Biochemistry and Molecular Biology, January 2008, Elsevier

    Dr Ed O'Brien

  55. The interaction and cellular localization of HSP27 and ERβ are modulated by 17β-estradiol and HSP27 phosphorylation

    Article • Molecular and Cellular Endocrinology, May 2007, Elsevier

    Dr Ed O'Brien

  56. Comparison of Early Mortality of Paramedic-Diagnosed ST-Segment Elevation Myocardial Infarction With Immediate Transport to a Designated Primary Percutaneous Coronary Intervention Center to That of Similar Patients Transported to the Nearest Hospital

    Article • The American Journal of Cardiology, November 2006, Elsevier

    Dr Michel Robert Le May, Dr Ed O'Brien

  57. NM23-H2, an estrogen receptor beta-associated protein, shows diminished expression with progression of atherosclerosis

    Article • AJP Regulatory Integrative and Comparative Physiology, September 2006, American Physiological Society

    Dr Ed O'Brien

  58. Comparison of Processing and Sectioning Methodologies for Arteries Containing Metallic Stents

    Article • Journal of Histochemistry & Cytochemistry, June 2006, SAGE Publications

    Dr Ed O'Brien

  59. Regulation of components of the brain and cardiac renin-angiotensin systems by 17beta-estradiol after myocardial infarction in female rats

    Article • AJP Regulatory Integrative and Comparative Physiology, February 2006, American Physiological Society

    Dr Ed O'Brien

  60. Combined Angioplasty and Pharmacological Intervention Versus Thrombolysis Alone in Acute Myocardial Infarction (CAPITAL AMI Study)

    Article • Journal of the American College of Cardiology, August 2005, Elsevier

    Dr Michel Robert Le May, Dr Ed O'Brien

  61. Novel Antiinflammatory Vascular Benefits of Systemic and Stent-Based Delivery of Ethylisopropylamiloride

    Article • Circulation, December 2004, Wolters Kluwer Health

    Dr Ed O'Brien

  62. 17 -Estradiol downregulates tissue angiotensin-converting enzyme and ANG II type 1 receptor in female rats

    Article • AJP Regulatory Integrative and Comparative Physiology, November 2004, American Physiological Society

    Dr Ed O'Brien

  63. c-kit-Immunopositive vascular progenitor cells populate human coronary in-stent restenosis but not primary atherosclerotic lesions

    Article • AJP Heart and Circulatory Physiology, August 2004, American Physiological Society

    Dr Ed O'Brien

  64. Novel anti-inflammatory properties of the Na+/H+ exchange inhibitor ethylisopropylamiloride result in attenuation of atherogenesis in apolipoprotein E-deficient mice

    Article • International Congress Series, May 2004, Elsevier

    Dr Ed O'Brien

  65. Antagonism of the  4 integrin subunit attenuates the acute inflammatory response to stent implantation yet is insufficient to prevent late intimal formation

    Article • Journal of Leukocyte Biology, March 2004, Society for Leukocyte Biology

    Dr Ed O'Brien

  66. Current Understanding of In-stent Restenosis and the Potential Benefit of Drug Eluting Stents

    Article • Current Drug Targets - Cardiovascular & Hematological Disorders, March 2004, Bentham Science Publishers

    Dr Ed O'Brien

  67. Hospitalization Costs of Primary Stenting Versus Thrombolysis in Acute Myocardial Infarction: Cost Analysis of the Canadian STAT Study

    Article • Circulation, November 2003, Wolters Kluwer Health

    Dr Ed O'Brien

  68. Involvement of Progenitor Cells in Vascular Repair

    Article • Trends in Cardiovascular Medicine, November 2003, Elsevier

    Dr Ed O'Brien

  69. Human in-stent restenosis tissue obtained by means of coronary atherectomy consists of an abundant proteoglycan matrix with a paucity of cell proliferation

    Article • American Heart Journal, October 2002, Elsevier

    Dr Ed O'Brien

  70. Evaluation of myocardial perfusion using rubidium-82 positron emission tomography after myocardial infarction in patients receiving primary stent implantation or thrombolytic therapy

    Article • The American Journal of Cardiology, October 2001, Elsevier

    Dr Michel Robert Le May, Dr Ed O'Brien

  71. Stenting versus thrombolysis in acute myocardial infarction trial (STAT)

    Article • Journal of the American College of Cardiology, March 2001, Elsevier

    Dr Michel Robert Le May, Dr Ed O'Brien

  72. Abundance of Plaque Microvessels is Associated With Constrictive Remodeling in Angioplastied Human Coronary Arteries

    Article • Japanese Circulation Journal, January 2001, Japanese Circulation Society

    Dr Ed O'Brien

  73. Replication in restenotic atherectomy tissue

    Article • Atherosclerosis, September 2000, Elsevier

    Dr Ed O'Brien

  74. Establishing an approach for patients with recent coronary occlusion: Identification of viable myocardium

    Article • Journal of Nuclear Cardiology, May 1999, Springer Science + Business Media

    Dr Ed O'Brien

  75. Predictors of long-term outcome after stent implantation in a saphenous vein graft

    Article • The American Journal of Cardiology, March 1999, Elsevier

    Dr Michel Robert Le May, Dr Ed O'Brien

  76. Time course and importance of neoadventitial formation in arterial remodeling following balloon angioplasty of porcine coronary arteries

    Article • Cardiovascular Research, January 1999, European Society of Cardiology

    Dr Ed O'Brien

  77. Late clinical and angiographic follow-up after stenting in evolving and recent myocardial infarction

    Article • American Heart Journal, April 1998, Elsevier

    Dr Michel Robert Le May, Dr Ed O'Brien

  78. Arterial expression of the plasminogen activator system early after cardiac transplantation

    Article • Cardiovascular Research, August 1997, European Society of Cardiology

    Dr Ed O'Brien

  79. Arterial Wall Neovascularization

    Article • Japanese Circulation Journal, January 1997, Japanese Circulation Society

    Dr Ed O'Brien

  80. The importance of thrombus organization and stellate cell phenotype in collagen I gene expression in human, coronary atherosclerotic and restenotic lesions

    Article • Cardiovascular Research, September 1996, Oxford University Press (OUP)

    Dr Ed O'Brien

  81. Usefulness of Intracoronary Stenting in Acute Myocardial Infarction

    Article • The American Journal of Cardiology, July 1996, Elsevier

    Dr Ed O'Brien

  82. Detection of Chlamydia pneumoniae TWAR in Human Coronary Atherectomy Tissues

    Article • The Journal of Infectious Diseases, August 1995, Oxford University Press (OUP)

    Dr Ed O'Brien

  83. Update on the biology and clinical study of restenosis

    Article • Trends in Cardiovascular Medicine, July 1994, Elsevier

    Dr Ed O'Brien