All Stories

  1. Finding the needle in a haystack: Mapping antifungal drug resistance in fungal pathogen by genomic approaches
  2. Azole Resistance of Environmental and Clinical Aspergillus fumigatus Isolates from Switzerland
  3. Identification and Mode of Action of a Plant Natural Product Targeting Human Fungal Pathogens
  4. Upregulation of the Adhesin Gene EPA1 Mediated by PDR1 in Candida glabrata Leads to Enhanced Host Colonization
  5. Activity of Isavuconazole and Other Azoles against Candida Clinical Isolates and Yeast Model Systems with Known Azole Resistance Mechanisms
  6. Acquired Multidrug Antifungal Resistance in Candida lusitaniae during Therapy
  7. RNA Enrichment Method for Quantitative Transcriptional Analysis of Pathogens In Vivo Applied to the Fungus Candida albicans
  8. Novel role of a family of major facilitator transporters in biofilm development and virulence of Candida albicans
  9. Molecular Principles of Antifungal Drug Resistance
  10. Distinct Roles of Candida albicans Drug Resistance Transcription FactorsTAC1,MRR1, andUPC2in Virulence
  11. Identification and antifungal susceptibility of a large collection of yeast strains isolated in Tunisian hospitals
  12. Novel Macrocyclic Amidinoureas: Potent Non-Azole Antifungals Active against Wild-Type and Resistant Candida Species
  13. Molecular Mechanisms of Drug Resistance in Clinical Candida Species Isolated from Tunisian Hospitals
  14. Gain-of-Function Mutations inPDR1, a Regulator of Antifungal Drug Resistance in Candida glabrata, Control Adherence to Host Cells
  15. Fermentative 2‐carbon metabolism produces carcinogenic levels of acetaldehyde in Candida albicans
  16. Milbemycins: More than Efflux Inhibitors for Fungal Pathogens
  17. Characterization of a New Clinical Yeast Species, Candida tunisiensis sp. nov., Isolated from a Strain Collection from Tunisian Hospitals
  18. Detection of antifungal compounds using lc microfractionation and bioautography with a hypersusceptible strain of C. albicans0
  19. The Candida albicans plasma membrane protein Rch1p, a member of the vertebrate SLC10 carrier family, is a novel regulator of cytosolic Ca 2+ homoeostasis
  20. Identification and Functional Characterization of Rca1, a Transcription Factor Involved in both Antifungal Susceptibility and Host Response in Candida albicans
  21. Sensing of mammalian IL-17A regulates fungal adaptation and virulence
  22. Azole Resistance by Loss of Function of the Sterol Δ5,6-Desaturase Gene (ERG3) in Candida albicans Does Not Necessarily Decrease Virulence
  23. The bZIP Transcription Factor Rca1p Is a Central Regulator of a Novel CO2 Sensing Pathway in Yeast
  24. Farnesol-Induced Apoptosis in Candida albicans Is Mediated by Cdr1-p Extrusion and Depletion of Intracellular Glutathione
  25. Three-dimensional models of 14α-sterol demethylase (Cyp51A) from Aspergillus lentulus and Aspergillus fumigatus: an insight into differences in voriconazole interaction
  26. In Vivo Systematic Analysis of Candida albicans Zn2-Cys6 Transcription Factors Mutants for Mice Organ Colonization
  27. In VitroEffect of Malachite Green on Candida albicans Involves Multiple Pathways and Transcriptional RegulatorsUPC2andSTP2
  28. ADH1 expression inversely correlates with CDR1 and CDR2 in Candida albicans from chronic oral candidosis in APECED (APS-I) patients
  29. The Quorum-Sensing Molecules Farnesol/Homoserine Lactone and Dodecanol Operate via Distinct Modes of Action in Candida albicans
  30. Diagnosis of Antifungal Drug Resistance Mechanisms in Fungal Pathogens: Transcriptional Gene Regulation
  31. Genome-wide expression profiling of the response to short-term exposure to fluconazole in Cryptococcus neoformans serotype A
  32. Probing the role of point mutations in the cyp 51A gene from Aspergillus fumigatus in the model yeast Saccharomyces cerevisiae
  33. Contribution of CgPDR1-Regulated Genes in Enhanced Virulence of Azole-Resistant Candida glabrata
  34. Loss of Mitochondrial Functions Associated with Azole Resistance in Candida glabrata Results in Enhanced Virulence in Mice
  35. Doxorubicin induces drug efflux pumps in Candida albicans
  36. Characterization of the Aspergillus nidulans biotin biosynthetic gene cluster and use of the bioDA gene as a new transformation marker
  37. Voriconazole-Induced Inhibition of the Fungicidal Activity of Amphotericin B inCandidaStrains with Reduced Susceptibility to Voriconazole: an Effect Not Predicted by the MIC Value Alone
  38. Overcoming the heterologous bias: An in vivo functional analysis of multidrug efflux transporter, CgCdr1p in matched pair clinical isolates of Candida glabrata
  39. Comparative Genomics Suggests that the Fungal Pathogen Pneumocystis Is an Obligate Parasite Scavenging Amino Acids from Its Host's Lungs
  40. Repercussion of a deficiency in mitochondrial ß-oxidation on the carbon flux of short-chain fatty acids to the peroxisomal ß-oxidation cycle in Aspergillus nidulans
  41. Resistance to Antifungal Drugs
  42. Ultra-Performance Liquid Chromatography Mass Spectrometry and Sensitive Bioassay Methods for Quantification of Posaconazole Plasma Concentrations after Oral Dosing
  43. Persistent Candida albicans colonization and molecular mechanisms of azole resistance in autoimmune polyendocrinopathy-candidiasis-ectodermal dystrophy (APECED) patients
  44. Novel Acid Phosphatase in Candida glabrata Suggests Selective Pressure and Niche Specialization in the Phosphate Signal Transduction Pathway
  45. Genetic Dissection of Azole Resistance Mechanisms in Candida albicans and Their Validation in a Mouse Model of Disseminated Infection
  46. PAP1 [poly(A) polymerase 1] homozygosity and hyperadenylation are major determinants of increased mRNA stability of CDR1 in azole-resistant clinical isolates of Candida albicans
  47. Antifungal drug resistance mechanisms in fungal pathogens from the perspective of transcriptional gene regulation
  48. MALDI‐TOF MS‐based drug susceptibility testing of pathogens: The example of Candida albicans and fluconazole
  49. Mechanisms of Multidrug Resistance in Fungal Pathogens
  50. Functional Analysis of cis- and trans-Acting Elements of the Candida albicans CDR2 Promoter with a Novel Promoter Reporter System
  51. Reliability of the Vitek 2 Yeast Susceptibility Test for Detection of In Vitro Resistance to Fluconazole and Voriconazole in Clinical Isolates of Candida albicans and Candida glabrata
  52. Gain of Function Mutations in CgPDR1 of Candida glabrata Not Only Mediate Antifungal Resistance but Also Enhance Virulence
  53. Divergent functions of three Candida albicans zinc-cluster transcription factors (CTA4, ASG1 and CTF1) complementing pleiotropic drug resistance in Saccharomyces cerevisiae
  54. The ATP‐binding cassette transporter–encoding gene CgSNQ2 is contributing to the CgPDR1‐dependent azole resistance of Candida glabrata
  55. Genotypic Evolution of Azole Resistance Mechanisms in Sequential Candida albicans Isolates
  56. Identification of promoter elements responsible for the regulation of MDR1 from Candida albicans, a major facilitator transporter involved in azole resistance
  57. Variability of Voriconazole Plasma Levels Measured by New High-Performance Liquid Chromatography and Bioassay Methods
  58. The CRH Family Coding for Cell Wall Glycosylphosphatidylinositol Proteins with a Predicted Transglycosidase Domain Affects Cell Wall Organization and Virulence of Candida albicans
  59. Overexpression of the MDR1 Gene Is Sufficient To Confer Increased Resistance to Toxic Compounds in Candida albicans
  60. Overexpression of the MDR1 Gene Is Sufficient To Confer Increased Resistance to Toxic Compounds in Candida albicans
  61. Roles of Cellular Respiration, CgCDR1, and CgCDR2 in Candida glabrata Resistance to Histatin 5
  62. CRZ1, a target of the calcineurin pathway in Candida albicans
  63. Candida yeast long chain fatty alcohol oxidase is a c-type haemoprotein and plays an important role in long chain fatty acid metabolism
  64. A Human-Curated Annotation of the Candida albicans Genome
  65. Reduced Azole Susceptibility in Genotype 3 Candida dubliniensis Isolates Associated with Increased CdCDR1 and CdCDR2 Expression
  66. Azole and fungicide resistance in clinical and environmental Aspergillus fumigatus isolates
  67. TAC1, Transcriptional Activator of CDR Genes, Is a New Transcription Factor Involved in the Regulation of Candida albicans ABC Transporters CDR1 and CDR2
  68. Comparison of Gene Expression Profiles of Candida albicans Azole-Resistant Clinical Isolates and Laboratory Strains Exposed to Drugs Inducing Multidrug Transporters
  69. Pneumocystis jiroveci Dihydropteroate Synthase Polymorphisms Confer Resistance to Sulfadoxine and Sulfanilamide in Saccharomyces cerevisiae
  70. Candida albicans Mutations in the Ergosterol Biosynthetic Pathway and Resistance to Several Antifungal Agents
  71. Molecular Mechanisms of Itraconazole Resistance in Candida dubliniensis
  72. Site‐Directed Mutagenesis of the Saccharomyces cerevisiae Dihydropteroate Synthase FOL1 Gene to Study Pneumocystis jirovecii Mutations in the Orthologue Gene FAS
  73. Resistance and tolerance mechanisms to antifungal drugs in fungal pathogens
  74. Calcineurin A of Candida albicans: involvement in antifungal tolerance, cell morphogenesis and virulence
  75. Fungicidal Synergism of Fluconazole and Cyclosporine in Candida albicans Is Not Dependent on Multidrug Efflux Transporters Encoded by the CDR1, CDR2, CaMDR1, and FLU1 Genes
  76. Identification and characterization of a Cryptococcus neoformans ATP binding cassette (ABC) transporter‐encoding gene, CnAFR1, involved in the resistance to fluconazole
  77. Resistance of human fungal pathogens to antifungal drugs
  78. Increased expression of a novel Aspergillus fumigatus ABC transporter gene, atrF, in the presence of itraconazole in an itraconazole resistant clinical isolate
  79. Analysis of Natural Variants of the Human Immunodeficiency Virus Type 1 gag-pol Frameshift Stem-Loop Structure
  80. Candida albicans Hyphal Formation and the Expression of the Efg1-Regulated Proteinases Sap4 to Sap6 Are Required for the Invasion of Parenchymal Organs
  81. Single-step extraction of fluconazole from plasma by ultra-filtration for the measurement of its free concentration by high performance liquid chromatography
  82. A common drug‐responsive element mediates the upregulation of the Candida albicans ABC transporters CDR1 and CDR2, two genes involved in antifungal drug resistance
  83. Resistance of Candida species to antifungal agents: molecular mechanisms and clinical consequences
  84. Clinical relevance of mechanisms of antifungal drug resistance in yeasts
  85. Prevalence of Molecular Mechanisms of Resistance to Azole Antifungal Agents in Candida albicans Strains Displaying High-Level Fluconazole Resistance Isolated from Human Immunodeficiency Virus-Infected Patients
  86. Role of ATP-Binding-Cassette Transporter Genes in High-Frequency Acquisition of Resistance to Azole Antifungals in Candida glabrata
  87. Sensitive Bioassay for Determination of Fluconazole Concentrations in Plasma Using a Candida albicans Mutant Hypersusceptible to Azoles
  88. Secreted Aspartic Proteinase Family ofCandida tropicalis
  89. Fluconazole plus Cyclosporine: a Fungicidal Combination Effective against Experimental Endocarditis Due to Candida albicans
  90. Potent Synergism of the Combination of Fluconazole and Cyclosporine in Candida albicans
  91. Experimental Induction of Fluconazole Resistance in Candida tropicalis ATCC 750
  92. Analysis of the oxidative stress regulation of the Candida albicans transcription factor, Cap1p
  93. Evolution of Drug Resistance in Experimental Populations of Candida albicans
  94. Protein kinase A encoded by TPK2 regulates dimorphism of Candida albicans
  95. HIV-Protease Inhibitors Reduce Cell Adherence of Candida Albicans Strains by Inhibition of Yeast Secreted Aspartic Proteases
  96. Production Of Alkanedioic Acids By Cytochrome P450Bm-3Monooxygenase: Oxidation Of 16-Hydroxyhexadecanoic Acid To Hexadecane-1, 16-Dioic Acid
  97. Evidence that Members of the Secretory Aspartyl Proteinase Gene Family, in Particular SAP2, Are Virulence Factors for Candida Vaginitis
  98. Synergic effects of tactolimus and azole antifungal agents against azole-resistant Candida albican strains
  99. Forschungsbericht zum Dr.‐Manfred‐Plempel‐Stipendium
  100. Differential regulation of SAP8 and SAPS, which encode two new members of the secreted aspartic proteinase family in Candida albicans
  101. Production of chiral hydroxy long chain fatty acids by whole cell biocatalysis of pentadecanoic acid with an E. coli recombinant containing cytochrome P450BM-3 monooxygenase
  102. Welche Funktionen haben sechs verschiedene Gene für sekretorische Proteinasen von Candida albicans?
  103. The expression of the secreted aspartyl proteinases Sap4 to Sap6 from Candida albicans in murine macrophages
  104. Altered adherence in strains of Candida albicans harbouring null mutations in secreted aspartic proteinase genes
  105. Genetic Separation of FK506 Susceptibility and Drug Transport in the Yeast Pdr5 ATP-binding Cassette Multidrug Resistance Transporter
  106. Functional Aspects of Secreted Candida Proteinases
  107. Multiple resistance mechanisms to azole antifungals in yeast clinical isolates
  108. ChemInform Abstract: Inhibitors of Ergosterol Biosynthesis as Antifungal Agents
  109. Cloning of Candida albicans genes conferring resistance to azole antifungal agents: characterization of CDR2, a new multidrug ABC transporter gene
  110. Acid Proteinase Secreted by Candida Tropicalis: Functional Analysis of Preproregion Cleavages in C. Tropicalis and Saccharomyces Cerevisiae
  111. Mechanisms of resistance to azole antifungal agents in Candida albicans isolates from AIDS patients involve specific multidrug transporters
  112. Multiplicity of genes encoding secreted aspartic proteinases in Candida species
  113. Acid proteinase secreted by Candida tropicalis : virulence in mice of a proteinase negative mutant
  114. Probing the membrane topology of Candida tropicalis cytochrome P450
  115. Cloning and sequencing of two Candida parapsilosis genes encoding acid proteases
  116. Cytochrome P450 in Unicellular Organisms
  117. Identification and Characterization of Additional Members of the Cytochrome P450 Multigene Family CYP52 of Candida tropicalis
  118. Disruption of the gene encoding the secreted acid protease ( ACP ) in the yeast Candida tropicalis
  119. Optimization of Candida tropicalis cytochrome P450alk gene expression in Saccharomyces cerevisiae with continuous cultures
  120. Characterization of a second alkane-inducible cytochrome P450-encoding gene, CYP52A2, from Candida tropicalis
  121. Isolation and nucleotide sequence of the extracellular acid protease gene (ACP) from the yeast Candida tropicalis
  122. Purification and properties of an aryl‐alcohol dehydrogenase from the white‐rot fungus Phanerochaete chrysosporium
  123. Azole susceptibility and hyphal formation in a cytochrome P-450-deficient mutant of Candida albicans.
  124. Functional Expression of the Alkane-Inducible Monooxygenase System of the Yeast: Candida tropicalis IN Saccharomyces cerevisiae
  125. Heterogeneity within the alkane‐inducible cytochrome P450 gene family of the yeast Candida tropicalis
  126. Oxidation and Reduction in Lignin Biodegradation
  127. Characterization of the alkane-inducible cytochrome P450 (P450alk) gene from the yeast Candida tropicalis: identification of a new P450 gene family
  128. Controlled expression of heterologous cytochrome P450e cDNA in Saccharomyces cerevisiae. I. Construction and expression of a complete rat cytochrome P450e cDNA
  129. Characterization of a cytochrome P450 deficient mutant of Candidaalbicans
  130. Isolation of the Candida tropicalis gene for P450 lanosterol demethylase and its expression in Saccharomyces cerevisiae
  131. Isolation of the alkane inducible cytochrome P450 (P450alk) gene from the yeast Candida tropicalis
  132. The distinction of different types of cytochromes P-450 from the yeasts Candida tropicalis and Saccharomyces uvarum
  133. Role of extracellular ligninases in biodegradation of benzo(a)pyrene by Phanerochaete chrysosporium