All Stories

  1. eIF3 musketeers: loyal in health, rogue in disease, and redeemed by therapeutic targeting
  2. 5′ UTR-mediated retention of eIF3 on 80S ribosomes promotes co-translational folding of ER membrane proteins
  3. 5’UTR-mediated retention of eIF3 on 80S ribosomes promotes co-translational folding of ER membrane proteins
  4. eIF3 mRNA selectivity profiling reveals eIF3k as a cancer‐relevant regulator of ribosome content
  5. NDC80 status pinpoints mitotic kinase inhibitors as emerging therapeutic options in clear cell renal cell carcinoma
  6. Transcript capture and ultradeep long-read RNA sequencing (CAPLRseq) to diagnose HNPCC/Lynch syndrome
  7. Parallel in-depth analysis of repeat expansions in ataxia patients by long-read sequencing
  8. Metabolic targeting of cancer by a ubiquinone uncompetitive inhibitor of mitochondrial complex I
  9. Constitutional chromothripsis of the APC locus as a cause of genetic predisposition to colon cancer
  10. Sensory neuropathy due to RFC1 in a patient with ALS: more than a coincidence?
  11. Dual roles of HSP70 chaperone HSPA1 in quality control of nascent and newly synthesized proteins
  12. CSN7B defines a variant COP9 signalosome complex with distinct function in DNA damage response
  13. eIF3 Associates with 80S Ribosomes to Promote Translation Elongation, Mitochondrial Homeostasis, and Muscle Health
  14. eIF-Three to Tango: emerging functions of translation initiation factor eIF3 in protein synthesis and disease
  15. Cross Talk between eIF2α and eEF2 Phosphorylation Pathways Optimizes Translational Arrest in Response to Oxidative Stress
  16. Reducing Mcl-1 gene dosage induces dopaminergic neuronal loss and motor impairments in Park2 knockout mice
  17. Oxidized analogs of Di(1H-indol-3-yl)methyl-4-substituted benzenes are NR4A1-dependent UPR inducers with potent and safe anti-cancer activity
  18. Cullin 3-Based Ubiquitin Ligases as Master Regulators of Mammalian Cell Differentiation
  19. Trade-off and flexibility in the dynamic regulation of the cullin-RING ubiquitin ligase repertoire
  20. Schizosaccharomyces pombe Polysome Profile Analysis and RNA Purification
  21. Ubiquitylation‐dependent oligomerization regulates activity of Nedd4 ligases
  22. Quantitative Analysis of Human Pluripotency and Neural Specification by In-Depth (Phospho)Proteomic Profiling
  23. A Transcript-Specific eIF3 Complex Mediates Global Translational Control of Energy Metabolism
  24. Identification and characterization of a novel ISG15-ubiquitin mixed chain and its role in regulating protein homeostasis
  25. Is Reliance on Mitochondrial Respiration a “Chink in the Armor” of Therapy-Resistant Cancer?
  26. Systems analysis of the prostate tumor suppressor NKX3.1 supports roles in DNA repair and luminal cell differentiation
  27. CAND1 controls in vivo dynamics of the cullin 1-RING ubiquitin ligase repertoire
  28. Relative impact of 3- and 5-hydroxyl groups of cytosporone B on cancer cell viability
  29. Combined Total Proteomic and Phosphoproteomic Analysis of Human Pluripotent Stem Cells
  30. Skipping Cancer: Small Molecule Inhibitors of SKP2-Mediated p27 Degradation
  31. Translational Control of Cell Division by Elongator
  32. Regulation of transcriptome, translation, and proteome in response to environmental stress in fission yeast
  33. Synthetic biology approach to reconstituting the ubiquitylation cascade in bacteria
  34. Urm1 couples sulfur transfer to ubiquitin-like protein function in oxidative stress
  35. Chemical genetics approach to restoring p27Kip1 reveals novel compounds with antiproliferative activity in prostate cancer cells
  36. The eIF3 Interactome Reveals the Translasome, a Supercomplex Linking Protein Synthesis and Degradation Machineries
  37. F-Box-Directed CRL Complex Assembly and Regulation by the CSN and CAND1
  38. Destruction of RhoA CULtivates Actin
  39. Zcchc11-dependent uridylation of microRNA directs cytokine expression
  40. Comprehensive proteomic analysis of Schizosaccharomyces pombe by two-dimensional HPLC-tandem mass spectrometry
  41. Rfu1: Stimulus for the Ubiquitin Economy
  42. Inflamed Snail Speeds Metastasis
  43. Snail puts melanoma on the fast track
  44. Comparative proteomic and transcriptomic profiling of the fission yeast Schizosaccharomyces pombe
  45. CSN facilitates Cullin–RING ubiquitin ligase function by counteracting autocatalytic adapter instability
  46. The COP9 signalosome: an assembly and maintenance platform for cullin ubiquitin ligases?
  47. Dynamic Release of Cdc34 from SCF
  48. BTB/POZ Domain Proteins Are Putative Substrate Adaptors for Cullin 3 Ubiquitin Ligases
  49. Fission Yeast COP9/Signalosome Suppresses Cullin Activity through Recruitment of the Deubiquitylating Enzyme Ubp12p
  50. Promotion of NEDD8-CUL1 Conjugate Cleavage by COP9 Signalosome
  51. Budding yeast Cdc6p induces re-replication in fission yeast by inhibition of SCF Pop -mediated proteolysis
  52. F-box/WD-repeat proteins Pop1p and Sud1p/Pop2p form complexes that bind and direct the proteolysis of Cdc18p
  53. Tumor Necrosis Factor-  Contributes to Ischemia- and Reperfusion-Induced Endothelial Activation in Isolated Hearts
  54. Cell cycle: Oiling the gears of anaphase
  55. Disruption of Re-replication Control by Overexpression of Human ORC1 in Fission Yeast
  56. Variable pause positions of RNA polymerase II lie proximal to the c- myc promoter irrespective of transcriptional activity
  57. Role of c-myc in simian virus 40 large tumor antigen-induced DNA synthesis in quiescent 3T3-L1 mouse fibroblasts.
  58. Activation of Pausing RNA Polymerases by Nuclear Run-on Experiments
  59. Transcriptional and posttranscriptional regulation of human androgen receptor expression by androgen.
  60. Transcriptional regulation of prostate kallikrein-like genes by androgen
  61. Transcriptional down-regulation of c-myc in human prostate carcinoma cells by the synthetic androgen mibolerone
  62. Synthetic androgens suppress the transformed phenotype in the human prostate carcinoma cell line LNCaP