All Stories

  1. 5’UTR-mediated retention of eIF3 on 80S ribosomes promotes co-translational folding of ER membrane proteins
  2. eIF3 mRNA selectivity profiling reveals eIF3k as a cancer‐relevant regulator of ribosome content
  3. NDC80 status pinpoints mitotic kinase inhibitors as emerging therapeutic options in clear cell renal cell carcinoma
  4. Transcript capture and ultradeep long-read RNA sequencing (CAPLRseq) to diagnose HNPCC/Lynch syndrome
  5. Parallel in-depth analysis of repeat expansions in ataxia patients by long-read sequencing
  6. Metabolic targeting of cancer by a ubiquinone uncompetitive inhibitor of mitochondrial complex I
  7. Constitutional chromothripsis of the APC locus as a cause of genetic predisposition to colon cancer
  8. Sensory neuropathy due to RFC1 in a patient with ALS: more than a coincidence?
  9. Dual roles of HSP70 chaperone HSPA1 in quality control of nascent and newly synthesized proteins
  10. CSN7B defines a variant COP9 signalosome complex with distinct function in DNA damage response
  11. eIF3 Associates with 80S Ribosomes to Promote Translation Elongation, Mitochondrial Homeostasis, and Muscle Health
  12. eIF-Three to Tango: emerging functions of translation initiation factor eIF3 in protein synthesis and disease
  13. Cross Talk between eIF2α and eEF2 Phosphorylation Pathways Optimizes Translational Arrest in Response to Oxidative Stress
  14. Reducing Mcl-1 gene dosage induces dopaminergic neuronal loss and motor impairments in Park2 knockout mice
  15. Oxidized analogs of Di(1H-indol-3-yl)methyl-4-substituted benzenes are NR4A1-dependent UPR inducers with potent and safe anti-cancer activity
  16. Cullin 3-Based Ubiquitin Ligases as Master Regulators of Mammalian Cell Differentiation
  17. Trade-off and flexibility in the dynamic regulation of the cullin-RING ubiquitin ligase repertoire
  18. Schizosaccharomyces pombe Polysome Profile Analysis and RNA Purification
  19. Ubiquitylation‐dependent oligomerization regulates activity of Nedd4 ligases
  20. Quantitative Analysis of Human Pluripotency and Neural Specification by In-Depth (Phospho)Proteomic Profiling
  21. A Transcript-Specific eIF3 Complex Mediates Global Translational Control of Energy Metabolism
  22. Identification and characterization of a novel ISG15-ubiquitin mixed chain and its role in regulating protein homeostasis
  23. Is Reliance on Mitochondrial Respiration a “Chink in the Armor” of Therapy-Resistant Cancer?
  24. Systems analysis of the prostate tumor suppressor NKX3.1 supports roles in DNA repair and luminal cell differentiation
  25. CAND1 controls in vivo dynamics of the cullin 1-RING ubiquitin ligase repertoire
  26. Relative impact of 3- and 5-hydroxyl groups of cytosporone B on cancer cell viability
  27. Combined Total Proteomic and Phosphoproteomic Analysis of Human Pluripotent Stem Cells
  28. Skipping Cancer: Small Molecule Inhibitors of SKP2-Mediated p27 Degradation
  29. Translational Control of Cell Division by Elongator
  30. Regulation of transcriptome, translation, and proteome in response to environmental stress in fission yeast
  31. Synthetic biology approach to reconstituting the ubiquitylation cascade in bacteria
  32. Urm1 couples sulfur transfer to ubiquitin-like protein function in oxidative stress
  33. Chemical genetics approach to restoring p27Kip1 reveals novel compounds with antiproliferative activity in prostate cancer cells
  34. The eIF3 Interactome Reveals the Translasome, a Supercomplex Linking Protein Synthesis and Degradation Machineries
  35. F-Box-Directed CRL Complex Assembly and Regulation by the CSN and CAND1
  36. Destruction of RhoA CULtivates Actin
  37. Zcchc11-dependent uridylation of microRNA directs cytokine expression
  38. Comprehensive proteomic analysis of Schizosaccharomyces pombe by two-dimensional HPLC-tandem mass spectrometry
  39. Rfu1: Stimulus for the Ubiquitin Economy
  40. Inflamed Snail Speeds Metastasis
  41. Snail puts melanoma on the fast track
  42. Comparative proteomic and transcriptomic profiling of the fission yeast Schizosaccharomyces pombe
  43. CSN facilitates Cullin–RING ubiquitin ligase function by counteracting autocatalytic adapter instability
  44. The COP9 signalosome: an assembly and maintenance platform for cullin ubiquitin ligases?
  45. Dynamic Release of Cdc34 from SCF
  46. BTB/POZ Domain Proteins Are Putative Substrate Adaptors for Cullin 3 Ubiquitin Ligases
  47. Fission Yeast COP9/Signalosome Suppresses Cullin Activity through Recruitment of the Deubiquitylating Enzyme Ubp12p
  48. Promotion of NEDD8-CUL1 Conjugate Cleavage by COP9 Signalosome
  49. Budding yeast Cdc6p induces re-replication in fission yeast by inhibition of SCF Pop -mediated proteolysis
  50. F-box/WD-repeat proteins Pop1p and Sud1p/Pop2p form complexes that bind and direct the proteolysis of Cdc18p
  51. Tumor Necrosis Factor-  Contributes to Ischemia- and Reperfusion-Induced Endothelial Activation in Isolated Hearts
  52. Cell cycle: Oiling the gears of anaphase
  53. Disruption of Re-replication Control by Overexpression of Human ORC1 in Fission Yeast
  54. Variable pause positions of RNA polymerase II lie proximal to the c- myc promoter irrespective of transcriptional activity
  55. Role of c-myc in simian virus 40 large tumor antigen-induced DNA synthesis in quiescent 3T3-L1 mouse fibroblasts.
  56. Activation of Pausing RNA Polymerases by Nuclear Run-on Experiments
  57. Transcriptional and posttranscriptional regulation of human androgen receptor expression by androgen.
  58. Transcriptional regulation of prostate kallikrein-like genes by androgen
  59. Transcriptional down-regulation of c-myc in human prostate carcinoma cells by the synthetic androgen mibolerone
  60. Synthetic androgens suppress the transformed phenotype in the human prostate carcinoma cell line LNCaP