All Stories

  1. On the influence of solvent on the stereoselectivity of glycosylation reactions

    Article • Carbohydrate Research, January 2024, Elsevier

    Dennis M. Whitfield

  2. Reducing the Toxicity of Designer Aminoglycosides as Nonsense Mutation Readthrough Agents for Therapeutic Targets

    Article • ACS Medicinal Chemistry Letters, August 2021, American Chemical Society (ACS)

    Dennis M. Whitfield

  3. Proton Transfer and Hydrogen Bonding in Glycosylation Reactions

    Article • Journal of Carbohydrate Chemistry, March 2017, Taylor & Francis

    Dennis M. Whitfield

  4. Total Biosynthesis of Legionaminic Acid, a Bacterial Sialic Acid Analogue

    Article • Angewandte Chemie, August 2016, Wiley

    Dennis M. Whitfield

  5. General low-temperature reaction pathway from precursors to monomers before nucleation of compound semiconductor nanocrystals

    Article • Nature Communications, August 2016, Springer Science + Business Media

    Dennis M. Whitfield

  6. Insights into the Mechanistic Role of Diphenylphosphine Selenide, Diphenylphosphine, and Primary Amines in the Formation of CdSe Monomers

    Article • The Journal of Physical Chemistry A, February 2016, American Chemical Society (ACS)

    Dennis M. Whitfield

  7. Utilizing CMP-Sialic Acid Analogs to Unravel Neisseria gonorrhoeae Lipooligosaccharide-Mediated Complement Resistance and Design Novel Therapeutics

    Article • PLoS Pathogens, December 2015, PLOS

    Dennis M. Whitfield

  8. In a glycosylation reaction how does a hydroxylic nucleophile find the activated anomeric carbon?

    Article • Carbohydrate Research, February 2015, Elsevier

    Dennis M. Whitfield

  9. Mechanistic Study of the Role of Primary Amines in Precursor Conversions to Semiconductor Nanocrystals at Low Temperature

    Article • Angewandte Chemie, May 2014, Wiley

    Dennis M. Whitfield

  10. Mechanistic Study of the Role of Primary Amines in Precursor Conversions to Semiconductor Nanocrystals at Low Temperature

    Article • Angewandte Chemie, May 2014, Wiley

    Dennis M. Whitfield

  11. Low-Temperature Approach to Highly Emissive Copper Indium Sulfide Colloidal Nanocrystals and Their Bioimaging Applications

    Article • ACS Applied Materials & Interfaces, March 2013, American Chemical Society (ACS)

    Dennis M. Whitfield

  12. Complications of modeling glycosylation reactions: can the anomeric conformation of a donor determine the glycopyranosyl oxacarbenium ring conformation?

    Article • Carbohydrate Research, July 2012, Elsevier

    Dennis M. Whitfield

  13. Plausible transition states for glycosylation reactions

    Article • Carbohydrate Research, July 2012, Elsevier

    Dennis M. Whitfield

  14. Could Diastereoselectivity in the Presence of O-2 Chiral Nonparticipating Groups Be an Indicator of Glycopyranosyl Oxacarbenium Ions in Glycosylation Reactions?

    Article • The Journal of Organic Chemistry, April 2012, American Chemical Society (ACS)

    Dennis M. Whitfield

  15. Synthetic Archaeosome Vaccines Containing Triglycosylarchaeols Can Provide Additive and Long-Lasting Immune Responses That Are Enhanced by Archaetidylserine

    Article • Archaea, January 2012, Hindawi Publishing Corporation

    Dennis M. Whitfield

  16. Practical Applications of Computational Studies of the Glycosylation Reaction

    Article • January 2012, American Chemical Society (ACS)

    Dennis M. Whitfield

  17. 1-Methyl 1′-cyclopropylmethyl (MCPM) as an anomeric protecting group

    Article • Tetrahedron, August 2011, Elsevier

    Dennis M. Whitfield

  18. Single-Domain Antibody Bioconjugated Near-IR Quantum Dots for Targeted Cellular Imaging of Pancreatic Cancer

    Article • Journal of Nanoscience and Nanotechnology, May 2011, American Scientific Publishers

    Dennis M. Whitfield

  19. Isopranoid- and dipalmitoyl-aminophospholipid adjuvants impact differently on longevity of CTL immune responses

    Article • Journal of Liposome Research, February 2010, Taylor & Francis

    Dennis M. Whitfield

  20. Development of new glycosylation methodologies for the synthesis of archaeal-derived glycolipid adjuvants

    Article • Carbohydrate Research, January 2010, Elsevier

    Dennis M. Whitfield

  21. Structural and Functional Analysis of Campylobacter jejuni PseG

    Article • Journal of Biological Chemistry, July 2009, Elsevier

    Dennis M. Whitfield

  22. The CMP-legionaminic acid pathway in Campylobacter: Biosynthesis involving novel GDP-linked precursors

    Article • Glycobiology, March 2009, Oxford University Press (OUP)

    Dennis M. Whitfield

  23. Single-Sized CdSe Nanocrystals with Bandgap Photoemission via a Noninjection One-Pot Approach

    Article • The Journal of Physical Chemistry C, February 2009, American Chemical Society (ACS)

    Dennis M. Whitfield

  24. Chapter 4 Computational Studies of the Role of Glycopyranosyl Oxacarbenium Ions in Glycobiology and Glycochemistry

    Article • January 2009, Elsevier

    Dennis M. Whitfield

  25. Single-Domain Antibody Functionalized CdSe/ZnS Quantum Dots for Cellular Imaging of Cancer Cells

    Article • The Journal of Physical Chemistry C, December 2008, American Chemical Society (ACS)

    Dennis M. Whitfield

  26. Installation of Electron-Donating Protective Groups, a Strategy for Glycosylating Unreactive Thioglycosyl Acceptors using the Preactivation-Based Glycosylation Method

    Article • The Journal of Organic Chemistry, September 2008, American Chemical Society (ACS)

    Dr Xuefei Huang, Dennis M. Whitfield

  27. Synthesis of archaeal glycolipid adjuvants—what is the optimum number of sugars?

    Article • Carbohydrate Research, September 2008, Elsevier

    Dennis M. Whitfield

  28. Adjuvant potential of archaeal synthetic glycolipid mimetics critically depends on the glyco head group structure

    Article • Glycobiology, May 2008, Oxford University Press (OUP)

    Dennis M. Whitfield

  29. CMP‐Pseudaminic Acid is a Natural Potent Inhibitor of PseB, the First Enzyme of the Pseudaminic Acid Pathway in Campylobacter jejuni and Helicobacter pylori

    Article • ChemMedChem, January 2008, Wiley

    Dennis M. Whitfield

  30. O-2 Substituted pyranosyl oxacarbenium ions are C-2–O-2 2-fold rotors with a strong syn preference

    Article • Carbohydrate Research, December 2007, Elsevier

    Dennis M. Whitfield

  31. DFT studies of the ionization of alpha and beta glycopyranosyl donors

    Article • Carbohydrate Research, September 2007, Elsevier

    Dennis M. Whitfield

  32. DFT studies of the role of C-2–O-2 bond rotation in neighboring-group glycosylation reactions

    Article • Carbohydrate Research, July 2007, Elsevier

    Dennis M. Whitfield

  33. Targeted Metabolomics Analysis ofCampylobacter coliVC167 Reveals Legionaminic Acid Derivatives as Novel Flagellar Glycans

    Article • Journal of Biological Chemistry, March 2007, American Society for Biochemistry & Molecular Biology (ASBMB)

    Dennis M. Whitfield

  34. Investigations into the role of oxacarbenium ions in glycosylation reactions by ab initio molecular dynamics

    Article • Carbohydrate Research, December 2006, Elsevier

    Dennis M. Whitfield

  35. Identification of Labile UDP‐Ketosugars in Helicobacter pylori, Campylobacter jejuni and Pseudomonas aeruginosa: Key Metabolites used to make Glycan Virulence Factors

    Article • ChemBioChem, November 2006, Wiley

    Dennis M. Whitfield

  36. Stereoselective Glycosylations Using (R)‐ or (S)‐(Ethoxycarbonyl)benzyl Chiral Auxiliaries at C‐2 of Glycopyranosyl Donors

    Article • European Journal of Organic Chemistry, October 2006, Wiley

    Dennis M. Whitfield

  37. The HS:19 serostrain ofCampylobacter jejunihas a hyaluronic acid‐type capsular polysaccharide with a nonstoichiometric sorbose branch andO‐methyl phosphoramidate group

    Article • FEBS Journal, July 2006, Wiley

    Dennis M. Whitfield

  38. Practical Applications of Computational Studies of the Glycosylation Reaction

    Article • June 2006, American Chemical Society (ACS)

    Dennis M. Whitfield

  39. Functional Characterization of Dehydratase/Aminotransferase Pairs fromHelicobacterandCampylobacter

    Article • Journal of Biological Chemistry, November 2005, American Society for Biochemistry & Molecular Biology (ASBMB)

    Professor Warren Wakarchuk, Dennis M. Whitfield

  40. Conformational Pathways of Saturated Six-Membered Rings. A Static and Dynamical Density Functional Study

    Article • The Journal of Physical Chemistry A, August 2005, American Chemical Society (ACS)

    Dennis M. Whitfield

  41. The two-conformer hypothesis: 2,3,4,6-tetra-O-methyl-mannopyranosyl and -glucopyranosyl oxacarbenium ions

    Article • Carbohydrate Research, April 2005, Elsevier

    Dennis M. Whitfield

  42. Development of specific inhibitors for heparin-binding proteins based on the cobra cardiotoxin structure: an effective synthetic strategy for rationally modified heparin-like disaccharides and a trisaccharide

    Article • Carbohydrate Research, February 2005, Elsevier

    Dennis M. Whitfield

  43. A selective Sc(OTf)3-catalyzed trialkylsilyl ether to acetyl ester exchange reaction with β-l-idopyranoside and 3,4-O-isopropylidene-β-d-galactopyranoside derivatives

    Article • Carbohydrate Research, December 2004, Elsevier

    Dennis M. Whitfield

  44. Is acyl migration to the aglycon avoidable in 2-acyl assisted glycosylation reactions?

    Article • Canadian Journal of Chemistry, July 2004, Canadian Science Publishing

    Dennis M. Whitfield

  45. Characterization of the  -1,2-N-acetylglucosaminyltransferase of Neisseria gonorrhoeae, a key control point in lipooligosaccharride biosynthesis

    Article • Glycobiology, January 2004, Oxford University Press (OUP)

    Professor Warren Wakarchuk, Dennis M. Whitfield

  46. A short route to l-iduronic acid building blocks for the syntheses of heparin-like disaccharides

    Article • Tetrahedron Letters, October 2003, Elsevier

    Dennis M. Whitfield

  47. Simplifying Oligosaccharide Synthesis:  Efficient Synthesis of Lactosamine and Siaylated Lactosamine Oligosaccharide Donors

    Article • The Journal of Organic Chemistry, February 2003, American Chemical Society (ACS)

    Professor Warren Wakarchuk, Dennis M. Whitfield

  48. Can the stereochemical outcome of glycosylation reactions be controlled by the conformational preferences of the glycosyl donor?

    Article • Carbohydrate Research, April 2002, Elsevier

    Dennis M. Whitfield

  49. SYNTHESIS, NMR, AND CONFORMATIONAL STUDIES OF FUCOIDAN FRAGMENTS. III. EFFECT OF BENZOYL GROUP AT O-3 ON STEREOSELECTIVITY OF GLYCOSYLATION BY 3-O- AND 3,4-DI-O-BENZOYLATED 2-O-BENZYLFUCOSYL BROMIDES

    Article • Journal of Carbohydrate Chemistry, December 2001, Taylor & Francis

    Dennis M. Whitfield

  50. Chemoenzymatic Iterative Synthesis of Difficult Linkages of Oligosaccharides on Soluble Polymeric Supports

    Article • Organic Letters, October 2001, American Chemical Society (ACS)

    Professor Warren Wakarchuk, Dennis M. Whitfield

  51. 1-Methyl 1′-cyclopropylmethyl: an acid labile O-protecting group for polymer-supported oligosaccharide synthesis

    Article • Tetrahedron, July 2001, Elsevier

    Dennis M. Whitfield

  52. The Conformational Origin of the Barrier to the Formation of Neighboring Group Assistance in Glycosylation Reactions:  A Dynamical Density Functional Theory Study

    Article • Journal of the American Chemical Society, May 2001, American Chemical Society (ACS)

    Dennis M. Whitfield

  53. Immunostimulant oxidized β-glucan conjugates

    Article • International Immunopharmacology, March 2001, Elsevier

    Dennis M. Whitfield

  54. Quantitative description of six-membered ring conformations following the IUPAC conformational nomenclature

    Article • Tetrahedron, January 2001, Elsevier

    Dennis M. Whitfield

  55. Polymer-supported and chemoenzymatic synthesis of the Neisseria meningitidis pentasaccharide: a methodological comparison

    Article • Carbohydrate Research, August 2000, Elsevier

    Professor Warren Wakarchuk, Dennis M. Whitfield

  56. Polymer-Supported Synthesis of a Branched Trisaccharide of the Type IA Group B Streptococcus Capsular Polysaccharide: 3-Iodo-4-methoxybenzyl as a New O-Protecting Group

    Article • Tetrahedron, August 2000, Elsevier

    Dennis M. Whitfield

  57. Ready Access to Sialylated Oligosaccharide Donors

    Article • Organic Letters, March 2000, American Chemical Society (ACS)

    Professor Warren Wakarchuk, Dennis M. Whitfield

  58. Acyl Transfer as a Problematic Side Reaction in Polymer-Supported Oligosaccharide Synthesis

    Article • The Journal of Organic Chemistry, November 1999, American Chemical Society (ACS)

    Dennis M. Whitfield

  59. Synthesis of a disialylated hexasaccharide of Type VIII Group B Streptococcus capsular polysaccharide

    Article • Carbohydrate Research, June 1999, Elsevier

    Dennis M. Whitfield

  60. Exploring the Mechanism of Neighboring Group Assisted Glycosylation Reactions

    Article • Journal of the American Chemical Society, December 1998, American Chemical Society (ACS)

    Dennis M. Whitfield

  61. Beneficial participation of the polymer: Improvement in polymer-supported oligosaccharide synthesis

    Article • Tetrahedron Letters, August 1998, Elsevier

    Dennis M. Whitfield

  62. Simplifying Oligosaccharide Synthesis: Boronate Diesters as Cleavable Protecting Groups

    Article • Synlett, May 1998, Thieme Publishing Group

    Dennis M. Whitfield

  63. Polymer-supported tin carbohydrate chemistry

    Article • Glycoconjugate Journal, January 1998, Springer Science + Business Media

    Dennis M. Whitfield

  64. Orientations of carbohydrate substituents

    Article • Journal of Molecular Structure THEOCHEM, May 1997, Elsevier

    Dennis M. Whitfield

  65. Synthesis of a Single Repeat Unit of Type VIII Group BStreptococcusCapsular Polysaccharide1

    Article • Journal of Carbohydrate Chemistry, May 1997, Taylor & Francis

    Dennis M. Whitfield

  66. Binding properties of carbohydrate sulfamates based on ab initio 6–31 + G∗∗ calculations on N-methyl and N-ethyl sulfamate anions

    Article • Carbohydrate Research, June 1996, Elsevier

    Dennis M. Whitfield

  67. Glycosylation reactions ? present status future directions

    Article • Glycoconjugate Journal, February 1996, Springer Science + Business Media

    Dennis M. Whitfield

  68. Polymer-Supported Solution Synthesis of Oligosaccharides Using a Novel Versatile Linker for the Synthesis of D-Mannopentaose, a Structural Unit of D-Mannans of Pathogenic Yeasts

    Article • Journal of the American Chemical Society, February 1995, American Chemical Society (ACS)

    Dennis M. Whitfield

  69. Differential reactivity of carbohydrate hydroxyls in glycosylations. II. The likely role of intramolecular hydrogen bonding on glycosylation reactions. Galactosylation of nucleoside 5′-hydroxyls for the syntheses of novel potential anticancer agents

    Article • Canadian Journal of Chemistry, November 1994, Canadian Science Publishing

    Dennis M. Whitfield

  70. [10] Galactosylation of nucleosides at 5′-position of pentofuranoses

    Article • January 1994, Elsevier

    Dennis M. Whitfield

  71. [26] Polymer-supported solution synthesis of oligosaccharides

    Article • January 1994, Elsevier

    Dennis M. Whitfield

  72. Binding properties of carbohydrate O-sulfate esters based on ab initio 6-31 +G** calculations on methyl and ethyl sulfate anions

    Article • Journal of the American Chemical Society, October 1993, American Chemical Society (ACS)

    Dennis M. Whitfield

  73. Metal coordination to carbohydrates. Structures and function

    Article • Coordination Chemistry Reviews, January 1993, Elsevier

    Dennis M. Whitfield

  74. Silver Trifluoromethanesulfonate(Triflate) Activation of Trichloroacetimidates in Glycosylation Reactions

    Article • Journal of Carbohydrate Chemistry, January 1993, Taylor & Francis

    Dennis M. Whitfield

  75. Metathesis of oligosaccharides. Relative stabilities of activated and deactivated glycosides of polyethylene glycol.

    Article • Tetrahedron Letters, November 1992, Elsevier

    Dennis M. Whitfield

  76. Differential reactivity of carbohydrate hydroxyls in glycosylations. I. Intramolecular interaction of the 5′-hydroxyl group with the heteroaromatic base in a model compound of 2′-deoxycytidine

    Article • Canadian Journal of Chemistry, September 1992, Canadian Science Publishing

    Dennis M. Whitfield

  77. Heavy metal binding to heparin disaccharides. I. Iduronic acid is the main binding site

    Article • Biopolymers, June 1992, Wiley

    Dennis M. Whitfield

  78. Heavy metal binding to heparin disaccharides. II. First evidence for zinc chelation

    Article • Biopolymers, June 1992, Wiley

    Dennis M. Whitfield

  79. Characterization and cellular distribution of acidic peptide and oligosaccharide metal-binding compounds from kidneys

    Article • Biochemical Journal, February 1992, Portland Press Ltd.

    Dennis M. Whitfield

  80. Polymer-supported solution synthesis of oligosaccharides

    Article • Journal of the American Chemical Society, June 1991, American Chemical Society (ACS)

    Dennis M. Whitfield

  81. Diagnostic methods for the determination of iduronic acid in oligosaccharides

    Article • Analytical Biochemistry, May 1991, Elsevier

    Dennis M. Whitfield

  82. Metal binding to heparin monosaccharides: D-glucosamine-6-sulphate, D-glucuronic acid, and L-iduronic acid

    Article • Journal of Inorganic Biochemistry, February 1991, Elsevier

    Dennis M. Whitfield

  83. Synthesis of L-Iduronic Acid Derivatives: Crystal Structure of Methyl (Methyl 2,3,4-Tri-O-Acetyl-β-L-Idopyranosid)Uronate

    Article • Journal of Carbohydrate Chemistry, January 1991, Taylor & Francis

    Dennis M. Whitfield

  84. Interactions of a molybdenum(VI) oxo-cation with some uronic acids: A 1H- and 13C-nuclear magnetic resonance study

    Article • Journal of Inorganic Biochemistry, June 1990, Elsevier

    Dennis M. Whitfield

  85. Syntheses of model oligosaccharides of biological significance. X.•Syntheses and NMR and mass spectral analysis of trideuteriomethyl di-3,6-O-(4-O-β-D-galactopyranosyl-2-acetamido-2-deoxy-β-D-glucopyranosyl)-β-D...

    Article • Canadian Journal of Chemistry, June 1990, Canadian Science Publishing

    Dennis M. Whitfield

  86. Syntheses of model oligosaccharides of biological significance. 9. Syntheses of trideuteriomethyl di-3,6-O-(2-acetamido-2-deoxy-β-D-glucopyranosyl)-β-D-galactopyranoside: the I antigen branch-point trisaccharide and related...

    Article • Canadian Journal of Chemistry, April 1987, Canadian Science Publishing

    Dennis M. Whitfield

  87. Syntheses of Model Oligosaccharides of Biological Significance. VI. Glycosylation at C-3 of Galactose: A Synthesis of Trideuterio-Methyl 3-O-(-Acetamido-2-Deoxy-β-D-Glucopyranosyl)-β-D-Galactopyranoside

    Article • Journal of Carbohydrate Chemistry, September 1985, Taylor & Francis

    Dennis M. Whitfield

  88. Insoluble Promoters of O-Glycosylation Reaction: Thallium, Cobalt, and Cadmium Zeolites 4A and 13X

    Article • Synthetic Communications, June 1985, Taylor & Francis

    Dennis M. Whitfield

  89. Synthesis of lipophilic 18-crown-6 diacids for the membrane transport of alkaline-earth cations

    Article • The Journal of Organic Chemistry, March 1984, American Chemical Society (ACS)

    Dennis M. Whitfield

  90. Membrane transport. A proton-driven potassium ion pump

    Article • Journal of the Chemical Society Chemical Communications, January 1980, Royal Society of Chemistry

    Dennis M. Whitfield