All Stories

  1. Recent advances in understanding the regulation of metalloproteinases
  2. Identification of long non-coding RNAs expressed in knee and hip osteoarthritic cartilage
  3. The long non-coding RNAROCRcontributes to SOX9 expression and chondrogenic differentiation of human mesenchymal stem cells
  4. Serum snoRNAs as biomarkers for joint ageing and post traumatic osteoarthritis
  5. The first international workshop on the epigenetics of osteoarthritis
  6. Detecting new microRNAs in human osteoarthritic chondrocytes identifies miR-3085 as a human, chondrocyte-selective, microRNA
  7. The microRNA-29 family in cartilage homeostasis and osteoarthritis
  8. Methylation quantitative trait locus analysis of osteoarthritis links epigenetics with genetic risk
  9. Genome-Wide MicroRNA and Gene Analysis of Mesenchymal Stem Cell Chondrogenesis Identifies an Essential Role and Multiple Targets for miR-140-5p
  10. Differential DNA methylation and expression of inflammatory and zinc transporter genes defines subgroups of osteoarthritic hip patients
  11. Oxidative changes and signalling pathways are pivotal in initiating age-related changes in articular cartilage
  12. Characterization of the Cartilage DNA Methylome in Knee and Hip Osteoarthritis
  13. Glycogen Synthase Kinase 3 Inhibition Stimulates Human Cartilage Destruction and Exacerbates Murine Osteoarthritis
  14. A Negative Feedback Loop Mediated by STAT3 Limits Human Th17 Responses
  15. Protection against murine osteoarthritis by inhibition of the 26S proteasome and lysine-48 linked ubiquitination
  16. Epigenetic Mechanisms and Non-coding RNAs in Osteoarthritis
  17. Class I Histone Deacetylase Inhibition Modulates Metalloproteinase Expression and Blocks Cytokine-Induced Cartilage Degradation
  18. The Identification of Trans-acting Factors That Regulate the Expression of GDF5 via the Osteoarthritis Susceptibility SNP rs143383
  19. Matrix Metalloproteinase 13 Expression in Response to Double-Stranded RNA in Human Chondrocytes
  20. Editorial: More evidence for a role of CpG methylation in the pathogenesis of osteoarthritis
  21. Mitochondrial dysfunction in osteoarthritis is associated with down-regulation of superoxide dismutase 2
  22. Understanding CpG methylation in the context of osteoarthritis
  23. Identification of the pathogenic pathways in osteoarthritic hip cartilage: commonality and discord between hip and knee OA
  24. microRNA in Chondrogenesis, Cartilage and Osteoarthritis
  25. The expression and function of microRNAs in chondrogenesis and osteoarthritis
  26. Epigenetic mechanisms in cartilage and osteoarthritis: DNA methylation, histone modifications and microRNAs
  27. A CD4 T cell gene signature for early rheumatoid arthritis implicates interleukin 6-mediated STAT3 signalling, particularly in anti-citrullinated peptide antibody-negative disease
  28. cAMP response element-binding (CREB) recruitment following a specific CpG demethylation leads to the elevated expression of the matrix metalloproteinase 13 in human articular chondrocytes and osteoarthritis
  29. Leptin produced by joint white adipose tissue induces cartilage degradation via upregulation and activation of matrix metalloproteinases
  30. Expression of the osteoarthritis-associated gene GDF5 is modulated epigenetically by DNA methylation
  31. HDAC-mediated control of ERK- and PI3K-dependent TGF-β-induced extracellular matrix-regulating genes
  32. Lipophilic statins prevent matrix metalloproteinase-mediated cartilage collagen breakdown by inhibiting protein geranylgeranylation
  33. Lithium protects cartilage from cytokine-mediated degradation by reducing collagen-degrading MMP production via inhibition of the P38 mitogen-activated protein kinase pathway
  34. Superoxide dismutase downregulation in osteoarthritis progression and end-stage disease
  35. Differential Gene Expression Profiling of Metalloproteinases and Their Inhibitors
  36. MMP28gene expression is regulated by Sp1 transcription factor acetylation
  37. Matriptase is a novel initiator of cartilage matrix degradation in osteoarthritis
  38. Proteinases involved in matrix turnover during cartilage and bone breakdown
  39. Pattern recognition receptor expression is not impaired in patients with chronic mucocutanous candidiasis with or without autoimmune polyendocrinopathy candidiasis ectodermal dystrophy
  40. Synergistic Collagenase Expression and Cartilage Collagenolysis Are Phosphatidylinositol 3-Kinase/Akt Signaling-dependent
  41. Activation of p38 and JNK MAPK pathways abrogates requirement for new protein synthesis for phorbol ester mediated induction of select MMP and TIMP genes
  42. Differential Toll-like receptor-dependent collagenase expression in chondrocytes
  43. Acetylation in the regulation of metalloproteinase and tissue inhibitor of metalloproteinases gene expression
  44. Collagenase gene regulation by pro-inflammatory cytokines in cartilage
  45. Rac upregulates tissue inhibitor of metalloproteinase-1 expression by redox-dependent activation of extracellular signal-regulated kinase signaling
  46. Oncostatin M in combination with tumour necrosis factor   induces a chondrocyte membrane associated aggrecanase that is distinct from ADAMTS aggrecanase-1 or -2
  47. British Society for Matrix Biology Autumn Meeting 
Joint with the UK Tissue & Cell Engineering Society, University of Bristol, UK
  48. Differential effects of histone deacetylase inhibitors on phorbol ester- and TGF-β1 induced murine tissue inhibitor of metalloproteinases-1 gene expression
  49. Expression of metalloproteinases and inhibitors in the differentiation of P19CL6 cells into cardiac myocytes
  50. Expression profiling of metalloproteinases and their inhibitors in cartilage
  51. The Comparative Role of Activator Protein 1 and Smad Factors in the Regulation ofTimp-1andMMP-1Gene Expression by Transforming Growth Factor-β1
  52. An enhancer complex confers both high-level and cell-specific expression of the human type X collagen gene
  53. Characterization of a gene encoding a single-subunit bacteriophage-type RNA polymerase from maize which is alternatively spliced