All Stories

  1. Recent advances in understanding the regulation of metalloproteinases

    Article • F1000Research, February 2019, Faculty of 1000, Ltd.

    David Young

  2. Identification of long non-coding RNAs expressed in knee and hip osteoarthritic cartilage

    Article • Osteoarthritis and Cartilage, January 2019, Elsevier

    David Young

  3. The long non-coding RNAROCRcontributes to SOX9 expression and chondrogenic differentiation of human mesenchymal stem cells

    Article • Development, October 2017, The Company of Biologists

    David Young

  4. Serum snoRNAs as biomarkers for joint ageing and post traumatic osteoarthritis

    Article • Scientific Reports, March 2017, Springer Science + Business Media

    David Young

  5. The first international workshop on the epigenetics of osteoarthritis

    Article • Connective Tissue Research, March 2016, Taylor & Francis

    David Young

  6. Detecting new microRNAs in human osteoarthritic chondrocytes identifies miR-3085 as a human, chondrocyte-selective, microRNA

    Article • Osteoarthritis and Cartilage, March 2016, Elsevier

    David Young

  7. The microRNA-29 family in cartilage homeostasis and osteoarthritis

    Article • Journal of Molecular Medicine, December 2015, Springer Science + Business Media

    David Young

  8. Methylation quantitative trait locus analysis of osteoarthritis links epigenetics with genetic risk

    Article • Human Molecular Genetics, October 2015, Oxford University Press (OUP)

    David Young

  9. Genome-Wide MicroRNA and Gene Analysis of Mesenchymal Stem Cell Chondrogenesis Identifies an Essential Role and Multiple Targets for miR-140-5p

    Article • Stem Cells, July 2015, Wiley

    David Young

  10. Differential DNA methylation and expression of inflammatory and zinc transporter genes defines subgroups of osteoarthritic hip patients

    Article • Annals of the Rheumatic Diseases, April 2015, BMJ

    David Young

  11. Oxidative changes and signalling pathways are pivotal in initiating age-related changes in articular cartilage

    Article • Annals of the Rheumatic Diseases, December 2014, BMJ

    David Young

  12. Characterization of the Cartilage DNA Methylome in Knee and Hip Osteoarthritis

    Article • Arthritis & Rheumatology, August 2014, Wiley

    David Young

  13. Glycogen Synthase Kinase 3 Inhibition Stimulates Human Cartilage Destruction and Exacerbates Murine Osteoarthritis

    Article • Arthritis & Rheumatology, July 2014, Wiley

    David Young

  14. A Negative Feedback Loop Mediated by STAT3 Limits Human Th17 Responses

    Article • The Journal of Immunology, June 2014, The American Association of Immunologists

    David Young

  15. Protection against murine osteoarthritis by inhibition of the 26S proteasome and lysine-48 linked ubiquitination

    Article • Annals of the Rheumatic Diseases, April 2014, BMJ

    David Young

  16. Epigenetic Mechanisms and Non-coding RNAs in Osteoarthritis

    Article • Current Rheumatology Reports, July 2013, Springer Science + Business Media

    David Young

  17. Class I Histone Deacetylase Inhibition Modulates Metalloproteinase Expression and Blocks Cytokine-Induced Cartilage Degradation

    Article • Arthritis & Rheumatism, July 2013, Wiley

    David Young

  18. The Identification of Trans-acting Factors That Regulate the Expression of GDF5 via the Osteoarthritis Susceptibility SNP rs143383

    Article • PLoS Genetics, June 2013, PLOS

    David Young

  19. Matrix Metalloproteinase 13 Expression in Response to Double-Stranded RNA in Human Chondrocytes

    Article • Arthritis & Rheumatism, April 2013, Wiley

    David Young

  20. Editorial: More evidence for a role of CpG methylation in the pathogenesis of osteoarthritis

    Article • Arthritis & Rheumatism, February 2013, Wiley

    David Young

  21. Mitochondrial dysfunction in osteoarthritis is associated with down-regulation of superoxide dismutase 2

    Article • Arthritis & Rheumatism, January 2013, Wiley

    David Young

  22. Understanding CpG methylation in the context of osteoarthritis

    Article • Epigenomics, December 2012, Future Medicine

    David Young

  23. Identification of the pathogenic pathways in osteoarthritic hip cartilage: commonality and discord between hip and knee OA

    Article • Osteoarthritis and Cartilage, September 2012, Elsevier

    David Young

  24. microRNA in Chondrogenesis, Cartilage and Osteoarthritis

    Article • Current Rheumatology Reviews, July 2012, Bentham Science Publishers

    David Young

  25. The expression and function of microRNAs in chondrogenesis and osteoarthritis

    Article • Arthritis & Rheumatism, May 2012, Wiley

    David Young

  26. Epigenetic mechanisms in cartilage and osteoarthritis: DNA methylation, histone modifications and microRNAs

    Article • Osteoarthritis and Cartilage, May 2012, Elsevier

    David Young

  27. A CD4 T cell gene signature for early rheumatoid arthritis implicates interleukin 6-mediated STAT3 signalling, particularly in anti-citrullinated peptide antibody-negative disease

    Article • Annals of the Rheumatic Diseases, April 2012, BMJ

    David Young

  28. cAMP response element-binding (CREB) recruitment following a specific CpG demethylation leads to the elevated expression of the matrix metalloproteinase 13 in human articular chondrocytes and osteoarthritis

    Article • The FASEB Journal, April 2012, Federation of American Societies For Experimental Biology (FASEB)

    David Young

  29. Leptin produced by joint white adipose tissue induces cartilage degradation via upregulation and activation of matrix metalloproteinases

    Article • Annals of the Rheumatic Diseases, November 2011, BMJ

    David Young

  30. Expression of the osteoarthritis-associated gene GDF5 is modulated epigenetically by DNA methylation

    Article • Human Molecular Genetics, June 2011, Oxford University Press (OUP)

    David Young

  31. HDAC-mediated control of ERK- and PI3K-dependent TGF-β-induced extracellular matrix-regulating genes

    Article • Matrix Biology, September 2010, Elsevier

    David Young

  32. Lipophilic statins prevent matrix metalloproteinase-mediated cartilage collagen breakdown by inhibiting protein geranylgeranylation

    Article • Annals of the Rheumatic Diseases, August 2010, BMJ

    David Young

  33. Lithium protects cartilage from cytokine-mediated degradation by reducing collagen-degrading MMP production via inhibition of the P38 mitogen-activated protein kinase pathway

    Article • Rheumatology, July 2010, Oxford University Press (OUP)

    David Young

  34. Superoxide dismutase downregulation in osteoarthritis progression and end-stage disease

    Article • Annals of the Rheumatic Diseases, May 2010, BMJ

    David Young

  35. Differential Gene Expression Profiling of Metalloproteinases and Their Inhibitors

    Article • Spine, May 2010, Wolters Kluwer Health

    David Young

  36. MMP28gene expression is regulated by Sp1 transcription factor acetylation

    Article • Biochemical Journal, May 2010, Portland Press Ltd.

    David Young

  37. Matriptase is a novel initiator of cartilage matrix degradation in osteoarthritis

    Article • Arthritis & Rheumatism, March 2010, Wiley

    David Young

  38. Proteinases involved in matrix turnover during cartilage and bone breakdown

    Article • Cell and Tissue Research, November 2009, Springer Science + Business Media

    David Young

  39. Pattern recognition receptor expression is not impaired in patients with chronic mucocutanous candidiasis with or without autoimmune polyendocrinopathy candidiasis ectodermal dystrophy

    Article • Clinical & Experimental Immunology, April 2009, Wiley

    David Young, Dr Colin Gillespie

  40. Synergistic Collagenase Expression and Cartilage Collagenolysis Are Phosphatidylinositol 3-Kinase/Akt Signaling-dependent

    Article • Journal of Biological Chemistry, March 2008, American Society for Biochemistry & Molecular Biology (ASBMB)

    David Young

  41. Activation of p38 and JNK MAPK pathways abrogates requirement for new protein synthesis for phorbol ester mediated induction of select MMP and TIMP genes

    Article • Matrix Biology, March 2008, Elsevier

    David Young

  42. Differential Toll-like receptor-dependent collagenase expression in chondrocytes

    Article • Annals of the Rheumatic Diseases, February 2008, BMJ

    David Young

  43. Acetylation in the regulation of metalloproteinase and tissue inhibitor of metalloproteinases gene expression

    Article • Frontiers in Bioscience, January 2007, Frontiers in Bioscience

    David Young

  44. Collagenase gene regulation by pro-inflammatory cytokines in cartilage

    Article • Frontiers in Bioscience, January 2007, Frontiers in Bioscience

    David Young

  45. Rac upregulates tissue inhibitor of metalloproteinase-1 expression by redox-dependent activation of extracellular signal-regulated kinase signaling

    Article • FEBS Journal, September 2006, Wiley

    Dr Helmut Sies, David Young

  46. Article • Arthritis Research & Therapy, January 2006, Springer Science + Business Media

    David Young

  47. Article • Arthritis Research & Therapy, January 2006, Springer Science + Business Media

    David Young

  48. Oncostatin M in combination with tumour necrosis factor   induces a chondrocyte membrane associated aggrecanase that is distinct from ADAMTS aggrecanase-1 or -2

    Article • Annals of the Rheumatic Diseases, August 2005, BMJ

    David Young

  49. British Society for Matrix Biology Autumn Meeting 
Joint with the UK Tissue & Cell Engineering Society, University of Bristol, UK

    Article • International Journal of Experimental Pathology, May 2005, Wiley

    Jonathan Knowles, David Young, Dr Isaac LIU

  50. Differential effects of histone deacetylase inhibitors on phorbol ester- and TGF-β1 induced murine tissue inhibitor of metalloproteinases-1 gene expression

    Article • FEBS Journal, March 2005, Wiley

    David Young

  51. Expression of metalloproteinases and inhibitors in the differentiation of P19CL6 cells into cardiac myocytes

    Article • Biochemical and Biophysical Research Communications, September 2004, Elsevier

    David Young

  52. Expression profiling of metalloproteinases and their inhibitors in cartilage

    Article • Arthritis & Rheumatism, January 2004, Wiley

    David Young

  53. The Comparative Role of Activator Protein 1 and Smad Factors in the Regulation ofTimp-1andMMP-1Gene Expression by Transforming Growth Factor-β1

    Article • Journal of Biological Chemistry, January 2003, American Society for Biochemistry & Molecular Biology (ASBMB)

    David Young

  54. An enhancer complex confers both high-level and cell-specific expression of the human type X collagen gene

    Article • FEBS Letters, October 2002, Wiley

    David Young

  55. Characterization of a gene encoding a single-subunit bacteriophage-type RNA polymerase from maize which is alternatively spliced

    Article • MGG Molecular & General Genetics, October 1998, Springer Science + Business Media

    David Young