All Stories

  1. Maintaining a Healthy Gut: Antiviral Pathway Controls Inflammatory Disease by Balancing Gut Bacteria

    Article • eLife, August 2021, eLife

    David Levy

  2. Mitochondrial STAT3 regulates antioxidant gene expression through complex I‐derived NAD in triple negative breast cancer

    Article • Molecular Oncology, April 2021, Wiley

    David Levy

  3. STAT3 Inhibitor OPB-51602 Is Cytotoxic to Tumor Cells Through Inhibition of Complex I and ROS Induction

    Article • iScience, December 2020, Elsevier

    David Levy

  4. HDAC stimulates gene expression through BRD4 availability in response to IFN and in interferonopathies

    Article • The Journal of Experimental Medicine, November 2018, Rockefeller University Press

    David Levy

  5. Mitochondrial dysfunction induced by a SH2 domain-targeting STAT3 inhibitor leads to metabolic synthetic lethality in cancer cells

    Article • Proceedings of the National Academy of Sciences, June 2017, Proceedings of the National Academy of Sciences

    David Levy

  6. The kinase TBK1 functions in dendritic cells to regulate T cell homeostasis, autoimmunity, and antitumor immunity

    Article • The Journal of Experimental Medicine, March 2017, Rockefeller University Press

    David Levy

  7. Cytoplasmic, full length and novel cleaved variant, TBLR1 reduces apoptosis in prostate cancer under androgen deprivation

    Article • Oncotarget, April 2016, Impact Journals, LLC

    David Levy

  8. PKR Transduces MDA5-Dependent Signals for Type I IFN Induction

    Article • PLoS Pathogens, March 2016, PLOS

    David Levy

  9. Insertional Mutagenesis Identifies a STAT3/Arid1b/β-catenin Pathway Driving Neurofibroma Initiation

    Article • Cell Reports, March 2016, Elsevier

    David Levy

  10. ID: 263

    Article • Cytokine, November 2015, Elsevier

    Dr Suzanne D Turner, David Levy

  11. A Synthetic Lethal Interaction between Glutathione Synthesis and Mitochondrial Reactive Oxygen Species Provides a Tumor-Specific Vulnerability Dependent on STAT3

    Article • Molecular and Cellular Biology, August 2015, ASM Journals

    Dr Daniel J Gough, David Levy

  12. STAT3 regulated ARF expression suppresses prostate cancer metastasis

    Article • Nature Communications, July 2015, Nature

    Dr Suzanne D Turner, David Levy

  13. STAT3 supports experimental K-RasG12D–induced murine myeloproliferative neoplasms dependent on serine phosphorylation

    Article • Blood, October 2014, American Society of Hematology

    David Levy

  14. The MEK-ERK Pathway Is Necessary for Serine Phosphorylation of Mitochondrial STAT3 and Ras-Mediated Transformation

    Article • PLoS ONE, November 2013, PLOS

    David Levy

  15. 100

    Article • Cytokine, September 2013, Elsevier

    David Levy

  16. The Human RVB Complex Is Required for Efficient Transcription of Type I Interferon-Stimulated Genes

    Article • Molecular and Cellular Biology, July 2013, ASM Journals

    David Levy

  17. Chemokine Gene Silencing in Decidual Stromal Cells Limits T Cell Access to the Maternal-Fetal Interface

    Article • Science, June 2012, American Association for the Advancement of Science

    David Levy

  18. STATus Report on Tetramers

    Article • Immunity, April 2012, Elsevier

    David Levy

  19. Inhibition of pyrimidine synthesis reverses viral virulence factor-mediated block of mRNA nuclear export

    Article • The Journal of Cell Biology, February 2012, Rockefeller University Press

    David Levy

  20. Constitutive Type I Interferon Modulates Homeostatic Balance through Tonic Signaling

    Article • Immunity, February 2012, Elsevier

    David Levy

  21. STAT1-deficient mice spontaneously develop estrogen receptor α-positive luminal mammary carcinomas

    Article • January 2012, Springer Science + Business Media

    David Levy

  22. Contribution of a TANK-Binding Kinase 1-Interferon (IFN) Regulatory Factor 7 Pathway to IFN- -Induced Gene Expression

    Article • Molecular and Cellular Biology, January 2012, ASM Journals

    David Levy

  23. Comparative evolutionary genomics of the STAT family of transcription factors

    Article • JAK-STAT, January 2012, Taylor & Francis

    David Levy

  24. Induction and function of type I and III interferon in response to viral infection

    Article • Current Opinion in Virology, December 2011, Elsevier

    David Levy

  25. STAT3 Negatively Regulates Type I IFN-Mediated Antiviral Response

    Article • The Journal of Immunology, September 2011, The American Association of Immunologists

    David Levy

  26. TLR4 Engagement during TLR3-Induced Proinflammatory Signaling in Dendritic Cells Promotes IL-10–Mediated Suppression of Antitumor Immunity

    Article • Cancer Research, August 2011, American Association for Cancer Research (AACR)

    David Levy

  27. STAT3 Plays a Critical Role in KRAS-Induced Pancreatic Tumorigenesis

    Article • Cancer Research, July 2011, American Association for Cancer Research (AACR)

    David Levy

  28. Inhibition of Nonsense-Mediated RNA Decay by the Tumor Microenvironment Promotes Tumorigenesis

    Article • Molecular and Cellular Biology, July 2011, ASM Journals

    David Levy

  29. STAT3-dependent IL-21 production from T helper cells regulates hematopoietic progenitor cell homeostasis

    Article • Blood, June 2011, American Society of Hematology

    David Levy

  30. Spatiotemporal trafficking of HIV in human plasmacytoid dendritic cells defines a persistently IFN-α–producing and partially matured phenotype

    Article • Journal of Clinical Investigation, March 2011, American Society for Clinical Investigation

    David Levy

  31. Distinct Inflammatory Signals Have Physiologically Divergent Effects on Epigenetic Regulation of Foxp3 Expression and Treg Function

    Article • American Journal of Transplantation, February 2011, Elsevier

    David Levy

  32. The Transcription Factor STAT3 Is Required for T Helper 2 Cell Development

    Article • Immunity, January 2011, Elsevier

    David Levy

  33. A STAT3-mediated metabolic switch is involved in tumour transformation and STAT3 addiction

    Article • Aging, November 2010, Impact Journals, LLC

    David Levy

  34. A cryptic sensor for HIV-1 activates antiviral innate immunity in dendritic cells

    Article • Nature, September 2010, Springer Science + Business Media

    David Levy

  35. NF-κB-ISGF3 Transcription Factor Cooperation: Coincidence Detector or Memory Chip?

    Article • Immunity, July 2010, Elsevier

    David Levy

  36. Functional Crosstalk between Type I and II Interferon through the Regulated Expression of STAT1

    Article • PLoS Biology, April 2010, PLOS

    David Levy

  37. Analysis of Interleukin-21-Induced Prdm1 Gene Regulation Reveals Functional Cooperation of STAT3 and IRF4 Transcription Factors

    Article • Immunity, December 2009, Elsevier

    David Levy

  38. Identification of a Stat3-Dependent Transcription Regulatory Network Involved in Metastatic Progression

    Article • Cancer Research, August 2009, American Association for Cancer Research (AACR)

    David Levy

  39. Signal transducer and activator of transcription 4 limits the development of adaptive regulatory T cells

    Article • Immunology, August 2009, Wiley

    David Levy

  40. Knockdown of Stat3 activity in vivo prevents diabetic glomerulopathy

    Article • Kidney International, July 2009, Elsevier

    David Levy

  41. Mitochondrial STAT3 Supports Ras-Dependent Oncogenic Transformation

    Article • Science, June 2009, American Association for the Advancement of Science

    David Levy

  42. c-Maf Regulates IL-10 Expression during Th17 Polarization

    Article • The Journal of Immunology, May 2009, The American Association of Immunologists

    David Levy

  43. IL-21 Mediates Suppressive Effects via Its Induction of IL-10

    Article • The Journal of Immunology, March 2009, The American Association of Immunologists

    David Levy

  44. Ancrod for Acute Ischemic Stroke: A New Dosing Regimen Derived from Analysis of Prior Ancrod Stroke Studies

    Article • Journal of Stroke and Cerebrovascular Diseases, January 2009, Elsevier

    David Levy

  45. Nucleoporin Levels Regulate Cell Cycle Progression and Phase-Specific Gene Expression

    Article • Developmental Cell, November 2008, Elsevier

    David Levy

  46. IFNγ signaling—Does it mean JAK–STAT?

    Article • Cytokine & Growth Factor Reviews, October 2008, Elsevier

    David Levy

  47. Identification of a PTEN-regulated STAT3 brain tumor suppressor pathway

    Article • Genes & Development, February 2008, Cold Spring Harbor Laboratory Press

    David Levy

  48. STAT3 Signaling and the Hyper-IgE Syndrome

    Article • New England Journal of Medicine, October 2007, New England Journal of Medicine (NEJM/MMS)

    David Levy

  49. The Zinc Finger Antiviral Protein Acts Synergistically with an Interferon-Induced Factor for Maximal Activity against Alphaviruses

    Article • Journal of Virology, October 2007, ASM Journals

    David Levy

  50. Nuclear Receptor Coregulator (NRC): Mapping of the Dimerization Domain, Activation of p53 and STAT-2, and Identification of the Activation Domain AD2 Necessary for Nuclear Receptor Signaling

    Article • Molecular Endocrinology, August 2007, Endocrine Society

    David Levy

  51. JAK-STAT Signaling: From Interferons to Cytokines

    Article • Journal of Biological Chemistry, July 2007, Elsevier

    David Levy

  52. IL-6 programs TH-17 cell differentiation by promoting sequential engagement of the IL-21 and IL-23 pathways

    Article • Nature Immunology, June 2007, Springer Science + Business Media

    David Levy

  53. Inhibition of Interferon Regulatory Factor 7 (IRF7)-Mediated Interferon Signal Transduction by the Kaposi's Sarcoma-Associated Herpesvirus Viral IRF Homolog vIRF3

    Article • Journal of Virology, May 2007, ASM Journals

    David Levy

  54. Restricted tissue tropism and acquired resistance to Sindbis viral vector expression in the absence of innate and adaptive immunity

    Article • Gene Therapy, May 2007, Springer Science + Business Media

    David Levy

  55. Influenza virus targets the mRNA export machinery and the nuclear pore complex

    Article • Proceedings of the National Academy of Sciences, February 2007, Proceedings of the National Academy of Sciences

    David Levy

  56. The molecular basis of IL-21–mediated proliferation

    Article • Blood, January 2007, American Society of Hematology

    David Levy

  57. STAT3 positively regulates an early step in B-cell development

    Article • Blood, November 2006, American Society of Hematology

    David Levy

  58. Regulation of Stat3 transcriptional activity by the conserved LPMSP motif for OSM and IL-6 signaling

    Article • FEBS Letters, October 2006, Wiley

    David Levy

  59. C. elegansSTAT: evolution of a regulatory switch

    Article • The FASEB Journal, August 2006, Wiley

    David Levy

  60. Nuclear and cytoplasmic mRNA quantification by SYBR green based real-time RT-PCR

    Article • Methods, August 2006, Elsevier

    David Levy

  61. STAT3: A multifaceted oncogene

    Article • Proceedings of the National Academy of Sciences, July 2006, Proceedings of the National Academy of Sciences

    David Levy

  62. STAT1 acts as a tumor promoter for leukemia development

    Article • Cancer Cell, July 2006, Elsevier

    David Levy

  63. IL-6 signaling via the STAT3/SOCS3 pathway: Functional Analysis of the Conserved STAT3 N-domain

    Article • Molecular and Cellular Biochemistry, May 2006, Springer Science + Business Media

    David Levy

  64. Regulation of IRF7 through cell type-specific protein stability

    Article • Biochemical and Biophysical Research Communications, March 2006, Elsevier

    David Levy

  65. The Nucleoporin Nup96 Is Required for Proper Expression of Interferon-Regulated Proteins and Functions

    Article • Immunity, March 2006, Elsevier

    David Levy

  66. Gr-1+CD115+ Immature Myeloid Suppressor Cells Mediate the Development of Tumor-Induced T Regulatory Cells and T-Cell Anergy in Tumor-Bearing Host

    Article • Cancer Research, January 2006, American Association for Cancer Research (AACR)

    David Levy

  67. C. elegans STAT Cooperates with DAF-7/TGF-β Signaling to Repress Dauer Formation

    Article • Current Biology, January 2006, Elsevier

    David Levy

  68. Interleukin-10 Induces Inhibitory C/EBPβ through STAT-3 and Represses HIV-1 Transcription in Macrophages

    Article • American Journal of Respiratory Cell and Molecular Biology, October 2005, American Thoracic Society

    David Levy

  69. New and Old Functions of STAT3: A Pivitol Target for Individualized Treatment of Cancer

    Article • Cell Cycle, June 2005, Taylor & Francis

    David Levy

  70. Regulatory Serine Residues Mediate Phosphorylation-dependent and Phosphorylation-independent Activation of Interferon Regulatory Factor 7

    Article • Journal of Biological Chemistry, May 2005, Elsevier

    David Levy

  71. Reduced STAT3 activity in mice mimics clinical disease syndromes

    Article • Biochemical and Biophysical Research Communications, April 2005, Elsevier

    David Levy

  72. Stat Acetylation--A Key Facet of Cytokine Signaling?

    Article • Science, January 2005, American Association for the Advancement of Science

    David Levy

  73. Activation of Mitogen-activated Protein Kinase Kinase (MKK) 3 and MKK6 by Type I Interferons

    Article • Journal of Biological Chemistry, January 2005, American Society for Biochemistry & Molecular Biology (ASBMB)

    Matthias Gaestel, David Levy

  74. Art and the Brain: The Influence of Art on Roger Shepard’s Studies of Mental Rotation

    Article • Journal of the History of the Neurosciences, March 2004, Taylor & Francis

    David Levy

  75. Role of p38  Map Kinase in Type I Interferon Signaling

    Article • Journal of Biological Chemistry, October 2003, American Society for Biochemistry & Molecular Biology (ASBMB)

    Matthias Gaestel, David Levy

  76. Central role for type I interferons and Tyk2 in lipopolysaccharide-induced endotoxin shock

    Article • Nature Immunology, April 2003, Springer Science + Business Media

    Professor Manuela Baccarini, David Levy

  77. Deletion of Stat3 Blocks Mammary Gland Involution and Extends Functional Competence of the Secretory Epithelium in the Absence of Lactogenic Stimuli

    Article • Endocrinology, September 2002, Endocrine Society

    David Levy

  78. STATs: transcriptional control and biological impact

    Article • Nature Reviews Molecular Cell Biology, September 2002, Springer Science + Business Media

    David Levy

  79. A Kaposi's sarcoma-associated herpesviral protein inhibits virus-mediated induction of type I interferon by blocking IRF-7 phosphorylation and nuclear accumulation

    Article • Proceedings of the National Academy of Sciences, April 2002, Proceedings of the National Academy of Sciences

    David Levy

  80. Role of Nucleoporin Induction in Releasing an mRNA Nuclear Export Block

    Article • Science, February 2002, American Association for the Advancement of Science

    David Levy

  81. Anaplastic lymphoma kinase (ALK) activates Stat3 and protects hematopoietic cells from cell death

    Article • Oncogene, February 2002, Nature

    David Levy

  82. IFN-Stimulated transcription through a TBP-free acetyltransferase complex escapes viral shutoff

    Article • Nature Cell Biology, January 2002, Springer Science + Business Media

    David Levy

  83. Review: Enhancement and Diversification of IFN Induction by IRF-7-Mediated Positive Feedback

    Article • Journal of Interferon & Cytokine Research, January 2002, Mary Ann Liebert Inc

    David Levy

  84. Hepatitis C Virus Nonstructural 5A Protein Induces Interleukin-8, Leading to Partial Inhibition of the Interferon-Induced Antiviral Response

    Article • Journal of Virology, July 2001, ASM Journals

    David Levy

  85. IRF3 and IRF7 Phosphorylation in Virus-infected Cells Does Not Require Double-stranded RNA-dependent Protein Kinase R or IκB Kinase but Is Blocked by Vaccinia Virus E3L Protein

    Article • Journal of Biological Chemistry, March 2001, Elsevier

    David Levy

  86. Specificity of signaling by STAT1 depends on SH2 and C-terminal domains that regulate Ser727 phosphorylation, differentially affecting specific target gene expression

    Article • The EMBO Journal, January 2001, Wiley

    David Levy

  87. Divergent roles of STAT1 and STAT5 in malignancy as revealed by gene disruptions in mice

    Article • Oncogene, May 2000, Springer Science + Business Media

    David Levy

  88. Mechanism of STAT3 Activation by Insulin-like Growth Factor I Receptor

    Article • Journal of Biological Chemistry, May 2000, Elsevier

    David Levy

  89. Physiological significance of STAT proteins: investigations through gene disruption in vivo

    Article • Cellular and Molecular Life Sciences, October 1999, Springer Science + Business Media

    David Levy

  90. Differential viral induction of distinct interferon-alpha genes by positive feedback through interferon regulatory factor-7

    Article • The EMBO Journal, November 1998, Wiley

    David Levy

  91. Proto-oncogene PML controls genes devoted to MHC class I antigen presentation

    Article • Nature, November 1998, Springer Science + Business Media

    David Levy

  92. Analysis of Interferon-Regulated Proteins Binding the Interferon-α-Stimulated Response Element

    Article • Methods, July 1998, Elsevier

    David Levy

  93. Activation of the JAK-STAT signal transduction pathway by oncostatin-M cultured human and mouse osteoblastic cells.

    Article • Endocrinology, April 1996, Endocrine Society

    David Levy

  94. Interferon-induced nuclear signalling by Jak protein tyrosine kinases

    Article • Nature, December 1993, Springer Science + Business Media

    David Levy

  95. Differences in cerebral blood flow and glucose utilization in vegetative versus locked-in patients

    Article • Annals of Neurology, December 1987, Wiley

    David Levy