All Stories

  1. Design of a Chemical Probe for the Bromodomain and Plant Homeodomain Finger-Containing (BRPF) Family of Proteins

    Article • Journal of Medicinal Chemistry, August 2017, American Chemical Society (ACS)

    Dr David M Andrews, Prof Paul Brennan

  2. Progress towards a public chemogenomic set for protein kinases and a call for contributions

    Article • PLoS ONE, August 2017, PLOS

    Dr David M Andrews

  3. Design of a Biased Potent Small Molecule Inhibitor of the Bromodomain and PHD Finger-Containing (BRPF) Proteins Suitable for Cellular and in Vivo Studies

    Article • Journal of Medicinal Chemistry, January 2017, American Chemical Society (ACS)

    Dr David M Andrews

  4. The creation and characterisation of a National Compound Collection: the Royal Society of Chemistry pilot

    Article • Chemical Science, January 2016, Royal Society of Chemistry

    Dr David M Andrews, Professor Joseph Sweeney, Rich Kidd

  5. Optimization of a Novel Binding Motif to ( E )-3-(3,5-Difluoro-4-((1 R ,3 R )-2-(2-fluoro-2-methylpropyl)-3-methyl-2,3,4,9-tetrahydro-1 H -pyrido[3,4- b ]indol-1-yl)phenyl)acrylic Acid (AZD9496), a Potent and Orally Bioavailable Selective Estrogen Rec...

    Article • Journal of Medicinal Chemistry, October 2015, American Chemical Society (ACS)

    Dr David M Andrews

  6. Compound Passport Service: supporting corporate compound collection owners in open innovation

    Article • Drug Discovery Today, October 2015, Elsevier

    Dr David M Andrews

  7. PI4 Kinase Inhibitors

    Article • Bioorganic & Medicinal Chemistry Letters, August 2015, Elsevier

    Dr David M Andrews

  8. Collaborative Medicinal Chemistry

    Article • Drug Discovery Today, April 2014, Elsevier

    Dr David M Andrews

  9. Potent, selective small molecule inhibitors of type III phosphatidylinositol-4-kinase α- and β-

    Article • Chemical Communications, January 2014, Royal Society of Chemistry

    Dr David M Andrews, Dr Michael J Waring

  10. Discovery and development of the anticancer agent gefitinib, an inhibitor of the epidermal growth factor receptor tyrosine kinase

    Article • January 2013, Elsevier

    Dr David M Andrews

  11. Flexible and Scalable Route to HDAc Inhibitors Containing an Unusual Trisubstituted Pyridine Core

    Article • Organic Process Research & Development, June 2012, American Chemical Society (ACS)

    Dr David M Andrews

  12. Protein–Ligand Crystal Structures Can Guide the Design of Selective Inhibitors of the FGFR Tyrosine Kinase

    Article • Journal of Medicinal Chemistry, May 2012, American Chemical Society (ACS)

    Dr David M Andrews

  13. Small-molecule androgen receptor downregulators as an approach to treatment of advanced prostate cancer

    Article • Bioorganic & Medicinal Chemistry Letters, September 2011, Elsevier

    Dr David M Andrews

  14. Fischer synthesis of isomeric thienopyrrole LHRH antagonists

    Article • Tetrahedron, July 2009, Elsevier

    Dr David M Andrews

  15. Imidazole pyrimidine amides as potent, orally bioavailable cyclin-dependent kinase inhibitors

    Article • Bioorganic & Medicinal Chemistry Letters, December 2008, Elsevier

    Dr David M Andrews

  16. The discovery of AZD5597, a potent imidazole pyrimidine amide CDK inhibitor suitable for intravenous dosing

    Article • Bioorganic & Medicinal Chemistry Letters, December 2008, Elsevier

    Dr David M Andrews

  17. Imidazoles: SAR and development of a potent class of cyclin-dependent kinase inhibitors

    Article • Bioorganic & Medicinal Chemistry Letters, October 2008, Elsevier

    Dr David M Andrews

  18. Imidazole piperazines: SAR and development of a potent class of cyclin-dependent kinase inhibitors with a novel binding mode

    Article • Bioorganic & Medicinal Chemistry Letters, August 2008, Elsevier

    Dr David M Andrews

  19. Design and campaign synthesis of piperidine- and thiazole-based histone deacetylase inhibitors

    Article • Bioorganic & Medicinal Chemistry Letters, April 2008, Elsevier

    Dr David M Andrews

  20. Design and campaign synthesis of pyridine-based histone deacetylase inhibitors

    Article • Bioorganic & Medicinal Chemistry Letters, April 2008, Elsevier

    Dr David M Andrews

  21. Optimization of Novel Acyl Pyrrolidine Inhibitors of Hepatitis C Virus RNA-Dependent RNA Polymerase Leading to a Development Candidate

    Article • Journal of Medicinal Chemistry, February 2007, American Chemical Society (ACS)

    Dr David M Andrews

  22. Preparation of New N‐Heterocyclic Carbene Metal—Alkyne Complexes and Application to a Stereocontrolled Pauson—Khand Reaction.

    Article • ChemInform, January 2005, Wiley

    Dr David M Andrews

  23. Applications of the amino-Cope rearrangement: synthesis of tetrahydropyran, δ-lactone and piperidine targets

    Article • Organic & Biomolecular Chemistry, January 2005, Royal Society of Chemistry

    Dr David M Andrews, Dr Munira Essat

  24. Preparation of New N -Heterocyclic Carbene Metal-Alkyne Complexes and Application to a Stereocontrolled Pauson-Khand Reaction

    Article • Synlett, January 2004, Thieme Publishing Group

    Dr David M Andrews

  25. Pyrrolidine-5,5-trans-lactams. 4. Incorporation of a P3/P4 Urea Leads to Potent Intracellular Inhibitors of Hepatitis C Virus NS3/4A Protease

    Article • Organic Letters, November 2003, American Chemical Society (ACS)

    Dr David M Andrews

  26. Pyrrolidine-5,5-trans-lactams. 5. Pharmacokinetic Optimization of Inhibitors of Hepatitis C Virus NS3/4A Protease

    Article • Organic Letters, November 2003, American Chemical Society (ACS)

    Dr David M Andrews

  27. Design and Synthesis of Spiro‐cyclopentenyl and Spiro‐[1,3]‐dithiolanyl Substituted Pyrrolidine‐5,5‐trans‐lactams as Inhibitors of Hepatitis C Virus NS3/4A Protease.

    Article • ChemInform, August 2003, Wiley

    Dr David M Andrews

  28. Pyrrolidine-5,5- trans -lactams 3. Alternative RegiochemicalOutcome of the Acyl-Iminium Coupling Reaction.

    Article • Synthesis, August 2003, Thieme Publishing Group

    Dr David M Andrews

  29. Short and Versatile Route to a Key Intermediate for Lactacystin Synthesis.

    Article • ChemInform, May 2003, Wiley

    Dr David M Andrews

  30. Design and synthesis of spiro-cyclopentenyl and spiro--dithiolanyl substituted pyrrolidine-5,5-trans-lactams as inhibitors of hepatitis C virus NS3/4A protease

    Article • Bioorganic & Medicinal Chemistry Letters, May 2003, Elsevier

    Dr David M Andrews

  31. 1S‐(−)‐1,3‐Dithiane 1‐Oxide

    Article • April 2003, Wiley

    Dr David M Andrews

  32. The design of potent, non-peptidic inhibitors of hepatitis C protease

    Article • European Journal of Medicinal Chemistry, April 2003, Elsevier

    Dr David M Andrews

  33. Short and Versatile Route to a Key Intermediate for Lactacystin Synthesis

    Article • Organic Letters, January 2003, American Chemical Society (ACS)

    Dr David M Andrews

  34. Design and synthesis of ethyl pyrrolidine-5,5-trans-lactams as inhibitors of hepatitis C virus NS3/4A protease

    Article • Bioorganic & Medicinal Chemistry Letters, December 2002, Elsevier

    Dr David M Andrews

  35. Pyrrolidine-5,5-trans-lactams. 1. Synthesis and Incorporation into Inhibitors of Hepatitis C Virus NS3/4A Protease

    Article • Organic Letters, November 2002, American Chemical Society (ACS)

    Dr David M Andrews

  36. Pyrrolidine-5,5-trans-lactams. 2. The Use of X-ray Crystal Structure Data in the Optimization of P3 and P4 Substituents

    Article • Organic Letters, November 2002, American Chemical Society (ACS)

    Dr David M Andrews

  37. Synthesis and influenza virus sialidase inhibitory activity of analogues of 4-Guanidino-Neu5Ac2en (Zanamivir) modified in the glycerol side-chain

    Article • European Journal of Medicinal Chemistry, July 1999, Elsevier

    Dr David M Andrews

  38. 1S-(−)-1,3-DITHIANE 1-OXIDE

    Article • Organic Syntheses, January 1999, Organic Syntheses

    Dr David M Andrews

  39. Sulfur Oxidation Mediated by Imine Derivatives

    Article • Synlett, December 1997, Thieme Publishing Group

    Dr David M Andrews

  40. A Convenient Procedure for the Preparation of Camphorsulfonyl Oxaziridines

    Article • The Journal of Organic Chemistry, August 1997, American Chemical Society (ACS)

    Dr David M Andrews

  41. Asymmetric sulfoxidation using [(3,3-Dimethoxycamphoryl)sulfonyl]oxaziridine

    Article • Tetrahedron Asymmetry, December 1995, Elsevier

    Dr David M Andrews

  42. Potential mechanism-based tyrosine kinase inhibitors. Part 1. Phosphorylation chemistry of pyridine N-oxides

    Article • Journal of the Chemical Society Perkin Transactions 1, January 1995, Royal Society of Chemistry

    Dr David M Andrews

  43. Potential mechanism-based tyrosine kinase inhibitors. Part 2. Design and synthesis of peptides containing heterocyclic tyrosine analogues

    Article • Journal of the Chemical Society Perkin Transactions 1, January 1995, Royal Society of Chemistry

    Dr David M Andrews

  44. A new system for catalytic asymmetric oxidation of sulfides using a hydrogen peroxide based reagent

    Article • Tetrahedron Letters, December 1994, Elsevier

    Dr David M Andrews

  45. ChemInform Abstract: Synthesis of and Glycosidase Inhibition by α‐L‐ Homofuconojirimycin.

    Article • ChemInform, July 1994, Wiley

    Dr David M Andrews

  46. Synthesis of and glycosidase inhibition by α-l-homofuconojirimycin

    Article • Bioorganic & Medicinal Chemistry Letters, December 1993, Elsevier

    Dr David M Andrews

  47. Solid‐phase synthesis of O‐mannosylated peptides: two strategies compared

    Article • International journal of peptide & protein research, August 1993, Wiley

    Dr David M Andrews

  48. The solid-phase synthesis of O-mannosylated peptides: A comparison of two strategies

    Article • January 1993, Springer Science + Business Media

    Dr David M Andrews

  49. ChemInform Abstract: Solid‐Phase Synthesis of a Range of O‐Phosphorylated Peptides by Post‐ Assembly Phosphitylation and Oxidation.

    Article • ChemInform, March 1992, Wiley

    Dr David M Andrews

  50. Synthesis of a dinucleoside 3′-S-phosphorothiolate containing 2′-deoxy-3′-thioadenosine

    Article • Tetrahedron, March 1992, Elsevier

    Dr David M Andrews

  51. The solid-phase synthesis of a range of O-phosphorylated peptides by post-assembly phosphitylation and oxidation

    Article • January 1992, Springer Science + Business Media

    Dr David M Andrews

  52. Solid‐phase synthesis of a range of O‐phosphorylated peptides by post‐assembly phosphitylation and oxidation

    Article • International journal of peptide & protein research, November 1991, Wiley

    Dr David M Andrews